Hub : Genes

PFN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0596 0.016 3.5e-08 0.033 0.024 0.028 0.034 0.029 3.9e-11 1.8e-08 1.6e-09 1.8e-11 7.7e-10
2 TCGA Pheochromocytoma and Paraganglioma 0.1560 0.082 8.6e-03 0.002 0.028 0.017 NA 0.008 2.6e-01 2.7e-02 6.6e-02 NA 1.5e-01
3 TCGA Thyroid Carcinoma 0.0360 0.022 7.4e-03 0.039 0.025 0.022 NA 0.035 1.1e-04 1.7e-03 3.2e-03 NA 2.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.7 1.0 -0.4 -0.9 -1.0
Bipolar Disorder or Schizophrenia 0.2 0.5 1.0 0.8 -1.0 -0.0
Depressed Affect (Nagel 2018) 1.5 3.1 3.9 1.6 2.0 -1.7
Depression (Nagel 2018) 4.8 7.3 11.2 3.4 1.4 -3.0
Intelligence (Savage-Jansen 2018) 0.5 1.5 2.2 0.1 -1.5 1.5
Neuroticism (Nagel 2018) 1.1 2.5 4.1 1.3 2.0 -1.3
Schizophrenia (2018) 0.5 0.9 1.9 1.4 -0.5 0.8
Schizophrenia vs Biploar Disorder 2.2 2.9 4.0 1.4 2.0 -1.7
Worry (Nagel 2018) 1.4 3.0 4.8 0.5 2.0 -2.2
Alzheimer’s Disease (in mother) 0.9 1.1 2.9 0.5 -0.3 1.7
Alzheimer’s Disease (in father) 1.0 1.1 1.7 1.3 -1.2 -0.0
Alzheimer’s Disease (including proxy) 2.3 3.3 6.0 0.9 -1.7 2.4
Crohns Disease (2017) 0.1 0.2 0.4 -0.1 -0.3 0.6
Irritable Bowel Disease (IBD) 0.6 1.4 2.5 0.6 1.6 -1.1
Ulcerative Colitis (UC) 2.6 4.8 7.1 0.5 2.7 -2.7
Major Depression (MDD) 0.4 0.5 1.0 -1.0 -0.6 -0.1
Reaction Time 0.8 1.6 3.5 0.6 -1.0 -1.9
Verbal and Numeric Reasoning (VNR) 2.9 6.9 10.0 -1.6 -3.2 2.9
Breast Cancer 1.0 2.4 4.3 -2.1 1.6 0.5
Ovarian Cancer 1.3 1.7 4.4 -2.1 -0.6 0.6
Prostate Cancer 1.3 1.8 4.0 2.0 -0.2 1.2
Age at First Birth 0.3 0.4 0.7 -0.6 0.8 -0.4
Bipolar Disorder (2011) 0.2 0.2 0.7 0.0 -0.2 0.8
Body Mass Index (BMI) (2010) 2.3 3.2 4.2 -1.4 -2.0 1.8
Coronary Artery Disease (CAD) 2.5 3.0 8.9 -0.2 3.0 -0.2
Crohns Disease (2012) 0.8 1.3 2.7 0.4 -1.6 1.1
Mean Putamen Volume 0.2 0.3 0.7 -0.3 -0.9 0.1
Fasting Glucose 1.5 1.7 2.6 1.3 -1.6 0.9
HbA1C 2.5 2.7 4.7 1.5 -1.1 2.2
HDL Cholesterol 0.1 0.2 0.3 -0.6 -0.4 -0.2
LDL Cholesterol 1.2 1.9 5.7 0.2 2.4 -0.2
Lupus 0.7 1.1 2.7 -0.1 -0.8 1.6
Neuroticism (2016) 2.0 2.9 6.1 -0.4 1.5 -2.5
Primary Biliary Cirrhosis 0.9 1.3 2.1 0.5 1.4 -1.3
Rheumatoid Arthritis 1.1 1.5 3.1 0.7 -1.0 1.7
Schizophrenia (2014) 0.6 1.4 2.7 1.6 0.9 -0.8
Triglycerides 0.5 0.8 1.2 1.1 0.7 0.8
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.5 0.5 -1.2 0.4
Ulcerative Colitis 3.7 5.4 8.1 1.1 2.8 -2.6
Blood Eosinophil Count 0.7 5.3 10.1 0.2 -2.4 3.2
Blood Platelet Count 5.4 62.7 125.4 2.2 -11.2 -7.6
Blood Red Count 0.4 3.7 5.6 -1.5 -1.8 2.4
Blood White Count 4.5 33.0 66.7 -1.9 -8.2 5.3
Heel T-Score 0.3 2.2 3.9 1.6 -0.4 2.0
BMI 2.3 13.2 21.8 1.3 -4.7 4.0
Height 0.5 9.2 13.3 -2.1 3.6 -3.2
Waist Hip Ratio (WHR) 0.3 1.4 4.0 -0.1 2.0 0.4
Systolic Blood Pressure 0.2 1.2 2.3 -1.2 -0.0 1.5
