Best TWAS P=4.54e-10 · Best GWAS P=2.37e-10 conditioned to 0.0115
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | ATP13A1 | 0.14 | 0.06 | lasso | 5 | 0.05 | 2.2e-04 | -5.3 | -5.5 | 3.0e-08 | 0.89 | 0.04 | 0.91 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | GATAD2A | 0.07 | 0.00 | lasso | 4 | 0.00 | 8.1e-01 | -4.6 | -6.2 | 4.5e-10 | 0.75 | 0.03 | 0.72 | TRUE |
| 3 | GTEx | Muscle Skeletal | MAU2 | 0.09 | 0.04 | lasso | 4 | 0.05 | 5.1e-06 | -4.9 | 5.4 | 6.7e-08 | -0.52 | 0.86 | 0.14 | FALSE |
| 4 | GTEx | Whole Blood | GATAD2A | 0.06 | 0.02 | lasso | 9 | 0.03 | 1.7e-03 | -4.8 | -5.5 | 3.4e-08 | 0.56 | 0.49 | 0.36 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ATP13A1 | 0.10 | 0.07 | lasso | 5 | 0.06 | 1.3e-08 | -5.7 | 5.7 | 1.2e-08 | -0.82 | 0.05 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HAPLN4 | 0.05 | 0.07 | lasso | 2 | 0.06 | 1.1e-07 | -4.9 | -5.2 | 1.5e-07 | 0.41 | 0.20 | 0.80 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TM6SF2 | 0.04 | 0.03 | blup | 35 | 0.03 | 2.5e-04 | -4.9 | -5.5 | 4.5e-08 | 0.66 | 0.13 | 0.67 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GATAD2A | 0.04 | 0.03 | lasso | 2 | 0.03 | 2.9e-04 | -4.6 | -5.2 | 1.5e-07 | 0.45 | 0.08 | 0.78 | FALSE |