TWAS hub - KPNB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.2400	0.0970	0.0074	-0.003	NA	0.002	NA	0.006	0.40000	NA	0.27000	NA	0.21000
2	YFS	Blood	0.0110	0.0051	0.0021	0.009	0.004	0.008	0.005	0.009	0.00044	0.0110	0.00076	0.0085	0.00046
3	TCGA	Breast Invasive Carcinoma	0.0181	0.0109	0.0021	0.011	0.011	0.006	NA	0.009	0.00160	0.0017	0.01500	NA	0.00480

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
High cholesterol (Self-reported)	10.1	17.9	31.1	1.4	5.6	4.5
LDL Cholesterol	8.8	13.9	23.8	-0.4	4.9	4.2
Chest pain or discomfort	7.4	10.7	18.5	-0.3	4.3	3.7
Medication: Levothyroxine sodium	6.6	11.1	16.2	-1.7	-4.0	-3.8
Medication: Simvastatin	5.9	8.6	13.0	0.6	3.6	3.5
Medication: Atorvastatin	5.8	7.1	16.9	0.4	4.1	2.1
Mouth/teeth dental problems	5.6	8.6	13.9	2.6	-3.7	-2.3
Medication: Cholesterol lowering	5.1	7.9	14.9	1.3	3.9	2.6
Hypothyroidism/myxoedema (self-reported)	5.0	9.8	14.6	-1.5	-3.8	-3.6
Hypothyroidism (self reported)	4.9	11.1	20.5	-0.9	-4.5	-3.5
Angina	4.9	6.5	9.9	0.8	3.2	3.0
Age when periods started (menarche)	4.8	11.4	13.8	2.6	-3.7	-3.7
Ever had prostate specific antigen (PSA) test	4.8	5.5	9.4	-1.1	-3.1	-2.4
Mouth/teeth dental problems: Dentures	4.7	8.0	10.5	-2.6	3.2	2.6
Cholesterol lowering medication	4.7	6.9	10.0	0.8	3.2	3.2
Trunk fat mass	4.5	19.5	26.8	-5.2	-4.0	-4.0
Pulse wave Arterial Stiffness index	4.5	5.2	11.8	0.8	-3.4	-1.8
Body Mass Index (BMI) (2010)	4.4	6.1	10.3	-3.2	-2.1	-1.9
Breastfed as a baby	4.2	5.2	9.8	-0.7	-2.3	-3.1
Angina (self-reported)	4.2	5.6	8.7	0.9	3.0	2.7
Eye problems/disorders: Glaucoma	4.2	5.0	8.3	0.1	2.9	2.6
Friendships satisfaction	4.1	5.1	10.8	3.3	1.1	1.8
Trunk fat percentage	3.9	15.6	19.1	-4.4	-3.5	-3.9
Hip circumference	3.9	16.8	19.8	-4.4	-4.2	-3.6
Eye problems/disorders: None of the above	3.9	4.6	6.9	-1.0	-2.6	-2.4
Number of incorrect matches in round	3.8	6.4	11.0	0.4	-3.3	-2.8
Diabetes (self-reported)	3.8	5.9	8.5	1.5	2.6	2.9
Medication for cholesterol, blood pressure or diabetes	3.8	6.3	10.9	-1.2	-3.3	-2.5
Birth weight	3.8	8.2	15.6	-0.5	-4.0	-2.9
Medication for pain relief, constipation, heartburn	3.8	6.5	10.6	2.1	-3.3	-2.1
Whole body fat mass	3.8	15.9	28.2	-5.3	-3.2	-3.1
Depression (Nagel 2018)	3.7	5.6	9.7	1.5	-3.1	-2.3
Cardiovascular Disease	3.7	12.1	19.9	1.6	4.5	3.7
Hearing difficulty/problems: Yes	3.7	5.7	13.0	0.7	1.9	3.6
Glaucoma (self-reported)	3.7	4.4	7.3	0.3	2.7	2.4
Height	3.6	68.6	127.7	-0.9	-11.3	-8.8
Weight	3.6	17.9	29.8	-5.5	-3.7	-3.1
Pulse wave peak to peak time	3.6	4.3	10.1	-0.8	3.2	1.5
Systolic Blood Pressure	3.5	17.7	46.1	6.8	2.0	1.7
Birth weight of first child	3.5	6.3	11.1	1.2	-3.3	-2.5
Ever smoked	3.5	6.2	9.4	-1.5	-3.1	-2.6
Risk taking	3.5	5.2	8.5	-1.7	-2.0	-2.9
Diabetes diagnosed by doctor	3.4	5.5	7.2	2.0	2.3	2.7
