Hub : Genes

KPNB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Nucleus accumbens basal ganglia 0.2400 0.0970 0.0074 -0.003 NA 0.002 NA 0.006 0.40000 NA 0.27000 NA 0.21000
2 YFS Blood 0.0110 0.0051 0.0021 0.009 0.004 0.008 0.005 0.009 0.00044 0.0110 0.00076 0.0085 0.00046
3 TCGA Breast Invasive Carcinoma 0.0181 0.0109 0.0021 0.011 0.011 0.006 NA 0.009 0.00160 0.0017 0.01500 NA 0.00480

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.3 2.1 5.2 -0.1 2.3 1.0
Bipolar Disorder or Schizophrenia 0.9 2.1 5.5 0.7 2.4 0.6
Depressed Affect (Nagel 2018) 0.2 0.4 1.0 0.5 -0.4 -1.0
Depression (Nagel 2018) 3.7 5.6 9.7 1.5 -3.1 -2.3
Intelligence (Savage-Jansen 2018) 1.0 3.0 5.8 2.4 0.4 1.7
Neuroticism (Nagel 2018) 0.4 1.0 1.5 1.2 -0.8 -1.0
Schizophrenia (2018) 0.4 0.9 1.4 1.1 1.2 -0.2
Schizophrenia vs Biploar Disorder 0.6 0.8 1.1 1.1 -0.9 -0.8
Worry (Nagel 2018) 0.6 1.3 2.6 0.1 -1.1 -1.6
Alzheimer’s Disease (in mother) 0.9 1.1 1.7 -1.2 -1.3 -0.3
Alzheimer’s Disease (in father) 0.3 0.3 0.9 0.1 -1.0 0.1
Alzheimer’s Disease (including proxy) 2.5 3.7 7.7 -1.3 -2.8 -1.2
Crohns Disease (2017) 0.6 1.4 2.8 1.7 -0.7 -1.0
Irritable Bowel Disease (IBD) 1.6 3.8 5.9 0.7 -2.4 -2.3
Ulcerative Colitis (UC) 1.8 3.3 6.1 -0.2 -2.5 -2.0
Major Depression (MDD) 0.7 0.9 1.4 -1.1 -1.2 -0.1
Reaction Time 1.4 2.7 4.0 -2.0 1.9 0.8
Verbal and Numeric Reasoning (VNR) 1.2 2.9 4.5 2.1 0.6 2.0
Breast Cancer 1.1 2.7 4.2 0.0 -2.0 -1.9
Ovarian Cancer 2.8 3.7 10.6 -3.2 -0.4 -0.5
Prostate Cancer 1.2 1.7 4.0 -1.0 -0.4 -2.0
Age at First Birth 0.3 0.4 1.0 -0.3 1.0 0.3
Bipolar Disorder (2011) 2.1 2.1 3.9 0.5 2.0 1.4
Body Mass Index (BMI) (2010) 4.4 6.1 10.3 -3.2 -2.1 -1.9
Coronary Artery Disease (CAD) 0.5 0.6 0.9 0.4 0.9 0.8
Crohns Disease (2012) 0.5 0.7 1.1 1.1 -0.5 -0.9
Mean Putamen Volume 0.4 0.5 1.2 -1.1 0.0 -0.5
Fasting Glucose 1.0 1.2 3.2 1.8 0.4 0.4
HbA1C 0.9 1.0 1.5 0.5 1.2 1.2
HDL Cholesterol 2.8 4.7 11.6 0.0 3.4 1.6
LDL Cholesterol 8.8 13.9 23.8 -0.4 4.9 4.2
Lupus 0.9 1.3 3.8 -0.3 0.2 2.0
Neuroticism (2016) 0.3 0.4 1.3 -1.1 0.1 0.0
Primary Biliary Cirrhosis 0.5 0.7 2.0 0.4 -0.2 1.4
Rheumatoid Arthritis 0.5 0.7 1.8 1.3 -0.4 0.3
Schizophrenia (2014) 0.3 0.6 1.2 0.4 1.1 -0.6
Triglycerides 2.2 3.6 8.7 0.6 -3.0 -1.3
Type 2 Diabetes (T2D) (2012) 1.5 1.7 4.3 2.1 -0.7 -0.6
Ulcerative Colitis 2.1 3.1 5.0 -0.7 -2.2 -2.0
Blood Eosinophil Count 1.2 8.9 20.5 1.8 4.5 1.7
Blood Platelet Count 0.3 3.3 8.6 0.9 2.9 0.7
Blood Red Count 0.5 4.6 8.4 -1.5 -1.8 -2.9
Blood White Count 1.0 7.2 11.0 0.6 -3.3 -3.2
Heel T-Score 0.1 0.8 1.2 -1.1 -0.2 -1.0
BMI 2.8 16.1 41.5 -6.4 -1.8 -1.9
Height 3.6 68.6 127.7 -0.9 -11.3 -8.8
Waist Hip Ratio (WHR) 0.8 3.4 5.3 -1.0 1.9 2.3
Systolic Blood Pressure 3.5 17.7 46.1 6.8 2.0 1.7
Smoking Status 2.2 5.4 6.9 -1.7 -2.5 -2.6
