[Hub]/) : Traits : Leg fat mass (left) :

chr6:33,686,103-36,581,149

Best TWAS P=1.94e-40 · Best GWAS P=1.46e-37 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C6orf106 0.29 0.21 bslmm 382 0.23 6.9e-28 12.4 10.0 1.6e-23 0.84 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex PACSIN1 0.07 0.01 lasso 6 0.02 1.1e-03 12.8 10.6 4.7e-26 0.82 0.01 0.97 FALSE
3 CommonMind Brain Pre-frontal Cortex SNRPC 0.10 0.16 lasso 4 0.15 3.6e-18 10.8 -11.5 2.1e-30 -0.65 1.00 0.00 FALSE
4 CommonMind Brain Pre-frontal Cortex UHRF1BP1 0.17 0.23 lasso 19 0.22 5.8e-27 10.8 10.8 3.4e-27 0.58 1.00 0.00 FALSE
5 GTEx Adipose Subcutaneous UHRF1BP1 0.30 0.35 enet 28 0.36 1.6e-30 10.8 11.2 5.8e-29 0.60 1.00 0.00 FALSE
6 GTEx Adipose Subcutaneous SNRPC 0.13 0.13 enet 21 0.13 1.2e-10 10.8 -9.6 5.9e-22 -0.39 1.00 0.00 FALSE
7 GTEx Adipose Visceral Omentum UHRF1BP1 0.30 0.34 lasso 3 0.34 3.0e-18 10.7 10.8 4.1e-27 0.58 1.00 0.00 FALSE
8 GTEx Adrenal Gland UHRF1BP1 0.32 0.26 enet 33 0.33 1.3e-12 10.8 7.0 2.6e-12 0.29 1.00 0.00 FALSE
9 GTEx Adrenal Gland SNRPC 0.13 0.04 lasso 6 0.03 2.7e-02 11.6 -10.1 5.1e-24 -0.57 0.17 0.36 FALSE
10 GTEx Artery Aorta ANKS1A 0.10 0.10 lasso 2 0.08 2.4e-05 -6.8 -7.0 3.8e-12 -0.17 0.39 0.03 FALSE
11 GTEx Artery Aorta UHRF1BP1 0.35 0.32 lasso 10 0.30 7.7e-17 10.8 11.0 6.2e-28 0.58 1.00 0.00 FALSE
12 GTEx Artery Coronary UHRF1BP1 0.33 0.36 lasso 2 0.35 1.6e-12 10.8 10.8 3.8e-27 0.59 1.00 0.00 FALSE
13 GTEx Artery Tibial UHRF1BP1 0.31 0.43 lasso 11 0.43 4.0e-36 10.8 10.2 2.8e-24 0.52 1.00 0.00 FALSE
14 GTEx Artery Tibial SNRPC 0.06 0.06 lasso 4 0.05 1.3e-04 10.8 -11.0 2.6e-28 -0.61 0.96 0.01 FALSE
15 GTEx Brain Caudate basal ganglia UHRF1BP1 0.19 0.14 lasso 7 0.12 3.1e-04 10.8 9.7 4.1e-22 0.46 0.40 0.05 TRUE
16 GTEx Brain Caudate basal ganglia SNRPC 0.19 0.15 lasso 3 0.06 7.7e-03 10.8 -11.7 8.7e-32 -0.65 0.36 0.21 FALSE
17 GTEx Brain Cerebellar Hemisphere UHRF1BP1 0.22 0.16 lasso 12 0.15 1.0e-04 10.8 11.0 3.8e-28 0.63 0.12 0.74 FALSE
18 GTEx Brain Cerebellum UHRF1BP1 0.14 0.09 enet 23 0.12 1.5e-04 10.8 9.5 1.8e-21 0.51 0.17 0.29 FALSE
19 GTEx Brain Cortex C6orf106 0.22 0.07 enet 16 0.10 1.1e-03 12.8 9.8 1.1e-22 0.75 0.01 0.98 TRUE
20 GTEx Brain Frontal Cortex BA9 RPS10 0.21 0.08 lasso 3 0.06 8.6e-03 3.2 5.3 1.1e-07 0.26 0.11 0.15 TRUE
