Hub : Genes

TNFSF12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1127 0.0445 2.4e-03 0.062 NA 0.030 NA 0.048 1.2e-05 NA 2.0e-03 NA 1.2e-04
2 GTEx Cells Transformed fibroblasts 0.2500 0.0460 1.0e-10 0.222 NA 0.196 NA 0.199 1.4e-16 NA 1.2e-14 NA 7.4e-15
3 GTEx Whole Blood 0.0870 0.0330 2.6e-03 0.026 NA 0.038 NA 0.033 1.7e-03 NA 1.9e-04 NA 5.1e-04
4 METSIM Adipose 0.1189 0.0328 3.5e-06 0.032 0.045 0.045 0.049 0.044 1.0e-05 2.7e-07 2.0e-07 7.3e-08 3.0e-07
5 NTR Blood 0.0647 0.0134 0.0e+00 0.070 0.064 0.070 0.074 0.070 1.3e-21 5.9e-20 1.7e-21 9.4e-23 1.2e-21
6 ROSMAP Brain Pre-frontal Cortex 0.1018 0.0284 5.5e-06 0.041 0.049 0.040 0.053 0.056 4.4e-06 5.8e-07 6.0e-06 2.4e-07 9.2e-08
7 YFS Blood 0.0985 0.0177 0.0e+00 0.117 0.099 0.124 0.119 0.126 2.4e-36 1.5e-30 3.0e-38 6.4e-37 6.1e-39
8 TCGA Kidney Renal Clear Cell Carcinoma 0.0364 0.0232 9.9e-03 0.006 0.003 0.008 NA 0.006 5.9e-02 1.3e-01 4.3e-02 NA 6.3e-02
9 TCGA Brain Lower Grade Glioma 0.0468 0.0228 6.3e-04 0.001 0.013 0.010 NA 0.000 2.5e-01 1.2e-02 2.4e-02 NA 3.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 3.1 4.9 16.1 -1.5 -1.9 -1.9 -1.7 -2.0 -1.9 0.0 4.0 -2.9
Bipolar Disorder or Schizophrenia 0.3 0.8 4.0 -0.4 -0.3 -0.8 -1.0 -0.9 -0.6 0.0 2.0 -0.3
Depressed Affect (Nagel 2018) 0.5 1.1 4.8 -0.6 -1.0 -0.4 -2.2 -0.2 -1.2 0.0 1.4 -0.7
Depression (Nagel 2018) 0.6 0.9 4.8 -1.4 -0.1 -0.0 -2.2 0.7 -0.3 0.0 -0.0 0.5
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.6 -1.3 -0.1 -0.3 -1.1 0.2 0.2 0.0 1.4 -1.6
Neuroticism (Nagel 2018) 0.5 1.2 7.0 -0.9 0.2 0.4 -2.6 0.9 0.4 0.0 1.0 -1.0
Schizophrenia (2018) 0.4 0.8 3.9 0.7 1.1 0.6 0.1 0.4 0.7 0.0 -0.8 2.0
Schizophrenia vs Biploar Disorder 1.7 2.2 7.0 1.1 1.0 1.4 1.2 0.5 1.0 0.0 -2.4 2.6
Worry (Nagel 2018) 1.1 2.4 6.1 -0.8 1.8 0.9 -2.4 2.5 1.9 0.0 -0.6 -0.6
Alzheimer’s Disease (in mother) 1.2 1.4 2.8 0.9 1.4 1.6 0.6 1.2 0.9 0.0 -1.5 1.7
Alzheimer’s Disease (in father) 0.6 0.6 1.9 0.4 -1.4 -0.7 0.7 -1.3 -0.8 0.0 -0.1 -0.5
Alzheimer’s Disease (including proxy) 0.8 1.1 2.7 1.3 0.8 1.1 0.6 0.6 0.7 0.0 -1.6 1.6
Crohns Disease (2017) 0.4 0.9 1.7 1.2 -1.2 -0.5 -1.3 -1.3 -1.1 0.0 0.7 0.5
Irritable Bowel Disease (IBD) 0.3 0.8 4.2 -0.0 -0.6 0.6 -2.0 -0.7 -0.9 0.0 0.9 0.3
Ulcerative Colitis (UC) 0.4 0.7 2.9 -1.1 0.2 1.2 -1.7 0.1 -0.6 0.0 0.4 0.1
Major Depression (MDD) 1.4 1.6 4.4 -1.4 1.4 0.8 -1.8 2.1 1.4 0.0 -0.4 -0.2
Reaction Time 1.1 2.0 6.2 0.9 -2.4 -0.8 -0.2 -2.5 -2.0 0.0 0.6 -0.8
Verbal and Numeric Reasoning (VNR) 0.4 1.0 4.9 -2.2 0.3 -0.5 -0.1 0.8 0.8 0.0 1.1 -1.1
Breast Cancer 0.3 0.6 3.3 1.8 0.6 -0.1 0.3 -0.0 0.8 0.0 0.3 1.1
Ovarian Cancer 0.2 0.3 0.6 -0.4 0.3 -0.8 -0.8 0.6 0.5 0.0 0.5 -0.5
Prostate Cancer 0.6 0.8 3.2 1.1 -0.3 -1.8 1.4 0.4 0.1 0.0 -0.1 -0.7
Age at First Birth 0.7 1.0 3.0 0.7 -0.9 -0.7 -1.2 -1.1 -0.8 0.0 1.7 -1.1
Bipolar Disorder (2011) 0.1 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -0.7