Smoking Status 1.5 3.5 8.1 1.6 -0.1 2.9
Allergy or Eczema 0.5 1.2 2.3 1.5 -1.1 0.3
Cardiovascular Disease 1.0 3.3 8.0 -1.0 -1.0 2.8
Hypothyroidism (self reported) 2.2 5.0 7.5 -2.4 -2.7 1.3
Respiratory disease 0.1 0.1 0.3 -0.1 -0.6 -0.2
Type 2 Diabetes (T2D) (2018) 3.1 5.9 12.2 0.4 -2.3 3.5
Lung FEV1/FVC ratio 0.7 3.6 8.9 3.0 -0.6 1.3
Lung FVC 0.5 2.3 3.5 -0.4 -1.9 1.8
Neuroticism 0.5 1.3 2.0 1.1 1.4 -0.8
Chronotype (morning person) 1.4 3.3 5.0 2.1 0.5 -2.2
Hair Pigment 0.0 0.6 1.4 -0.2 0.6 1.2
Tanning 0.0 0.5 1.1 0.4 -1.0 0.6
Hand grip strength (left) 0.2 0.5 1.1 -1.0 -0.3 0.7
Number of treatments/medications taken 1.4 2.5 4.0 -1.6 -2.0 0.9
Average weekly spirits intake 1.1 1.4 2.6 1.2 -1.6 -0.0
Sensitivity / hurt feelings 0.1 0.2 0.5 0.7 0.2 -0.3
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.5 1.6 0.8 -1.0
Hearing difficulty/problems: Yes 1.9 2.8 5.4 2.3 0.8 -1.6
Relative age of first facial hair 0.2 0.4 0.6 -0.6 0.8 0.3
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 4.2 0.6 -2.0 1.7
Ever used hormone-replacement therapy (HRT) 1.4 1.8 5.3 2.3 0.1 -0.3
Ever had hysterectomy (womb removed) 0.6 0.7 1.4 0.6 0.4 -1.2
Systolic blood pressure, automated reading 0.6 1.8 3.7 1.1 -0.7 1.9
Eye problems/disorders: Diabetes related eye disease 4.3 4.7 6.8 -1.7 -2.6 2.1
Angina 0.3 0.4 0.8 -0.7 -0.9 -0.1
Medication for hormone replacement therapy 2.2 2.4 2.8 -1.7 -1.5 1.5
Vitamin and mineral supplements 2.1 2.9 6.2 -0.4 -1.5 2.5
Supplements: Zinc 0.6 0.7 1.7 0.3 -0.5 -1.3
Medication: Co-codamol 2.5 2.9 3.7 1.9 1.2 -1.9
Medication: Metformin 2.9 4.1 8.4 -0.5 -2.9 1.9
Diabetes (father) 0.8 1.0 2.2 -1.5 -0.7 0.6
Diabetes (mother) 0.2 0.2 0.3 -0.3 0.5 -0.6
Severe depression (siblings) 0.1 0.2 0.2 0.5 -0.4 0.3
Pack years adult smoking proportion 0.1 0.2 0.4 -0.2 0.3 0.7
Impedance of leg (right) 0.8 4.1 6.5 -0.3 2.4 -2.6
Leg fat-free mass (left) 0.9 4.9 7.9 -0.2 -2.6 2.8
Trunk fat percentage 2.1 8.4 19.6 0.1 -4.4 2.4
Hand grip strength (right) 0.1 0.1 0.2 0.1 -0.5 0.4
Townsend deprivation index at recruitment 0.4 0.6 1.2 -0.4 0.6 1.1
Current tobacco smoking 1.0 1.7 3.1 1.3 -0.7 1.8
Average weekly fortified wine intake 2.2 2.6 4.8 -0.1 -1.7 -2.2
Maternal smoking around birth 0.8 1.1 2.8 0.6 -0.5 1.7
Fed-up feelings 0.5 0.9 1.6 1.0 1.3 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.8 7.3 2.7 1.2 -1.6
Relative age voice broke 0.7 1.1 3.2 0.3 1.8 0.1
Taking other prescription medications 0.9 1.4 1.7 -1.3 -1.2 1.0
Age when periods started (menarche) 1.6 3.7 10.6 -0.2 3.3 -0.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.6 0.8 0.3 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 3.3 1.8 0.5 1.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.9 -0.4 -0.9 0.4