Allergy or Eczema 0.7 1.8 2.7 0.5 -1.6 -1.6
Cardiovascular Disease 3.7 12.1 19.9 1.6 4.5 3.7
Hypothyroidism (self reported) 4.9 11.1 20.5 -0.9 -4.5 -3.5
Respiratory disease 0.2 0.5 1.4 -1.2 0.5 0.0
Type 2 Diabetes (T2D) (2018) 2.4 4.4 5.9 2.4 1.4 2.4
Lung FEV1/FVC ratio 0.4 2.2 4.7 0.7 1.2 2.2
Lung FVC 0.2 1.2 2.8 -0.0 -0.8 -1.7
Neuroticism 0.2 0.4 0.7 0.8 -0.5 -0.5
Chronotype (morning person) 1.8 4.2 11.8 -3.4 -0.6 -0.6
Hair Pigment 0.3 7.9 19.5 -1.6 1.2 4.4
Tanning 0.4 5.3 15.3 -3.9 -0.0 -0.7
Hand grip strength (left) 0.9 2.3 6.2 -2.5 0.2 -0.8
Number of treatments/medications taken 0.2 0.3 0.7 -0.8 0.3 0.4
Average weekly spirits intake 1.5 1.9 5.3 -2.3 -0.3 0.5
Sensitivity / hurt feelings 1.1 2.0 3.5 1.0 -1.9 -1.2
Frequency of depressed mood in last 2 weeks 1.0 1.5 2.2 1.5 -1.3 -0.7
Hearing difficulty/problems: Yes 3.7 5.7 13.0 0.7 1.9 3.6
Relative age of first facial hair 1.1 2.3 4.2 -0.9 1.4 2.0
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 4.3 -0.9 -2.1 -1.5
Ever used hormone-replacement therapy (HRT) 0.8 1.1 1.3 -1.2 -0.7 -1.2
Ever had hysterectomy (womb removed) 0.8 0.9 1.2 -0.6 1.1 1.1
Systolic blood pressure, automated reading 2.2 6.5 15.0 3.9 1.4 1.6
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.2 1.0 0.9 1.5
Angina 4.9 6.5 9.9 0.8 3.2 3.0
Medication for hormone replacement therapy 1.7 1.9 3.7 0.2 -1.5 -1.9
Vitamin and mineral supplements 1.3 1.7 3.0 -1.7 1.3 0.8
Supplements: Zinc 0.1 0.2 0.3 0.5 0.4 0.2
Medication: Co-codamol 1.2 1.3 2.8 1.1 0.1 1.7
Medication: Metformin 2.9 4.1 5.7 1.5 2.1 2.4
Diabetes (father) 0.5 0.6 1.4 -0.2 0.6 1.2
Diabetes (mother) 1.0 1.3 2.5 1.6 -0.3 -1.1
Severe depression (siblings) 0.2 0.3 0.8 0.9 0.2 0.0
Pack years adult smoking proportion 0.5 0.7 1.8 -0.1 1.3 0.7
Impedance of leg (right) 0.8 3.7 6.5 2.1 -0.1 -2.6
Leg fat-free mass (left) 2.1 11.4 20.5 -4.5 -3.1 -2.0
Trunk fat percentage 3.9 15.6 19.1 -4.4 -3.5 -3.9
Hand grip strength (right) 0.6 1.7 5.0 -2.2 0.1 -0.2
Townsend deprivation index at recruitment 0.5 0.6 1.3 1.1 -0.1 0.8
Current tobacco smoking 0.5 0.9 1.9 -1.4 0.1 -0.8
Average weekly fortified wine intake 0.9 1.0 1.6 1.1 -0.5 1.3
Maternal smoking around birth 0.5 0.7 1.7 -1.3 0.3 -0.5
Fed-up feelings 0.1 0.3 0.7 0.9 0.2 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 3.8 0.3 -1.8 -1.9
Relative age voice broke 0.7 1.1 1.8 -0.9 1.3 0.8
Taking other prescription medications 0.4 0.7 1.7 -1.3 0.5 0.2
Age when periods started (menarche) 4.8 11.4 13.8 2.6 -3.7 -3.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 0.8 -0.0 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 1.4 0.5 -1.2 -0.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 0.1 -0.5 -0.6
Qualifications: CSEs or equivalent 0.4 0.5 0.8 -0.9 0.7 -0.4
