[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr2:26,223,547-29,344,127

Best TWAS P=2.9e-31 · Best GWAS P=2.02e-29 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	-11.3	11.6	2.9e-31	-0.99	0.00	0.96	TRUE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	7.9	9.6	5.8e-22	-0.40	0.19	0.15	TRUE
21	ROSMAP	Brain Pre-frontal Cortex	KCNK3	0.24	0.15	lasso	3	0.15	6.5e-19	6.8	-7.2	5.9e-13	0.09	0.00	1.00	TRUE
4	GTEx	Breast Mammary Tissue (Female)	AC074117.10	0.06	0.01	lasso	2	0.04	2.7e-02	5.8	6.5	1.0e-10	-0.23	0.04	0.05	TRUE
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	3.9	-5.9	3.0e-09	0.72	0.28	0.72	TRUE
26	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SUPT7L	0.06	0.03	blup	29	0.05	2.0e-03	7.8	5.7	1.4e-08	-0.04	0.04	0.05	TRUE
16	GTEx	Thyroid	RP11-373D23.3	0.16	0.07	enet	19	0.04	2.6e-04	3.8	-5.2	1.8e-07	0.15	0.29	0.28	TRUE
5	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	3.9	-5.2	2.5e-07	0.64	0.43	0.30	TRUE
31	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	7.1	9.5	2.6e-21	-0.70	0.41	0.59	FALSE
15	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	6.9	9.4	3.3e-21	-0.69	0.67	0.33	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	6.9	8.8	1.0e-18	-0.64	0.91	0.09	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	7.5	8.4	6.2e-17	-0.54	0.02	0.27	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	-9.2	-7.8	4.6e-15	0.54	0.00	0.99	FALSE
14	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	3.9	-7.7	1.8e-14	0.85	0.05	0.94	FALSE
12	GTEx	Stomach	AC074117.10	0.06	0.01	lasso	7	0.01	7.8e-02	5.3	7.6	2.8e-14	-0.36	0.20	0.08	FALSE
7	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	5.3	-7.3	2.4e-13	0.82	0.01	0.97	FALSE
13	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	5.3	-7.1	1.1e-12	0.80	0.03	0.96	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	4.6	6.9	4.5e-12	-0.63	0.43	0.49	FALSE
6	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	5.3	-6.7	1.8e-11	0.74	0.94	0.06	FALSE
10	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	3.8	-6.5	5.7e-11	0.77	0.04	0.80	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX17	0.08	0.01	blup	25	0.02	6.6e-05	3.4	6.0	1.4e-09	-0.55	0.02	0.34	FALSE
17	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	3.3	-5.9	3.4e-09	0.72	0.08	0.57	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	3.8	5.7	1.6e-08	-0.75	0.48	0.52	FALSE
18	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	5.3	-5.5	3.3e-08	0.67	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf18	0.20	0.02	blup	30	0.06	6.7e-03	4.9	5.5	4.5e-08	-0.04	0.01	0.40	FALSE
9	GTEx	Muscle Skeletal	GPN1	0.06	0.02	enet	9	0.02	2.9e-03	-1.6	-5.4	5.8e-08	0.43	0.29	0.07	FALSE
11	GTEx	Skin Sun Exposed Lower leg	SLC35F6	0.10	0.04	lasso	4	0.05	4.2e-05	-4.1	5.3	8.9e-08	-0.01	0.38	0.22	FALSE
3	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	5.3	-5.3	1.0e-07	0.65	0.45	0.27	FALSE
8	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	5.3	-5.3	1.1e-07	0.65	0.73	0.26	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	5.3	-5.3	1.1e-07	0.67	0.02	0.09	FALSE
19	METSIM	Adipose	SLC5A6	0.03	0.02	bslmm	298	0.01	3.9e-03	2.9	-5.2	1.6e-07	0.43	0.25	0.04	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	SLC35F6	0.05	0.04	enet	11	0.04	8.0e-06	-4.1	5.2	1.7e-07	-0.07	0.21	0.78	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	5.3	-5.2	2.0e-07	0.65	0.04	0.70	FALSE