Qualifications: CSEs or equivalent 2.2 3.0 4.0 -1.0 -2.0 1.9
Serious illness, injury or assault to yourself 1.2 1.5 2.6 0.7 -1.2 1.6
High blood pressure 0.1 0.2 0.4 -0.7 -0.0 0.3
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.3 1.8 -1.4 -0.3
Multivitamins +/- minerals 3.4 4.4 10.7 0.3 1.5 -3.3
Stomach or abdominal pain in last month 0.8 1.0 2.4 -0.1 -1.6 0.8
Supplements: Glucosamine 0.3 0.4 0.6 -0.1 -0.8 -0.8
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 2.4 -1.5 -1.1 0.9
Medication: Atenolol 2.3 2.8 6.7 0.3 1.3 -2.6
Medication: Levothyroxine sodium 3.4 5.8 7.5 -2.6 -2.7 1.8
Sitting height 0.1 0.6 1.1 0.7 1.0 -0.4
Chronic bronchitis/emphysema (father) 0.7 0.8 1.3 1.1 0.1 -1.1
High blood pressure (mother) 0.8 1.1 3.1 1.8 -0.3 -0.1
Body mass index (BMI) 2.7 11.6 20.6 1.1 -4.5 3.6
Impedance of leg (left) 0.8 4.1 6.8 -0.2 2.3 -2.6
Leg predicted mass (left) 1.0 5.1 8.6 -0.2 -2.6 2.9
Trunk fat mass 1.9 8.2 17.7 0.0 -4.2 2.6
Waist circumference 2.0 7.2 11.7 0.5 -3.4 3.1
Number of incorrect matches in round 1.2 2.0 4.0 1.2 0.9 -2.0
Past tobacco smoking 1.1 2.0 5.4 -0.7 -0.4 -2.3
Alcohol usually taken with meals 1.1 1.8 5.1 -0.3 0.5 -2.3
Nervous feelings 0.8 1.5 2.7 -0.8 1.1 -1.6
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 5.1 0.5 1.2 -2.2
Hearing difficulty/problems with background noise 1.2 1.9 3.9 2.0 0.7 -1.1
Hair/balding pattern: Pattern 2 1.5 1.9 2.9 1.7 -0.2 1.7
Had menopause 0.6 0.7 1.3 0.9 0.1 -1.1
Had other major operations 1.0 1.2 2.7 1.6 0.5 -0.8
Forced vital capacity (FVC) 0.3 1.0 2.1 -0.4 0.8 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 3.4 1.9 1.0 0.6
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.4 -0.7 0.4 -0.3
Qualifications: None of the above 0.3 0.6 1.2 -1.1 0.6 -0.6
Financial difficulties in last 2 years 0.3 0.3 0.9 0.9 0.4 0.1
Mouth/teeth dental problems 0.8 1.2 2.2 -1.1 0.4 1.5
Heart attack 0.8 1.0 2.7 -1.6 -0.4 -0.3
Allergy 0.9 2.1 4.7 -0.9 2.2 0.9
Pain all over the body in last month 1.8 2.0 5.6 0.3 -2.4 -0.4
Diabetes (self-reported) 3.4 5.2 8.1 -1.1 -2.5 2.8
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.6 -0.8 -0.0
Medication: Ramipril 0.5 0.7 1.3 -1.1 -0.9 0.2
Medication: Simvastatin 0.2 0.2 0.6 0.0 0.8 0.2
Fluid intelligence score 1.4 2.8 5.4 -0.4 -2.3 1.7
Illnesses of siblings 0.4 0.5 0.5 0.7 0.7 0.7
Neuroticism score 0.2 0.4 0.8 0.5 0.9 0.2
Weight 1.2 5.8 9.7 0.2 -3.1 2.8
Impedance of arm (right) 0.9 4.4 8.1 -1.9 1.2 -2.8
Arm fat percentage (right) 3.2 12.5 26.8 -0.3 -5.2 3.2
Trunk fat-free mass 0.3 1.5 3.9 0.0 -0.7 2.0
Hip circumference 2.0 8.7 18.0 0.4 -4.2 2.8
Time employed in main current job 0.7 0.8 1.1 1.0 0.8 0.8
Alcohol intake versus 10 years previously 0.2 0.3 0.6 -0.6 0.8 -0.2
Father’s age at death 1.7 2.3 4.0 0.8 2.0 -1.6
