[Hub]/) : Traits : Leg fat mass (left) : ← →

chr6:33,686,103-36,581,149

Best TWAS P=1.94e-40 · Best GWAS P=1.46e-37 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
61	GTEx	Uterus	UHRF1BP1	0.20	0.03	lasso	4	0.07	1.8e-02	10.8	13.3	1.9e-40	0.72	0.08	0.33	TRUE
48	GTEx	Pancreas	C6orf106	0.14	0.11	enet	11	0.13	2.8e-06	11.6	12.1	1.7e-33	0.89	0.02	0.98	TRUE
97	The Cancer Genome Atlas	Soft Tissue Sarcoma	UHRF1BP1	0.08	0.09	blup	71	0.08	1.0e-05	10.8	10.6	2.2e-26	0.50	0.70	0.12	TRUE
19	GTEx	Brain Cortex	C6orf106	0.22	0.07	enet	16	0.10	1.1e-03	12.8	9.8	1.1e-22	0.75	0.01	0.98	TRUE
15	GTEx	Brain Caudate basal ganglia	UHRF1BP1	0.19	0.14	lasso	7	0.12	3.1e-04	10.8	9.7	4.1e-22	0.46	0.40	0.05	TRUE
38	GTEx	Heart Atrial Appendage	UHRF1BP1	0.13	0.07	enet	17	0.05	1.9e-03	10.8	9.6	5.3e-22	0.38	0.53	0.08	TRUE
64	METSIM	Adipose	C6orf106	0.04	0.02	blup	381	0.02	7.7e-04	8.4	8.8	1.5e-18	0.60	0.03	0.92	TRUE
25	GTEx	Cells EBV-transformed lymphocytes	UHRF1BP1	0.37	0.08	enet	46	0.11	1.7e-04	10.8	6.7	2.6e-11	0.52	0.20	0.58	TRUE
35	GTEx	Esophagus Mucosa	RPL10A	0.14	0.10	enet	17	0.09	2.1e-06	-3.0	-5.8	6.1e-09	-0.15	0.94	0.01	TRUE
52	GTEx	Skin Sun Exposed Lower leg	SRPK1	0.14	0.00	enet	27	0.02	1.2e-02	-4.6	5.4	7.8e-08	0.18	0.24	0.07	TRUE
20	GTEx	Brain Frontal Cortex BA9	RPS10	0.21	0.08	lasso	3	0.06	8.6e-03	3.2	5.3	1.1e-07	0.26	0.11	0.15	TRUE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf106	0.04	0.05	lasso	4	0.03	8.1e-05	12.8	12.7	7.6e-37	0.99	0.01	0.99	FALSE
67	NTR	Blood	C6orf106	0.03	0.02	lasso	6	0.02	7.2e-07	12.7	12.4	1.7e-35	0.98	0.01	0.99	FALSE
44	GTEx	Muscle Skeletal	C6orf106	0.08	0.06	lasso	4	0.06	7.1e-07	11.5	-12.3	1.6e-34	-0.88	0.02	0.98	FALSE
56	GTEx	Stomach	UHRF1BP1	0.24	0.22	enet	20	0.23	2.2e-11	10.9	11.9	7.2e-33	0.57	1.00	0.00	FALSE
43	GTEx	Muscle Skeletal	SNRPC	0.03	0.02	lasso	3	0.02	8.3e-03	10.8	-11.8	2.4e-32	-0.69	0.14	0.63	FALSE
16	GTEx	Brain Caudate basal ganglia	SNRPC	0.19	0.15	lasso	3	0.06	7.7e-03	10.8	-11.7	8.7e-32	-0.65	0.36	0.21	FALSE
99	The Cancer Genome Atlas	Thyroid Carcinoma	SNRPC	0.05	0.05	blup	31	0.05	2.9e-05	10.8	-11.7	1.0e-31	-0.67	0.76	0.15	FALSE
28	GTEx	Cells Transformed fibroblasts	UHRF1BP1	0.34	0.32	enet	44	0.31	2.4e-23	10.8	11.6	3.2e-31	0.64	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SNRPC	0.10	0.16	lasso	4	0.15	3.6e-18	10.8	-11.5	2.1e-30	-0.65	1.00	0.00	FALSE
33	GTEx	Esophagus Mucosa	UHRF1BP1	0.14	0.15	enet	28	0.17	1.3e-11	10.7	11.4	2.7e-30	0.65	1.00	0.00	FALSE
30	GTEx	Colon Transverse	UHRF1BP1	0.42	0.28	lasso	4	0.28	1.6e-13	10.7	11.4	2.8e-30	0.64	1.00	0.00	FALSE
54	GTEx	Small Intestine Terminal Ileum	UHRF1BP1	0.20	0.03	lasso	5	0.00	3.4e-01	10.8	11.3	9.8e-30	0.60	0.14	0.11	FALSE
41	GTEx	Lung	UHRF1BP1	0.17	0.20	enet	22	0.18	4.3e-14	10.8	11.2	3.3e-29	0.57	1.00	0.00	FALSE
40	GTEx	Liver	UHRF1BP1	0.13	0.04	lasso	3	0.05	1.8e-02	10.8	11.2	3.6e-29	0.50	0.14	0.22	FALSE
