Best TWAS P=7.2e-09 · Best GWAS P=1.14e-12 conditioned to 2.94e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TPM2 | 0.13 | 0.06 | lasso | 4 | 0.09 | 1.7e-11 | -5.1 | -5.4 | 5.9e-08 | -0.49 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Artery Aorta | SPAG8 | 0.11 | 0.10 | lasso | 7 | 0.06 | 2.0e-04 | 5.5 | -5.8 | 7.2e-09 | -0.86 | 0.02 | 0.97 | TRUE |
| 3 | GTEx | Liver | NPR2 | 0.18 | 0.04 | lasso | 3 | 0.02 | 1.1e-01 | 5.7 | -5.7 | 1.5e-08 | -0.88 | 0.03 | 0.79 | FALSE |
| 4 | GTEx | Thyroid | RP11-112J3.16 | 0.26 | 0.13 | lasso | 7 | 0.13 | 1.9e-10 | 5.5 | -5.8 | 8.8e-09 | -0.83 | 0.41 | 0.59 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | RP11-112J3.16 | 0.11 | 0.12 | bslmm | 410 | 0.11 | 1.5e-13 | 5.5 | -5.4 | 8.7e-08 | -0.89 | 0.16 | 0.84 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C9orf128 | 0.14 | 0.15 | blup | 50 | 0.16 | 1.4e-32 | 5.0 | -5.2 | 2.3e-07 | -0.84 | 0.10 | 0.90 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | C9orf128 | 0.07 | 0.03 | blup | 50 | 0.06 | 2.3e-04 | 5.0 | -5.4 | 7.0e-08 | -0.85 | 0.02 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C9orf128 | 0.04 | 0.06 | lasso | 2 | 0.05 | 2.8e-04 | 5.2 | -5.2 | 2.2e-07 | -0.85 | 0.02 | 0.79 | FALSE |