Worrier / anxious feelings 0.6 1.1 1.6 1.1 1.3 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.5 -0.1 -0.4
Falls in the last year 0.5 0.6 0.9 1.0 -1.0 0.0
Hair/balding pattern: Pattern 3 0.2 0.3 1.0 -1.0 -0.1 0.1
Number of live births 1.4 2.0 4.0 -0.9 -1.0 2.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 4.5 0.2 0.2 2.1
Pulse rate 1.6 2.7 3.8 1.8 1.1 -2.0
Happiness 0.5 0.5 1.1 -0.4 1.1 -0.6
Noisy workplace 0.8 1.0 2.4 -0.3 1.6 -0.8
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.3 0.7 1.2 0.3
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 3.2 0.6 -0.1 1.8
Mouth/teeth dental problems: Dentures 1.9 3.1 5.6 1.6 -1.1 -2.4
Asthma 0.5 0.9 1.8 -0.6 -1.3 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 0.8 0.5 0.4
Medication: Cholesterol lowering 0.3 0.5 0.9 -0.7 -0.9 0.5
Depression (self-reported) 0.4 0.5 0.9 0.9 0.1 -0.8
Medication: Lansoprazole 0.0 0.0 0.1 -0.3 0.1 0.1
Prospective memory result 2.7 3.3 4.6 1.8 2.1 -1.5
Lung cancer (father) 3.9 4.6 8.8 3.0 2.1 -0.7
Illnesses of mother 0.5 0.7 1.6 -0.2 0.6 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.6 -0.6 0.3 1.6
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 -0.5 -0.7 -0.0
Impedance of arm (left) 0.8 3.9 8.4 -1.4 1.1 -2.9
Arm fat mass (right) 2.5 10.4 20.8 -0.0 -4.6 3.2
Trunk predicted mass 0.2 1.4 3.7 0.1 -0.7 1.9
Standing height 0.4 3.7 5.7 -1.8 2.4 -1.5
Length of working week for main job 0.7 0.8 1.0 0.9 -0.7 1.0
Exposure to tobacco smoke at home 0.6 0.6 1.1 1.1 -0.4 -0.8
Breastfed as a baby 0.8 1.0 1.9 0.9 0.6 -1.4
Tense / ‘highly strung’ 2.2 3.6 6.9 1.4 2.6 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.1 -0.9 -0.4 -1.0
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 0.2 0.2 0.1
Birth weight of first child 0.4 0.7 1.3 0.9 0.2 -1.1
Peak expiratory flow (PEF) 0.4 0.8 1.0 1.0 0.7 1.0
Pulse wave reflection index 1.3 1.6 3.2 0.1 -1.2 1.8
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.2 -0.9 -0.2 1.5
Loud music exposure frequency 1.2 1.4 2.7 -1.0 -0.6 1.6
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.4 -0.4 -1.6 1.5
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.8 -0.9 -0.3 0.1
Blood clot in the leg (DVT) 0.7 0.9 2.1 0.5 -1.5 0.6
Medication: Paracetamol 1.6 2.7 4.8 -0.1 -1.8 2.2
Headache pain in last month 0.3 0.5 0.8 0.9 0.2 0.8
Medication for cholesterol, blood pressure or diabetes 0.0 0.0 0.0 0.0 0.2 -0.2
Glaucoma (self-reported) 0.5 0.6 1.8 0.1 0.2 1.3
Gout (self-reported) 1.5 2.0 5.5 -2.3 0.3 0.7
Hypothyroidism/myxoedema (self-reported) 2.8 5.5 8.9 -2.5 -3.0 1.1
Medication: Amlodipine 1.1 1.6 3.4 1.0 1.8 -0.7
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.3 -0.5 0.4 -0.5
Birth weight 0.9 1.9 3.9 0.7 1.0 -2.0