Chronic bronchitis/emphysema (father)	3.3	3.9	5.7	-2.4	-1.6	-1.8
Arm fat mass (right)	3.3	13.4	28.7	-5.4	-2.6	-2.2
Arm fat mass (left)	3.2	13.0	28.0	-5.3	-2.5	-2.2
Leg fat mass (left)	3.2	12.6	27.8	-5.3	-2.1	-2.4
Happiness	3.1	3.7	4.9	1.8	1.7	2.2
Body fat percentage	3.1	12.0	20.2	-4.5	-2.5	-3.1
Leg fat mass (right)	3.1	11.9	26.6	-5.2	-1.8	-2.4
Worry too long after embarrassment	3.0	5.0	9.1	0.7	2.3	3.0
Qualifications: NVQ or HND or HNC or equivalent	3.0	3.6	7.8	-0.5	2.8	1.6
Medication: Metformin	2.9	4.1	5.7	1.5	2.1	2.4
Past tobacco smoking	2.9	5.3	7.0	2.0	2.6	2.2
Father’s age at death	2.9	3.8	7.8	-0.3	-2.8	-1.9
Standing height	2.9	28.3	43.8	-1.9	-6.6	-6.1
Ovarian Cancer	2.8	3.7	10.6	-3.2	-0.4	-0.5
HDL Cholesterol	2.8	4.7	11.6	0.0	3.4	1.6
BMI	2.8	16.1	41.5	-6.4	-1.8	-1.9
Waist circumference	2.7	10.0	25.0	-5.0	-1.8	-1.3
Ever depressed for a whole week	2.6	3.2	5.7	0.2	2.4	1.9
Alzheimer’s Disease (including proxy)	2.5	3.7	7.7	-1.3	-2.8	-1.2
Alcohol usually taken with meals	2.5	4.0	6.7	-0.1	-2.6	-2.3
Number of live births	2.5	3.6	8.5	-2.9	1.1	1.0
Basal metabolic rate	2.5	13.7	24.8	-5.0	-3.3	-2.3
Arm predicted mass (left)	2.5	12.8	23.5	-4.8	-3.1	-2.3
Type 2 Diabetes (T2D) (2018)	2.4	4.4	5.9	2.4	1.4	2.4
Arm fat percentage (right)	2.4	9.5	19.1	-4.4	-2.0	-2.3
Leg fat percentage (right)	2.4	8.9	20.5	-4.5	-1.1	-2.2
Illnesses of father: Heart disease	2.4	3.3	5.1	-0.0	2.2	2.3
Leg fat percentage (left)	2.4	8.8	20.2	-4.5	-1.3	-2.1
Arm fat-free mass (left)	2.4	12.2	23.0	-4.8	-3.0	-2.2
Irritability	2.4	4.0	6.3	1.4	2.5	2.0
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.2	0.5	-1.6	-2.3
Arm fat percentage (left)	2.3	9.3	20.2	-4.5	-2.0	-2.0
Alcohol drinker status: Never	2.3	2.8	3.5	-1.6	-1.4	-1.9
Triglycerides	2.2	3.6	8.7	0.6	-3.0	-1.3
Smoking Status	2.2	5.4	6.9	-1.7	-2.5	-2.6
Systolic blood pressure, automated reading	2.2	6.5	15.0	3.9	1.4	1.6
Impedance of arm (right)	2.2	10.3	15.0	2.8	-2.8	-3.9
Forced vital capacity (FVC), Best measure	2.2	8.1	12.2	-0.1	-3.5	-3.5
Bipolar Disorder (2011)	2.1	2.1	3.9	0.5	2.0	1.4
Ulcerative Colitis	2.1	3.1	5.0	-0.7	-2.2	-2.0
Leg fat-free mass (left)	2.1	11.4	20.5	-4.5	-3.1	-2.0
Leg predicted mass (left)	2.1	11.2	21.2	-4.6	-3.0	-1.8
Medication: Lansoprazole	2.1	2.4	3.9	-1.8	0.3	2.0
Smoking status: Previous	2.1	3.1	4.9	-1.1	-2.2	-1.8
Whole body fat-free mass	2.1	11.8	21.7	-4.7	-3.2	-1.9
Whole body water mass	2.1	11.8	21.3	-4.6	-3.2	-1.9
Vascular/heart problems diagnosed by doctor	2.1	5.8	7.5	-2.0	-2.4	-2.7
Body mass index (BMI)	2.0	8.5	25.0	-5.0	-0.7	-0.4
Forced vital capacity (FVC)	2.0	7.7	11.4	-0.6	-3.4	-3.4
Trunk predicted mass	2.0	11.4	20.1	-4.5	-3.2	-2.0
Medication: Paracetamol	2.0	3.3	5.4	-0.3	2.3	2.1
Arm fat-free mass (right)	2.0	10.5	22.6	-4.8	-2.6	-1.5
