TWAS hub - PFN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0596	0.016	3.5e-08	0.033	0.024	0.028	0.034	0.029	3.9e-11	1.8e-08	1.6e-09	1.8e-11	7.7e-10
2	TCGA	Pheochromocytoma and Paraganglioma	0.1560	0.082	8.6e-03	0.002	0.028	0.017	NA	0.008	2.6e-01	2.7e-02	6.6e-02	NA	1.5e-01
3	TCGA	Thyroid Carcinoma	0.0360	0.022	7.4e-03	0.039	0.025	0.022	NA	0.035	1.1e-04	1.7e-03	3.2e-03	NA	2.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Platelet Count	5.4	62.7	125.4	2.2	-11.2	-7.6
Depression (Nagel 2018)	4.8	7.3	11.2	3.4	1.4	-3.0
Blood White Count	4.5	33.0	66.7	-1.9	-8.2	5.3
Eye problems/disorders: Diabetes related eye disease	4.3	4.7	6.8	-1.7	-2.6	2.1
Lung cancer (father)	3.9	4.6	8.8	3.0	2.1	-0.7
Ulcerative Colitis	3.7	5.4	8.1	1.1	2.8	-2.6
Age started oral contraceptive pill	3.7	4.6	7.7	2.2	2.8	-1.2
Number of children fathered	3.5	4.0	7.1	0.9	-2.0	2.7
Multivitamins +/- minerals	3.4	4.4	10.7	0.3	1.5	-3.3
Medication: Levothyroxine sodium	3.4	5.8	7.5	-2.6	-2.7	1.8
Diabetes (self-reported)	3.4	5.2	8.1	-1.1	-2.5	2.8
Pulse rate, automated reading	3.4	10.9	23.9	0.6	2.9	-4.9
Diabetes diagnosed by doctor	3.3	5.5	8.8	-0.8	-2.6	3.0
Arm fat percentage (right)	3.2	12.5	26.8	-0.3	-5.2	3.2
Type 2 Diabetes (T2D) (2018)	3.1	5.9	12.2	0.4	-2.3	3.5
Health satisfaction	3.0	4.0	7.7	1.1	1.7	-2.8
Arm fat percentage (left)	3.0	11.9	26.6	0.0	-5.2	3.0
Verbal and Numeric Reasoning (VNR)	2.9	6.9	10.0	-1.6	-3.2	2.9
Medication: Metformin	2.9	4.1	8.4	-0.5	-2.9	1.9
Chronic bronchitis/emphysema (mother)	2.9	3.4	8.1	-2.8	-0.9	1.1
Leg fat mass (right)	2.9	11.1	19.6	0.8	-4.4	3.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	7.3	2.7	1.2	-1.6
Hypothyroidism/myxoedema (self-reported)	2.8	5.5	8.9	-2.5	-3.0	1.1
Body mass index (BMI)	2.7	11.6	20.6	1.1	-4.5	3.6
Prospective memory result	2.7	3.3	4.6	1.8	2.1	-1.5
Leg fat percentage (right)	2.7	9.7	18.4	1.4	-4.3	3.0
Financial situation satisfaction	2.7	3.4	5.9	0.7	2.0	-2.4
Ulcerative Colitis (UC)	2.6	4.8	7.1	0.5	2.7	-2.7
Leg fat percentage (left)	2.6	9.5	17.4	1.5	-4.2	3.0
Leg fat mass (left)	2.6	10.3	18.4	0.9	-4.3	3.4
Coronary Artery Disease (CAD)	2.5	3.0	8.9	-0.2	3.0	-0.2
HbA1C	2.5	2.7	4.7	1.5	-1.1	2.2
Medication: Co-codamol	2.5	2.9	3.7	1.9	1.2	-1.9
Arm fat mass (right)	2.5	10.4	20.8	-0.0	-4.6	3.2
Body fat percentage	2.5	9.8	21.7	0.3	-4.7	2.8
Arm fat mass (left)	2.5	10.2	20.8	0.1	-4.6	3.1
Commuting to job workplace: Car/motor vehicle	2.4	2.8	6.1	-0.1	-1.5	2.5
Supplements: Fish oil (including cod liver oil)	2.4	3.1	8.1	1.0	0.5	-2.9
Alzheimer’s Disease (including proxy)	2.3	3.3	6.0	0.9	-1.7	2.4
Body Mass Index (BMI) (2010)	2.3	3.2	4.2	-1.4	-2.0	1.8
BMI	2.3	13.2	21.8	1.3	-4.7	4.0
Medication: Atenolol	2.3	2.8	6.7	0.3	1.3	-2.6