21 GTEx Brain Putamen basal ganglia UHRF1BP1 0.20 0.17 lasso 2 0.16 1.5e-04 10.7 10.8 4.4e-27 0.59 0.22 0.18 FALSE
22 GTEx Breast Mammary Tissue UHRF1BP1 0.34 0.28 enet 46 0.29 4.7e-15 10.7 10.0 2.0e-23 0.51 1.00 0.00 FALSE
23 GTEx Breast Mammary Tissue (Male) UHRF1BP1 0.19 0.16 enet 24 0.08 5.6e-03 10.7 10.9 8.0e-28 0.59 0.43 0.09 FALSE
24 GTEx Breast Mammary Tissue (Female) UHRF1BP1 0.23 0.21 lasso 3 0.20 1.0e-06 10.8 9.9 2.5e-23 0.49 0.80 0.07 FALSE
25 GTEx Cells EBV-transformed lymphocytes UHRF1BP1 0.37 0.08 enet 46 0.11 1.7e-04 10.8 6.7 2.6e-11 0.52 0.20 0.58 TRUE
26 GTEx Cells EBV-transformed lymphocytes C6orf106 0.20 0.00 lasso 5 0.00 2.7e-01 12.0 10.5 7.4e-26 0.80 0.03 0.57 FALSE
27 GTEx Cells Transformed fibroblasts DEF6 0.14 0.03 enet 35 0.04 9.7e-04 5.1 -7.0 1.8e-12 -0.17 0.60 0.01 FALSE
28 GTEx Cells Transformed fibroblasts UHRF1BP1 0.34 0.32 enet 44 0.31 2.4e-23 10.8 11.6 3.2e-31 0.64 1.00 0.00 FALSE
29 GTEx Colon Sigmoid UHRF1BP1 0.44 0.36 lasso 12 0.38 1.8e-14 10.8 9.6 1.0e-21 0.44 1.00 0.00 FALSE
30 GTEx Colon Transverse UHRF1BP1 0.42 0.28 lasso 4 0.28 1.6e-13 10.7 11.4 2.8e-30 0.64 1.00 0.00 FALSE
31 GTEx Colon Transverse C6orf106 0.15 0.05 lasso 1 0.03 1.5e-02 10.0 10.0 1.8e-23 0.61 0.05 0.69 FALSE
32 GTEx Esophagus Gastroesophageal Junction UHRF1BP1 0.47 0.38 enet 22 0.43 7.3e-17 10.5 9.2 2.4e-20 0.50 1.00 0.00 FALSE
33 GTEx Esophagus Mucosa UHRF1BP1 0.14 0.15 enet 28 0.17 1.3e-11 10.7 11.4 2.7e-30 0.65 1.00 0.00 FALSE
34 GTEx Esophagus Mucosa SNRPC 0.12 0.10 lasso 2 0.08 4.8e-06 10.8 -10.8 3.2e-27 -0.58 0.99 0.00 FALSE
35 GTEx Esophagus Mucosa RPL10A 0.14 0.10 enet 17 0.09 2.1e-06 -3.0 -5.8 6.1e-09 -0.15 0.94 0.01 TRUE
36 GTEx Esophagus Muscularis UHRF1BP1 0.42 0.35 enet 48 0.33 1.0e-20 10.8 10.7 9.9e-27 0.46 1.00 0.00 FALSE
37 GTEx Esophagus Muscularis SNRPC 0.09 0.11 lasso 3 0.07 3.8e-05 10.8 -10.6 2.2e-26 -0.59 0.98 0.00 FALSE
38 GTEx Heart Atrial Appendage UHRF1BP1 0.13 0.07 enet 17 0.05 1.9e-03 10.8 9.6 5.3e-22 0.38 0.53 0.08 TRUE
39 GTEx Heart Left Ventricle UHRF1BP1 0.23 0.12 lasso 7 0.22 1.2e-11 10.7 7.3 2.2e-13 0.33 1.00 0.00 FALSE
40 GTEx Liver UHRF1BP1 0.13 0.04 lasso 3 0.05 1.8e-02 10.8 11.2 3.6e-29 0.50 0.14 0.22 FALSE
41 GTEx Lung UHRF1BP1 0.17 0.20 enet 22 0.18 4.3e-14 10.8 11.2 3.3e-29 0.57 1.00 0.00 FALSE