Body Mass Index (BMI) (2010) 0.8 1.2 4.9 -1.7 0.4 0.6 -2.2 0.5 -0.7 0.0 1.1 -0.1
Coronary Artery Disease (CAD) 0.2 0.2 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.4
Crohns Disease (2012) 0.3 0.4 1.5 1.2 -0.3 0.1 -1.0 -0.6 0.1 0.0 0.8 -0.3
Mean Putamen Volume 0.1 0.1 0.3 0.4 -0.2 -0.5 0.0 -0.1 0.1 0.0 0.0 -0.4
Fasting Glucose 0.4 0.5 1.4 0.4 -1.2 -1.0 -0.3 -0.8 -1.1 0.0 0.0 -0.3
HbA1C 2.1 2.3 5.9 -0.5 -2.4 -2.0 0.7 -1.9 -2.4 0.0 0.6 0.1
HDL Cholesterol 0.9 1.5 4.5 -0.6 1.8 0.7 -0.9 1.5 2.1 0.0 0.2 -1.2
LDL Cholesterol 0.4 0.6 2.4 -0.9 -0.3 -0.9 0.7 -0.0 -1.0 0.0 0.0 1.5
Lupus 3.7 5.6 13.2 1.0 3.3 2.5 0.3 2.8 3.6 0.0 -2.9 1.4
Neuroticism (2016) 1.3 1.9 4.8 -0.8 1.9 1.4 -0.3 2.2 2.2 0.0 -0.5 0.9
Primary Biliary Cirrhosis 1.2 1.6 5.6 0.8 1.8 0.9 -0.4 1.1 2.4 0.0 -1.0 1.5
Rheumatoid Arthritis 0.5 0.7 2.0 1.4 0.0 -1.0 1.0 -0.0 0.3 0.0 1.3 -1.0
Schizophrenia (2014) 0.2 0.3 1.0 0.3 -0.0 -0.2 -0.5 -0.8 -0.3 0.0 1.0 0.9
Triglycerides 0.7 1.2 3.9 -2.0 -1.0 -0.4 -0.8 -0.3 -1.6 0.0 -0.1 1.5
Type 2 Diabetes (T2D) (2012) 1.9 2.2 4.5 -0.1 -1.8 -2.1 0.5 -1.9 -1.6 0.0 1.5 -1.6
Ulcerative Colitis 0.4 0.5 1.5 -0.2 -0.0 1.1 -1.2 -0.3 -0.9 0.0 0.8 -0.6
Blood Eosinophil Count 1.0 7.6 48.7 -7.0 0.1 -0.3 -4.1 0.6 -1.4 0.0 0.8 -0.3
Blood Platelet Count 1.7 19.7 54.0 -3.1 -6.0 -6.5 1.2 -4.9 -7.3 0.0 2.4 -2.0
Blood Red Count 0.7 6.8 33.8 -5.8 1.4 0.7 -2.5 2.7 -0.3 0.0 -1.3 3.0
Blood White Count 1.3 9.5 21.1 -0.4 -4.4 -4.2 0.6 -3.9 -4.6 0.0 2.7 -2.2
Heel T-Score 1.4 10.8 36.4 -6.0 -2.5 -1.9 -2.6 -1.2 -4.4 0.0 4.8 -0.7
BMI 0.7 4.2 9.5 -1.7 2.1 0.9 -2.5 3.1 1.2 0.0 -2.2 2.7
Height 2.4 47.2 246.5 15.7 -3.5 -5.6 6.8 -5.3 -0.3 0.0 3.3 -7.0
Waist Hip Ratio (WHR) 4.4 19.9 46.5 3.2 -6.1 -5.4 5.1 -6.8 -5.1 0.0 1.9 -1.0
Systolic Blood Pressure 7.3 36.7 70.1 -5.1 7.7 5.2 -3.6 8.4 6.8 0.0 -7.2 6.0
Smoking Status 1.9 4.5 13.9 -1.2 2.0 2.5 -3.7 2.7 2.5 0.0 -0.9 0.3
Allergy or Eczema 0.4 1.1 6.1 2.5 -0.8 -0.3 0.6 -1.4 -0.1 0.0 0.8 0.2
Cardiovascular Disease 3.7 12.2 26.2 -3.2 4.0 2.9 -2.3 4.5 3.6 0.0 -5.1 3.1
Hypothyroidism (self reported) 0.1 0.3 0.9 0.0 0.8 0.8 -0.4 0.6 1.0 0.0 -0.6 0.3
Respiratory disease 4.1 9.1 19.5 4.4 -3.2 -3.3 4.3 -3.6 -2.5 0.0 1.6 -0.8
Type 2 Diabetes (T2D) (2018) 1.2 2.2 5.8 1.0 -2.0 -2.4 1.6 -1.9 -1.6 0.0 0.3 0.3
Lung FEV1/FVC ratio 1.3 6.7 11.8 -3.3 -2.0 -2.8 -2.5 -1.9 -3.4 0.0 3.4 -2.2
Lung FVC 1.3 6.5 24.5 -5.0 1.4 1.4 -4.8 2.8 0.0 0.0 0.5 0.2
Neuroticism 0.4 1.1 3.5 -1.2 0.5 0.5 -1.9 1.6 0.8 0.0 0.3 -0.9
Chronotype (morning person) 0.1 0.2 1.0 -0.1 0.5 1.0 -0.2 0.4 -0.2 0.0 0.1 -0.0
Hair Pigment 0.1 2.7 12.6 -0.8 1.0 1.4 0.6 0.9 1.3 0.0 -3.5 2.2
Tanning 0.0 0.6 1.8 -1.4 -0.7 0.6 -0.9 -0.2 -0.8 0.0 0.4 -0.9
Hand grip strength (left) 2.1 5.5 9.0 3.0 -2.9 -2.6 1.8 -2.5 -2.2 0.0 2.2 -2.4
Number of treatments/medications taken 0.7 1.3 3.5 -1.0 1.2 0.3 -1.0 1.5 0.6 0.0 -1.9 1.4