Serious illness, injury or assault to yourself 0.4 0.4 0.7 0.7 0.9 -0.2
High blood pressure 1.8 4.9 6.4 2.2 1.9 2.5
Hayfever, allergic rhinitis or eczema 0.8 1.8 2.0 1.4 -1.3 -1.4
Multivitamins +/- minerals 1.2 1.5 1.9 1.3 -1.4 -1.0
Stomach or abdominal pain in last month 0.5 0.6 1.3 -0.7 1.2 -0.0
Supplements: Glucosamine 0.2 0.3 0.7 0.6 -0.1 -0.8
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 5.2 0.5 -1.6 -2.3
Medication: Atenolol 1.9 2.4 4.0 0.8 1.6 2.0
Medication: Levothyroxine sodium 6.6 11.1 16.2 -1.7 -4.0 -3.8
Sitting height 1.3 9.0 13.8 -0.3 -3.6 -3.7
Chronic bronchitis/emphysema (father) 3.3 3.9 5.7 -2.4 -1.6 -1.8
High blood pressure (mother) 0.1 0.1 0.2 0.1 -0.5 -0.4
Body mass index (BMI) 2.0 8.5 25.0 -5.0 -0.7 -0.4
Impedance of leg (left) 0.9 4.3 6.7 2.4 -0.7 -2.6
Leg predicted mass (left) 2.1 11.2 21.2 -4.6 -3.0 -1.8
Trunk fat mass 4.5 19.5 26.8 -5.2 -4.0 -4.0
Waist circumference 2.7 10.0 25.0 -5.0 -1.8 -1.3
Number of incorrect matches in round 3.8 6.4 11.0 0.4 -3.3 -2.8
Past tobacco smoking 2.9 5.3 7.0 2.0 2.6 2.2
Alcohol usually taken with meals 2.5 4.0 6.7 -0.1 -2.6 -2.3
Nervous feelings 0.1 0.1 0.3 -0.0 -0.6 -0.2
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.4 6.3 0.1 -2.5 -1.0
Hearing difficulty/problems with background noise 1.5 2.3 4.2 1.2 1.2 2.1
Hair/balding pattern: Pattern 2 0.6 0.7 1.1 -1.1 0.8 0.7
Had menopause 0.2 0.3 0.4 -0.6 -0.7 0.1
Had other major operations 0.5 0.6 0.9 -1.0 0.8 -0.5
Forced vital capacity (FVC) 2.0 7.7 11.4 -0.6 -3.4 -3.4
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 1.8 -0.0 -1.3 -0.9
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 -0.5 0.1 -0.1
Qualifications: None of the above 0.2 0.5 1.2 -1.1 0.3 -0.5
Financial difficulties in last 2 years 0.5 0.6 1.7 -0.4 0.3 -1.3
Mouth/teeth dental problems 5.6 8.6 13.9 2.6 -3.7 -2.3
Heart attack 1.3 1.7 3.0 0.6 1.3 1.7
Allergy 0.1 0.3 0.5 -0.7 0.5 0.2
Pain all over the body in last month 0.8 0.8 1.9 0.3 0.8 1.4
Diabetes (self-reported) 3.8 5.9 8.5 1.5 2.6 2.9
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.8 0.9 -0.7 0.2
Medication: Ramipril 0.4 0.5 1.3 -0.4 -0.0 1.2
Medication: Simvastatin 5.9 8.6 13.0 0.6 3.6 3.5
Fluid intelligence score 0.7 1.5 2.4 1.2 0.8 1.6
Illnesses of siblings 0.2 0.3 0.6 -0.8 -0.5 -0.4
Neuroticism score 0.1 0.2 0.4 0.7 0.4 0.1
Weight 3.6 17.9 29.8 -5.5 -3.7 -3.1
Impedance of arm (right) 2.2 10.3 15.0 2.8 -2.8 -3.9
Arm fat percentage (right) 2.4 9.5 19.1 -4.4 -2.0 -2.3
Trunk fat-free mass 1.9 10.9 19.6 -4.4 -3.1 -1.9
Hip circumference 3.9 16.8 19.8 -4.4 -4.2 -3.6
Time employed in main current job 1.2 1.4 1.9 1.3 -0.7 -1.4
Alcohol intake versus 10 years previously 0.1 0.2 0.2 0.3 -0.4 -0.4
Father’s age at death 2.9 3.8 7.8 -0.3 -2.8 -1.9