Mineral and other dietary supplements	2.3	3.0	8.1	-1.0	0.0	2.9
Schizophrenia vs Biploar Disorder	2.2	2.9	4.0	1.4	2.0	-1.7
Hypothyroidism (self reported)	2.2	5.0	7.5	-2.4	-2.7	1.3
Medication for hormone replacement therapy	2.2	2.4	2.8	-1.7	-1.5	1.5
Average weekly fortified wine intake	2.2	2.6	4.8	-0.1	-1.7	-2.2
Qualifications: CSEs or equivalent	2.2	3.0	4.0	-1.0	-2.0	1.9
Tense / ‘highly strung’	2.2	3.6	6.9	1.4	2.6	-1.4
Vitamin and mineral supplements	2.1	2.9	6.2	-0.4	-1.5	2.5
Trunk fat percentage	2.1	8.4	19.6	0.1	-4.4	2.4
Neuroticism (2016)	2.0	2.9	6.1	-0.4	1.5	-2.5
Waist circumference	2.0	7.2	11.7	0.5	-3.4	3.1
Hip circumference	2.0	8.7	18.0	0.4	-4.2	2.8
Whole body fat mass	2.0	8.1	16.4	0.2	-4.0	2.8
Hearing difficulty/problems: Yes	1.9	2.8	5.4	2.3	0.8	-1.6
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.2	0.6	-2.0	1.7
Trunk fat mass	1.9	8.2	17.7	0.0	-4.2	2.6
Mouth/teeth dental problems: Dentures	1.9	3.1	5.6	1.6	-1.1	-2.4
Risk taking	1.9	2.8	4.1	2.0	-0.5	2.0
Pain all over the body in last month	1.8	2.0	5.6	0.3	-2.4	-0.4
Myopia	1.8	2.6	4.2	1.3	2.0	-1.4
Father’s age at death	1.7	2.3	4.0	0.8	2.0	-1.6
Medication: Allopurinol	1.7	2.2	4.0	-2.0	0.6	1.5
Age at last live birth	1.7	2.5	3.0	1.7	1.6	1.4
Illnesses of siblings: Diabetes	1.7	2.1	3.1	-1.8	-1.7	0.6
Average weekly red wine intake	1.7	2.6	7.2	0.7	0.0	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.8	1.1	0.6	-2.0
Wears glasses or contact lenses	1.7	1.9	3.0	0.1	-1.7	-1.7
Age when periods started (menarche)	1.6	3.7	10.6	-0.2	3.3	-0.7
Pulse rate	1.6	2.7	3.8	1.8	1.1	-2.0
Medication: Paracetamol	1.6	2.7	4.8	-0.1	-1.8	2.2
Eye problems/disorders: None of the above	1.6	1.8	2.5	-0.6	1.6	-1.6
Ever smoked	1.6	2.8	6.8	1.3	-0.1	2.6
Depressed Affect (Nagel 2018)	1.5	3.1	3.9	1.6	2.0	-1.7
Fasting Glucose	1.5	1.7	2.6	1.3	-1.6	0.9
Smoking Status	1.5	3.5	8.1	1.6	-0.1	2.9
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.1	0.5	1.2	-2.2
Hair/balding pattern: Pattern 2	1.5	1.9	2.9	1.7	-0.2	1.7
Gout (self-reported)	1.5	2.0	5.5	-2.3	0.3	0.7
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	2.7	-1.0	1.4	-1.6
Supplements: Calcium	1.5	1.6	3.9	-0.2	0.9	-2.0
Worry (Nagel 2018)	1.4	3.0	4.8	0.5	2.0	-2.2
Chronotype (morning person)	1.4	3.3	5.0	2.1	0.5	-2.2
Number of treatments/medications taken	1.4	2.5	4.0	-1.6	-2.0	0.9
Ever used hormone-replacement therapy (HRT)	1.4	1.8	5.3	2.3	0.1	-0.3
Fluid intelligence score	1.4	2.8	5.4	-0.4	-2.3	1.7
Number of live births	1.4	2.0	4.0	-0.9	-1.0	2.0
Mean time to correctly identify matches	1.4	2.7	6.9	1.0	-0.6	-2.6
Mood swings	1.4	2.6	5.5	1.5	2.3	-0.2
Osteoarthritis (self-reported)	1.4	1.8	4.8	-0.1	-2.2	0.7
Ovarian Cancer	1.3	1.7	4.4	-2.1	-0.6	0.6
Prostate Cancer	1.3	1.8	4.0	2.0	-0.2	1.2
