[Hub]/) : Traits : Leg fat-free mass (left) :

chr2:35,883,253-37,567,226

Best TWAS P=1.56e-12 · Best GWAS P=1.7e-12 conditioned to 0.0597

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FEZ2 0.16 0.24 lasso 2 0.22 1.3e-26 6.9 -6.9 5.0e-12 -0.97 0.00 1.00 FALSE
2 GTEx Adipose Subcutaneous AC007401.1 0.10 0.02 lasso 4 0.02 5.4e-03 6.2 6.9 5.2e-12 0.87 0.02 0.96 FALSE
3 GTEx Artery Tibial CRIM1 0.10 0.04 lasso 4 0.05 1.4e-04 6.2 -7.1 1.6e-12 -0.86 0.02 0.98 TRUE
4 GTEx Artery Tibial RP11-78I14.1 0.10 0.08 enet 16 0.07 4.2e-06 6.2 -6.8 9.2e-12 -0.71 0.12 0.83 FALSE
5 GTEx Brain Cerebellar Hemisphere CRIM1 0.36 0.21 lasso 5 0.16 5.4e-05 6.4 6.5 7.1e-11 0.85 0.05 0.87 FALSE
6 GTEx Brain Cerebellar Hemisphere FEZ2 0.41 0.30 lasso 6 0.28 8.6e-08 6.0 6.1 8.5e-10 0.89 0.04 0.95 FALSE
7 GTEx Brain Cerebellar Hemisphere AC007401.1 0.40 0.26 lasso 4 0.22 2.3e-06 6.4 6.2 4.5e-10 0.87 0.06 0.92 FALSE
8 GTEx Brain Cerebellar Hemisphere RP11-490M8.1 0.37 0.18 lasso 4 0.15 1.2e-04 6.0 6.2 6.6e-10 0.90 0.03 0.88 FALSE
9 GTEx Brain Cerebellum FEZ2 0.44 0.26 lasso 6 0.23 2.6e-07 5.6 5.8 5.6e-09 0.84 0.19 0.80 FALSE
10 GTEx Brain Cerebellum AC007401.1 0.27 0.21 enet 5 0.20 1.5e-06 6.4 6.3 2.2e-10 0.86 0.08 0.88 FALSE
11 GTEx Brain Cerebellum RP11-490M8.1 0.21 0.21 lasso 4 0.20 1.4e-06 5.8 6.0 2.6e-09 0.82 0.05 0.92 FALSE
12 GTEx Spleen FEZ2 0.42 0.16 enet 25 0.17 3.9e-05 5.8 6.9 6.0e-12 0.66 0.04 0.89 FALSE
13 GTEx Whole Blood AC007401.1 0.06 0.06 lasso 5 0.05 4.6e-05 6.0 6.2 4.1e-10 0.89 0.12 0.84 FALSE
14 NTR Blood CRIM1 0.09 0.10 lasso 6 0.11 3.1e-32 6.0 -6.1 1.2e-09 -0.91 0.21 0.79 FALSE
15 ROSMAP Brain Pre-frontal Cortex FEZ2 0.41 0.55 lasso 5 0.58 3.1e-93 6.2 -6.3 2.8e-10 -0.93 0.36 0.64 FALSE
16 The Cancer Genome Atlas Breast Invasive Carcinoma FEZ2 0.01 0.01 blup 85 0.01 1.0e-03 6.0 -7.1 1.7e-12 -0.90 0.01 0.97 FALSE
17 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FEZ2 0.06 0.05 lasso 4 0.04 3.3e-03 6.2 -6.1 9.7e-10 -0.92 0.04 0.83 FALSE
18 The Cancer Genome Atlas Colon Adenocarcinoma FEZ2 0.11 0.03 blup 84 0.07 6.1e-05 6.9 -5.7 1.3e-08 -0.89 0.02 0.96 FALSE
19 The Cancer Genome Atlas Esophageal Carcinoma FEZ2 0.11 0.01 blup 87 0.02 7.1e-02 5.6 -5.2 1.9e-07 -0.80 0.05 0.25 FALSE
20 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FEZ2 0.04 0.00 blup 88 0.02 6.1e-03 5.7 -5.2 2.1e-07 -0.83 0.02 0.86 FALSE
21 The Cancer Genome Atlas Prostate Adenocarcinoma FEZ2 0.06 0.05 blup 87 0.08 1.4e-08 6.2 -6.6 3.4e-11 -0.91 0.08 0.92 FALSE
22 The Cancer Genome Atlas Testicular Germ Cell Tumors FEZ2 0.18 0.21 lasso 6 0.21 5.3e-08 -4.2 -5.3 8.6e-08 -0.67 0.15 0.82 FALSE
23 The Cancer Genome Atlas Thyroid Carcinoma FEZ2 0.07 0.06 blup 87 0.06 2.4e-06 6.0 -5.4 7.5e-08 -0.80 0.39 0.60 FALSE