Worrier / anxious feelings 0.7 1.4 4.0 2.0 -0.0 0.4
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 6.0 -0.0 -2.4 -1.8
Falls in the last year 0.8 1.0 2.8 0.5 -1.7 -0.2
Hair/balding pattern: Pattern 3 0.3 0.5 1.0 -1.0 -0.5 -0.4
Number of live births 2.5 3.6 8.5 -2.9 1.1 1.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 5.0 -0.5 -2.2 -1.7
Pulse rate 0.2 0.3 0.6 -0.8 -0.2 -0.5
Happiness 3.1 3.7 4.9 1.8 1.7 2.2
Noisy workplace 1.6 1.9 3.9 -2.0 1.3 0.5
Qualifications: A levels/AS levels or equivalent 1.5 3.3 6.9 2.6 1.2 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.0 1.7 0.1 0.3
Mouth/teeth dental problems: Dentures 4.7 8.0 10.5 -2.6 3.2 2.6
Asthma 0.2 0.3 0.6 0.3 0.8 0.5
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 2.4 -1.2 1.5 0.7
Medication: Cholesterol lowering 5.1 7.9 14.9 1.3 3.9 2.6
Depression (self-reported) 0.8 1.0 1.4 1.2 -1.2 -0.3
Medication: Lansoprazole 2.1 2.4 3.9 -1.8 0.3 2.0
Prospective memory result 1.5 1.9 3.1 -0.0 -1.8 -1.6
Lung cancer (father) 0.7 0.8 1.6 0.8 0.3 1.3
Illnesses of mother 1.2 1.5 2.5 1.4 0.3 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 5.8 -0.4 -2.4 -1.9
Pulse wave Arterial Stiffness index 4.5 5.2 11.8 0.8 -3.4 -1.8
Impedance of arm (left) 1.8 8.3 11.1 2.7 -2.6 -3.3
Arm fat mass (right) 3.3 13.4 28.7 -5.4 -2.6 -2.2
Trunk predicted mass 2.0 11.4 20.1 -4.5 -3.2 -2.0
Standing height 2.9 28.3 43.8 -1.9 -6.6 -6.1
Length of working week for main job 0.2 0.2 0.6 -0.2 0.3 0.8
Exposure to tobacco smoke at home 0.2 0.2 0.3 -0.6 -0.4 -0.4
Breastfed as a baby 4.2 5.2 9.8 -0.7 -2.3 -3.1
Tense / ‘highly strung’ 1.4 2.3 2.9 -1.7 -1.5 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.6 1.2 0.4 0.3
Hair/balding pattern: Pattern 4 0.4 0.9 2.4 -0.3 -0.2 -1.6
Birth weight of first child 3.5 6.3 11.1 1.2 -3.3 -2.5
Peak expiratory flow (PEF) 0.5 1.2 3.1 0.4 -1.8 -0.6
Pulse wave reflection index 1.6 2.0 5.2 -0.2 -2.3 -0.9
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.2 -0.5 0.3 1.5
Loud music exposure frequency 1.2 1.3 2.7 -1.1 -0.1 -1.6
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.0 1.0 0.7 0.8
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.4 0.1 1.2 0.9
Blood clot in the leg (DVT) 1.3 1.6 3.4 -1.8 0.8 0.9
Medication: Paracetamol 2.0 3.3 5.4 -0.3 2.3 2.1
Headache pain in last month 1.6 2.7 5.2 -2.3 1.4 1.1
Medication for cholesterol, blood pressure or diabetes 3.8 6.3 10.9 -1.2 -3.3 -2.5
Glaucoma (self-reported) 3.7 4.4 7.3 0.3 2.7 2.4
Gout (self-reported) 1.4 1.9 3.0 1.7 1.5 0.6
Hypothyroidism/myxoedema (self-reported) 5.0 9.8 14.6 -1.5 -3.8 -3.6
Medication: Amlodipine 0.1 0.2 0.5 0.2 0.3 0.7
Medication: Ventolin 100micrograms inhaler 1.4 1.8 4.4 -2.1 -0.3 -1.0
Birth weight 3.8 8.2 15.6 -0.5 -4.0 -2.9