Pulse wave reflection index	1.3	1.6	3.2	0.1	-1.2	1.8
Qualifications: nursing, teaching	1.3	2.0	5.1	2.3	-0.5	-0.9
Back pain experienced in last month	1.3	1.9	2.2	-1.4	-1.5	1.1
LDL Cholesterol	1.2	1.9	5.7	0.2	2.4	-0.2
Serious illness, injury or assault to yourself	1.2	1.5	2.6	0.7	-1.2	1.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	2.4	-1.5	-1.1	0.9
Number of incorrect matches in round	1.2	2.0	4.0	1.2	0.9	-2.0
Hearing difficulty/problems with background noise	1.2	1.9	3.9	2.0	0.7	-1.1
Weight	1.2	5.8	9.7	0.2	-3.1	2.8
Loud music exposure frequency	1.2	1.4	2.7	-1.0	-0.6	1.6
Hearing aid user	1.2	1.3	2.9	-1.0	0.2	-1.7
Alcohol drinker status: Previous	1.2	1.3	3.2	-1.8	0.1	0.9
Neuroticism (Nagel 2018)	1.1	2.5	4.1	1.3	2.0	-1.3
Rheumatoid Arthritis	1.1	1.5	3.1	0.7	-1.0	1.7
Average weekly spirits intake	1.1	1.4	2.6	1.2	-1.6	-0.0
Past tobacco smoking	1.1	2.0	5.4	-0.7	-0.4	-2.3
Alcohol usually taken with meals	1.1	1.8	5.1	-0.3	0.5	-2.3
Medication: Amlodipine	1.1	1.6	3.4	1.0	1.8	-0.7
Illnesses of father: None of the above (group 1)	1.1	1.4	2.5	-1.6	-0.3	-1.2
Alzheimer’s Disease (in father)	1.0	1.1	1.7	1.3	-1.2	-0.0
Breast Cancer	1.0	2.4	4.3	-2.1	1.6	0.5
Cardiovascular Disease	1.0	3.3	8.0	-1.0	-1.0	2.8
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.5	1.6	0.8	-1.0
Current tobacco smoking	1.0	1.7	3.1	1.3	-0.7	1.8
Leg predicted mass (left)	1.0	5.1	8.6	-0.2	-2.6	2.9
Had other major operations	1.0	1.2	2.7	1.6	0.5	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.2	0.6	-0.1	1.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.4	-0.4	-1.6	1.5
Age at first live birth	1.0	1.8	4.1	1.0	2.0	0.7
Medication for cholesterol	1.0	1.6	3.3	1.1	0.5	-1.8
Smoking status: Current	1.0	1.6	2.6	1.4	-0.7	1.6
Ever taken oral contraceptive pill	1.0	1.1	1.7	1.0	-0.8	1.3
Number of operations (self-reported)	1.0	1.4	3.9	2.0	-0.6	0.3
Irritability	1.0	1.7	2.9	1.4	0.2	1.7
Impedance of whole body	1.0	5.1	10.5	-0.8	2.1	-3.2
Alzheimer’s Disease (in mother)	0.9	1.1	2.9	0.5	-0.3	1.7
Primary Biliary Cirrhosis	0.9	1.3	2.1	0.5	1.4	-1.3
Leg fat-free mass (left)	0.9	4.9	7.9	-0.2	-2.6	2.8
Taking other prescription medications	0.9	1.4	1.7	-1.3	-1.2	1.0
Allergy	0.9	2.1	4.7	-0.9	2.2	0.9
Impedance of arm (right)	0.9	4.4	8.1	-1.9	1.2	-2.8
Birth weight	0.9	1.9	3.9	0.7	1.0	-2.0
High blood pressure (siblings)	0.9	1.3	3.1	-1.8	-0.9	-0.3
Leg fat-free mass (right)	0.9	4.6	7.8	-0.2	-2.4	2.8
Commuting to job workplace: Walk	0.9	1.0	1.2	-1.1	0.8	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.1	1.8	1.0	0.2
Osteoporosis (self-reported)	0.9	1.2	2.9	-1.7	-0.1	-0.8
Medication: Gliclazide	0.9	1.0	2.0	-0.6	-1.4	0.7
Leg predicted mass (right)	0.9	4.7	8.1	-0.1	-2.5	2.8
Eye problems/disorders: Glaucoma	0.9	1.1	2.9	0.4	-0.5	1.7
