Hub : Genes

PFN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0596	0.016	3.5e-08	0.033	0.024	0.028	0.034	0.029	3.9e-11	1.8e-08	1.6e-09	1.8e-11	7.7e-10
2	TCGA	Pheochromocytoma and Paraganglioma	0.1560	0.082	8.6e-03	0.002	0.028	0.017	NA	0.008	2.6e-01	2.7e-02	6.6e-02	NA	1.5e-01
3	TCGA	Thyroid Carcinoma	0.0360	0.022	7.4e-03	0.039	0.025	0.022	NA	0.035	1.1e-04	1.7e-03	3.2e-03	NA	2.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	1.0	-0.4	-0.9	-1.0
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.8	-1.0	-0.0
Depressed Affect (Nagel 2018)	1.5	3.1	3.9	1.6	2.0	-1.7
Depression (Nagel 2018)	4.8	7.3	11.2	3.4	1.4	-3.0
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.2	0.1	-1.5	1.5
Neuroticism (Nagel 2018)	1.1	2.5	4.1	1.3	2.0	-1.3
Schizophrenia (2018)	0.5	0.9	1.9	1.4	-0.5	0.8
Schizophrenia vs Biploar Disorder	2.2	2.9	4.0	1.4	2.0	-1.7
Worry (Nagel 2018)	1.4	3.0	4.8	0.5	2.0	-2.2
Alzheimer’s Disease (in mother)	0.9	1.1	2.9	0.5	-0.3	1.7
Alzheimer’s Disease (in father)	1.0	1.1	1.7	1.3	-1.2	-0.0
Alzheimer’s Disease (including proxy)	2.3	3.3	6.0	0.9	-1.7	2.4
Crohns Disease (2017)	0.1	0.2	0.4	-0.1	-0.3	0.6
Irritable Bowel Disease (IBD)	0.6	1.4	2.5	0.6	1.6	-1.1
Ulcerative Colitis (UC)	2.6	4.8	7.1	0.5	2.7	-2.7
Major Depression (MDD)	0.4	0.5	1.0	-1.0	-0.6	-0.1
Reaction Time	0.8	1.6	3.5	0.6	-1.0	-1.9
Verbal and Numeric Reasoning (VNR)	2.9	6.9	10.0	-1.6	-3.2	2.9
Breast Cancer	1.0	2.4	4.3	-2.1	1.6	0.5
Ovarian Cancer	1.3	1.7	4.4	-2.1	-0.6	0.6
Prostate Cancer	1.3	1.8	4.0	2.0	-0.2	1.2
Age at First Birth	0.3	0.4	0.7	-0.6	0.8	-0.4
Bipolar Disorder (2011)	0.2	0.2	0.7	0.0	-0.2	0.8
Body Mass Index (BMI) (2010)	2.3	3.2	4.2	-1.4	-2.0	1.8
Coronary Artery Disease (CAD)	2.5	3.0	8.9	-0.2	3.0	-0.2
Crohns Disease (2012)	0.8	1.3	2.7	0.4	-1.6	1.1
Mean Putamen Volume	0.2	0.3	0.7	-0.3	-0.9	0.1
Fasting Glucose	1.5	1.7	2.6	1.3	-1.6	0.9
HbA1C	2.5	2.7	4.7	1.5	-1.1	2.2
HDL Cholesterol	0.1	0.2	0.3	-0.6	-0.4	-0.2
LDL Cholesterol	1.2	1.9	5.7	0.2	2.4	-0.2
Lupus	0.7	1.1	2.7	-0.1	-0.8	1.6
Neuroticism (2016)	2.0	2.9	6.1	-0.4	1.5	-2.5
Primary Biliary Cirrhosis	0.9	1.3	2.1	0.5	1.4	-1.3
Rheumatoid Arthritis	1.1	1.5	3.1	0.7	-1.0	1.7
Schizophrenia (2014)	0.6	1.4	2.7	1.6	0.9	-0.8
Triglycerides	0.5	0.8	1.2	1.1	0.7	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.5	0.5	-1.2	0.4
Ulcerative Colitis	3.7	5.4	8.1	1.1	2.8	-2.6
Blood Eosinophil Count	0.7	5.3	10.1	0.2	-2.4	3.2
Blood Platelet Count	5.4	62.7	125.4	2.2	-11.2	-7.6
Blood Red Count	0.4	3.7	5.6	-1.5	-1.8	2.4
Blood White Count	4.5	33.0	66.7	-1.9	-8.2	5.3
Heel T-Score	0.3	2.2	3.9	1.6	-0.4	2.0
BMI	2.3	13.2	21.8	1.3	-4.7	4.0
Height	0.5	9.2	13.3	-2.1	3.6	-3.2
Waist Hip Ratio (WHR)	0.3	1.4	4.0	-0.1	2.0	0.4
Systolic Blood Pressure	0.2	1.2	2.3	-1.2	-0.0	1.5