Average weekly spirits intake 0.5 0.6 3.0 0.0 -0.4 -0.2 -1.7 -0.2 -1.0 0.0 0.6 -1.0
Sensitivity / hurt feelings 0.5 0.9 2.7 -1.5 0.1 -0.1 -0.9 0.6 0.8 0.0 1.2 -1.6
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.2 -1.6 0.9 0.8 -1.8 1.5 0.7 0.0 -1.1 1.3
Hearing difficulty/problems: Yes 0.5 0.7 2.5 1.4 -0.7 -0.4 1.6 -0.4 -0.5 0.0 0.6 -0.6
Relative age of first facial hair 2.5 5.2 11.2 -1.2 3.3 2.9 -3.1 2.6 2.8 0.0 -0.8 0.9
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.9 -2.0 -0.9 -1.4 -0.4 -0.5 -1.7 0.0 -0.2 0.2
Ever used hormone-replacement therapy (HRT) 1.4 1.8 5.2 1.8 1.0 0.3 2.3 0.7 1.6 0.0 -1.6 0.9
Ever had hysterectomy (womb removed) 1.5 1.7 3.1 -1.3 1.7 0.8 0.6 1.8 1.1 0.0 -1.8 1.4
Systolic blood pressure, automated reading 6.8 19.9 36.4 -3.0 5.6 4.4 -2.3 6.0 4.5 0.0 -6.0 4.7
Eye problems/disorders: Diabetes related eye disease 2.4 2.6 6.6 2.6 -1.6 -2.1 2.2 -1.6 -1.0 0.0 0.6 0.8
Angina 0.2 0.3 0.7 0.3 -0.4 -0.7 0.1 -0.7 -0.2 0.0 0.9 -0.7
Medication for hormone replacement therapy 0.3 0.4 1.3 1.1 0.4 0.2 -0.1 0.3 1.0 0.0 -0.2 -0.9
Vitamin and mineral supplements 0.8 1.1 3.8 -1.9 -0.4 1.6 0.3 -0.4 -0.6 0.0 -1.0 1.4
Supplements: Zinc 0.3 0.4 1.7 1.3 -0.5 -1.0 -0.3 -0.0 -0.1 0.0 -0.1 -0.4
Medication: Co-codamol 2.8 3.2 7.8 -0.4 2.1 1.7 -0.2 2.2 2.8 0.0 -2.4 1.8
Medication: Metformin 1.3 1.9 5.2 1.4 -1.4 -2.3 2.0 -1.6 -0.9 0.0 -0.2 0.5
Diabetes (father) 1.6 2.0 5.3 0.3 -2.2 -2.3 0.8 -2.0 -1.4 0.0 0.9 -0.9
Diabetes (mother) 0.9 1.1 3.5 1.4 -1.1 -1.9 1.0 -1.2 -0.8 0.0 0.2 0.3
Severe depression (siblings) 0.3 0.3 1.3 0.1 -0.5 -0.9 -0.4 -0.1 -1.1 0.0 0.6 -0.3
Pack years adult smoking proportion 0.5 0.7 4.2 -2.1 0.4 1.2 -0.5 0.3 0.1 0.0 -0.2 0.2
Impedance of leg (right) 1.6 7.8 15.6 -1.5 3.2 3.9 0.6 2.8 3.9 0.0 -3.6 2.4
Leg fat-free mass (left) 1.3 6.6 19.8 4.5 -2.4 -3.9 -0.0 -1.9 -1.6 0.0 1.4 -3.3
Trunk fat percentage 3.7 14.7 30.0 -1.6 5.1 4.0 -2.4 5.5 4.8 0.0 -4.2 3.3
Hand grip strength (right) 4.0 10.8 18.9 2.6 -4.3 -4.0 0.6 -3.9 -3.9 0.0 3.4 -3.6
Townsend deprivation index at recruitment 0.9 1.2 3.6 -0.6 1.4 0.7 -0.3 1.0 1.0 0.0 -1.7 1.9
Current tobacco smoking 1.1 1.8 10.3 -0.9 0.9 1.1 -3.2 1.3 0.8 0.0 0.2 -0.9
Average weekly fortified wine intake 0.1 0.1 0.5 -0.3 -0.2 -0.3 -0.5 -0.4 -0.7 0.0 0.2 -0.3
Maternal smoking around birth 0.4 0.6 1.8 0.9 -0.9 -0.5 -1.1 -0.3 -0.7 0.0 1.3 -0.2
Fed-up feelings 0.4 0.7 3.0 -1.4 -0.2 -0.4 -1.7 1.0 -0.3 0.0 0.5 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.5 -1.2 -0.3 -0.5 -1.2 0.2 -0.0 0.0 -0.0 0.3
Relative age voice broke 1.0 1.5 3.8 -0.4 1.8 0.5 -1.6 1.6 1.9 0.0 0.5 -0.9
Taking other prescription medications 0.7 1.1 3.6 -1.3 0.7 0.6 -1.9 0.7 -0.0 0.0 -1.5 1.1
Age when periods started (menarche) 0.4 1.0 3.2 -1.2 0.2 -0.1 0.9 0.6 0.4 0.0 -1.6 1.8
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.8 1.0 0.2 -1.0 1.4 -0.0 0.7 0.0 0.5 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.7 9.2 -1.2 -2.1 -2.3 -0.7 -2.0 -3.0 0.0 3.0 -0.2
