Best TWAS P=5.42e-10 · Best GWAS P=5.31e-09 conditioned to 0.0783
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | TRPT1 | 0.16 | 0.05 | lasso | 5 | 0.04 | 3.0e-03 | -5.2 | -6.0 | 2.0e-09 | 0.60 | 0.07 | 0.52 | FALSE |
| 2 | GTEx | Colon Transverse | TRPT1 | 0.24 | 0.20 | lasso | 5 | 0.17 | 1.6e-08 | -5.4 | -5.2 | 1.8e-07 | 0.56 | 0.05 | 0.95 | FALSE |
| 3 | GTEx | Esophagus Mucosa | PLCB3 | 0.28 | 0.24 | lasso | 6 | 0.23 | 1.1e-15 | -5.8 | 5.3 | 9.0e-08 | -0.94 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | TRPT1 | 0.20 | 0.12 | enet | 18 | 0.15 | 2.3e-09 | -5.1 | -5.7 | 1.5e-08 | 0.67 | 0.08 | 0.92 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | TRPT1 | 0.19 | 0.14 | lasso | 7 | 0.15 | 2.0e-07 | -5.0 | -5.2 | 1.8e-07 | 0.63 | 0.11 | 0.89 | FALSE |
| 6 | GTEx | Nerve Tibial | TRPT1 | 0.14 | 0.03 | lasso | 6 | 0.07 | 1.8e-05 | -5.1 | -5.4 | 6.9e-08 | 0.55 | 0.06 | 0.90 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PRDX5 | 0.10 | 0.05 | lasso | 6 | 0.08 | 2.8e-10 | -5.5 | 5.2 | 2.3e-07 | -0.84 | 0.01 | 0.99 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | KCNK4 | 0.14 | 0.12 | bslmm | 334 | 0.11 | 3.0e-14 | -5.5 | -5.7 | 1.1e-08 | 0.96 | 0.00 | 1.00 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | TEX40 | 0.25 | 0.23 | lasso | 3 | 0.23 | 2.5e-29 | -5.8 | 5.8 | 8.4e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | RP11-783K16.10 | 0.07 | 0.05 | lasso | 6 | 0.06 | 9.6e-08 | -5.8 | 5.7 | 1.6e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 11 | YFS | Blood | PRDX5 | 0.51 | 0.40 | lasso | 9 | 0.43 | 4.0e-157 | -5.5 | -5.4 | 6.7e-08 | 0.92 | 0.02 | 0.98 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C11orf20 | 0.06 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -5.7 | 5.7 | 1.1e-08 | -0.94 | 0.00 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C11orf20 | 0.07 | 0.07 | lasso | 4 | 0.07 | 6.4e-08 | -5.8 | 5.8 | 6.1e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C11orf20 | 0.04 | 0.03 | lasso | 2 | 0.03 | 4.2e-04 | -5.5 | 5.5 | 3.9e-08 | -0.96 | 0.00 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | VEGFB | 0.04 | 0.04 | blup | 47 | 0.02 | 8.9e-03 | -5.2 | 6.2 | 5.4e-10 | -0.75 | 0.02 | 0.60 | TRUE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | VEGFB | 0.09 | 0.10 | lasso | 7 | 0.07 | 1.0e-03 | -5.4 | 5.4 | 6.2e-08 | -0.59 | 0.03 | 0.69 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | PRDX5 | 0.05 | 0.04 | lasso | 3 | 0.02 | 1.6e-03 | -5.8 | 5.9 | 4.6e-09 | -0.98 | 0.00 | 0.95 | FALSE |