42 GTEx Muscle Skeletal UHRF1BP1 0.34 0.34 enet 45 0.39 4.3e-40 10.8 8.3 1.1e-16 0.34 1.00 0.00 FALSE
43 GTEx Muscle Skeletal SNRPC 0.03 0.02 lasso 3 0.02 8.3e-03 10.8 -11.8 2.4e-32 -0.69 0.14 0.63 FALSE
44 GTEx Muscle Skeletal C6orf106 0.08 0.06 lasso 4 0.06 7.1e-07 11.5 -12.3 1.6e-34 -0.88 0.02 0.98 FALSE
45 GTEx Nerve Tibial UHRF1BP1 0.31 0.31 lasso 6 0.31 3.9e-22 10.8 11.0 5.0e-28 0.58 1.00 0.00 FALSE
46 GTEx Nerve Tibial SNRPC 0.12 0.10 lasso 4 0.08 1.5e-06 10.8 -10.8 2.6e-27 -0.59 1.00 0.00 FALSE
47 GTEx Nerve Tibial C6orf106 0.11 0.07 enet 17 0.07 1.3e-05 12.6 11.1 8.3e-29 0.89 0.01 0.99 FALSE
48 GTEx Pancreas C6orf106 0.14 0.11 enet 11 0.13 2.8e-06 11.6 12.1 1.7e-33 0.89 0.02 0.98 TRUE
49 GTEx Skin Not Sun Exposed Suprapubic UHRF1BP1 0.20 0.10 enet 30 0.15 2.1e-08 10.7 6.4 1.7e-10 0.21 0.99 0.00 FALSE
50 GTEx Skin Not Sun Exposed Suprapubic SNRPC 0.18 0.04 enet 37 0.03 1.0e-02 10.6 -5.6 2.7e-08 -0.17 0.24 0.05 FALSE
51 GTEx Skin Sun Exposed Lower leg UHRF1BP1 0.19 0.13 enet 33 0.14 2.7e-11 10.8 10.3 4.9e-25 0.53 1.00 0.00 FALSE
52 GTEx Skin Sun Exposed Lower leg SRPK1 0.14 0.00 enet 27 0.02 1.2e-02 -4.6 5.4 7.8e-08 0.18 0.24 0.07 TRUE
53 GTEx Skin Sun Exposed Lower leg SNRPC 0.03 0.04 lasso 2 0.03 1.9e-03 10.8 -10.8 2.9e-27 -0.59 0.54 0.07 FALSE
54 GTEx Small Intestine Terminal Ileum UHRF1BP1 0.20 0.03 lasso 5 0.00 3.4e-01 10.8 11.3 9.8e-30 0.60 0.14 0.11 FALSE
55 GTEx Spleen UHRF1BP1 0.34 0.21 enet 36 0.17 4.5e-05 10.8 10.9 1.3e-27 0.54 0.61 0.06 FALSE
56 GTEx Stomach UHRF1BP1 0.24 0.22 enet 20 0.23 2.2e-11 10.9 11.9 7.2e-33 0.57 1.00 0.00 FALSE
57 GTEx Thyroid UHRF1BP1 0.13 0.06 enet 37 0.08 5.9e-07 4.0 7.2 7.5e-13 0.23 0.99 0.00 FALSE
58 GTEx Thyroid SNRPC 0.07 0.04 lasso 6 0.05 1.6e-04 10.8 -10.7 8.0e-27 -0.57 0.81 0.03 FALSE
59 GTEx Thyroid C6orf106 0.09 0.01 enet 29 0.01 1.1e-01 12.8 8.8 1.7e-18 0.75 0.01 0.86 FALSE
60 GTEx Thyroid RPL10A 0.16 0.09 lasso 11 0.07 8.9e-06 -5.8 -5.7 9.5e-09 -0.16 0.89 0.00 FALSE
61 GTEx Uterus UHRF1BP1 0.20 0.03 lasso 4 0.07 1.8e-02 10.8 13.3 1.9e-40 0.72 0.08 0.33 TRUE
62 GTEx Vagina UHRF1BP1 0.31 0.05 lasso 8 0.04 5.0e-02 10.8 11.0 4.2e-28 0.59 0.09 0.51 FALSE
63 GTEx Whole Blood UHRF1BP1 0.14 0.14 lasso 7 0.14 2.9e-13 10.8 11.0 4.9e-28 0.55 1.00 0.00 FALSE
64 METSIM Adipose C6orf106 0.04 0.02 blup 381 0.02 7.7e-04 8.4 8.8 1.5e-18 0.60 0.03 0.92 TRUE