Arm predicted mass (right)	2.0	10.2	22.2	-4.7	-2.5	-1.5
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.3	-0.9	-2.1	-1.5
Medication: Atenolol	1.9	2.4	4.0	0.8	1.6	2.0
Trunk fat-free mass	1.9	10.9	19.6	-4.4	-3.1	-1.9
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	6.0	-0.0	-2.4	-1.8
Number of full brothers	1.9	2.3	5.9	-0.5	2.4	0.9
Leg fat-free mass (right)	1.9	10.1	17.1	-4.1	-3.2	-1.7
Handedness (chirality/laterality): Left-handed	1.9	2.3	5.9	2.4	1.0	0.0
Ever had bowel cancer screening	1.9	2.3	4.0	-1.1	-1.3	-2.0
Leg predicted mass (right)	1.9	9.9	17.1	-4.1	-3.2	-1.6
Medication: Paracetamol	1.9	2.9	4.7	-0.2	2.2	2.0
Ulcerative Colitis (UC)	1.8	3.3	6.1	-0.2	-2.5	-2.0
Chronotype (morning person)	1.8	4.2	11.8	-3.4	-0.6	-0.6
High blood pressure	1.8	4.9	6.4	2.2	1.9	2.5
Impedance of arm (left)	1.8	8.3	11.1	2.7	-2.6	-3.3
Medication: Allopurinol	1.8	2.4	6.4	2.5	0.8	0.0
Hypertension (Self-reported)	1.8	4.9	6.6	2.0	2.0	2.6
Medication for hormone replacement therapy	1.7	1.9	3.7	0.2	-1.5	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.8	0.3	-1.8	-1.9
Mother’s age at death	1.7	2.1	3.1	0.8	-1.8	-1.6
Irritable Bowel Disease (IBD)	1.6	3.8	5.9	0.7	-2.4	-2.3
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	6.3	0.1	-2.5	-1.0
Noisy workplace	1.6	1.9	3.9	-2.0	1.3	0.5
Pulse wave reflection index	1.6	2.0	5.2	-0.2	-2.3	-0.9
Headache pain in last month	1.6	2.7	5.2	-2.3	1.4	1.1
Medication: Ibuprofen	1.6	1.9	3.5	-0.8	1.9	1.2
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.3	2.1	-0.7	-0.6
Average weekly spirits intake	1.5	1.9	5.3	-2.3	-0.3	0.5
Hearing difficulty/problems with background noise	1.5	2.3	4.2	1.2	1.2	2.1
Qualifications: A levels/AS levels or equivalent	1.5	3.3	6.9	2.6	1.2	1.1
Prospective memory result	1.5	1.9	3.1	-0.0	-1.8	-1.6
Alcohol intake frequency.	1.5	3.5	7.3	-0.3	-2.7	-1.7
Reaction Time	1.4	2.7	4.0	-2.0	1.9	0.8
Tense / ‘highly strung’	1.4	2.3	2.9	-1.7	-1.5	-1.3
Gout (self-reported)	1.4	1.9	3.0	1.7	1.5	0.6
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.4	-2.1	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	3.4	-1.3	-1.8	-1.9
Osteoarthritis (self-reported)	1.4	1.8	3.8	1.0	0.7	2.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.9	-2.0	0.9	0.8
Impedance of whole body	1.4	7.2	9.4	3.0	-1.8	-3.1
Bipolar Disorder (2018)	1.3	2.1	5.2	-0.1	2.3	1.0
Vitamin and mineral supplements	1.3	1.7	3.0	-1.7	1.3	0.8
Sitting height	1.3	9.0	13.8	-0.3	-3.6	-3.7
Heart attack	1.3	1.7	3.0	0.6	1.3	1.7
Blood clot in the leg (DVT)	1.3	1.6	3.4	-1.8	0.8	0.9
Exposure to tobacco smoke outside home	1.3	1.7	3.9	-0.9	2.0	0.5
Overall health rating	1.3	2.8	5.2	0.5	2.3	1.8
Back pain experienced in last month	1.3	1.8	3.7	1.4	-1.9	-0.0
Medication: Gliclazide	1.3	1.5	2.0	1.3	1.4	0.9