Smoking Status	1.5	3.5	8.1	1.6	-0.1	2.9
Allergy or Eczema	0.5	1.2	2.3	1.5	-1.1	0.3
Cardiovascular Disease	1.0	3.3	8.0	-1.0	-1.0	2.8
Hypothyroidism (self reported)	2.2	5.0	7.5	-2.4	-2.7	1.3
Respiratory disease	0.1	0.1	0.3	-0.1	-0.6	-0.2
Type 2 Diabetes (T2D) (2018)	3.1	5.9	12.2	0.4	-2.3	3.5
Lung FEV1/FVC ratio	0.7	3.6	8.9	3.0	-0.6	1.3
Lung FVC	0.5	2.3	3.5	-0.4	-1.9	1.8
Neuroticism	0.5	1.3	2.0	1.1	1.4	-0.8
Chronotype (morning person)	1.4	3.3	5.0	2.1	0.5	-2.2
Hair Pigment	0.0	0.6	1.4	-0.2	0.6	1.2
Tanning	0.0	0.5	1.1	0.4	-1.0	0.6
Hand grip strength (left)	0.2	0.5	1.1	-1.0	-0.3	0.7
Number of treatments/medications taken	1.4	2.5	4.0	-1.6	-2.0	0.9
Average weekly spirits intake	1.1	1.4	2.6	1.2	-1.6	-0.0
Sensitivity / hurt feelings	0.1	0.2	0.5	0.7	0.2	-0.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.5	1.6	0.8	-1.0
Hearing difficulty/problems: Yes	1.9	2.8	5.4	2.3	0.8	-1.6
Relative age of first facial hair	0.2	0.4	0.6	-0.6	0.8	0.3
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.2	0.6	-2.0	1.7
Ever used hormone-replacement therapy (HRT)	1.4	1.8	5.3	2.3	0.1	-0.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	0.6	0.4	-1.2
Systolic blood pressure, automated reading	0.6	1.8	3.7	1.1	-0.7	1.9
Eye problems/disorders: Diabetes related eye disease	4.3	4.7	6.8	-1.7	-2.6	2.1
Angina	0.3	0.4	0.8	-0.7	-0.9	-0.1
Medication for hormone replacement therapy	2.2	2.4	2.8	-1.7	-1.5	1.5
Vitamin and mineral supplements	2.1	2.9	6.2	-0.4	-1.5	2.5
Supplements: Zinc	0.6	0.7	1.7	0.3	-0.5	-1.3
Medication: Co-codamol	2.5	2.9	3.7	1.9	1.2	-1.9
Medication: Metformin	2.9	4.1	8.4	-0.5	-2.9	1.9
Diabetes (father)	0.8	1.0	2.2	-1.5	-0.7	0.6
Diabetes (mother)	0.2	0.2	0.3	-0.3	0.5	-0.6
Severe depression (siblings)	0.1	0.2	0.2	0.5	-0.4	0.3
Pack years adult smoking proportion	0.1	0.2	0.4	-0.2	0.3	0.7
Impedance of leg (right)	0.8	4.1	6.5	-0.3	2.4	-2.6
Leg fat-free mass (left)	0.9	4.9	7.9	-0.2	-2.6	2.8
Trunk fat percentage	2.1	8.4	19.6	0.1	-4.4	2.4
Hand grip strength (right)	0.1	0.1	0.2	0.1	-0.5	0.4
Townsend deprivation index at recruitment	0.4	0.6	1.2	-0.4	0.6	1.1
Current tobacco smoking	1.0	1.7	3.1	1.3	-0.7	1.8
Average weekly fortified wine intake	2.2	2.6	4.8	-0.1	-1.7	-2.2
Maternal smoking around birth	0.8	1.1	2.8	0.6	-0.5	1.7
Fed-up feelings	0.5	0.9	1.6	1.0	1.3	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	7.3	2.7	1.2	-1.6
Relative age voice broke	0.7	1.1	3.2	0.3	1.8	0.1
Taking other prescription medications	0.9	1.4	1.7	-1.3	-1.2	1.0
Age when periods started (menarche)	1.6	3.7	10.6	-0.2	3.3	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	0.8	0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.3	1.8	0.5	1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.4	-0.9	0.4
