[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr3:51,860,817-53,860,103

Best TWAS P=1.54e-09 · Best GWAS P=1.33e-08 conditioned to 0.77

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	The Cancer Genome Atlas	Lung Adenocarcinoma	SPCS1	0.11	0.00	blup	41	0.01	9.9e-03	-3.5	6.0	1.5e-09	0.53	0.00	0.35	TRUE
3	GTEx	Prostate	RFT1	0.39	0.18	enet	17	0.24	1.1e-06	2.9	5.5	3.0e-08	0.49	0.14	0.77	TRUE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM110	0.20	0.06	blup	59	0.10	1.2e-10	5.5	6.0	2.0e-09	0.65	0.00	0.99	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM110	0.20	0.13	blup	59	0.15	3.0e-10	5.5	5.9	4.3e-09	0.61	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM110	0.13	0.06	blup	59	0.08	3.3e-09	4.1	5.8	6.4e-09	0.50	0.61	0.36	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPCS1	0.15	0.03	lasso	3	0.04	4.3e-05	5.4	5.8	6.6e-09	0.95	0.00	0.95	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMEM110	0.12	0.07	blup	59	0.12	7.5e-08	5.5	5.8	7.0e-09	0.52	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RFT1	0.31	0.07	blup	45	0.19	1.8e-09	2.7	5.7	1.3e-08	0.48	0.02	0.97	FALSE
36	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RFT1	0.29	0.15	blup	45	0.15	6.5e-05	4.4	5.7	1.4e-08	0.43	0.02	0.83	FALSE
33	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM110	0.19	0.12	blup	59	0.13	1.6e-09	4.9	5.6	1.9e-08	0.61	0.06	0.94	FALSE
10	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM110	0.24	0.09	blup	59	0.14	1.4e-07	4.8	5.6	2.0e-08	0.59	0.02	0.97	FALSE
34	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM110	0.20	0.01	lasso	2	0.09	3.2e-04	5.5	5.6	2.0e-08	0.56	0.00	0.87	FALSE
7	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM110	0.19	0.13	blup	59	0.13	4.2e-11	4.8	5.6	2.6e-08	0.58	0.04	0.95	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM110	0.36	0.05	blup	59	0.08	3.4e-04	5.0	5.5	3.2e-08	0.56	0.02	0.66	FALSE
32	The Cancer Genome Atlas	Stomach Adenocarcinoma	RFT1	0.13	0.05	blup	45	0.10	6.9e-08	5.2	5.5	3.9e-08	0.44	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM110	0.19	0.10	lasso	5	0.11	2.1e-12	5.0	5.5	4.3e-08	0.45	0.05	0.94	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	GLT8D1	0.10	0.01	enet	7	0.03	4.4e-06	5.4	5.5	4.5e-08	0.67	0.00	0.95	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM110	0.27	0.10	blup	59	0.14	3.0e-15	5.1	5.5	4.5e-08	0.61	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	GLT8D1	0.22	0.08	lasso	1	0.07	8.5e-09	5.4	5.4	6.1e-08	0.99	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GLT8D1	0.20	0.05	lasso	1	0.04	1.0e-03	5.4	5.4	6.1e-08	0.99	0.00	0.96	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	NISCH	0.06	0.05	lasso	4	0.04	7.5e-06	5.5	5.4	8.1e-08	0.96	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RFT1	0.29	0.04	blup	45	0.11	8.2e-04	4.8	5.4	8.3e-08	0.44	0.01	0.83	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NT5DC2	0.11	0.05	enet	22	0.04	5.0e-06	3.3	-5.3	9.7e-08	-0.66	0.10	0.88	FALSE
6	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RFT1	0.18	0.10	lasso	7	0.10	1.8e-08	5.1	5.3	1.0e-07	0.55	0.00	0.99	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM110	0.09	0.00	blup	59	0.02	1.0e-02	4.4	5.3	1.1e-07	0.42	0.02	0.25	FALSE
5	GTEx	Stomach	RFT1	0.23	0.03	enet	19	0.06	6.3e-04	2.9	5.3	1.3e-07	0.46	0.11	0.78	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM110	0.13	0.09	lasso	3	0.10	5.9e-20	5.0	5.3	1.3e-07	0.62	0.07	0.93	FALSE
15	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM110	0.21	0.10	lasso	4	0.08	2.3e-05	4.8	5.3	1.4e-07	0.54	0.04	0.96	FALSE
2	GTEx	Pancreas	RFT1	0.32	0.13	lasso	4	0.17	1.3e-07	5.7	5.3	1.5e-07	0.52	0.01	0.99	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	GNL3	0.07	0.06	lasso	4	0.06	4.5e-04	4.0	5.2	1.7e-07	0.89	0.02	0.93	FALSE
21	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFMBT1	0.17	0.08	lasso	2	0.06	5.5e-04	5.2	5.2	1.7e-07	0.56	0.01	0.94	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM110	0.26	0.09	lasso	4	0.09	1.6e-04	4.9	5.2	1.7e-07	0.45	0.04	0.90	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM110	0.29	0.16	lasso	6	0.17	1.8e-18	5.0	5.2	2.0e-07	0.51	0.07	0.93	FALSE
14	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPCS1	0.28	0.04	lasso	2	0.01	4.6e-02	5.4	5.2	2.3e-07	0.98	0.00	0.94	FALSE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	RFT1	0.10	0.05	enet	12	0.05	1.0e-03	5.2	5.1	2.9e-07	0.49	0.01	0.92	FALSE
29	The Cancer Genome Atlas	Soft Tissue Sarcoma	RFT1	0.16	0.12	enet	16	0.14	1.7e-08	5.2	5.1	2.9e-07	0.50	0.00	0.99	FALSE