65 METSIM Adipose SNRPC 0.05 0.05 lasso 7 0.07 2.9e-11 10.8 -7.9 3.9e-15 -0.32 1.00 0.00 FALSE
66 METSIM Adipose UHRF1BP1 0.16 0.31 enet 30 0.32 1.0e-49 10.8 9.7 3.7e-22 0.49 1.00 0.00 FALSE
67 NTR Blood C6orf106 0.03 0.02 lasso 6 0.02 7.2e-07 12.7 12.4 1.7e-35 0.98 0.01 0.99 FALSE
68 NTR Blood UHRF1BP1 0.03 0.05 enet 19 0.05 7.4e-15 10.5 10.7 1.5e-26 0.63 1.00 0.00 FALSE
69 ROSMAP Brain Pre-frontal Cortex UHRF1BP1 0.16 0.27 lasso 10 0.28 2.7e-36 10.5 10.4 2.6e-25 0.54 1.00 0.00 FALSE
70 ROSMAP Brain Pre-frontal Cortex PACSIN1 0.09 0.00 blup 359 0.02 4.5e-04 12.4 7.4 1.1e-13 0.69 0.01 0.94 FALSE
71 ROSMAP Brain Pre-frontal Cortex SNRPC 0.15 0.27 lasso 4 0.27 4.0e-35 10.8 -10.8 2.3e-27 -0.58 1.00 0.00 FALSE
72 ROSMAP Brain Pre-frontal Cortex C6orf106 0.30 0.26 bslmm 372 0.33 9.3e-44 12.7 10.1 3.7e-24 0.86 0.01 0.99 FALSE
73 YFS Blood SNRPC 0.02 0.03 lasso 5 0.02 3.0e-08 10.5 -10.4 2.8e-25 -0.62 0.98 0.02 FALSE
74 YFS Blood UHRF1BP1 0.18 0.34 enet 36 0.34 2.5e-117 10.8 11.1 7.3e-29 0.63 1.00 0.00 FALSE
75 The Cancer Genome Atlas Bladder Urothelial Carcinoma UHRF1BP1 0.03 0.04 lasso 3 0.04 1.7e-04 10.8 10.8 3.5e-27 0.59 0.32 0.04 FALSE
76 The Cancer Genome Atlas Breast Invasive Carcinoma SNRPC 0.01 0.01 blup 31 0.00 3.0e-02 4.5 -10.8 5.0e-27 -0.56 0.03 0.04 FALSE
77 The Cancer Genome Atlas Breast Invasive Carcinoma UHRF1BP1 0.04 0.05 lasso 3 0.04 8.4e-09 10.8 10.8 3.2e-27 0.58 1.00 0.00 FALSE
78 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma UHRF1BP1 0.07 0.11 lasso 3 0.07 2.6e-04 10.7 10.7 8.0e-27 0.58 0.73 0.05 FALSE
79 The Cancer Genome Atlas Colon Adenocarcinoma UHRF1BP1 0.08 0.11 lasso 12 0.10 2.3e-06 10.8 10.7 7.3e-27 0.58 0.98 0.00 FALSE
80 The Cancer Genome Atlas Esophageal Carcinoma UHRF1BP1 0.19 0.20 lasso 10 0.17 5.2e-06 10.7 10.8 5.2e-27 0.58 0.87 0.03 FALSE
81 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SNRPC 0.06 0.07 lasso 2 0.07 6.7e-08 10.8 -10.8 3.2e-27 -0.58 1.00 0.00 FALSE
82 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma UHRF1BP1 0.06 0.06 enet 8 0.06 1.3e-07 10.5 8.8 1.0e-18 0.36 0.97 0.01 FALSE
83 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C6orf106 0.04 0.01 blup 68 0.01 2.4e-02 12.7 10.5 5.1e-26 0.88 0.01 0.75 FALSE
84 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UHRF1BP1 0.18 0.28 lasso 5 0.27 1.0e-30 10.8 11.0 3.8e-28 0.61 1.00 0.00 FALSE