Qualifications: CSEs or equivalent	2.2	3.0	4.0	-1.0	-2.0	1.9
Serious illness, injury or assault to yourself	1.2	1.5	2.6	0.7	-1.2	1.6
High blood pressure	0.1	0.2	0.4	-0.7	-0.0	0.3
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.3	1.8	-1.4	-0.3
Multivitamins +/- minerals	3.4	4.4	10.7	0.3	1.5	-3.3
Stomach or abdominal pain in last month	0.8	1.0	2.4	-0.1	-1.6	0.8
Supplements: Glucosamine	0.3	0.4	0.6	-0.1	-0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	2.4	-1.5	-1.1	0.9
Medication: Atenolol	2.3	2.8	6.7	0.3	1.3	-2.6
Medication: Levothyroxine sodium	3.4	5.8	7.5	-2.6	-2.7	1.8
Sitting height	0.1	0.6	1.1	0.7	1.0	-0.4
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	1.1	0.1	-1.1
High blood pressure (mother)	0.8	1.1	3.1	1.8	-0.3	-0.1
Body mass index (BMI)	2.7	11.6	20.6	1.1	-4.5	3.6
Impedance of leg (left)	0.8	4.1	6.8	-0.2	2.3	-2.6
Leg predicted mass (left)	1.0	5.1	8.6	-0.2	-2.6	2.9
Trunk fat mass	1.9	8.2	17.7	0.0	-4.2	2.6
Waist circumference	2.0	7.2	11.7	0.5	-3.4	3.1
Number of incorrect matches in round	1.2	2.0	4.0	1.2	0.9	-2.0
Past tobacco smoking	1.1	2.0	5.4	-0.7	-0.4	-2.3
Alcohol usually taken with meals	1.1	1.8	5.1	-0.3	0.5	-2.3
Nervous feelings	0.8	1.5	2.7	-0.8	1.1	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.1	0.5	1.2	-2.2
Hearing difficulty/problems with background noise	1.2	1.9	3.9	2.0	0.7	-1.1
Hair/balding pattern: Pattern 2	1.5	1.9	2.9	1.7	-0.2	1.7
Had menopause	0.6	0.7	1.3	0.9	0.1	-1.1
Had other major operations	1.0	1.2	2.7	1.6	0.5	-0.8
Forced vital capacity (FVC)	0.3	1.0	2.1	-0.4	0.8	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.4	1.9	1.0	0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.7	0.4	-0.3
Qualifications: None of the above	0.3	0.6	1.2	-1.1	0.6	-0.6
Financial difficulties in last 2 years	0.3	0.3	0.9	0.9	0.4	0.1
Mouth/teeth dental problems	0.8	1.2	2.2	-1.1	0.4	1.5
Heart attack	0.8	1.0	2.7	-1.6	-0.4	-0.3
Allergy	0.9	2.1	4.7	-0.9	2.2	0.9
Pain all over the body in last month	1.8	2.0	5.6	0.3	-2.4	-0.4
Diabetes (self-reported)	3.4	5.2	8.1	-1.1	-2.5	2.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.6	-0.8	-0.0
Medication: Ramipril	0.5	0.7	1.3	-1.1	-0.9	0.2
Medication: Simvastatin	0.2	0.2	0.6	0.0	0.8	0.2
Fluid intelligence score	1.4	2.8	5.4	-0.4	-2.3	1.7
Illnesses of siblings	0.4	0.5	0.5	0.7	0.7	0.7
Neuroticism score	0.2	0.4	0.8	0.5	0.9	0.2
Weight	1.2	5.8	9.7	0.2	-3.1	2.8
Impedance of arm (right)	0.9	4.4	8.1	-1.9	1.2	-2.8
Arm fat percentage (right)	3.2	12.5	26.8	-0.3	-5.2	3.2
Trunk fat-free mass	0.3	1.5	3.9	0.0	-0.7	2.0
Hip circumference	2.0	8.7	18.0	0.4	-4.2	2.8
Time employed in main current job	0.7	0.8	1.1	1.0	0.8	0.8
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.6	0.8	-0.2
