[Hub]/) : Traits : Leg predicted mass (left) : ← →

chr4:122,028,784-124,538,705

Best TWAS P=1.13e-17 · Best GWAS P=4.05e-13 conditioned to 6.47e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BBS7	0.19	0.21	bslmm	423	0.23	1.8e-27	-6.80	-7.2	4.4e-13	-0.01	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	lasso	3	0.02	6.5e-04	5.65	5.6	1.9e-08	0.74	0.71	0.04	FALSE
3	GTEx	Artery Tibial	FGF2	0.18	0.05	lasso	3	0.02	1.3e-02	5.10	5.2	1.6e-07	0.36	0.08	0.11	FALSE
4	GTEx	Artery Tibial	NUDT6	0.08	0.08	lasso	5	0.05	5.6e-05	5.46	5.5	3.5e-08	0.73	0.64	0.10	FALSE
5	GTEx	Brain Cerebellar Hemisphere	BBS7	0.27	0.05	lasso	3	0.08	4.7e-03	-5.36	-5.4	5.8e-08	-0.01	0.08	0.32	FALSE
6	GTEx	Brain Cerebellum	BBS7	0.20	-0.01	enet	24	0.01	2.2e-01	-5.29	-5.7	9.6e-09	-0.03	0.07	0.72	FALSE
7	GTEx	Breast Mammary Tissue	NUDT6	0.25	0.10	lasso	3	0.08	4.2e-05	5.49	5.5	3.6e-08	0.83	0.09	0.87	FALSE
8	GTEx	Breast Mammary Tissue (Male)	NUDT6	0.29	0.00	lasso	6	0.00	3.5e-01	5.47	5.5	4.7e-08	0.74	0.04	0.41	FALSE
9	GTEx	Breast Mammary Tissue (Female)	NUDT6	0.30	-0.01	enet	30	0.00	2.6e-01	5.67	5.2	2.5e-07	0.62	0.03	0.33	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	EXOSC9	0.29	0.17	lasso	7	0.16	6.6e-06	6.12	6.8	1.5e-11	0.01	0.17	0.80	FALSE
11	GTEx	Cells Transformed fibroblasts	BBS7	0.16	0.09	lasso	7	0.16	2.9e-12	-6.91	-7.3	2.7e-13	-0.03	0.00	1.00	FALSE
12	GTEx	Colon Transverse	BBS12	0.12	0.05	enet	29	0.12	3.2e-06	0.41	5.3	1.0e-07	0.48	0.04	0.59	FALSE
13	GTEx	Muscle Skeletal	NUDT6	0.15	0.12	lasso	3	0.11	1.1e-10	5.65	5.7	1.2e-08	0.74	0.97	0.03	FALSE
14	GTEx	Muscle Skeletal	RP11-170N16.3	0.07	0.07	lasso	3	0.06	8.8e-07	4.92	5.6	2.2e-08	0.74	0.23	0.76	FALSE
15	GTEx	Nerve Tibial	NUDT6	0.11	0.08	lasso	3	0.05	2.1e-04	5.22	5.2	1.8e-07	0.69	0.79	0.03	FALSE
16	GTEx	Skin Sun Exposed Lower leg	NUDT6	0.11	0.08	lasso	3	0.08	6.2e-07	5.47	5.5	3.9e-08	0.70	0.94	0.03	FALSE
17	GTEx	Testis	EXOSC9	0.17	0.07	lasso	8	0.10	2.5e-05	-5.36	7.0	3.0e-12	0.04	0.02	0.98	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	EXOSC9	0.05	0.02	lasso	7	0.02	5.3e-04	4.67	5.4	6.3e-08	-0.03	0.10	0.84	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	enet	9	0.03	2.0e-04	5.52	5.2	1.5e-07	0.64	0.60	0.18	FALSE
20	YFS	Blood	EXOSC9	0.06	0.09	bslmm	401	0.09	7.0e-28	6.15	6.6	3.3e-11	0.00	0.24	0.76	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXOSC9	0.03	0.04	enet	9	0.04	2.8e-08	6.52	7.2	7.0e-13	0.02	0.07	0.93	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUDT6	0.02	0.02	lasso	4	0.01	5.4e-03	5.46	5.5	4.8e-08	0.72	0.13	0.14	FALSE
23	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCNA2	0.11	-0.01	enet	14	0.02	4.4e-02	0.51	5.4	7.2e-08	0.09	0.00	0.26	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	BBS7	0.05	0.00	blup	47	0.02	1.9e-02	6.57	-6.9	6.0e-12	-0.03	0.02	0.25	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCNA2	0.03	0.01	blup	34	0.02	1.5e-03	-6.76	8.6	1.1e-17	0.02	0.00	0.97	TRUE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BBS7	0.04	0.04	lasso	2	0.03	6.1e-04	-6.80	-6.8	9.6e-12	-0.03	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FGF2	0.06	0.04	blup	65	0.05	4.4e-06	6.06	5.8	5.4e-09	0.85	0.01	0.98	TRUE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EXOSC9	0.03	0.02	lasso	2	0.02	1.0e-03	6.16	6.6	3.7e-11	0.01	0.06	0.50	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUDT6	0.10	0.07	lasso	6	0.07	1.0e-07	5.46	5.2	1.6e-07	0.71	0.95	0.05	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	EXOSC9	0.04	0.05	lasso	2	0.04	7.1e-05	6.52	7.3	3.0e-13	0.03	0.02	0.96	FALSE