Best TWAS P=7.19e-09 · Best GWAS P=3.86e-08 conditioned to 0.868
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TRIM47 | 0.15 | 0.12 | enet | 13 | 0.14 | 2.8e-17 | 4.5 | -5.3 | 1.2e-07 | -0.94 | 0.00 | 0.99 | FALSE |
| 2 | GTEx | Brain Cerebellum | TRIM47 | 0.30 | 0.17 | lasso | 2 | 0.17 | 1.1e-05 | 5.5 | -5.2 | 1.5e-07 | -0.96 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | TRIM65 | 0.18 | 0.13 | lasso | 8 | 0.12 | 4.0e-09 | 5.5 | 5.4 | 5.6e-08 | 0.98 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Lung | RP11-552F3.10 | 0.12 | 0.02 | lasso | 2 | 0.03 | 4.4e-03 | 5.5 | -5.8 | 7.2e-09 | -0.94 | 0.02 | 0.60 | TRUE |
| 5 | GTEx | Nerve Tibial | TRIM65 | 0.25 | 0.10 | lasso | 6 | 0.16 | 8.7e-12 | 4.7 | 5.2 | 2.6e-07 | 0.88 | 0.01 | 0.99 | FALSE |
| 6 | YFS | Blood | GALK1 | 0.05 | 0.04 | enet | 26 | 0.04 | 2.4e-13 | 4.8 | -5.6 | 2.1e-08 | -0.64 | 0.12 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRIM47 | 0.04 | 0.01 | blup | 30 | 0.03 | 2.7e-04 | 5.5 | -5.2 | 1.6e-07 | -0.86 | 0.00 | 0.81 | FALSE |