Father’s age at death	1.7	2.3	4.0	0.8	2.0	-1.6
Worrier / anxious feelings	0.6	1.1	1.6	1.1	1.3	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.5	-0.1	-0.4
Falls in the last year	0.5	0.6	0.9	1.0	-1.0	0.0
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	-1.0	-0.1	0.1
Number of live births	1.4	2.0	4.0	-0.9	-1.0	2.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.5	0.2	0.2	2.1
Pulse rate	1.6	2.7	3.8	1.8	1.1	-2.0
Happiness	0.5	0.5	1.1	-0.4	1.1	-0.6
Noisy workplace	0.8	1.0	2.4	-0.3	1.6	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	0.7	1.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.2	0.6	-0.1	1.8
Mouth/teeth dental problems: Dentures	1.9	3.1	5.6	1.6	-1.1	-2.4
Asthma	0.5	0.9	1.8	-0.6	-1.3	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.8	0.5	0.4
Medication: Cholesterol lowering	0.3	0.5	0.9	-0.7	-0.9	0.5
Depression (self-reported)	0.4	0.5	0.9	0.9	0.1	-0.8
Medication: Lansoprazole	0.0	0.0	0.1	-0.3	0.1	0.1
Prospective memory result	2.7	3.3	4.6	1.8	2.1	-1.5
Lung cancer (father)	3.9	4.6	8.8	3.0	2.1	-0.7
Illnesses of mother	0.5	0.7	1.6	-0.2	0.6	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.6	-0.6	0.3	1.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.5	-0.7	-0.0
Impedance of arm (left)	0.8	3.9	8.4	-1.4	1.1	-2.9
Arm fat mass (right)	2.5	10.4	20.8	-0.0	-4.6	3.2
Trunk predicted mass	0.2	1.4	3.7	0.1	-0.7	1.9
Standing height	0.4	3.7	5.7	-1.8	2.4	-1.5
Length of working week for main job	0.7	0.8	1.0	0.9	-0.7	1.0
Exposure to tobacco smoke at home	0.6	0.6	1.1	1.1	-0.4	-0.8
Breastfed as a baby	0.8	1.0	1.9	0.9	0.6	-1.4
Tense / ‘highly strung’	2.2	3.6	6.9	1.4	2.6	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.1	-0.9	-0.4	-1.0
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.2	0.2	0.1
Birth weight of first child	0.4	0.7	1.3	0.9	0.2	-1.1
Peak expiratory flow (PEF)	0.4	0.8	1.0	1.0	0.7	1.0
Pulse wave reflection index	1.3	1.6	3.2	0.1	-1.2	1.8
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.2	-0.9	-0.2	1.5
Loud music exposure frequency	1.2	1.4	2.7	-1.0	-0.6	1.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.4	-0.4	-1.6	1.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.9	-0.3	0.1
Blood clot in the leg (DVT)	0.7	0.9	2.1	0.5	-1.5	0.6
Medication: Paracetamol	1.6	2.7	4.8	-0.1	-1.8	2.2
Headache pain in last month	0.3	0.5	0.8	0.9	0.2	0.8
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	0.0	0.2	-0.2
Glaucoma (self-reported)	0.5	0.6	1.8	0.1	0.2	1.3
Gout (self-reported)	1.5	2.0	5.5	-2.3	0.3	0.7
Hypothyroidism/myxoedema (self-reported)	2.8	5.5	8.9	-2.5	-3.0	1.1
Medication: Amlodipine	1.1	1.6	3.4	1.0	1.8	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	-0.5	0.4	-0.5
Birth weight	0.9	1.9	3.9	0.7	1.0	-2.0