Chronic bronchitis/emphysema (mother) 2.9 3.4 8.1 -2.8 -0.9 1.1
High blood pressure (siblings) 0.9 1.3 3.1 -1.8 -0.9 -0.3
Forced vital capacity (FVC), Best measure 0.2 0.8 1.8 -0.4 1.3 0.6
Body fat percentage 2.5 9.8 21.7 0.3 -4.7 2.8
Leg fat percentage (right) 2.7 9.7 18.4 1.4 -4.3 3.0
Arm fat-free mass (right) 0.6 2.9 6.5 0.8 -1.3 2.5
Exposure to tobacco smoke outside home 0.7 0.9 2.1 1.4 -0.1 0.8
Comparative body size at age 10 0.2 0.4 1.2 -0.2 0.2 -1.1
Number of full brothers 0.1 0.1 0.2 0.5 -0.4 0.1
Worry too long after embarrassment 0.4 0.7 1.2 -1.1 0.9 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.4 -0.0 -0.3 -0.6
Wheeze or whistling in the chest in last year 0.5 0.9 1.3 1.1 0.5 -1.1
Number of children fathered 3.5 4.0 7.1 0.9 -2.0 2.7
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.2 -1.1 -0.5 -1.0
Age at first live birth 1.0 1.8 4.1 1.0 2.0 0.7
Pulse wave peak to peak time 0.3 0.4 1.0 0.2 1.0 -0.1
Health satisfaction 3.0 4.0 7.7 1.1 1.7 -2.8
Shortness of breath walking on level ground 0.1 0.1 0.2 0.4 0.2 -0.4
Qualifications: College or University degree 0.1 0.5 0.9 0.9 0.7 -0.2
Eye problems/disorders: None of the above 1.6 1.8 2.5 -0.6 1.6 -1.6
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.7 0.6 0.6 -1.3
Emphysema/chronic bronchitis 0.2 0.2 0.3 -0.1 -0.6 -0.5
Medication for pain relief, constipation, heartburn 0.5 0.8 1.5 -0.1 0.9 -1.2
Neck or shoulder pain in last month 0.6 0.9 2.1 -1.4 0.8 0.1
Medication: Blood pressure 0.1 0.1 0.4 0.0 0.6 0.0
Angina (self-reported) 0.5 0.7 1.1 -1.1 -1.0 0.0
Migraine (self-reported) 0.3 0.4 0.8 -0.5 0.9 -0.3
Medication: Ibuprofen 0.3 0.4 0.7 0.5 0.3 0.9
Medication: Allopurinol 1.7 2.2 4.0 -2.0 0.6 1.5
Medication: Omeprazole 0.4 0.4 0.9 0.6 1.0 -0.1
Medication: Seretide 50 evohaler 0.6 0.7 1.3 -0.6 -1.2 0.5
Mean time to correctly identify matches 1.4 2.7 6.9 1.0 -0.6 -2.6
Heart disease (mother) 0.4 0.5 1.5 -0.0 0.3 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.5 -0.3 0.3 0.7
Whole body fat mass 2.0 8.1 16.4 0.2 -4.0 2.8
Leg fat mass (right) 2.9 11.1 19.6 0.8 -4.4 3.6
Arm predicted mass (right) 0.5 2.7 5.4 0.7 -1.4 2.3
Pulse rate, automated reading 3.4 10.9 23.9 0.6 2.9 -4.9
Alcohol intake frequency. 0.7 1.6 3.3 -1.8 0.7 0.9
Comparative height size at age 10 0.3 1.8 4.0 0.0 1.2 -2.0
Number of full sisters 0.5 0.6 1.7 -1.3 0.2 -0.3
Suffer from ‘nerves’ 0.8 1.2 2.5 0.4 1.6 -1.0
Overall health rating 0.2 0.5 1.1 0.1 0.5 -1.0
Chest pain or discomfort 0.1 0.1 0.2 -0.4 0.2 -0.3
Had major operations 0.0 0.1 0.1 0.4 0.2 -0.0
Age at last live birth 1.7 2.5 3.0 1.7 1.6 1.4
Family relationship satisfaction 0.4 0.5 1.4 -0.2 -0.1 -1.2
Leg pain on walking 0.1 0.2 0.3 0.3 0.5 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.2 1.5 -0.3 0.3