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 3.3 1.8 -0.6 -1.5 0.6 -1.2 -0.7 0.0 1.3 0.5
Qualifications: CSEs or equivalent 0.5 0.7 3.1 -0.9 0.3 -0.1 -1.8 1.2 0.1 0.0 -0.1 0.8
Serious illness, injury or assault to yourself 0.7 0.8 2.5 0.5 -0.9 -1.6 0.7 -1.0 -0.5 0.0 1.3 -0.5
High blood pressure 7.8 21.7 46.0 -3.0 5.7 4.7 -1.2 6.1 5.3 0.0 -6.8 4.5
Hayfever, allergic rhinitis or eczema 0.2 0.4 2.6 1.6 -0.2 0.1 -0.4 -0.7 0.2 0.0 -0.2 0.5
Multivitamins +/- minerals 0.9 1.1 4.2 2.1 -0.0 -1.8 0.7 0.1 0.5 0.0 1.1 -0.9
Stomach or abdominal pain in last month 2.7 3.4 17.3 -1.0 1.4 2.4 -4.2 1.8 0.9 0.0 0.3 -0.8
Supplements: Glucosamine 1.0 1.2 5.6 2.4 -0.2 -0.6 2.2 -0.5 0.2 0.0 -0.0 0.2
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.8 -1.5 -0.8 1.1 -1.7 0.1 -0.7 0.0 1.0 -1.0
Medication: Atenolol 1.9 2.4 5.1 -1.7 1.9 0.7 -1.0 2.2 1.6 0.0 -2.0 1.6
Medication: Levothyroxine sodium 0.1 0.1 0.3 -0.2 0.2 0.4 -0.6 0.3 0.2 0.0 -0.5 0.2
Sitting height 1.6 11.1 58.4 7.6 -2.5 -2.9 3.8 -2.5 -0.4 0.0 -1.1 -2.1
Chronic bronchitis/emphysema (father) 1.4 1.7 10.4 3.2 -0.4 -0.5 1.7 -0.9 -0.4 0.0 -0.1 0.6
High blood pressure (mother) 1.9 2.7 7.6 -2.8 1.4 1.9 -1.3 1.9 1.1 0.0 -1.7 1.2
Body mass index (BMI) 0.3 1.1 3.6 -1.1 0.9 -0.1 -1.9 1.9 0.3 0.0 -0.6 0.8
Impedance of leg (left) 1.3 6.1 12.7 -1.4 2.8 3.5 1.3 2.4 3.6 0.0 -3.0 2.2
Leg predicted mass (left) 1.3 6.7 19.5 4.4 -2.4 -3.9 -0.1 -1.9 -1.6 0.0 1.5 -3.4
Trunk fat mass 1.4 5.9 13.1 0.7 3.2 1.8 -1.3 3.6 3.4 0.0 -3.1 1.6
Waist circumference 0.2 0.9 3.3 1.6 -0.6 -1.8 0.5 -0.4 -0.4 0.0 -0.9 0.4
Number of incorrect matches in round 1.1 1.8 4.2 -0.2 1.8 2.0 -1.3 1.7 1.3 0.0 -1.1 1.3
Past tobacco smoking 0.3 0.5 2.4 -0.2 -0.0 0.0 1.6 0.1 -1.2 0.0 -0.6 0.2
Alcohol usually taken with meals 2.3 3.8 8.0 1.6 -1.9 -2.3 0.9 -2.7 -1.3 0.0 2.0 -2.8
Nervous feelings 0.3 0.6 2.6 -0.2 0.9 0.7 -1.6 0.9 0.9 0.0 -0.2 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 3.1 -0.4 -1.3 -1.5 -1.3 -0.8 -1.5 0.0 1.8 -1.2
Hearing difficulty/problems with background noise 0.7 1.2 2.1 1.2 -1.0 -1.3 1.1 -1.4 -1.1 0.0 1.4 -0.7
Hair/balding pattern: Pattern 2 0.4 0.6 2.8 0.6 0.8 -0.4 -0.1 0.9 0.4 0.0 -0.3 1.7
Had menopause 1.0 1.2 4.5 1.0 0.7 0.1 2.1 0.6 0.9 0.0 -1.3 1.4
Had other major operations 5.5 6.8 11.9 -2.4 3.2 3.1 -1.3 3.5 2.9 0.0 -2.2 2.8
Forced vital capacity (FVC) 1.0 3.8 10.1 3.0 -1.2 -2.2 -1.0 -1.1 -0.4 0.0 2.6 -3.2
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.0 8.8 -2.2 -2.1 -2.8 -0.7 -1.5 -3.0 0.0 2.7 -0.2
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.0 -1.0 0.2 -0.1 -0.6 0.5 0.4 0.0 0.5 -0.1
Qualifications: None of the above 1.1 2.3 6.3 -0.4 1.4 1.7 -0.4 1.3 1.4 0.0 -2.4 2.5
Financial difficulties in last 2 years 0.2 0.2 0.5 -0.5 -0.2 -0.6 -0.7 -0.6 -0.2 0.0 0.1 0.6