Chronic bronchitis/emphysema (mother)	2.9	3.4	8.1	-2.8	-0.9	1.1
High blood pressure (siblings)	0.9	1.3	3.1	-1.8	-0.9	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.8	1.8	-0.4	1.3	0.6
Body fat percentage	2.5	9.8	21.7	0.3	-4.7	2.8
Leg fat percentage (right)	2.7	9.7	18.4	1.4	-4.3	3.0
Arm fat-free mass (right)	0.6	2.9	6.5	0.8	-1.3	2.5
Exposure to tobacco smoke outside home	0.7	0.9	2.1	1.4	-0.1	0.8
Comparative body size at age 10	0.2	0.4	1.2	-0.2	0.2	-1.1
Number of full brothers	0.1	0.1	0.2	0.5	-0.4	0.1
Worry too long after embarrassment	0.4	0.7	1.2	-1.1	0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.0	-0.3	-0.6
Wheeze or whistling in the chest in last year	0.5	0.9	1.3	1.1	0.5	-1.1
Number of children fathered	3.5	4.0	7.1	0.9	-2.0	2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.2	-1.1	-0.5	-1.0
Age at first live birth	1.0	1.8	4.1	1.0	2.0	0.7
Pulse wave peak to peak time	0.3	0.4	1.0	0.2	1.0	-0.1
Health satisfaction	3.0	4.0	7.7	1.1	1.7	-2.8
Shortness of breath walking on level ground	0.1	0.1	0.2	0.4	0.2	-0.4
Qualifications: College or University degree	0.1	0.5	0.9	0.9	0.7	-0.2
Eye problems/disorders: None of the above	1.6	1.8	2.5	-0.6	1.6	-1.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	0.6	0.6	-1.3
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.1	-0.6	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.8	1.5	-0.1	0.9	-1.2
Neck or shoulder pain in last month	0.6	0.9	2.1	-1.4	0.8	0.1
Medication: Blood pressure	0.1	0.1	0.4	0.0	0.6	0.0
Angina (self-reported)	0.5	0.7	1.1	-1.1	-1.0	0.0
Migraine (self-reported)	0.3	0.4	0.8	-0.5	0.9	-0.3
Medication: Ibuprofen	0.3	0.4	0.7	0.5	0.3	0.9
Medication: Allopurinol	1.7	2.2	4.0	-2.0	0.6	1.5
Medication: Omeprazole	0.4	0.4	0.9	0.6	1.0	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	1.3	-0.6	-1.2	0.5
Mean time to correctly identify matches	1.4	2.7	6.9	1.0	-0.6	-2.6
Heart disease (mother)	0.4	0.5	1.5	-0.0	0.3	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.3	0.3	0.7
Whole body fat mass	2.0	8.1	16.4	0.2	-4.0	2.8
Leg fat mass (right)	2.9	11.1	19.6	0.8	-4.4	3.6
Arm predicted mass (right)	0.5	2.7	5.4	0.7	-1.4	2.3
Pulse rate, automated reading	3.4	10.9	23.9	0.6	2.9	-4.9
Alcohol intake frequency.	0.7	1.6	3.3	-1.8	0.7	0.9
Comparative height size at age 10	0.3	1.8	4.0	0.0	1.2	-2.0
Number of full sisters	0.5	0.6	1.7	-1.3	0.2	-0.3
Suffer from ‘nerves’	0.8	1.2	2.5	0.4	1.6	-1.0
Overall health rating	0.2	0.5	1.1	0.1	0.5	-1.0
Chest pain or discomfort	0.1	0.1	0.2	-0.4	0.2	-0.3
Had major operations	0.0	0.1	0.1	0.4	0.2	-0.0
Age at last live birth	1.7	2.5	3.0	1.7	1.6	1.4
Family relationship satisfaction	0.4	0.5	1.4	-0.2	-0.1	-1.2
Leg pain on walking	0.1	0.2	0.3	0.3	0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.2	1.5	-0.3	0.3