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.1 -0.3 0.1 -0.2
High blood pressure (siblings) 0.2 0.4 0.6 0.6 0.8 0.3
Forced vital capacity (FVC), Best measure 2.2 8.1 12.2 -0.1 -3.5 -3.5
Body fat percentage 3.1 12.0 20.2 -4.5 -2.5 -3.1
Leg fat percentage (right) 2.4 8.9 20.5 -4.5 -1.1 -2.2
Arm fat-free mass (right) 2.0 10.5 22.6 -4.8 -2.6 -1.5
Exposure to tobacco smoke outside home 1.3 1.7 3.9 -0.9 2.0 0.5
Comparative body size at age 10 0.2 0.5 0.6 -0.8 -0.7 -0.6
Number of full brothers 1.9 2.3 5.9 -0.5 2.4 0.9
Worry too long after embarrassment 3.0 5.0 9.1 0.7 2.3 3.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.4 -0.2 -0.6 0.2
Wheeze or whistling in the chest in last year 0.3 0.6 0.9 -0.7 1.0 0.6
Number of children fathered 0.9 1.0 3.1 -1.8 -0.1 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.4 -1.2 -0.2 -0.5
Age at first live birth 0.1 0.2 0.4 0.2 -0.4 -0.6
Pulse wave peak to peak time 3.6 4.3 10.1 -0.8 3.2 1.5
Health satisfaction 1.0 1.4 2.6 -0.4 1.1 1.6
Shortness of breath walking on level ground 0.9 1.1 2.9 -1.7 -0.2 -0.5
Qualifications: College or University degree 0.4 1.4 2.2 1.5 -1.4 -0.1
Eye problems/disorders: None of the above 3.9 4.6 6.9 -1.0 -2.6 -2.4
Mouth/teeth dental problems: Loose teeth 0.9 1.1 1.8 -1.2 1.3 0.4
Emphysema/chronic bronchitis 0.5 0.6 0.6 -0.7 0.8 -0.8
Medication for pain relief, constipation, heartburn 3.8 6.5 10.6 2.1 -3.3 -2.1
Neck or shoulder pain in last month 0.5 0.7 1.4 -0.1 1.2 0.7
Medication: Blood pressure 1.1 2.0 3.5 0.5 1.5 1.9
Angina (self-reported) 4.2 5.6 8.7 0.9 3.0 2.7
Migraine (self-reported) 0.2 0.3 0.7 -0.2 -0.4 0.8
Medication: Ibuprofen 1.6 1.9 3.5 -0.8 1.9 1.2
Medication: Allopurinol 1.8 2.4 6.4 2.5 0.8 0.0
Medication: Omeprazole 0.9 1.1 3.2 -1.8 -0.1 -0.5
Medication: Seretide 50 evohaler 0.9 1.1 1.6 -1.1 0.8 1.2
Mean time to correctly identify matches 0.8 1.5 3.6 -1.9 1.0 0.2
Heart disease (mother) 0.5 0.6 0.9 -0.8 1.0 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 1.8 -0.9 1.2 1.4
Whole body fat mass 3.8 15.9 28.2 -5.3 -3.2 -3.1
Leg fat mass (right) 3.1 11.9 26.6 -5.2 -1.8 -2.4
Arm predicted mass (right) 2.0 10.2 22.2 -4.7 -2.5 -1.5
Pulse rate, automated reading 0.6 2.0 3.0 -1.0 1.7 1.4
Alcohol intake frequency. 1.5 3.5 7.3 -0.3 -2.7 -1.7
Comparative height size at age 10 0.5 2.9 6.2 -2.5 -1.4 -0.6
Number of full sisters 0.1 0.1 0.3 0.0 -0.2 -0.5
Suffer from ‘nerves’ 0.4 0.6 0.9 -0.1 -0.9 -1.0
Overall health rating 1.3 2.8 5.2 0.5 2.3 1.8
Chest pain or discomfort 7.4 10.7 18.5 -0.3 4.3 3.7
Had major operations 0.2 0.2 0.6 0.8 -0.1 -0.1
Age at last live birth 0.1 0.2 0.3 -0.5 -0.2 -0.6
Family relationship satisfaction 0.7 0.9 2.4 1.5 0.1 0.5
Leg pain on walking 0.6 0.7 1.1 -1.0 0.7 0.8