Basal cell carcinoma (self-reported)	0.9	1.1	3.0	0.4	-0.3	1.7
Reaction Time	0.8	1.6	3.5	0.6	-1.0	-1.9
Crohns Disease (2012)	0.8	1.3	2.7	0.4	-1.6	1.1
Diabetes (father)	0.8	1.0	2.2	-1.5	-0.7	0.6
Impedance of leg (right)	0.8	4.1	6.5	-0.3	2.4	-2.6
Maternal smoking around birth	0.8	1.1	2.8	0.6	-0.5	1.7
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.3	1.8	-1.4	-0.3
Stomach or abdominal pain in last month	0.8	1.0	2.4	-0.1	-1.6	0.8
High blood pressure (mother)	0.8	1.1	3.1	1.8	-0.3	-0.1
Impedance of leg (left)	0.8	4.1	6.8	-0.2	2.3	-2.6
Nervous feelings	0.8	1.5	2.7	-0.8	1.1	-1.6
Mouth/teeth dental problems	0.8	1.2	2.2	-1.1	0.4	1.5
Heart attack	0.8	1.0	2.7	-1.6	-0.4	-0.3
Noisy workplace	0.8	1.0	2.4	-0.3	1.6	-0.8
Impedance of arm (left)	0.8	3.9	8.4	-1.4	1.1	-2.9
Breastfed as a baby	0.8	1.0	1.9	0.9	0.6	-1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.2	-0.9	-0.2	1.5
Suffer from ‘nerves’	0.8	1.2	2.5	0.4	1.6	-1.0
Number of self-reported non-cancer illnesses	0.8	1.4	3.6	-0.7	-1.9	0.4
High cholesterol (Self-reported)	0.8	1.4	3.8	-0.4	-0.4	2.0
Medication: Paracetamol	0.8	1.3	2.3	0.3	-1.5	1.2
Medication: Atorvastatin	0.8	1.0	1.7	-0.6	-1.0	1.3
Basal metabolic rate	0.8	4.2	7.9	-0.2	-2.1	2.8
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.8	-1.7	-0.2	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.1	0.5	-1.4	0.8
Lupus	0.7	1.1	2.7	-0.1	-0.8	1.6
Blood Eosinophil Count	0.7	5.3	10.1	0.2	-2.4	3.2
Lung FEV1/FVC ratio	0.7	3.6	8.9	3.0	-0.6	1.3
Relative age voice broke	0.7	1.1	3.2	0.3	1.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.3	1.8	0.5	1.1
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	1.1	0.1	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.4	1.9	1.0	0.6
Time employed in main current job	0.7	0.8	1.1	1.0	0.8	0.8
Length of working week for main job	0.7	0.8	1.0	0.9	-0.7	1.0
Blood clot in the leg (DVT)	0.7	0.9	2.1	0.5	-1.5	0.6
Exposure to tobacco smoke outside home	0.7	0.9	2.1	1.4	-0.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.2	-1.1	-0.5	-1.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	0.6	0.6	-1.3
Alcohol intake frequency.	0.7	1.6	3.3	-1.8	0.7	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.2	1.5	-0.3	0.3
Friendships satisfaction	0.7	0.9	1.6	-0.6	0.7	-1.3
Guilty feelings	0.7	1.1	2.6	-1.6	-0.2	0.8
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.3	0.1	0.4	-1.5
Arm fat-free mass (left)	0.7	3.4	7.0	0.5	-1.7	2.6
Fractured/broken bones in last 5 years	0.7	0.9	1.4	-0.9	-0.7	1.2
Ever depressed for a whole week	0.7	0.8	1.3	-1.2	-0.5	0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.0	0.7	1.4	0.1
Arm predicted mass (left)	0.7	3.5	7.9	0.5	-1.6	2.8
Irritable Bowel Disease (IBD)	0.6	1.4	2.5	0.6	1.6	-1.1