Commuting to job workplace: Car/motor vehicle	2.4	2.8	6.1	-0.1	-1.5	2.5
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	2.7	-1.0	1.4	-1.6
Medication: Aspirin	0.3	0.4	0.6	0.7	0.5	-0.7
Supplements: Vitamin C	0.1	0.1	0.1	-0.3	0.0	-0.3
Knee pain experienced in last month	0.2	0.2	0.7	0.2	0.1	0.8
Hypertension (Self-reported)	0.2	0.7	1.2	-0.7	-0.7	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.0	0.5	-0.2
Illnesses of father: Heart disease	0.5	0.7	1.9	1.4	-0.2	-0.4
Illnesses of siblings: Diabetes	1.7	2.1	3.1	-1.8	-1.7	0.6
Smoking status: Previous	0.6	0.9	2.5	-0.1	0.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.9	-0.9	0.6	-0.8
Whole body fat-free mass	0.5	3.0	6.4	0.0	-1.6	2.5
Leg fat-free mass (right)	0.9	4.6	7.8	-0.2	-2.4	2.8
Arm fat percentage (left)	3.0	11.9	26.6	0.0	-5.2	3.0
Average weekly red wine intake	1.7	2.6	7.2	0.7	0.0	-2.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-1.0	-0.4	0.1
Mood swings	1.4	2.6	5.5	1.5	2.3	-0.2
Loneliness, isolation	0.6	0.8	1.8	-0.3	1.3	-0.7
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.7	0.1	-0.4
Ever had bowel cancer screening	0.1	0.2	0.3	0.5	0.1	-0.4
Diabetes diagnosed by doctor	3.3	5.5	8.8	-0.8	-2.6	3.0
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.8	1.1	0.6	-2.0
Friendships satisfaction	0.7	0.9	1.6	-0.6	0.7	-1.3
Qualifications: nursing, teaching	1.3	2.0	5.1	2.3	-0.5	-0.9
Commuting to job workplace: Walk	0.9	1.0	1.2	-1.1	0.8	-1.1
Eye problems/disorders: Cataract	0.4	0.5	1.4	1.2	0.2	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.1	1.8	1.0	0.2
Medication for cholesterol	1.0	1.6	3.3	1.1	0.5	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	1.1	0.6	-0.7
Back pain experienced in last month	1.3	1.9	2.2	-1.4	-1.5	1.1
Mineral and other dietary supplements	2.3	3.0	8.1	-1.0	0.0	2.9
Breast cancer (self-reported)	0.6	0.7	2.0	0.4	1.4	0.1
Asthma (self-reported)	0.4	0.7	1.6	-0.5	-1.2	0.6
Osteoporosis (self-reported)	0.9	1.2	2.9	-1.7	-0.1	-0.8
Osteoarthritis (self-reported)	1.4	1.8	4.8	-0.1	-2.2	0.7
Medication: Aspirin	0.5	0.6	1.2	1.1	0.3	-0.7
Medication: Gliclazide	0.9	1.0	2.0	-0.6	-1.4	0.7
Illnesses of father: None of the above (group 1)	1.1	1.4	2.5	-1.6	-0.3	-1.2
Smoking status: Current	1.0	1.6	2.6	1.4	-0.7	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.5	1.6	0.6	0.4
Whole body water mass	0.5	3.0	6.2	0.0	-1.6	2.5
Leg predicted mass (right)	0.9	4.7	8.1	-0.1	-2.5	2.8
Arm fat mass (left)	2.5	10.2	20.8	0.1	-4.6	3.1
Number of self-reported non-cancer illnesses	0.8	1.4	3.6	-0.7	-1.9	0.4
Average weekly champagne plus white wine intake	0.4	0.6	1.2	0.8	1.1	-0.1
Miserableness	0.1	0.2	0.4	0.2	0.5	-0.6
Guilty feelings	0.7	1.1	2.6	-1.6	-0.2	0.8