Qualifications: NVQ or HND or HNC or equivalent 3.0 3.6 7.8 -0.5 2.8 1.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.4 0.1 0.6 0.0
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 1.9 -0.0 -0.1 1.4
Medication: Aspirin 0.9 1.2 2.0 -0.5 1.4 1.1
Supplements: Vitamin C 0.3 0.3 0.5 0.7 -0.6 -0.3
Knee pain experienced in last month 0.1 0.2 0.3 -0.1 -0.4 0.6
Hypertension (Self-reported) 1.8 4.9 6.6 2.0 2.0 2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 -0.8 0.3 1.0
Illnesses of father: Heart disease 2.4 3.3 5.1 -0.0 2.2 2.3
Illnesses of siblings: Diabetes 0.8 1.0 1.9 0.9 0.5 1.4
Smoking status: Previous 2.1 3.1 4.9 -1.1 -2.2 -1.8
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.8 3.4 -1.3 -1.8 -1.9
Whole body fat-free mass 2.1 11.8 21.7 -4.7 -3.2 -1.9
Leg fat-free mass (right) 1.9 10.1 17.1 -4.1 -3.2 -1.7
Arm fat percentage (left) 2.3 9.3 20.2 -4.5 -2.0 -2.0
Average weekly red wine intake 1.0 1.5 1.7 -1.3 -1.1 -1.2
Handedness (chirality/laterality): Left-handed 1.9 2.3 5.9 2.4 1.0 0.0
Mood swings 0.1 0.1 0.3 0.6 -0.0 -0.3
Loneliness, isolation 0.9 1.3 2.0 1.4 0.4 1.3
Long-standing illness, disability or infirmity 0.1 0.2 0.3 -0.6 0.6 -0.1
Ever had bowel cancer screening 1.9 2.3 4.0 -1.1 -1.3 -2.0
Diabetes diagnosed by doctor 3.4 5.5 7.2 2.0 2.3 2.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 -0.3 -0.7 -0.6
Friendships satisfaction 4.1 5.1 10.8 3.3 1.1 1.8
Qualifications: nursing, teaching 0.6 1.0 2.1 1.4 -0.7 -0.5
Commuting to job workplace: Walk 0.6 0.7 1.7 -1.3 0.3 -0.4
Eye problems/disorders: Cataract 0.6 0.7 1.6 0.6 1.3 0.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.8 -0.8 1.3 0.4
Medication for cholesterol 0.5 0.8 2.0 -1.4 0.2 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.4 -0.3 0.1
Back pain experienced in last month 1.3 1.8 3.7 1.4 -1.9 -0.0
Mineral and other dietary supplements 0.4 0.6 1.6 -1.3 0.0 0.1
Breast cancer (self-reported) 0.7 0.8 2.1 -0.6 1.4 -0.3
Asthma (self-reported) 0.1 0.1 0.2 0.3 0.4 0.3
Osteoporosis (self-reported) 0.0 0.0 0.1 -0.2 0.3 -0.1
Osteoarthritis (self-reported) 1.4 1.8 3.8 1.0 0.7 2.0
Medication: Aspirin 1.0 1.3 1.8 -0.9 1.3 1.2
Medication: Gliclazide 1.3 1.5 2.0 1.3 1.4 0.9
Illnesses of father: None of the above (group 1) 1.3 1.6 4.7 2.2 -0.3 0.0
Smoking status: Current 0.9 1.4 2.9 -1.7 -0.2 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 1.1 -0.1 -1.0 -0.7
Whole body water mass 2.1 11.8 21.3 -4.6 -3.2 -1.9
Leg predicted mass (right) 1.9 9.9 17.1 -4.1 -3.2 -1.6
Arm fat mass (left) 3.2 13.0 28.0 -5.3 -2.5 -2.2
Number of self-reported non-cancer illnesses 1.0 1.7 2.7 0.7 1.4 1.6
Average weekly champagne plus white wine intake 0.6 0.8 2.2 1.5 0.4 0.3
Miserableness 0.8 1.4 2.4 -0.0 1.3 1.5
Guilty feelings 0.6 0.9 1.5 0.1 1.1 1.2