Mouth/teeth dental problems 1.7 2.5 4.9 1.8 1.8 1.6 0.3 1.6 2.0 0.0 -2.2 1.7
Heart attack 1.9 2.4 6.4 1.1 -1.5 -1.8 -1.4 -2.0 -0.9 0.0 2.5 -1.4
Allergy 0.4 1.0 5.3 -2.3 0.6 0.1 -0.6 1.1 0.1 0.0 0.7 -1.0
Pain all over the body in last month 0.9 0.9 2.0 0.2 1.4 0.8 -0.7 1.1 1.3 0.0 -1.0 1.0
Diabetes (self-reported) 0.5 0.8 4.1 -0.1 -1.0 -2.0 1.0 -0.9 -0.6 0.0 -0.4 0.3
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 4.5 0.1 -1.8 -2.1 1.8 -1.7 -1.4 0.0 0.9 -0.3
Medication: Ramipril 0.5 0.6 1.5 -0.8 0.9 0.7 -0.6 1.1 1.2 0.0 -0.5 -0.4
Medication: Simvastatin 0.3 0.5 2.3 -1.5 0.1 -0.3 -0.3 0.9 -0.6 0.0 -0.5 0.6
Fluid intelligence score 0.3 0.7 3.0 -1.7 -0.8 -0.8 -0.4 -0.4 -0.2 0.0 1.1 -0.7
Illnesses of siblings 1.3 1.8 7.7 0.9 -0.9 -0.6 -1.1 -0.8 -1.1 0.0 1.9 -2.8
Neuroticism score 0.4 0.8 2.0 -1.4 -0.3 -0.8 -1.2 0.6 0.0 0.0 1.3 -1.2
Weight 0.4 2.1 13.0 3.6 -0.3 -1.9 0.1 0.2 0.4 0.0 -0.5 -1.2
Impedance of arm (right) 7.7 36.1 70.9 -1.8 8.0 8.3 -1.4 7.0 8.4 0.0 -6.6 5.0
Arm fat percentage (right) 3.3 13.1 27.8 -1.8 4.8 3.6 -3.1 5.3 4.3 0.0 -3.6 3.0
Trunk fat-free mass 4.1 23.4 54.2 7.4 -5.2 -7.0 2.5 -5.0 -3.6 0.0 3.1 -5.2
Hip circumference 0.5 2.3 5.5 1.5 2.0 0.5 -1.2 2.3 2.1 0.0 -1.6 0.1
Time employed in main current job 1.1 1.3 8.1 1.2 -0.7 -0.9 2.8 -0.4 -0.3 0.0 -0.7 0.3
Alcohol intake versus 10 years previously 2.9 4.4 9.7 2.5 -2.7 -2.1 1.9 -3.1 -2.6 0.0 1.4 -0.2
Father’s age at death 0.8 1.0 3.8 1.6 -0.6 -0.9 1.9 -0.9 -0.5 0.0 0.8 -0.1
Worrier / anxious feelings 0.7 1.3 8.0 -0.7 0.1 0.4 -2.8 0.3 0.3 0.0 0.8 -1.4
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 4.3 -1.8 -0.1 0.1 -2.1 0.7 -0.0 0.0 0.5 -0.4
Falls in the last year 0.5 0.7 3.2 -1.5 0.2 0.1 -1.8 0.5 -0.1 0.0 0.2 0.4
Hair/balding pattern: Pattern 3 0.8 1.2 3.8 -0.2 -1.9 -0.6 0.6 -1.6 -2.0 0.0 0.5 -0.2
Number of live births 2.1 3.0 8.5 -2.3 1.8 2.9 -1.5 1.7 0.6 0.0 -1.2 1.7
Forced expiratory volume in 1-second (FEV1) 1.0 3.4 10.8 1.6 -1.0 -2.0 -1.6 -0.7 -0.8 0.0 2.9 -3.3
Pulse rate 1.7 2.9 7.3 -0.3 -2.7 -2.7 1.7 -1.8 -2.1 0.0 0.5 -0.8
Happiness 1.7 2.1 5.1 -0.4 2.1 1.3 -0.8 2.2 1.5 0.0 -1.7 1.4
Noisy workplace 0.3 0.4 1.2 -0.8 0.5 -0.4 -0.6 0.5 0.4 0.0 -0.5 1.1
Qualifications: A levels/AS levels or equivalent 2.6 5.8 15.8 1.4 -2.4 -2.8 1.0 -2.7 -1.8 0.0 3.0 -4.0
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.7 -0.4 1.6 0.9 -0.4 1.6 1.6 0.0 -0.3 0.5
Mouth/teeth dental problems: Dentures 0.4 0.7 1.8 0.1 -0.9 -1.1 0.5 -1.2 -0.5 0.0 1.4 -0.3
Asthma 1.7 3.4 7.4 2.7 -1.9 -1.9 2.2 -2.4 -1.8 0.0 1.1 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.2 0.8 -0.4 -0.6 -0.3 -0.1 -1.1 0.0 0.4 0.0
Medication: Cholesterol lowering 3.2 5.0 10.4 -0.5 -3.2 -2.9 -0.4 -2.8 -2.9 0.0 2.1 -2.3
Depression (self-reported) 1.0 1.3 4.6 -0.0 -1.2 -1.4 0.8 -0.8 -1.0 0.0 2.1 -1.0
Medication: Lansoprazole 0.6 0.7 2.9 -1.7 -0.7 -0.9 -0.8 -0.1 -0.9 0.0 0.9 -0.0
