[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr3:182,655,858-186,072,370

Best TWAS P=5.55e-22 · Best GWAS P=4.3e-21 conditioned to 0.16

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ECE2	0.24	0.20	bslmm	542	0.19	1.6e-22	8.6	8.5	2.7e-17	-0.37	0.55	0.45	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KLHL24	0.42	0.60	bslmm	493	0.66	4.5e-107	-5.6	-5.5	4.3e-08	0.05	0.02	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SENP2	0.21	0.18	enet	33	0.19	4.2e-22	-5.4	5.6	1.9e-08	0.02	1.00	0.00	TRUE
4	GTEx	Adipose Subcutaneous	KLHL24	0.15	0.10	lasso	6	0.10	1.4e-08	-5.5	5.6	1.8e-08	-0.04	0.02	0.98	FALSE
5	GTEx	Artery Tibial	PSMD2	0.13	0.09	lasso	5	0.08	1.3e-06	-6.0	6.2	4.5e-10	-0.42	0.88	0.02	FALSE
6	GTEx	Brain Caudate basal ganglia	KLHL24	0.22	0.21	lasso	3	0.19	3.5e-06	-5.5	5.6	2.5e-08	-0.04	0.02	0.97	FALSE
7	GTEx	Brain Cerebellum	KLHL24	0.52	0.14	enet	26	0.16	1.9e-05	-5.5	6.0	1.6e-09	-0.04	0.02	0.97	TRUE
8	GTEx	Brain Cortex	KLHL24	0.21	0.15	lasso	3	0.07	6.1e-03	-5.5	5.6	2.5e-08	-0.05	0.03	0.93	FALSE
9	GTEx	Brain Frontal Cortex BA9	KLHL24	0.36	0.23	lasso	6	0.15	9.3e-05	-5.6	5.2	2.2e-07	-0.04	0.02	0.96	FALSE
10	GTEx	Brain Putamen basal ganglia	ECE2	0.38	0.03	enet	22	0.11	1.4e-03	8.7	6.3	2.4e-10	-0.28	0.08	0.17	FALSE
11	GTEx	Breast Mammary Tissue	KLHL24	0.25	0.13	lasso	5	0.11	3.4e-06	-5.5	5.7	1.1e-08	-0.05	0.02	0.98	FALSE
12	GTEx	Breast Mammary Tissue (Female)	KLHL24	0.25	0.19	lasso	14	0.16	2.3e-05	-4.9	5.2	2.6e-07	-0.08	0.03	0.94	FALSE
13	GTEx	Esophagus Mucosa	ABCF3	0.11	0.10	lasso	3	0.08	3.6e-06	-5.3	5.5	4.9e-08	-0.31	0.37	0.54	TRUE
14	GTEx	Esophagus Muscularis	KLHL24	0.10	0.12	lasso	1	0.09	4.4e-06	-5.6	5.6	2.8e-08	-0.04	0.02	0.98	FALSE
15	GTEx	Nerve Tibial	KLHL24	0.08	0.06	lasso	3	0.05	1.5e-04	-5.6	5.5	3.7e-08	-0.04	0.02	0.97	FALSE
16	GTEx	Pancreas	ECE2	0.26	0.04	enet	24	0.09	1.2e-04	8.6	5.9	4.9e-09	-0.24	0.15	0.16	FALSE
17	GTEx	Pituitary	ECE2	0.52	0.30	lasso	7	0.23	1.5e-06	8.7	7.6	3.7e-14	-0.31	0.30	0.41	FALSE
18	GTEx	Skin Sun Exposed Lower leg	KLHL24	0.09	0.06	lasso	10	0.05	9.5e-05	-5.5	5.6	2.6e-08	-0.04	0.02	0.98	FALSE
19	GTEx	Skin Sun Exposed Lower leg	ABCF3	0.13	0.08	lasso	4	0.11	1.6e-09	5.2	7.0	2.8e-12	-0.36	0.98	0.01	FALSE
20	GTEx	Skin Sun Exposed Lower leg	PSMD2	0.13	0.14	lasso	4	0.15	1.4e-12	-6.0	6.0	1.9e-09	-0.39	1.00	0.00	FALSE
21	GTEx	Testis	KLHL24	0.17	0.10	lasso	4	0.10	4.0e-05	-5.6	5.5	2.9e-08	-0.04	0.02	0.97	FALSE
22	METSIM	Adipose	SENP2	0.06	0.04	lasso	5	0.03	6.2e-06	-5.4	-5.3	1.2e-07	-0.04	0.99	0.00	FALSE
23	YFS	Blood	PSMD2	0.26	0.22	lasso	5	0.24	2.4e-77	-5.9	5.8	5.8e-09	-0.39	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ETV5	0.03	0.01	blup	55	0.02	1.3e-03	-8.0	-7.9	3.4e-15	-0.04	0.01	0.85	TRUE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	ECE2	0.04	0.02	blup	61	0.03	3.5e-04	8.7	8.1	5.0e-16	-0.24	0.40	0.28	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	KLHL24	0.05	0.05	blup	53	0.05	1.1e-06	-5.6	5.6	2.1e-08	-0.05	0.02	0.98	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	PSMD2	0.09	0.02	blup	50	0.05	1.2e-06	-8.7	9.6	5.5e-22	-0.73	0.03	0.84	TRUE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CAMK2N2	0.04	0.01	enet	8	0.03	3.9e-04	3.2	5.7	1.5e-08	-0.32	0.14	0.07	FALSE
29	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PSMD2	0.05	0.00	enet	10	0.01	3.6e-02	8.6	6.8	1.2e-11	-0.49	0.01	0.10	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	KLHL24	0.03	0.04	enet	5	0.04	5.1e-05	-5.4	5.3	1.1e-07	-0.06	0.02	0.97	FALSE
31	The Cancer Genome Atlas	Testicular Germ Cell Tumors	KLHL24	0.16	0.16	blup	53	0.21	4.3e-08	-5.5	5.4	8.0e-08	-0.06	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Testicular Germ Cell Tumors	VWA5B2	0.10	0.04	blup	51	0.04	1.8e-02	5.2	-8.4	3.4e-17	0.43	0.03	0.33	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	KLHL24	0.10	0.09	blup	53	0.09	1.7e-09	-5.2	5.2	2.2e-07	-0.07	0.02	0.98	FALSE