Commuting to job workplace: Car/motor vehicle 2.4 2.8 6.1 -0.1 -1.5 2.5
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 2.7 -1.0 1.4 -1.6
Medication: Aspirin 0.3 0.4 0.6 0.7 0.5 -0.7
Supplements: Vitamin C 0.1 0.1 0.1 -0.3 0.0 -0.3
Knee pain experienced in last month 0.2 0.2 0.7 0.2 0.1 0.8
Hypertension (Self-reported) 0.2 0.7 1.2 -0.7 -0.7 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.0 0.5 -0.2
Illnesses of father: Heart disease 0.5 0.7 1.9 1.4 -0.2 -0.4
Illnesses of siblings: Diabetes 1.7 2.1 3.1 -1.8 -1.7 0.6
Smoking status: Previous 0.6 0.9 2.5 -0.1 0.3 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 0.9 -0.9 0.6 -0.8
Whole body fat-free mass 0.5 3.0 6.4 0.0 -1.6 2.5
Leg fat-free mass (right) 0.9 4.6 7.8 -0.2 -2.4 2.8
Arm fat percentage (left) 3.0 11.9 26.6 0.0 -5.2 3.0
Average weekly red wine intake 1.7 2.6 7.2 0.7 0.0 -2.7
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 -1.0 -0.4 0.1
Mood swings 1.4 2.6 5.5 1.5 2.3 -0.2
Loneliness, isolation 0.6 0.8 1.8 -0.3 1.3 -0.7
Long-standing illness, disability or infirmity 0.1 0.2 0.4 0.7 0.1 -0.4
Ever had bowel cancer screening 0.1 0.2 0.3 0.5 0.1 -0.4
Diabetes diagnosed by doctor 3.3 5.5 8.8 -0.8 -2.6 3.0
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 3.8 1.1 0.6 -2.0
Friendships satisfaction 0.7 0.9 1.6 -0.6 0.7 -1.3
Qualifications: nursing, teaching 1.3 2.0 5.1 2.3 -0.5 -0.9
Commuting to job workplace: Walk 0.9 1.0 1.2 -1.1 0.8 -1.1
Eye problems/disorders: Cataract 0.4 0.5 1.4 1.2 0.2 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 3.1 1.8 1.0 0.2
Medication for cholesterol 1.0 1.6 3.3 1.1 0.5 -1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.2 1.1 0.6 -0.7
Back pain experienced in last month 1.3 1.9 2.2 -1.4 -1.5 1.1
Mineral and other dietary supplements 2.3 3.0 8.1 -1.0 0.0 2.9
Breast cancer (self-reported) 0.6 0.7 2.0 0.4 1.4 0.1
Asthma (self-reported) 0.4 0.7 1.6 -0.5 -1.2 0.6
Osteoporosis (self-reported) 0.9 1.2 2.9 -1.7 -0.1 -0.8
Osteoarthritis (self-reported) 1.4 1.8 4.8 -0.1 -2.2 0.7
Medication: Aspirin 0.5 0.6 1.2 1.1 0.3 -0.7
Medication: Gliclazide 0.9 1.0 2.0 -0.6 -1.4 0.7
Illnesses of father: None of the above (group 1) 1.1 1.4 2.5 -1.6 -0.3 -1.2
Smoking status: Current 1.0 1.6 2.6 1.4 -0.7 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.5 1.6 0.6 0.4
Whole body water mass 0.5 3.0 6.2 0.0 -1.6 2.5
Leg predicted mass (right) 0.9 4.7 8.1 -0.1 -2.5 2.8
Arm fat mass (left) 2.5 10.2 20.8 0.1 -4.6 3.1
Number of self-reported non-cancer illnesses 0.8 1.4 3.6 -0.7 -1.9 0.4
Average weekly champagne plus white wine intake 0.4 0.6 1.2 0.8 1.1 -0.1
Miserableness 0.1 0.2 0.4 0.2 0.5 -0.6
Guilty feelings 0.7 1.1 2.6 -1.6 -0.2 0.8