Schizophrenia (2014)	0.6	1.4	2.7	1.6	0.9	-0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.5	0.5	-1.2	0.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	0.6	0.4	-1.2
Systolic blood pressure, automated reading	0.6	1.8	3.7	1.1	-0.7	1.9
Supplements: Zinc	0.6	0.7	1.7	0.3	-0.5	-1.3
Had menopause	0.6	0.7	1.3	0.9	0.1	-1.1
Worrier / anxious feelings	0.6	1.1	1.6	1.1	1.3	-0.7
Exposure to tobacco smoke at home	0.6	0.6	1.1	1.1	-0.4	-0.8
Arm fat-free mass (right)	0.6	2.9	6.5	0.8	-1.3	2.5
Neck or shoulder pain in last month	0.6	0.9	2.1	-1.4	0.8	0.1
Medication: Seretide 50 evohaler	0.6	0.7	1.3	-0.6	-1.2	0.5
Smoking status: Previous	0.6	0.9	2.5	-0.1	0.3	1.6
Loneliness, isolation	0.6	0.8	1.8	-0.3	1.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	1.1	0.6	-0.7
Breast cancer (self-reported)	0.6	0.7	2.0	0.4	1.4	0.1
Cholesterol lowering medication	0.6	0.9	2.2	0.4	0.6	1.5
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.2	0.1	-1.5	1.5
Schizophrenia (2018)	0.5	0.9	1.9	1.4	-0.5	0.8
Triglycerides	0.5	0.8	1.2	1.1	0.7	0.8
Height	0.5	9.2	13.3	-2.1	3.6	-3.2
Allergy or Eczema	0.5	1.2	2.3	1.5	-1.1	0.3
Lung FVC	0.5	2.3	3.5	-0.4	-1.9	1.8
Neuroticism	0.5	1.3	2.0	1.1	1.4	-0.8
Fed-up feelings	0.5	0.9	1.6	1.0	1.3	-0.0
Medication: Ramipril	0.5	0.7	1.3	-1.1	-0.9	0.2
Falls in the last year	0.5	0.6	0.9	1.0	-1.0	0.0
Happiness	0.5	0.5	1.1	-0.4	1.1	-0.6
Asthma	0.5	0.9	1.8	-0.6	-1.3	0.8
Illnesses of mother	0.5	0.7	1.6	-0.2	0.6	-1.3
Glaucoma (self-reported)	0.5	0.6	1.8	0.1	0.2	1.3
Wheeze or whistling in the chest in last year	0.5	0.9	1.3	1.1	0.5	-1.1
Medication for pain relief, constipation, heartburn	0.5	0.8	1.5	-0.1	0.9	-1.2
Angina (self-reported)	0.5	0.7	1.1	-1.1	-1.0	0.0
Arm predicted mass (right)	0.5	2.7	5.4	0.7	-1.4	2.3
Number of full sisters	0.5	0.6	1.7	-1.3	0.2	-0.3
Illnesses of father: Heart disease	0.5	0.7	1.9	1.4	-0.2	-0.4
Whole body fat-free mass	0.5	3.0	6.4	0.0	-1.6	2.5
Medication: Aspirin	0.5	0.6	1.2	1.1	0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.5	1.6	0.6	0.4
Whole body water mass	0.5	3.0	6.2	0.0	-1.6	2.5
Average weekly beer plus cider intake	0.5	0.7	1.1	0.4	-0.9	1.0
Heart disease (siblings)	0.5	0.6	1.6	-0.2	-1.3	0.5
Bipolar Disorder (2018)	0.4	0.7	1.0	-0.4	-0.9	-1.0
Major Depression (MDD)	0.4	0.5	1.0	-1.0	-0.6	-0.1
Blood Red Count	0.4	3.7	5.6	-1.5	-1.8	2.4
Townsend deprivation index at recruitment	0.4	0.6	1.2	-0.4	0.6	1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.4	-0.9	0.4
Illnesses of siblings	0.4	0.5	0.5	0.7	0.7	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.5	0.2	0.2	2.1
Depression (self-reported)	0.4	0.5	0.9	0.9	0.1	-0.8
Standing height	0.4	3.7	5.7	-1.8	2.4	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.1	-0.9	-0.4	-1.0