Prospective memory result 1.8 2.2 5.2 -0.9 1.6 2.3 -1.2 1.9 1.1 0.0 -1.5 1.7
Lung cancer (father) 0.4 0.4 1.6 -0.2 0.6 0.0 1.3 0.6 0.8 0.0 -0.7 0.5
Illnesses of mother 0.2 0.2 0.9 -0.4 0.2 0.0 -1.0 0.0 0.2 0.0 0.3 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 9.4 1.5 -0.6 -1.4 -1.5 -0.5 0.0 0.0 2.1 -3.1
Pulse wave Arterial Stiffness index 0.7 0.8 5.0 0.7 -0.3 0.1 2.2 -0.2 0.1 0.0 -1.4 -0.1
Impedance of arm (left) 7.2 33.3 69.7 -2.3 7.7 8.3 -1.9 6.6 7.8 0.0 -5.9 4.6
Arm fat mass (right) 0.8 3.4 8.9 0.6 2.3 1.1 -1.7 3.0 2.2 0.0 -2.3 1.3
Trunk predicted mass 4.2 23.9 54.6 7.4 -5.3 -7.0 2.5 -5.0 -3.7 0.0 3.2 -5.2
Standing height 2.1 20.5 110.2 10.5 -2.6 -4.0 4.3 -3.5 0.4 0.0 0.1 -4.5
Length of working week for main job 2.1 2.3 6.9 2.6 -1.4 -1.5 2.1 -1.9 -0.3 0.0 0.7 -0.9
Exposure to tobacco smoke at home 0.8 0.9 3.4 0.3 -1.3 -0.4 -0.4 -1.1 -1.8 0.0 1.0 0.5
Breastfed as a baby 0.5 0.6 2.6 -1.6 0.2 -0.7 -0.4 0.6 0.2 0.0 -1.1 0.7
Tense / ‘highly strung’ 1.1 1.8 3.9 -0.7 1.7 1.6 -1.3 1.9 2.0 0.0 -0.8 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.7 0.6 1.5 -0.2 -0.0 1.6 1.6 0.0 -1.1 0.8
Hair/balding pattern: Pattern 4 1.8 4.3 10.3 0.5 -2.3 -2.8 3.2 -2.1 -2.3 0.0 1.2 -1.8
Birth weight of first child 2.0 3.7 14.4 3.8 -1.5 -2.8 0.3 -1.7 -0.8 0.0 1.2 -1.9
Peak expiratory flow (PEF) 1.3 3.0 9.7 1.6 -0.8 -1.4 -1.3 -0.9 -0.5 0.0 3.1 -3.1
Pulse wave reflection index 0.4 0.5 2.1 -0.5 0.6 1.5 -0.3 0.7 0.8 0.0 0.0 -0.5
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.1 -0.1 -0.6 -0.2 -0.9 0.1 -0.4 0.0 1.0 -0.3
Loud music exposure frequency 0.1 0.1 0.3 0.0 -0.0 0.6 -0.3 0.3 0.2 0.0 0.4 0.2
Qualifications: O levels/GCSEs or equivalent 2.6 4.1 13.8 1.4 -1.7 -2.1 -0.6 -1.7 -1.6 0.0 2.9 -3.7
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.4 -1.4 -1.2 -1.1 0.7 -1.1 -1.8 0.0 1.3 -0.7
Blood clot in the leg (DVT) 3.2 4.1 5.7 -1.9 2.2 2.4 -2.4 2.2 1.8 0.0 -2.1 2.2
Medication: Paracetamol 0.1 0.2 1.0 0.1 -0.2 0.4 -0.5 0.1 -0.5 0.0 -0.2 1.0
Headache pain in last month 0.9 1.6 3.0 -1.7 -1.3 -1.4 -1.6 -0.5 -1.7 0.0 1.5 -0.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.2 1.5 -0.1 -0.1 0.9 -0.3 -0.1 0.0 1.4 -0.5
Glaucoma (self-reported) 0.2 0.2 0.7 -0.8 -0.2 0.4 -0.7 -0.2 -0.6 0.0 -0.4 0.1
Gout (self-reported) 2.1 2.9 6.9 -2.6 1.8 1.1 -1.2 2.1 1.7 0.0 -2.0 1.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.7 -0.5 1.0 1.1 -0.9 1.2 0.8 0.0 -1.3 0.7
Medication: Amlodipine 9.2 13.0 23.6 -4.5 3.7 4.0 -3.1 4.6 2.0 0.0 -4.9 2.8
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.5 -0.2 0.7 0.1 -0.3 0.1 0.2 0.0 -0.6 0.4
Birth weight 3.7 8.1 20.6 0.7 -2.8 -4.5 -2.6 -2.7 -2.3 0.0 3.2 -3.8
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.0 0.6 0.8 0.1 0.0 0.9 1.0 0.0 -0.9 0.7
High blood pressure (siblings) 2.4 3.5 6.0 -1.8 2.2 1.7 -0.3 2.3 2.0 0.0 -2.4 2.2