Illnesses of father: None of the above (group 1)	1.3	1.6	4.7	2.2	-0.3	0.0
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.2	0.6	1.2	1.8
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.5	2.1	0.6	2.0
Prostate Cancer	1.2	1.7	4.0	-1.0	-0.4	-2.0
Blood Eosinophil Count	1.2	8.9	20.5	1.8	4.5	1.7
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.2	1.0	0.9	1.5
Medication: Co-codamol	1.2	1.3	2.8	1.1	0.1	1.7
Multivitamins +/- minerals	1.2	1.5	1.9	1.3	-1.4	-1.0
Time employed in main current job	1.2	1.4	1.9	1.3	-0.7	-1.4
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.4	-1.2	1.5	0.7
Illnesses of mother	1.2	1.5	2.5	1.4	0.3	1.6
Loud music exposure frequency	1.2	1.3	2.7	-1.1	-0.1	-1.6
Breast Cancer	1.1	2.7	4.2	0.0	-2.0	-1.9
Sensitivity / hurt feelings	1.1	2.0	3.5	1.0	-1.9	-1.2
Relative age of first facial hair	1.1	2.3	4.2	-0.9	1.4	2.0
Medication: Blood pressure	1.1	2.0	3.5	0.5	1.5	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	1.8	-0.9	1.2	1.4
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.8	2.4	0.4	1.7
Fasting Glucose	1.0	1.2	3.2	1.8	0.4	0.4
Blood White Count	1.0	7.2	11.0	0.6	-3.3	-3.2
Frequency of depressed mood in last 2 weeks	1.0	1.5	2.2	1.5	-1.3	-0.7
Diabetes (mother)	1.0	1.3	2.5	1.6	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	5.8	-0.4	-2.4	-1.9
Health satisfaction	1.0	1.4	2.6	-0.4	1.1	1.6
Average weekly red wine intake	1.0	1.5	1.7	-1.3	-1.1	-1.2
Medication: Aspirin	1.0	1.3	1.8	-0.9	1.3	1.2
Number of self-reported non-cancer illnesses	1.0	1.7	2.7	0.7	1.4	1.6
Bipolar Disorder or Schizophrenia	0.9	2.1	5.5	0.7	2.4	0.6
Alzheimer’s Disease (in mother)	0.9	1.1	1.7	-1.2	-1.3	-0.3
HbA1C	0.9	1.0	1.5	0.5	1.2	1.2
Lupus	0.9	1.3	3.8	-0.3	0.2	2.0
Hand grip strength (left)	0.9	2.3	6.2	-2.5	0.2	-0.8
Average weekly fortified wine intake	0.9	1.0	1.6	1.1	-0.5	1.3
Impedance of leg (left)	0.9	4.3	6.7	2.4	-0.7	-2.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.0	1.7	0.1	0.3
Number of children fathered	0.9	1.0	3.1	-1.8	-0.1	0.1
Shortness of breath walking on level ground	0.9	1.1	2.9	-1.7	-0.2	-0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.8	-1.2	1.3	0.4
Medication: Omeprazole	0.9	1.1	3.2	-1.8	-0.1	-0.5
Medication: Seretide 50 evohaler	0.9	1.1	1.6	-1.1	0.8	1.2
Medication: Aspirin	0.9	1.2	2.0	-0.5	1.4	1.1
Loneliness, isolation	0.9	1.3	2.0	1.4	0.4	1.3
Smoking status: Current	0.9	1.4	2.9	-1.7	-0.2	-1.1
Medication: Lisinopril	0.9	1.1	1.6	1.3	1.3	0.3
Basal cell carcinoma (self-reported)	0.9	1.0	3.0	-1.7	0.4	-0.1
Waist Hip Ratio (WHR)	0.8	3.4	5.3	-1.0	1.9	2.3
Ever used hormone-replacement therapy (HRT)	0.8	1.1	1.3	-1.2	-0.7	-1.2
Ever had hysterectomy (womb removed)	0.8	0.9	1.2	-0.6	1.1	1.1
Impedance of leg (right)	0.8	3.7	6.5	2.1	-0.1	-2.6
Hayfever, allergic rhinitis or eczema	0.8	1.8	2.0	1.4	-1.3	-1.4