Birth weight of first child	0.4	0.7	1.3	0.9	0.2	-1.1
Peak expiratory flow (PEF)	0.4	0.8	1.0	1.0	0.7	1.0
Worry too long after embarrassment	0.4	0.7	1.2	-1.1	0.9	-0.1
Medication: Omeprazole	0.4	0.4	0.9	0.6	1.0	-0.1
Heart disease (mother)	0.4	0.5	1.5	-0.0	0.3	1.2
Family relationship satisfaction	0.4	0.5	1.4	-0.2	-0.1	-1.2
Eye problems/disorders: Cataract	0.4	0.5	1.4	1.2	0.2	-0.1
Asthma (self-reported)	0.4	0.7	1.6	-0.5	-1.2	0.6
Average weekly champagne plus white wine intake	0.4	0.6	1.2	0.8	1.1	-0.1
Mother’s age at death	0.4	0.5	1.2	-0.3	-1.1	-0.6
Diastolic blood pressure, automated reading	0.4	1.2	2.3	0.4	-1.0	1.5
Unable to work because of sickness or disability	0.4	0.6	1.1	-1.1	-0.7	0.4
Pain experienced in last month	0.4	0.6	1.1	0.1	-0.9	-1.1
Age at First Birth	0.3	0.4	0.7	-0.6	0.8	-0.4
Heel T-Score	0.3	2.2	3.9	1.6	-0.4	2.0
Waist Hip Ratio (WHR)	0.3	1.4	4.0	-0.1	2.0	0.4
Angina	0.3	0.4	0.8	-0.7	-0.9	-0.1
Supplements: Glucosamine	0.3	0.4	0.6	-0.1	-0.8	-0.8
Forced vital capacity (FVC)	0.3	1.0	2.1	-0.4	0.8	1.4
Qualifications: None of the above	0.3	0.6	1.2	-1.1	0.6	-0.6
Financial difficulties in last 2 years	0.3	0.3	0.9	0.9	0.4	0.1
Trunk fat-free mass	0.3	1.5	3.9	0.0	-0.7	2.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	0.7	1.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.8	0.5	0.4
Medication: Cholesterol lowering	0.3	0.5	0.9	-0.7	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.6	-0.6	0.3	1.6
Headache pain in last month	0.3	0.5	0.8	0.9	0.2	0.8
Pulse wave peak to peak time	0.3	0.4	1.0	0.2	1.0	-0.1
Migraine (self-reported)	0.3	0.4	0.8	-0.5	0.9	-0.3
Medication: Ibuprofen	0.3	0.4	0.7	0.5	0.3	0.9
Comparative height size at age 10	0.3	1.8	4.0	0.0	1.2	-2.0
Medication: Aspirin	0.3	0.4	0.6	0.7	0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.9	-0.9	0.6	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-1.0	-0.4	0.1
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.2	0.2	-1.1
Medication: Lisinopril	0.3	0.4	0.8	0.9	-0.1	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.8	-0.3	-0.6
Commuting to job workplace: Cycle	0.3	0.3	0.8	-0.9	0.3	0.0
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.8	-1.0	-0.0
Bipolar Disorder (2011)	0.2	0.2	0.7	0.0	-0.2	0.8
Mean Putamen Volume	0.2	0.3	0.7	-0.3	-0.9	0.1
Systolic Blood Pressure	0.2	1.2	2.3	-1.2	-0.0	1.5
Hand grip strength (left)	0.2	0.5	1.1	-1.0	-0.3	0.7
Relative age of first facial hair	0.2	0.4	0.6	-0.6	0.8	0.3
Diabetes (mother)	0.2	0.2	0.3	-0.3	0.5	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	0.8	0.3	-0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.7	0.4	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.6	-0.8	-0.0
Medication: Simvastatin	0.2	0.2	0.6	0.0	0.8	0.2
