Best TWAS P=6.37e-09 · Best GWAS P=6.96e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-298P3.4 | 0.09 | 0.01 | lasso | 7 | 0.00 | 1.9e-01 | -5.7 | -5.8 | 6.4e-09 | 0.97 | 0.03 | 0.92 | TRUE |
2 | GTEx | Artery Aorta | N4BP2L2 | 0.13 | 0.10 | lasso | 3 | 0.09 | 1.1e-05 | -5.4 | -5.2 | 1.7e-07 | 0.78 | 0.04 | 0.95 | FALSE |
3 | GTEx | Whole Blood | KL | 0.12 | 0.00 | lasso | 7 | 0.00 | 4.9e-01 | -2.4 | 5.5 | 3.5e-08 | -0.65 | 0.05 | 0.68 | FALSE |
4 | YFS | Blood | PDS5B | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.4e-11 | -5.1 | -5.1 | 2.9e-07 | 0.93 | 0.09 | 0.91 | FALSE |
5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CG030 | 0.04 | 0.01 | lasso | 3 | 0.02 | 2.1e-04 | -5.4 | 5.3 | 1.2e-07 | -0.75 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | N4BP2L2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.4e-03 | -5.5 | -5.5 | 4.6e-08 | 0.76 | 0.01 | 0.96 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | N4BP2L2 | 0.04 | 0.03 | blup | 69 | 0.02 | 9.4e-04 | -5.4 | -5.1 | 3.0e-07 | 0.74 | 0.01 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | N4BP2L2 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.5e-04 | -5.5 | -5.6 | 2.1e-08 | 0.77 | 0.00 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CG030 | 0.08 | 0.04 | blup | 38 | 0.04 | 1.4e-03 | -5.2 | 5.2 | 2.5e-07 | -0.70 | 0.00 | 0.89 | FALSE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | N4BP2L2 | 0.12 | 0.14 | enet | 7 | 0.16 | 1.1e-15 | -4.7 | -5.3 | 1.2e-07 | 0.77 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | PDS5B | 0.02 | 0.01 | blup | 78 | 0.02 | 1.2e-02 | -5.1 | 5.4 | 5.5e-08 | -0.90 | 0.04 | 0.66 | FALSE |