Forced vital capacity (FVC), Best measure 0.6 2.1 7.3 2.4 -0.5 -1.4 -0.9 -0.5 0.5 0.0 1.5 -2.7
Body fat percentage 3.1 12.4 26.4 -2.0 4.7 3.6 -2.5 5.1 4.2 0.0 -3.7 3.0
Leg fat percentage (right) 1.4 5.1 10.8 -2.1 2.6 1.9 -2.1 3.3 2.2 0.0 -2.5 2.0
Arm fat-free mass (right) 3.5 18.2 41.9 5.3 -5.0 -6.5 2.0 -4.4 -4.0 0.0 3.1 -4.4
Exposure to tobacco smoke outside home 0.7 1.0 3.7 0.3 -1.0 -1.9 1.0 -1.0 -1.0 0.0 0.2 0.9
Comparative body size at age 10 0.8 2.3 8.2 0.6 -1.0 -1.0 -0.7 -0.6 -1.4 0.0 2.9 -2.7
Number of full brothers 0.2 0.3 0.7 0.2 0.8 0.6 -0.8 0.4 0.4 0.0 -0.4 0.6
Worry too long after embarrassment 0.2 0.4 1.2 0.1 -0.3 -0.1 0.6 -0.8 0.3 0.0 1.1 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.5 -0.1 0.7 0.8 1.2 1.1 1.1 0.0 -1.2 0.8
Wheeze or whistling in the chest in last year 0.6 1.0 3.0 1.7 0.9 -0.2 0.9 0.5 1.3 0.0 -1.2 1.0
Number of children fathered 0.2 0.2 1.2 0.3 0.1 -0.2 0.4 0.1 0.3 0.0 0.1 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.5 0.3 0.3 0.2 -0.7 -0.6 0.3 0.0 0.1 -0.2
Age at first live birth 0.2 0.4 1.2 0.3 0.6 0.6 1.1 0.6 1.0 0.0 -0.7 0.0
Pulse wave peak to peak time 0.6 0.7 3.4 0.1 0.1 -0.5 -1.9 -0.0 -0.1 0.0 1.5 -0.3
Health satisfaction 0.3 0.3 1.0 0.3 -0.7 -0.2 1.0 -0.8 -0.3 0.0 0.1 -0.8
Shortness of breath walking on level ground 0.6 0.7 1.8 -0.0 -0.8 -1.1 0.2 -1.0 -0.9 0.0 1.4 -0.3
Qualifications: College or University degree 0.3 0.9 2.1 0.8 1.4 0.7 1.5 0.3 1.2 0.0 -0.3 -0.9
Eye problems/disorders: None of the above 0.6 0.6 1.7 0.4 -1.3 -0.5 1.0 -1.3 -0.9 0.0 0.7 -0.2
Mouth/teeth dental problems: Loose teeth 0.5 0.7 3.4 -1.9 -0.4 -0.0 -0.8 -0.4 -0.7 0.0 1.0 0.0
Emphysema/chronic bronchitis 0.5 0.5 2.2 0.8 0.1 -0.4 1.1 0.1 0.3 0.0 -1.5 0.8
Medication for pain relief, constipation, heartburn 0.3 0.5 2.3 -0.6 -0.2 -0.5 -0.3 -0.8 0.4 0.0 0.6 -1.5
Neck or shoulder pain in last month 0.4 0.6 1.3 1.0 0.7 0.8 -1.1 0.4 1.1 0.0 0.3 0.0
Medication: Blood pressure 3.6 6.3 16.3 -2.5 2.7 2.8 -1.1 2.9 2.3 0.0 -4.0 2.0
Angina (self-reported) 0.2 0.3 1.0 0.3 -0.3 -0.5 -0.1 -0.7 -0.2 0.0 1.0 -0.9
Migraine (self-reported) 0.4 0.5 2.7 -1.6 -0.3 -1.0 -0.2 -0.0 -0.6 0.0 0.1 -0.5
Medication: Ibuprofen 0.3 0.4 1.8 0.8 -0.5 -0.7 -0.6 -0.1 -1.4 0.0 0.2 0.3
Medication: Allopurinol 3.4 4.5 8.0 -2.8 2.2 2.0 -1.6 2.3 2.1 0.0 -2.7 2.1
Medication: Omeprazole 0.2 0.2 1.0 0.7 -0.0 -0.0 1.0 -0.5 0.0 0.0 -0.5 -0.3
Medication: Seretide 50 evohaler 0.0 0.0 0.2 -0.0 -0.1 -0.1 0.3 -0.0 -0.1 0.0 -0.4 0.2
Mean time to correctly identify matches 1.7 3.2 8.8 2.3 -2.3 -1.2 1.3 -3.0 -2.1 0.0 0.8 -0.8
Heart disease (mother) 0.9 1.1 3.7 1.4 -1.3 -1.9 0.6 -1.1 -0.7 0.0 0.7 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 2.9 -0.3 -1.1 -1.0 -0.9 -0.9 -1.4 0.0 1.5 -1.7
Whole body fat mass 0.9 3.8 9.9 0.5 2.6 1.2 -1.4 3.2 2.6 0.0 -2.3 1.2
Leg fat mass (right) 0.3 1.1 3.7 0.4 1.2 0.2 -1.1 1.9 1.3 0.0 -1.4 0.4