Pain all over the body in last month	0.8	0.8	1.9	0.3	0.8	1.4
Falls in the last year	0.8	1.0	2.8	0.5	-1.7	-0.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	5.0	-0.5	-2.2	-1.7
Depression (self-reported)	0.8	1.0	1.4	1.2	-1.2	-0.3
Mean time to correctly identify matches	0.8	1.5	3.6	-1.9	1.0	0.2
Illnesses of siblings: Diabetes	0.8	1.0	1.9	0.9	0.5	1.4
Miserableness	0.8	1.4	2.4	-0.0	1.3	1.5
Ever taken oral contraceptive pill	0.8	0.9	1.4	0.7	-1.2	-1.0
Medication: Blood pressure	0.8	1.6	3.0	1.7	0.6	1.1
Diastolic blood pressure, automated reading	0.8	2.5	4.1	1.6	0.9	2.0
Major Depression (MDD)	0.7	0.9	1.4	-1.1	-1.2	-0.1
Allergy or Eczema	0.7	1.8	2.7	0.5	-1.6	-1.6
Relative age voice broke	0.7	1.1	1.8	-0.9	1.3	0.8
Fluid intelligence score	0.7	1.5	2.4	1.2	0.8	1.6
Worrier / anxious feelings	0.7	1.4	4.0	2.0	-0.0	0.4
Lung cancer (father)	0.7	0.8	1.6	0.8	0.3	1.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.2	-0.5	0.3	1.5
Family relationship satisfaction	0.7	0.9	2.4	1.5	0.1	0.5
Breast cancer (self-reported)	0.7	0.8	2.1	-0.6	1.4	-0.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.1	1.1	-0.9	-0.8
Worry (Nagel 2018)	0.6	1.3	2.6	0.1	-1.1	-1.6
Crohns Disease (2017)	0.6	1.4	2.8	1.7	-0.7	-1.0
Hand grip strength (right)	0.6	1.7	5.0	-2.2	0.1	-0.2
Hair/balding pattern: Pattern 2	0.6	0.7	1.1	-1.1	0.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.4	0.1	1.2	0.9
Pulse rate, automated reading	0.6	2.0	3.0	-1.0	1.7	1.4
Leg pain on walking	0.6	0.7	1.1	-1.0	0.7	0.8
Qualifications: nursing, teaching	0.6	1.0	2.1	1.4	-0.7	-0.5
Commuting to job workplace: Walk	0.6	0.7	1.7	-1.3	0.3	-0.4
Eye problems/disorders: Cataract	0.6	0.7	1.6	0.6	1.3	0.4
Average weekly champagne plus white wine intake	0.6	0.8	2.2	1.5	0.4	0.3
Guilty feelings	0.6	0.9	1.5	0.1	1.1	1.2
Fractured/broken bones in last 5 years	0.6	0.8	1.0	-0.8	-1.0	-0.9
Age started oral contraceptive pill	0.6	0.8	1.5	0.6	1.2	0.6
Alcohol drinker status: Previous	0.6	0.7	2.0	0.3	-1.4	-0.2
Coronary Artery Disease (CAD)	0.5	0.6	0.9	0.4	0.9	0.8
Crohns Disease (2012)	0.5	0.7	1.1	1.1	-0.5	-0.9
Primary Biliary Cirrhosis	0.5	0.7	2.0	0.4	-0.2	1.4
Rheumatoid Arthritis	0.5	0.7	1.8	1.3	-0.4	0.3
Blood Red Count	0.5	4.6	8.4	-1.5	-1.8	-2.9
Diabetes (father)	0.5	0.6	1.4	-0.2	0.6	1.2
Pack years adult smoking proportion	0.5	0.7	1.8	-0.1	1.3	0.7
Townsend deprivation index at recruitment	0.5	0.6	1.3	1.1	-0.1	0.8
Current tobacco smoking	0.5	0.9	1.9	-1.4	0.1	-0.8
Maternal smoking around birth	0.5	0.7	1.7	-1.3	0.3	-0.5
Stomach or abdominal pain in last month	0.5	0.6	1.3	-0.7	1.2	-0.0
Had other major operations	0.5	0.6	0.9	-1.0	0.8	-0.5
Financial difficulties in last 2 years	0.5	0.6	1.7	-0.4	0.3	-1.3