Wears glasses or contact lenses 0.4 0.5 0.6 0.7 -0.6 0.8
Ever taken oral contraceptive pill 0.8 0.9 1.4 0.7 -1.2 -1.0
Hearing aid user 0.5 0.6 1.1 -1.1 0.8 0.3
Mother’s age at death 1.7 2.1 3.1 0.8 -1.8 -1.6
Financial situation satisfaction 0.3 0.4 1.3 1.1 -0.1 0.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.2 -1.1 0.7 0.4
Commuting to job workplace: Public transport 0.1 0.1 0.4 -0.0 -0.0 0.7
Eye problems/disorders: Glaucoma 4.2 5.0 8.3 0.1 2.9 2.6
Medication: Blood pressure 0.8 1.6 3.0 1.7 0.6 1.1
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.8 -0.4 0.7 0.9
Supplements: Fish oil (including cod liver oil) 0.3 0.5 0.9 0.6 0.9 0.4
High cholesterol (Self-reported) 10.1 17.9 31.1 1.4 5.6 4.5
Medication: Bendroflumethiazide 0.5 0.8 2.2 1.5 -0.4 0.4
Medication: Paracetamol 1.9 2.9 4.7 -0.2 2.2 2.0
Medication: Lisinopril 0.9 1.1 1.6 1.3 1.3 0.3
Medication: Atorvastatin 5.8 7.1 16.9 0.4 4.1 2.1
Illnesses of father: High blood pressure 0.4 0.5 1.6 -1.2 0.2 0.2
Alcohol drinker status: Never 2.3 2.8 3.5 -1.6 -1.4 -1.9
Ever smoked 3.5 6.2 9.4 -1.5 -3.1 -2.6
Basal metabolic rate 2.5 13.7 24.8 -5.0 -3.3 -2.3
Leg fat percentage (left) 2.4 8.8 20.2 -4.5 -1.3 -2.1
Arm fat-free mass (left) 2.4 12.2 23.0 -4.8 -3.0 -2.2
Number of operations (self-reported) 0.2 0.3 0.7 -0.4 -0.4 -0.9
Average weekly beer plus cider intake 0.4 0.5 1.1 -1.0 -0.2 -0.7
Irritability 2.4 4.0 6.3 1.4 2.5 2.0
Risk taking 3.5 5.2 8.5 -1.7 -2.0 -2.9
Ever had prostate specific antigen (PSA) test 4.8 5.5 9.4 -1.1 -3.1 -2.4
Fractured/broken bones in last 5 years 0.6 0.8 1.0 -0.8 -1.0 -0.9
Age started oral contraceptive pill 0.6 0.8 1.5 0.6 1.2 0.6
Diastolic blood pressure, automated reading 0.8 2.5 4.1 1.6 0.9 2.0
Ever depressed for a whole week 2.6 3.2 5.7 0.2 2.4 1.9
Unable to work because of sickness or disability 0.1 0.1 0.2 0.1 -0.4 -0.2
Commuting to job workplace: Cycle 0.2 0.3 0.8 0.9 0.1 0.2
Myopia 0.3 0.5 1.1 0.6 -1.1 -0.2
Vascular/heart problems diagnosed by doctor 2.1 5.8 7.5 -2.0 -2.4 -2.7
Cholesterol lowering medication 4.7 6.9 10.0 0.8 3.2 3.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.7 -0.8 0.2 -0.1
Pain experienced in last month 0.3 0.5 1.0 0.6 -0.2 -1.0
Supplements: Calcium 0.4 0.5 1.1 1.1 0.1 -0.6
Basal cell carcinoma (self-reported) 0.9 1.0 3.0 -1.7 0.4 -0.1
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.2 0.6 1.2 1.8
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 3.9 -2.0 0.9 0.8
Heart disease (siblings) 0.4 0.5 1.0 0.3 0.6 1.0
Alcohol drinker status: Previous 0.6 0.7 2.0 0.3 -1.4 -0.2
Pack years of smoking 0.3 0.5 0.9 -0.3 1.0 0.7
Impedance of whole body 1.4 7.2 9.4 3.0 -1.8 -3.1
Leg fat mass (left) 3.2 12.6 27.8 -5.3 -2.1 -2.4
Arm predicted mass (left) 2.5 12.8 23.5 -4.8 -3.1 -2.3