5	GTEx	Adipose Subcutaneous	UHRF1BP1	0.30	0.35	enet	28	0.36	1.6e-30	10.8	11.2	5.8e-29	0.60	1.00	0.00	FALSE
74	YFS	Blood	UHRF1BP1	0.18	0.34	enet	36	0.34	2.5e-117	10.8	11.1	7.3e-29	0.63	1.00	0.00	FALSE
47	GTEx	Nerve Tibial	C6orf106	0.11	0.07	enet	17	0.07	1.3e-05	12.6	11.1	8.3e-29	0.89	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UHRF1BP1	0.08	0.09	blup	71	0.10	2.0e-06	10.8	11.1	1.1e-28	0.59	0.66	0.32	FALSE
14	GTEx	Artery Tibial	SNRPC	0.06	0.06	lasso	4	0.05	1.3e-04	10.8	-11.0	2.6e-28	-0.61	0.96	0.01	FALSE
17	GTEx	Brain Cerebellar Hemisphere	UHRF1BP1	0.22	0.16	lasso	12	0.15	1.0e-04	10.8	11.0	3.8e-28	0.63	0.12	0.74	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UHRF1BP1	0.18	0.28	lasso	5	0.27	1.0e-30	10.8	11.0	3.8e-28	0.61	1.00	0.00	FALSE
62	GTEx	Vagina	UHRF1BP1	0.31	0.05	lasso	8	0.04	5.0e-02	10.8	11.0	4.2e-28	0.59	0.09	0.51	FALSE
63	GTEx	Whole Blood	UHRF1BP1	0.14	0.14	lasso	7	0.14	2.9e-13	10.8	11.0	4.9e-28	0.55	1.00	0.00	FALSE
45	GTEx	Nerve Tibial	UHRF1BP1	0.31	0.31	lasso	6	0.31	3.9e-22	10.8	11.0	5.0e-28	0.58	1.00	0.00	FALSE
94	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UHRF1BP1	0.20	0.23	lasso	16	0.25	8.3e-11	10.8	11.0	5.0e-28	0.57	0.99	0.01	FALSE
11	GTEx	Artery Aorta	UHRF1BP1	0.35	0.32	lasso	10	0.30	7.7e-17	10.8	11.0	6.2e-28	0.58	1.00	0.00	FALSE
23	GTEx	Breast Mammary Tissue (Male)	UHRF1BP1	0.19	0.16	enet	24	0.08	5.6e-03	10.7	10.9	8.0e-28	0.59	0.43	0.09	FALSE
55	GTEx	Spleen	UHRF1BP1	0.34	0.21	enet	36	0.17	4.5e-05	10.8	10.9	1.3e-27	0.54	0.61	0.06	FALSE
98	The Cancer Genome Atlas	Stomach Adenocarcinoma	UHRF1BP1	0.08	0.10	lasso	1	0.10	7.1e-08	10.8	10.8	2.1e-27	0.59	0.99	0.00	FALSE
71	ROSMAP	Brain Pre-frontal Cortex	SNRPC	0.15	0.27	lasso	4	0.27	4.0e-35	10.8	-10.8	2.3e-27	-0.58	1.00	0.00	FALSE
46	GTEx	Nerve Tibial	SNRPC	0.12	0.10	lasso	4	0.08	1.5e-06	10.8	-10.8	2.6e-27	-0.59	1.00	0.00	FALSE
53	GTEx	Skin Sun Exposed Lower leg	SNRPC	0.03	0.04	lasso	2	0.03	1.9e-03	10.8	-10.8	2.9e-27	-0.59	0.54	0.07	FALSE
34	GTEx	Esophagus Mucosa	SNRPC	0.12	0.10	lasso	2	0.08	4.8e-06	10.8	-10.8	3.2e-27	-0.58	0.99	0.00	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	UHRF1BP1	0.04	0.05	lasso	3	0.04	8.4e-09	10.8	10.8	3.2e-27	0.58	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNRPC	0.06	0.07	lasso	2	0.07	6.7e-08	10.8	-10.8	3.2e-27	-0.58	1.00	0.00	FALSE
101	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SNRPC	0.09	0.11	lasso	2	0.10	8.1e-04	10.8	-10.8	3.2e-27	-0.59	0.06	0.22	FALSE
4	CommonMind	Brain Pre-frontal Cortex	UHRF1BP1	0.17	0.23	lasso	19	0.22	5.8e-27	10.8	10.8	3.4e-27	0.58	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UHRF1BP1	0.03	0.04	lasso	3	0.04	1.7e-04	10.8	10.8	3.5e-27	0.59	0.32	0.04	FALSE
12	GTEx	Artery Coronary	UHRF1BP1	0.33	0.36	lasso	2	0.35	1.6e-12	10.8	10.8	3.8e-27	0.59	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	UHRF1BP1	0.30	0.34	lasso	3	0.34	3.0e-18	10.7	10.8	4.1e-27	0.58	1.00	0.00	FALSE
