Best TWAS P=2.75e-09 · Best GWAS P=5.96e-09 conditioned to 0.109
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | NOP14 | 0.12 | 0.06 | enet | 11 | 0.09 | 2.9e-07 | -3.8 | 5.7 | 1.4e-08 | 0.17 | 0.59 | 0.35 | FALSE |
| 2 | GTEx | Colon Transverse | GRK4 | 0.27 | 0.25 | enet | 18 | 0.25 | 2.4e-12 | -4.5 | 5.4 | 8.0e-08 | 0.15 | 0.36 | 0.63 | FALSE |
| 3 | GTEx | Whole Blood | HTT | 0.10 | 0.00 | enet | 15 | 0.03 | 1.4e-03 | 5.8 | 6.0 | 2.7e-09 | 0.60 | 0.01 | 0.93 | TRUE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RNF4 | 0.14 | 0.02 | blup | 47 | 0.07 | 3.1e-04 | 3.0 | 5.2 | 2.2e-07 | 0.19 | 0.00 | 0.02 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf44 | 0.03 | 0.02 | blup | 42 | 0.02 | 8.0e-04 | -4.6 | 5.3 | 9.0e-08 | 0.48 | 0.25 | 0.28 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GRK4 | 0.09 | 0.18 | lasso | 5 | 0.20 | 1.5e-22 | -5.1 | 5.1 | 3.0e-07 | 0.16 | 0.01 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | C4orf44 | 0.03 | 0.04 | lasso | 4 | 0.05 | 2.9e-06 | -4.6 | 5.5 | 5.1e-08 | 0.48 | 0.36 | 0.58 | FALSE |
| 8 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GRK4 | 0.08 | 0.07 | blup | 77 | 0.09 | 4.4e-06 | -4.4 | 5.1 | 3.1e-07 | 0.18 | 0.06 | 0.91 | FALSE |