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chr11:64,948,277-67,070,766

Best TWAS P=8.83e-12 · Best GWAS P=2.13e-08 conditioned to 0.000596

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Esophagus Muscularis	CTD-3074O7.5	0.22	0.02	enet	17	0.09	3.7e-06	-4.5	6.8	8.8e-12	0.32	0.32	0.41	TRUE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX32	0.12	0.13	blup	60	0.13	1.2e-09	4.7	5.9	4.3e-09	0.03	0.06	0.92	TRUE
13	ROSMAP	Brain Pre-frontal Cortex	CCS	0.08	0.04	lasso	9	0.06	8.9e-08	-5.3	5.8	7.7e-09	0.05	0.03	0.97	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSF	0.05	0.04	blup	35	0.04	1.2e-05	-4.5	-5.7	1.1e-08	-0.07	0.23	0.69	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC87	0.03	0.02	blup	34	0.02	2.0e-03	-4.8	-5.7	1.5e-08	-0.17	0.04	0.35	FALSE
2	GTEx	Adrenal Gland	CTSW	0.13	0.08	lasso	12	0.06	3.0e-03	5.3	-5.6	1.7e-08	-0.06	0.10	0.73	FALSE
17	The Cancer Genome Atlas	Glioblastoma Multiforme	CTSW	0.16	0.18	enet	16	0.19	2.3e-06	5.3	-5.6	2.1e-08	-0.08	0.01	0.98	FALSE
5	GTEx	Esophagus Mucosa	CTD-3074O7.5	0.25	0.11	lasso	4	0.19	5.1e-13	4.8	5.5	3.6e-08	0.01	0.40	0.59	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	CTD-3074O7.5	0.14	0.03	lasso	8	0.04	1.8e-03	4.8	5.5	4.5e-08	0.00	0.16	0.47	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZDHHC24	0.03	0.03	blup	47	0.03	1.5e-04	-4.5	-5.4	5.4e-08	-0.01	0.02	0.96	FALSE
4	GTEx	Esophagus Gastroesophageal Junction	CTD-3074O7.12	0.11	0.00	enet	7	0.01	9.7e-02	4.8	5.4	6.1e-08	0.00	0.08	0.69	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	CTSW	0.06	0.03	bslmm	328	0.03	3.6e-05	4.9	-5.4	7.0e-08	-0.09	0.24	0.60	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	CCS	0.21	0.24	enet	11	0.21	2.0e-07	-5.4	5.4	7.1e-08	0.01	0.02	0.98	FALSE
11	NTR	Blood	CCS	0.03	0.04	lasso	2	0.04	1.2e-11	-5.3	5.4	8.1e-08	0.02	0.02	0.97	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	CTSF	0.07	0.08	blup	244	0.07	1.6e-09	-4.5	-5.3	8.7e-08	0.01	0.67	0.32	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FIBP	0.08	0.11	enet	20	0.12	8.1e-14	4.6	5.3	1.0e-07	0.07	0.28	0.71	FALSE
15	YFS	Blood	CCS	0.17	0.27	lasso	11	0.28	6.6e-94	-5.5	5.3	1.1e-07	0.01	0.02	0.98	FALSE
7	GTEx	Heart Atrial Appendage	KLC2	0.10	0.04	lasso	8	0.09	1.1e-04	4.0	-5.3	1.4e-07	-0.44	0.35	0.24	FALSE
8	GTEx	Nerve Tibial	CTD-3074O7.12	0.14	0.10	lasso	8	0.11	5.6e-08	-4.5	5.2	1.5e-07	0.02	0.66	0.32	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	CTSW	0.27	0.22	lasso	12	0.22	1.9e-12	4.7	-5.2	2.0e-07	-0.01	0.23	0.76	FALSE
21	The Cancer Genome Atlas	Soft Tissue Sarcoma	SNX32	0.08	0.08	lasso	2	0.10	1.5e-06	4.5	5.2	2.3e-07	0.00	0.04	0.95	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DPP3	0.05	0.02	blup	41	0.02	2.8e-02	-4.3	5.1	2.7e-07	0.06	0.02	0.48	FALSE