Best TWAS P=7.2e-14 · Best GWAS P=1.66e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | SLC44A2 | 0.13 | 0.00 | lasso | 6 | 0.02 | 1.4e-02 | 4.3 | -5.4 | 7.4e-08 | -0.46 | 0.08 | 0.48 | FALSE |
| 2 | GTEx | Esophagus Mucosa | ILF3-AS1 | 0.11 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | 7.3 | -5.3 | 1.2e-07 | -0.77 | 0.03 | 0.76 | FALSE |
| 3 | GTEx | Muscle Skeletal | SLC44A2 | 0.19 | 0.18 | lasso | 5 | 0.19 | 5.1e-18 | 6.5 | 6.9 | 4.7e-12 | 0.79 | 0.80 | 0.20 | FALSE |
| 4 | GTEx | Nerve Tibial | ILF3-AS1 | 0.14 | 0.04 | lasso | 3 | 0.08 | 3.8e-06 | 7.2 | -5.8 | 6.9e-09 | -0.77 | 0.02 | 0.96 | FALSE |
| 5 | GTEx | Testis | PDE4A | 0.20 | 0.02 | enet | 39 | 0.04 | 6.4e-03 | 5.2 | 6.1 | 1.4e-09 | 0.06 | 0.06 | 0.05 | TRUE |
| 6 | GTEx | Whole Blood | CTD-2369P2.8 | 0.12 | 0.11 | lasso | 3 | 0.10 | 9.2e-10 | 5.2 | 5.8 | 8.8e-09 | 0.06 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FDX1L | 0.06 | 0.00 | blup | 53 | 0.02 | 5.1e-03 | -3.7 | -5.5 | 4.4e-08 | 0.05 | 0.00 | 0.27 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC147727 | 0.07 | 0.02 | lasso | 2 | 0.02 | 5.4e-03 | 7.3 | -7.5 | 7.2e-14 | -0.99 | 0.02 | 0.76 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC44A2 | 0.32 | 0.22 | enet | 14 | 0.25 | 3.8e-24 | 7.4 | 5.9 | 2.8e-09 | 0.85 | 0.01 | 0.99 | FALSE |