Best TWAS P=1.12e-12 · Best GWAS P=6.43e-13 conditioned to 8.15e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | LUZP1 | 0.23 | 0.14 | lasso | 5 | 0.10 | 7.8e-04 | -6.4 | 6.5 | 1.0e-10 | -0.02 | 0.02 | 0.80 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | LUZP1 | 0.09 | 0.09 | lasso | 4 | 0.08 | 2.8e-06 | -6.4 | 6.4 | 1.3e-10 | -0.02 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Testis | LUZP1 | 0.17 | 0.09 | lasso | 4 | 0.08 | 2.6e-04 | -6.1 | -5.8 | 6.7e-09 | 0.07 | 0.05 | 0.84 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WNT4 | 0.03 | 0.01 | blup | 72 | 0.02 | 3.8e-05 | 5.3 | 7.1 | 1.1e-12 | 0.46 | 0.27 | 0.45 | TRUE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | HTR1D | 0.10 | 0.07 | enet | 7 | 0.08 | 3.8e-05 | -4.6 | 5.6 | 2.3e-08 | 0.00 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HTR1D | 0.24 | 0.12 | lasso | 4 | 0.12 | 1.2e-05 | -6.2 | 6.5 | 6.2e-11 | -0.07 | 0.02 | 0.97 | TRUE |
| 7 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HTR1D | 0.19 | 0.12 | enet | 11 | 0.13 | 7.3e-04 | -6.5 | 5.8 | 5.1e-09 | -0.01 | 0.01 | 0.90 | FALSE |