Best TWAS P=2.75e-08 · Best GWAS P=1.03e-08 conditioned to 0.0537
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MGAT3 | 0.08 | 0.04 | lasso | 4 | 0.04 | 4.3e-04 | -5.6 | 5.1 | 3.0e-07 | 0.04 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Heart Atrial Appendage | MGAT3 | 0.14 | 0.14 | lasso | 2 | 0.12 | 3.5e-06 | -5.4 | 5.5 | 3.9e-08 | 0.02 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Nerve Tibial | SYNGR1 | 0.26 | 0.18 | enet | 27 | 0.21 | 3.6e-15 | -4.1 | -5.1 | 3.0e-07 | -0.04 | 0.07 | 0.93 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | MGAT3 | 0.13 | 0.05 | lasso | 3 | 0.02 | 4.7e-03 | -5.4 | 5.6 | 2.8e-08 | 0.01 | 0.01 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 1.6e-04 | -5.6 | -5.2 | 2.1e-07 | 0.86 | 0.00 | 0.94 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 8.9e-03 | -5.4 | -5.2 | 1.7e-07 | 0.82 | 0.01 | 0.61 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 6.6e-03 | -5.5 | -5.5 | 4.5e-08 | 0.97 | 0.00 | 0.81 | FALSE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 7.7e-02 | -5.7 | -5.5 | 4.0e-08 | 0.91 | 0.00 | 0.76 | TRUE |