Neuroticism score	0.2	0.4	0.8	0.5	0.9	0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.6	0.8	-0.2
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	-1.0	-0.1	0.1
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.5	-0.7	-0.0
Trunk predicted mass	0.2	1.4	3.7	0.1	-0.7	1.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	-0.9	-0.3	0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	-0.5	0.4	-0.5
Forced vital capacity (FVC), Best measure	0.2	0.8	1.8	-0.4	1.3	0.6
Comparative body size at age 10	0.2	0.4	1.2	-0.2	0.2	-1.1
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.1	-0.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.3	0.3	0.7
Overall health rating	0.2	0.5	1.1	0.1	0.5	-1.0
Knee pain experienced in last month	0.2	0.2	0.7	0.2	0.1	0.8
Hypertension (Self-reported)	0.2	0.7	1.2	-0.7	-0.7	1.1
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.0	0.1	-0.8
Alcohol drinker status: Never	0.2	0.3	0.7	-0.1	-0.4	-0.8
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.0	1.0	0.1	-0.9
Crohns Disease (2017)	0.1	0.2	0.4	-0.1	-0.3	0.6
HDL Cholesterol	0.1	0.2	0.3	-0.6	-0.4	-0.2
Respiratory disease	0.1	0.1	0.3	-0.1	-0.6	-0.2
Sensitivity / hurt feelings	0.1	0.2	0.5	0.7	0.2	-0.3
Severe depression (siblings)	0.1	0.2	0.2	0.5	-0.4	0.3
Pack years adult smoking proportion	0.1	0.2	0.4	-0.2	0.3	0.7
Hand grip strength (right)	0.1	0.1	0.2	0.1	-0.5	0.4
High blood pressure	0.1	0.2	0.4	-0.7	-0.0	0.3
Sitting height	0.1	0.6	1.1	0.7	1.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.5	-0.1	-0.4
Number of full brothers	0.1	0.1	0.2	0.5	-0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.0	-0.3	-0.6
Shortness of breath walking on level ground	0.1	0.1	0.2	0.4	0.2	-0.4
Qualifications: College or University degree	0.1	0.5	0.9	0.9	0.7	-0.2
Medication: Blood pressure	0.1	0.1	0.4	0.0	0.6	0.0
Chest pain or discomfort	0.1	0.1	0.2	-0.4	0.2	-0.3
Leg pain on walking	0.1	0.2	0.3	0.3	0.5	-0.4
Supplements: Vitamin C	0.1	0.1	0.1	-0.3	0.0	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.0	0.5	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.7	0.1	-0.4
Ever had bowel cancer screening	0.1	0.2	0.3	0.5	0.1	-0.4
Miserableness	0.1	0.2	0.4	0.2	0.5	-0.6
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.4	-0.2	0.3
Pack years of smoking	0.1	0.1	0.3	-0.3	0.2	0.5
Hair Pigment	0.0	0.6	1.4	-0.2	0.6	1.2
Tanning	0.0	0.5	1.1	0.4	-1.0	0.6
Medication: Lansoprazole	0.0	0.0	0.1	-0.3	0.1	0.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.2	0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	0.0	0.2	-0.2
Had major operations	0.0	0.1	0.1	0.4	0.2	-0.0
Medication: Blood pressure	0.0	0.0	0.0	-0.1	0.0	0.1
Medication: Bendroflumethiazide	0.0	0.1	0.2	-0.1	0.4	0.2

Hub : Genes

PFN1

Models

Trait associations