21	GTEx	Brain Putamen basal ganglia	UHRF1BP1	0.20	0.17	lasso	2	0.16	1.5e-04	10.7	10.8	4.4e-27	0.59	0.22	0.18	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNRPC	0.01	0.01	blup	31	0.00	3.0e-02	4.5	-10.8	5.0e-27	-0.56	0.03	0.04	FALSE
80	The Cancer Genome Atlas	Esophageal Carcinoma	UHRF1BP1	0.19	0.20	lasso	10	0.17	5.2e-06	10.7	10.8	5.2e-27	0.58	0.87	0.03	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	UHRF1BP1	0.08	0.11	lasso	12	0.10	2.3e-06	10.8	10.7	7.3e-27	0.58	0.98	0.00	FALSE
58	GTEx	Thyroid	SNRPC	0.07	0.04	lasso	6	0.05	1.6e-04	10.8	-10.7	8.0e-27	-0.57	0.81	0.03	FALSE
78	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	UHRF1BP1	0.07	0.11	lasso	3	0.07	2.6e-04	10.7	10.7	8.0e-27	0.58	0.73	0.05	FALSE
36	GTEx	Esophagus Muscularis	UHRF1BP1	0.42	0.35	enet	48	0.33	1.0e-20	10.8	10.7	9.9e-27	0.46	1.00	0.00	FALSE
68	NTR	Blood	UHRF1BP1	0.03	0.05	enet	19	0.05	7.4e-15	10.5	10.7	1.5e-26	0.63	1.00	0.00	FALSE
37	GTEx	Esophagus Muscularis	SNRPC	0.09	0.11	lasso	3	0.07	3.8e-05	10.8	-10.6	2.2e-26	-0.59	0.98	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PACSIN1	0.07	0.01	lasso	6	0.02	1.1e-03	12.8	10.6	4.7e-26	0.82	0.01	0.97	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C6orf106	0.04	0.01	blup	68	0.01	2.4e-02	12.7	10.5	5.1e-26	0.88	0.01	0.75	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	C6orf106	0.20	0.00	lasso	5	0.00	2.7e-01	12.0	10.5	7.4e-26	0.80	0.03	0.57	FALSE
93	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	UHRF1BP1	0.06	0.07	lasso	1	0.05	1.5e-04	10.5	10.5	1.1e-25	0.56	0.82	0.03	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	UHRF1BP1	0.16	0.27	lasso	10	0.28	2.7e-36	10.5	10.4	2.6e-25	0.54	1.00	0.00	FALSE
73	YFS	Blood	SNRPC	0.02	0.03	lasso	5	0.02	3.0e-08	10.5	-10.4	2.8e-25	-0.62	0.98	0.02	FALSE
51	GTEx	Skin Sun Exposed Lower leg	UHRF1BP1	0.19	0.13	enet	33	0.14	2.7e-11	10.8	10.3	4.9e-25	0.53	1.00	0.00	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf106	0.03	0.03	lasso	3	0.01	7.6e-03	8.4	10.3	4.9e-25	0.79	0.01	0.89	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	UHRF1BP1	0.10	0.20	lasso	5	0.19	1.6e-19	10.8	10.3	6.8e-25	0.53	1.00	0.00	FALSE
13	GTEx	Artery Tibial	UHRF1BP1	0.31	0.43	lasso	11	0.43	4.0e-36	10.8	10.2	2.8e-24	0.52	1.00	0.00	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	C6orf106	0.30	0.26	bslmm	372	0.33	9.3e-44	12.7	10.1	3.7e-24	0.86	0.01	0.99	FALSE
9	GTEx	Adrenal Gland	SNRPC	0.13	0.04	lasso	6	0.03	2.7e-02	11.6	-10.1	5.1e-24	-0.57	0.17	0.36	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	UHRF1BP1	0.06	0.07	enet	20	0.08	6.4e-10	10.8	10.1	5.3e-24	0.49	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C6orf106	0.29	0.21	bslmm	382	0.23	6.9e-28	12.4	10.0	1.6e-23	0.84	0.01	0.99	FALSE
31	GTEx	Colon Transverse	C6orf106	0.15	0.05	lasso	1	0.03	1.5e-02	10.0	10.0	1.8e-23	0.61	0.05	0.69	FALSE
22	GTEx	Breast Mammary Tissue	UHRF1BP1	0.34	0.28	enet	46	0.29	4.7e-15	10.7	10.0	2.0e-23	0.51	1.00	0.00	FALSE