85 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma UHRF1BP1 0.08 0.09 blup 71 0.10 2.0e-06 10.8 11.1 1.1e-28 0.59 0.66 0.32 FALSE
86 The Cancer Genome Atlas Brain Lower Grade Glioma C6orf106 0.04 0.05 lasso 4 0.03 8.1e-05 12.8 12.7 7.6e-37 0.99 0.01 0.99 FALSE
87 The Cancer Genome Atlas Brain Lower Grade Glioma UHRF1BP1 0.06 0.05 blup 70 0.04 8.6e-06 4.5 7.5 4.9e-14 0.20 0.97 0.00 FALSE
88 The Cancer Genome Atlas Liver Hepatocellular Carcinoma UHRF1BP1 0.12 0.09 blup 70 0.06 5.6e-04 10.8 9.2 4.5e-20 0.56 0.26 0.13 FALSE
89 The Cancer Genome Atlas Lung Adenocarcinoma C6orf106 0.03 0.03 lasso 3 0.01 7.6e-03 8.4 10.3 4.9e-25 0.79 0.01 0.89 FALSE
90 The Cancer Genome Atlas Lung Adenocarcinoma UHRF1BP1 0.06 0.07 enet 20 0.08 6.4e-10 10.8 10.1 5.3e-24 0.49 1.00 0.00 FALSE
91 The Cancer Genome Atlas Lung Squamous Cell Carcinoma UHRF1BP1 0.04 0.06 blup 70 0.06 1.5e-07 10.8 8.1 5.1e-16 0.36 0.98 0.00 FALSE
92 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C6orf106 0.14 0.07 enet 6 0.06 1.0e-04 12.7 9.9 3.0e-23 0.88 0.01 0.98 FALSE
93 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma UHRF1BP1 0.06 0.07 lasso 1 0.05 1.5e-04 10.5 10.5 1.1e-25 0.56 0.82 0.03 FALSE
94 The Cancer Genome Atlas Pancreatic Adenocarcinoma UHRF1BP1 0.20 0.23 lasso 16 0.25 8.3e-11 10.8 11.0 5.0e-28 0.57 0.99 0.01 FALSE
95 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma UHRF1BP1 0.13 0.09 enet 13 0.10 6.4e-05 10.8 9.4 3.7e-21 0.52 0.31 0.36 FALSE
96 The Cancer Genome Atlas Prostate Adenocarcinoma UHRF1BP1 0.10 0.20 lasso 5 0.19 1.6e-19 10.8 10.3 6.8e-25 0.53 1.00 0.00 FALSE
97 The Cancer Genome Atlas Soft Tissue Sarcoma UHRF1BP1 0.08 0.09 blup 71 0.08 1.0e-05 10.8 10.6 2.2e-26 0.50 0.70 0.12 TRUE
98 The Cancer Genome Atlas Stomach Adenocarcinoma UHRF1BP1 0.08 0.10 lasso 1 0.10 7.1e-08 10.8 10.8 2.1e-27 0.59 0.99 0.00 FALSE
99 The Cancer Genome Atlas Thyroid Carcinoma SNRPC 0.05 0.05 blup 31 0.05 2.9e-05 10.8 -11.7 1.0e-31 -0.67 0.76 0.15 FALSE
100 The Cancer Genome Atlas Thyroid Carcinoma UHRF1BP1 0.07 0.03 blup 71 0.05 2.8e-05 10.8 6.7 2.5e-11 0.20 0.77 0.01 FALSE
101 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma SNRPC 0.09 0.11 lasso 2 0.10 8.1e-04 10.8 -10.8 3.2e-27 -0.59 0.06 0.22 FALSE