Best TWAS P=6.48e-16 · Best GWAS P=5.15e-19 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC441454 | 0.05 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | 5.21 | 5.4 | 5.7e-08 | 0.04 | 0.05 | 0.47 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | 8.27 | -8.1 | 6.5e-16 | -0.95 | 0.02 | 0.93 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | CDC14B | 0.16 | 0.02 | enet | 21 | 0.02 | 3.7e-02 | 6.10 | -5.2 | 1.6e-07 | -0.02 | 0.13 | 0.73 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | AAED1 | 0.17 | 0.02 | lasso | 3 | 0.04 | 2.4e-02 | 6.09 | 5.3 | 1.0e-07 | 0.02 | 0.06 | 0.35 | FALSE |
| 5 | GTEx | Liver | PTCH1 | 0.25 | 0.06 | enet | 11 | 0.03 | 4.9e-02 | 8.61 | 5.7 | 1.2e-08 | 0.26 | 0.04 | 0.74 | FALSE |
| 6 | GTEx | Nerve Tibial | ZNF367 | 0.10 | 0.05 | lasso | 3 | 0.02 | 7.9e-03 | 6.37 | 5.6 | 1.8e-08 | 0.04 | 0.08 | 0.88 | FALSE |
| 7 | GTEx | Spleen | PTCH1 | 0.33 | 0.08 | lasso | 8 | 0.18 | 1.9e-05 | -0.48 | 5.1 | 2.7e-07 | 0.28 | 0.11 | 0.42 | TRUE |
| 8 | GTEx | Testis | HABP4 | 0.19 | 0.22 | lasso | 9 | 0.21 | 1.1e-09 | 6.24 | 6.2 | 4.7e-10 | 0.04 | 0.12 | 0.88 | FALSE |
| 9 | GTEx | Thyroid | CDC14B | 0.15 | 0.10 | lasso | 5 | 0.08 | 5.3e-07 | 5.85 | -6.0 | 1.7e-09 | -0.04 | 0.32 | 0.68 | FALSE |
| 10 | NTR | Blood | PTCH1 | 0.04 | 0.02 | blup | 433 | 0.02 | 4.1e-08 | 6.21 | 5.6 | 1.9e-08 | 0.09 | 0.08 | 0.92 | TRUE |
| 11 | YFS | Blood | ANP32B | 0.03 | 0.02 | lasso | 9 | 0.02 | 1.9e-08 | -5.03 | 5.7 | 1.0e-08 | 0.00 | 0.00 | 0.99 | TRUE |
| 12 | YFS | Blood | HABP4 | 0.08 | 0.09 | enet | 24 | 0.11 | 5.9e-34 | 6.55 | -5.8 | 6.1e-09 | -0.09 | 0.02 | 0.98 | FALSE |
| 13 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | 6.18 | 6.8 | 1.3e-11 | 0.42 | 0.14 | 0.86 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC14B | 0.02 | 0.01 | lasso | 1 | 0.01 | 3.0e-03 | 6.35 | -6.4 | 2.1e-10 | -0.04 | 0.04 | 0.38 | FALSE |
| 15 | The Cancer Genome Atlas | Glioblastoma Multiforme | CDC14B | 0.16 | 0.17 | blup | 41 | 0.19 | 2.6e-06 | 6.09 | -5.4 | 5.6e-08 | -0.01 | 0.09 | 0.86 | FALSE |
| 16 | The Cancer Genome Atlas | Glioblastoma Multiforme | HABP4 | 0.08 | 0.06 | blup | 44 | 0.05 | 1.6e-02 | 5.74 | -6.5 | 8.7e-11 | -0.06 | 0.03 | 0.49 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HABP4 | 0.02 | 0.02 | blup | 44 | 0.02 | 7.1e-03 | 6.09 | 6.5 | 9.4e-11 | 0.04 | 0.04 | 0.56 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDC14B | 0.03 | 0.02 | blup | 42 | 0.02 | 2.1e-03 | 6.09 | -6.4 | 1.3e-10 | -0.04 | 0.06 | 0.41 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDC14B | 0.05 | 0.06 | lasso | 5 | 0.06 | 6.5e-07 | 6.05 | -5.3 | 1.1e-07 | -0.04 | 0.19 | 0.81 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HABP4 | 0.05 | 0.08 | lasso | 5 | 0.08 | 6.9e-09 | 5.67 | -5.8 | 5.8e-09 | -0.05 | 0.26 | 0.74 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PTCH1 | 0.02 | 0.01 | blup | 54 | 0.02 | 1.1e-03 | 7.04 | -7.0 | 2.0e-12 | -0.86 | 0.02 | 0.70 | FALSE |
| 22 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CDC14B | 0.08 | 0.02 | blup | 41 | 0.04 | 1.0e-03 | 5.21 | -7.0 | 2.9e-12 | -0.08 | 0.03 | 0.55 | TRUE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC14B | 0.05 | 0.07 | blup | 42 | 0.08 | 4.8e-08 | 6.15 | -6.2 | 7.0e-10 | -0.03 | 0.13 | 0.87 | FALSE |