24	GTEx	Breast Mammary Tissue (Female)	UHRF1BP1	0.23	0.21	lasso	3	0.20	1.0e-06	10.8	9.9	2.5e-23	0.49	0.80	0.07	FALSE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C6orf106	0.14	0.07	enet	6	0.06	1.0e-04	12.7	9.9	3.0e-23	0.88	0.01	0.98	FALSE
66	METSIM	Adipose	UHRF1BP1	0.16	0.31	enet	30	0.32	1.0e-49	10.8	9.7	3.7e-22	0.49	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	SNRPC	0.13	0.13	enet	21	0.13	1.2e-10	10.8	-9.6	5.9e-22	-0.39	1.00	0.00	FALSE
29	GTEx	Colon Sigmoid	UHRF1BP1	0.44	0.36	lasso	12	0.38	1.8e-14	10.8	9.6	1.0e-21	0.44	1.00	0.00	FALSE
18	GTEx	Brain Cerebellum	UHRF1BP1	0.14	0.09	enet	23	0.12	1.5e-04	10.8	9.5	1.8e-21	0.51	0.17	0.29	FALSE
95	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UHRF1BP1	0.13	0.09	enet	13	0.10	6.4e-05	10.8	9.4	3.7e-21	0.52	0.31	0.36	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	UHRF1BP1	0.47	0.38	enet	22	0.43	7.3e-17	10.5	9.2	2.4e-20	0.50	1.00	0.00	FALSE
88	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	UHRF1BP1	0.12	0.09	blup	70	0.06	5.6e-04	10.8	9.2	4.5e-20	0.56	0.26	0.13	FALSE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UHRF1BP1	0.06	0.06	enet	8	0.06	1.3e-07	10.5	8.8	1.0e-18	0.36	0.97	0.01	FALSE
59	GTEx	Thyroid	C6orf106	0.09	0.01	enet	29	0.01	1.1e-01	12.8	8.8	1.7e-18	0.75	0.01	0.86	FALSE
42	GTEx	Muscle Skeletal	UHRF1BP1	0.34	0.34	enet	45	0.39	4.3e-40	10.8	8.3	1.1e-16	0.34	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UHRF1BP1	0.04	0.06	blup	70	0.06	1.5e-07	10.8	8.1	5.1e-16	0.36	0.98	0.00	FALSE
65	METSIM	Adipose	SNRPC	0.05	0.05	lasso	7	0.07	2.9e-11	10.8	-7.9	3.9e-15	-0.32	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	UHRF1BP1	0.06	0.05	blup	70	0.04	8.6e-06	4.5	7.5	4.9e-14	0.20	0.97	0.00	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	PACSIN1	0.09	0.00	blup	359	0.02	4.5e-04	12.4	7.4	1.1e-13	0.69	0.01	0.94	FALSE
39	GTEx	Heart Left Ventricle	UHRF1BP1	0.23	0.12	lasso	7	0.22	1.2e-11	10.7	7.3	2.2e-13	0.33	1.00	0.00	FALSE
57	GTEx	Thyroid	UHRF1BP1	0.13	0.06	enet	37	0.08	5.9e-07	4.0	7.2	7.5e-13	0.23	0.99	0.00	FALSE
27	GTEx	Cells Transformed fibroblasts	DEF6	0.14	0.03	enet	35	0.04	9.7e-04	5.1	-7.0	1.8e-12	-0.17	0.60	0.01	FALSE
8	GTEx	Adrenal Gland	UHRF1BP1	0.32	0.26	enet	33	0.33	1.3e-12	10.8	7.0	2.6e-12	0.29	1.00	0.00	FALSE
10	GTEx	Artery Aorta	ANKS1A	0.10	0.10	lasso	2	0.08	2.4e-05	-6.8	-7.0	3.8e-12	-0.17	0.39	0.03	FALSE
100	The Cancer Genome Atlas	Thyroid Carcinoma	UHRF1BP1	0.07	0.03	blup	71	0.05	2.8e-05	10.8	6.7	2.5e-11	0.20	0.77	0.01	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	UHRF1BP1	0.20	0.10	enet	30	0.15	2.1e-08	10.7	6.4	1.7e-10	0.21	0.99	0.00	FALSE
60	GTEx	Thyroid	RPL10A	0.16	0.09	lasso	11	0.07	8.9e-06	-5.8	-5.7	9.5e-09	-0.16	0.89	0.00	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	SNRPC	0.18	0.04	enet	37	0.03	1.0e-02	10.6	-5.6	2.7e-08	-0.17	0.24	0.05	FALSE