Wears glasses or contact lenses 1.7 1.9 3.0 0.1 -1.7 -1.7
Ever taken oral contraceptive pill 1.0 1.1 1.7 1.0 -0.8 1.3
Hearing aid user 1.2 1.3 2.9 -1.0 0.2 -1.7
Mother’s age at death 0.4 0.5 1.2 -0.3 -1.1 -0.6
Financial situation satisfaction 2.7 3.4 5.9 0.7 2.0 -2.4
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.3 0.1 0.4 -1.5
Commuting to job workplace: Public transport 0.3 0.4 1.1 0.2 0.2 -1.1
Eye problems/disorders: Glaucoma 0.9 1.1 2.9 0.4 -0.5 1.7
Medication: Blood pressure 0.0 0.0 0.0 -0.1 0.0 0.1
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 -0.4 -0.2 0.3
Supplements: Fish oil (including cod liver oil) 2.4 3.1 8.1 1.0 0.5 -2.9
High cholesterol (Self-reported) 0.8 1.4 3.8 -0.4 -0.4 2.0
Medication: Bendroflumethiazide 0.0 0.1 0.2 -0.1 0.4 0.2
Medication: Paracetamol 0.8 1.3 2.3 0.3 -1.5 1.2
Medication: Lisinopril 0.3 0.4 0.8 0.9 -0.1 0.5
Medication: Atorvastatin 0.8 1.0 1.7 -0.6 -1.0 1.3
Illnesses of father: High blood pressure 0.2 0.2 0.6 0.0 0.1 -0.8
Alcohol drinker status: Never 0.2 0.3 0.7 -0.1 -0.4 -0.8
Ever smoked 1.6 2.8 6.8 1.3 -0.1 2.6
Basal metabolic rate 0.8 4.2 7.9 -0.2 -2.1 2.8
Leg fat percentage (left) 2.6 9.5 17.4 1.5 -4.2 3.0
Arm fat-free mass (left) 0.7 3.4 7.0 0.5 -1.7 2.6
Number of operations (self-reported) 1.0 1.4 3.9 2.0 -0.6 0.3
Average weekly beer plus cider intake 0.5 0.7 1.1 0.4 -0.9 1.0
Irritability 1.0 1.7 2.9 1.4 0.2 1.7
Risk taking 1.9 2.8 4.1 2.0 -0.5 2.0
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.6 0.8 -0.3 -0.6
Fractured/broken bones in last 5 years 0.7 0.9 1.4 -0.9 -0.7 1.2
Age started oral contraceptive pill 3.7 4.6 7.7 2.2 2.8 -1.2
Diastolic blood pressure, automated reading 0.4 1.2 2.3 0.4 -1.0 1.5
Ever depressed for a whole week 0.7 0.8 1.3 -1.2 -0.5 0.9
Unable to work because of sickness or disability 0.4 0.6 1.1 -1.1 -0.7 0.4
Commuting to job workplace: Cycle 0.3 0.3 0.8 -0.9 0.3 0.0
Myopia 1.8 2.6 4.2 1.3 2.0 -1.4
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.0 1.0 0.1 -0.9
Cholesterol lowering medication 0.6 0.9 2.2 0.4 0.6 1.5
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.0 0.7 1.4 0.1
Pain experienced in last month 0.4 0.6 1.1 0.1 -0.9 -1.1
Supplements: Calcium 1.5 1.6 3.9 -0.2 0.9 -2.0
Basal cell carcinoma (self-reported) 0.9 1.1 3.0 0.4 -0.3 1.7
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.8 -1.7 -0.2 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.1 0.5 -1.4 0.8
Heart disease (siblings) 0.5 0.6 1.6 -0.2 -1.3 0.5
Alcohol drinker status: Previous 1.2 1.3 3.2 -1.8 0.1 0.9
Pack years of smoking 0.1 0.1 0.3 -0.3 0.2 0.5
Impedance of whole body 1.0 5.1 10.5 -0.8 2.1 -3.2
Leg fat mass (left) 2.6 10.3 18.4 0.9 -4.3 3.4
Arm predicted mass (left) 0.7 3.5 7.9 0.5 -1.6 2.8