Best TWAS P=8.83e-12 · Best GWAS P=2.13e-08 conditioned to 0.000596
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FIBP | 0.08 | 0.11 | enet | 20 | 0.12 | 8.1e-14 | 4.6 | 5.3 | 1.0e-07 | 0.07 | 0.28 | 0.71 | FALSE |
| 2 | GTEx | Adrenal Gland | CTSW | 0.13 | 0.08 | lasso | 12 | 0.06 | 3.0e-03 | 5.3 | -5.6 | 1.7e-08 | -0.06 | 0.10 | 0.73 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | CCS | 0.21 | 0.24 | enet | 11 | 0.21 | 2.0e-07 | -5.4 | 5.4 | 7.1e-08 | 0.01 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | CTD-3074O7.12 | 0.11 | 0.00 | enet | 7 | 0.01 | 9.7e-02 | 4.8 | 5.4 | 6.1e-08 | 0.00 | 0.08 | 0.69 | FALSE |
| 5 | GTEx | Esophagus Mucosa | CTD-3074O7.5 | 0.25 | 0.11 | lasso | 4 | 0.19 | 5.1e-13 | 4.8 | 5.5 | 3.6e-08 | 0.01 | 0.40 | 0.59 | FALSE |
| 6 | GTEx | Esophagus Muscularis | CTD-3074O7.5 | 0.22 | 0.02 | enet | 17 | 0.09 | 3.7e-06 | -4.5 | 6.8 | 8.8e-12 | 0.32 | 0.32 | 0.41 | TRUE |
| 7 | GTEx | Heart Atrial Appendage | KLC2 | 0.10 | 0.04 | lasso | 8 | 0.09 | 1.1e-04 | 4.0 | -5.3 | 1.4e-07 | -0.44 | 0.35 | 0.24 | FALSE |
| 8 | GTEx | Nerve Tibial | CTD-3074O7.12 | 0.14 | 0.10 | lasso | 8 | 0.11 | 5.6e-08 | -4.5 | 5.2 | 1.5e-07 | 0.02 | 0.66 | 0.32 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | CTSW | 0.27 | 0.22 | lasso | 12 | 0.22 | 1.9e-12 | 4.7 | -5.2 | 2.0e-07 | -0.01 | 0.23 | 0.76 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | CTD-3074O7.5 | 0.14 | 0.03 | lasso | 8 | 0.04 | 1.8e-03 | 4.8 | 5.5 | 4.5e-08 | 0.00 | 0.16 | 0.47 | FALSE |
| 11 | NTR | Blood | CCS | 0.03 | 0.04 | lasso | 2 | 0.04 | 1.2e-11 | -5.3 | 5.4 | 8.1e-08 | 0.02 | 0.02 | 0.97 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | CTSW | 0.06 | 0.03 | bslmm | 328 | 0.03 | 3.6e-05 | 4.9 | -5.4 | 7.0e-08 | -0.09 | 0.24 | 0.60 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | CCS | 0.08 | 0.04 | lasso | 9 | 0.06 | 8.9e-08 | -5.3 | 5.8 | 7.7e-09 | 0.05 | 0.03 | 0.97 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | CTSF | 0.07 | 0.08 | blup | 244 | 0.07 | 1.6e-09 | -4.5 | -5.3 | 8.7e-08 | 0.01 | 0.67 | 0.32 | FALSE |
| 15 | YFS | Blood | CCS | 0.17 | 0.27 | lasso | 11 | 0.28 | 6.6e-94 | -5.5 | 5.3 | 1.1e-07 | 0.01 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DPP3 | 0.05 | 0.02 | blup | 41 | 0.02 | 2.8e-02 | -4.3 | 5.1 | 2.7e-07 | 0.06 | 0.02 | 0.48 | FALSE |
| 17 | The Cancer Genome Atlas | Glioblastoma Multiforme | CTSW | 0.16 | 0.18 | enet | 16 | 0.19 | 2.3e-06 | 5.3 | -5.6 | 2.1e-08 | -0.08 | 0.01 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZDHHC24 | 0.03 | 0.03 | blup | 47 | 0.03 | 1.5e-04 | -4.5 | -5.4 | 5.4e-08 | -0.01 | 0.02 | 0.96 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC87 | 0.03 | 0.02 | blup | 34 | 0.02 | 2.0e-03 | -4.8 | -5.7 | 1.5e-08 | -0.17 | 0.04 | 0.35 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CTSF | 0.05 | 0.04 | blup | 35 | 0.04 | 1.2e-05 | -4.5 | -5.7 | 1.1e-08 | -0.07 | 0.23 | 0.69 | FALSE |
| 21 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SNX32 | 0.08 | 0.08 | lasso | 2 | 0.10 | 1.5e-06 | 4.5 | 5.2 | 2.3e-07 | 0.00 | 0.04 | 0.95 | FALSE |
| 22 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SNX32 | 0.12 | 0.13 | blup | 60 | 0.13 | 1.2e-09 | 4.7 | 5.9 | 4.3e-09 | 0.03 | 0.06 | 0.92 | TRUE |