Peak expiratory flow (PEF)	0.5	1.2	3.1	0.4	-1.8	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	-1.2	-0.2	-0.5
Emphysema/chronic bronchitis	0.5	0.6	0.6	-0.7	0.8	-0.8
Neck or shoulder pain in last month	0.5	0.7	1.4	-0.1	1.2	0.7
Heart disease (mother)	0.5	0.6	0.9	-0.8	1.0	0.3
Comparative height size at age 10	0.5	2.9	6.2	-2.5	-1.4	-0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.9	-0.0	-0.1	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.8	0.3	1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	-0.8	1.3	0.4
Medication for cholesterol	0.5	0.8	2.0	-1.4	0.2	-0.6
Hearing aid user	0.5	0.6	1.1	-1.1	0.8	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	-1.1	0.7	0.4
Medication: Bendroflumethiazide	0.5	0.8	2.2	1.5	-0.4	0.4
Neuroticism (Nagel 2018)	0.4	1.0	1.5	1.2	-0.8	-1.0
Schizophrenia (2018)	0.4	0.9	1.4	1.1	1.2	-0.2
Mean Putamen Volume	0.4	0.5	1.2	-1.1	0.0	-0.5
Lung FEV1/FVC ratio	0.4	2.2	4.7	0.7	1.2	2.2
Tanning	0.4	5.3	15.3	-3.9	-0.0	-0.7
Taking other prescription medications	0.4	0.7	1.7	-1.3	0.5	0.2
Qualifications: CSEs or equivalent	0.4	0.5	0.8	-0.9	0.7	-0.4
Serious illness, injury or assault to yourself	0.4	0.4	0.7	0.7	0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.8	-0.0	-1.3	-0.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	0.9	-0.7	0.2
Medication: Ramipril	0.4	0.5	1.3	-0.4	-0.0	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	1.2	0.4	0.3
Hair/balding pattern: Pattern 4	0.4	0.9	2.4	-0.3	-0.2	-1.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.0	1.0	0.7	0.8
Qualifications: College or University degree	0.4	1.4	2.2	1.5	-1.4	-0.1
Suffer from ‘nerves’	0.4	0.6	0.9	-0.1	-0.9	-1.0
Mineral and other dietary supplements	0.4	0.6	1.6	-1.3	0.0	0.1
Wears glasses or contact lenses	0.4	0.5	0.6	0.7	-0.6	0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	-0.4	0.7	0.9
Illnesses of father: High blood pressure	0.4	0.5	1.6	-1.2	0.2	0.2
Average weekly beer plus cider intake	0.4	0.5	1.1	-1.0	-0.2	-0.7
Supplements: Calcium	0.4	0.5	1.1	1.1	0.1	-0.6
Heart disease (siblings)	0.4	0.5	1.0	0.3	0.6	1.0
Alzheimer’s Disease (in father)	0.3	0.3	0.9	0.1	-1.0	0.1
Age at First Birth	0.3	0.4	1.0	-0.3	1.0	0.3
Neuroticism (2016)	0.3	0.4	1.3	-1.1	0.1	0.0
Schizophrenia (2014)	0.3	0.6	1.2	0.4	1.1	-0.6
Blood Platelet Count	0.3	3.3	8.6	0.9	2.9	0.7
Hair Pigment	0.3	7.9	19.5	-1.6	1.2	4.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.4	0.5	-1.2	-0.8
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	-1.0	-0.5	-0.4
Wheeze or whistling in the chest in last year	0.3	0.6	0.9	-0.7	1.0	0.6
Supplements: Vitamin C	0.3	0.3	0.5	0.7	-0.6	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.3	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.1	-0.1	-1.0	-0.7
Financial situation satisfaction	0.3	0.4	1.3	1.1	-0.1	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.5	0.9	0.6	0.9	0.4