Wears glasses or contact lenses	1.7	1.9	3.0	0.1	-1.7	-1.7
Ever taken oral contraceptive pill	1.0	1.1	1.7	1.0	-0.8	1.3
Hearing aid user	1.2	1.3	2.9	-1.0	0.2	-1.7
Mother’s age at death	0.4	0.5	1.2	-0.3	-1.1	-0.6
Financial situation satisfaction	2.7	3.4	5.9	0.7	2.0	-2.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.3	0.1	0.4	-1.5
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.2	0.2	-1.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.9	0.4	-0.5	1.7
Medication: Blood pressure	0.0	0.0	0.0	-0.1	0.0	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.4	-0.2	0.3
Supplements: Fish oil (including cod liver oil)	2.4	3.1	8.1	1.0	0.5	-2.9
High cholesterol (Self-reported)	0.8	1.4	3.8	-0.4	-0.4	2.0
Medication: Bendroflumethiazide	0.0	0.1	0.2	-0.1	0.4	0.2
Medication: Paracetamol	0.8	1.3	2.3	0.3	-1.5	1.2
Medication: Lisinopril	0.3	0.4	0.8	0.9	-0.1	0.5
Medication: Atorvastatin	0.8	1.0	1.7	-0.6	-1.0	1.3
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.0	0.1	-0.8
Alcohol drinker status: Never	0.2	0.3	0.7	-0.1	-0.4	-0.8
Ever smoked	1.6	2.8	6.8	1.3	-0.1	2.6
Basal metabolic rate	0.8	4.2	7.9	-0.2	-2.1	2.8
Leg fat percentage (left)	2.6	9.5	17.4	1.5	-4.2	3.0
Arm fat-free mass (left)	0.7	3.4	7.0	0.5	-1.7	2.6
Number of operations (self-reported)	1.0	1.4	3.9	2.0	-0.6	0.3
Average weekly beer plus cider intake	0.5	0.7	1.1	0.4	-0.9	1.0
Irritability	1.0	1.7	2.9	1.4	0.2	1.7
Risk taking	1.9	2.8	4.1	2.0	-0.5	2.0
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.8	-0.3	-0.6
Fractured/broken bones in last 5 years	0.7	0.9	1.4	-0.9	-0.7	1.2
Age started oral contraceptive pill	3.7	4.6	7.7	2.2	2.8	-1.2
Diastolic blood pressure, automated reading	0.4	1.2	2.3	0.4	-1.0	1.5
Ever depressed for a whole week	0.7	0.8	1.3	-1.2	-0.5	0.9
Unable to work because of sickness or disability	0.4	0.6	1.1	-1.1	-0.7	0.4
Commuting to job workplace: Cycle	0.3	0.3	0.8	-0.9	0.3	0.0
Myopia	1.8	2.6	4.2	1.3	2.0	-1.4
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.0	1.0	0.1	-0.9
Cholesterol lowering medication	0.6	0.9	2.2	0.4	0.6	1.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.0	0.7	1.4	0.1
Pain experienced in last month	0.4	0.6	1.1	0.1	-0.9	-1.1
Supplements: Calcium	1.5	1.6	3.9	-0.2	0.9	-2.0
Basal cell carcinoma (self-reported)	0.9	1.1	3.0	0.4	-0.3	1.7
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.8	-1.7	-0.2	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.1	0.5	-1.4	0.8
Heart disease (siblings)	0.5	0.6	1.6	-0.2	-1.3	0.5
Alcohol drinker status: Previous	1.2	1.3	3.2	-1.8	0.1	0.9
Pack years of smoking	0.1	0.1	0.3	-0.3	0.2	0.5
Impedance of whole body	1.0	5.1	10.5	-0.8	2.1	-3.2
Leg fat mass (left)	2.6	10.3	18.4	0.9	-4.3	3.4
Arm predicted mass (left)	0.7	3.5	7.9	0.5	-1.6	2.8