Myopia	0.3	0.5	1.1	0.6	-1.1	-0.2
Pain experienced in last month	0.3	0.5	1.0	0.6	-0.2	-1.0
Pack years of smoking	0.3	0.5	0.9	-0.3	1.0	0.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	0.5	-0.4	-1.0
Respiratory disease	0.2	0.5	1.4	-1.2	0.5	0.0
Lung FVC	0.2	1.2	2.8	-0.0	-0.8	-1.7
Neuroticism	0.2	0.4	0.7	0.8	-0.5	-0.5
Number of treatments/medications taken	0.2	0.3	0.7	-0.8	0.3	0.4
Severe depression (siblings)	0.2	0.3	0.8	0.9	0.2	0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.8	-0.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.1	-0.5	-0.6
Supplements: Glucosamine	0.2	0.3	0.7	0.6	-0.1	-0.8
Had menopause	0.2	0.3	0.4	-0.6	-0.7	0.1
Qualifications: None of the above	0.2	0.5	1.2	-1.1	0.3	-0.5
Illnesses of siblings	0.2	0.3	0.6	-0.8	-0.5	-0.4
Pulse rate	0.2	0.3	0.6	-0.8	-0.2	-0.5
Asthma	0.2	0.3	0.6	0.3	0.8	0.5
Length of working week for main job	0.2	0.2	0.6	-0.2	0.3	0.8
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.6	-0.4	-0.4
High blood pressure (siblings)	0.2	0.4	0.6	0.6	0.8	0.3
Comparative body size at age 10	0.2	0.5	0.6	-0.8	-0.7	-0.6
Migraine (self-reported)	0.2	0.3	0.7	-0.2	-0.4	0.8
Had major operations	0.2	0.2	0.6	0.8	-0.1	-0.1
Number of operations (self-reported)	0.2	0.3	0.7	-0.4	-0.4	-0.9
Commuting to job workplace: Cycle	0.2	0.3	0.8	0.9	0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.7	-0.8	0.2	-0.1
Heel T-Score	0.1	0.8	1.2	-1.1	-0.2	-1.0
Supplements: Zinc	0.1	0.2	0.3	0.5	0.4	0.2
Fed-up feelings	0.1	0.3	0.7	0.9	0.2	0.1
High blood pressure (mother)	0.1	0.1	0.2	0.1	-0.5	-0.4
Nervous feelings	0.1	0.1	0.3	-0.0	-0.6	-0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.5	0.1	-0.1
Allergy	0.1	0.3	0.5	-0.7	0.5	0.2
Neuroticism score	0.1	0.2	0.4	0.7	0.4	0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.2	0.3	-0.4	-0.4
Medication: Amlodipine	0.1	0.2	0.5	0.2	0.3	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.2	-0.6	0.2
Age at first live birth	0.1	0.2	0.4	0.2	-0.4	-0.6
Number of full sisters	0.1	0.1	0.3	0.0	-0.2	-0.5
Age at last live birth	0.1	0.2	0.3	-0.5	-0.2	-0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.1	0.6	0.0
Knee pain experienced in last month	0.1	0.2	0.3	-0.1	-0.4	0.6
Mood swings	0.1	0.1	0.3	0.6	-0.0	-0.3
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.6	0.6	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.3	0.1
Asthma (self-reported)	0.1	0.1	0.2	0.3	0.4	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.4	-0.0	-0.0	0.7
Unable to work because of sickness or disability	0.1	0.1	0.2	0.1	-0.4	-0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	-0.3	0.1	-0.2
Osteoporosis (self-reported)	0.0	0.0	0.1	-0.2	0.3	-0.1

Hub : Genes

KPNB1

Models

Trait associations