Arm predicted mass (right) 3.8 19.2 42.5 5.5 -5.2 -6.5 1.9 -4.5 -4.2 0.0 3.4 -4.6
Pulse rate, automated reading 2.6 8.4 15.8 1.7 -3.8 -4.0 3.4 -3.8 -2.6 0.0 1.8 -2.7
Alcohol intake frequency. 1.2 2.9 7.7 -1.2 -0.5 -1.7 2.8 0.4 -1.0 0.0 -2.3 2.8
Comparative height size at age 10 0.4 2.3 6.6 2.6 -2.1 -1.8 1.4 -1.6 -0.8 0.0 -0.0 -1.1
Number of full sisters 0.7 0.9 2.6 0.2 -1.4 -1.6 -0.9 -1.0 -1.1 0.0 0.5 -0.2
Suffer from ‘nerves’ 0.5 0.7 3.3 -0.2 -0.1 -0.4 -1.8 0.4 0.2 0.0 1.0 -1.4
Overall health rating 0.2 0.5 1.6 -0.1 -0.8 -0.7 -1.0 -1.3 -0.5 0.0 0.2 0.7
Chest pain or discomfort 1.3 1.8 4.4 0.5 -1.1 -2.1 -0.1 -2.0 -1.3 0.0 1.8 -1.2
Had major operations 0.7 0.8 2.8 0.2 0.5 0.2 1.7 0.6 0.8 0.0 -1.6 1.0
Age at last live birth 0.3 0.4 1.1 0.7 0.6 0.8 0.7 0.5 1.1 0.0 0.0 -0.3
Family relationship satisfaction 2.8 3.5 7.1 2.0 2.3 2.1 -0.7 1.8 2.7 0.0 -2.4 1.2
Leg pain on walking 0.7 0.8 1.7 1.3 -1.3 -0.4 1.0 -1.3 -1.0 0.0 -0.6 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.6 0.5 -0.5 -0.5 0.8 -0.0 0.6 0.0 0.5 -0.2
Commuting to job workplace: Car/motor vehicle 1.9 2.2 4.2 -0.6 -1.9 -2.0 -0.6 -1.6 -1.7 0.0 1.9 -1.5
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 4.0 -1.6 0.8 2.0 -1.9 0.8 0.2 0.0 -1.0 0.8
Medication: Aspirin 0.8 1.0 3.9 -0.2 1.3 0.7 0.4 1.3 0.9 0.0 -0.9 2.0
Supplements: Vitamin C 0.7 0.8 2.1 1.3 0.3 -0.7 -1.4 -0.0 0.2 0.0 0.7 -1.4
Knee pain experienced in last month 0.5 0.8 2.2 -0.5 0.5 0.4 -0.6 0.8 1.0 0.0 -1.4 1.5
Hypertension (Self-reported) 7.4 20.7 41.6 -2.9 5.6 4.7 -1.7 5.9 5.0 0.0 -6.4 4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 3.2 -0.7 -1.1 -0.5 0.3 -0.7 -1.8 0.0 1.2 -0.1
Illnesses of father: Heart disease 0.3 0.4 1.1 -0.2 -0.1 -1.1 -0.8 0.4 -0.1 0.0 1.0 -0.8
Illnesses of siblings: Diabetes 2.1 2.6 5.2 -1.7 -2.3 -1.9 0.8 -2.0 -2.0 0.0 1.5 0.8
Smoking status: Previous 0.2 0.3 2.2 0.3 0.2 0.3 -0.2 -0.0 1.5 0.0 -0.2 0.5
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.3 17.1 4.1 -1.5 -2.4 1.1 -2.2 0.1 0.0 1.2 -2.4
Whole body fat-free mass 3.1 17.5 38.9 6.2 -4.5 -6.2 1.6 -4.0 -3.2 0.0 2.8 -4.7
Leg fat-free mass (right) 1.6 8.4 21.7 4.7 -2.9 -4.4 0.4 -2.3 -2.0 0.0 2.0 -3.5
Arm fat percentage (left) 3.6 14.3 29.9 -2.4 5.0 3.9 -3.7 5.5 4.2 0.0 -3.5 3.0
Average weekly red wine intake 0.5 0.8 2.2 1.3 0.3 -1.5 -0.1 -0.5 0.8 0.0 1.0 -1.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.3 -0.5 -0.4 -0.1 -0.2 0.3 0.2 0.0 0.4 -0.5
Mood swings 0.6 1.2 2.6 -0.5 -1.1 -1.2 -1.1 -0.1 -1.3 0.0 1.6 -1.4
Loneliness, isolation 0.4 0.6 1.5 -0.7 -1.0 -0.4 -1.1 -0.5 -0.7 0.0 1.2 -0.6
Long-standing illness, disability or infirmity 0.6 0.9 2.8 -0.7 0.2 -1.2 -0.1 0.5 0.3 0.0 -1.7 1.6
Ever had bowel cancer screening 0.4 0.4 1.2 0.7 0.7 0.5 -0.7 -0.0 1.0 0.0 -1.1 0.5
Diabetes diagnosed by doctor 1.1 1.8 6.8 0.1 -1.7 -2.6 1.6 -1.4 -1.5 0.0 -0.1 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 4.0 0.1 1.5 2.0 -0.6 1.9 1.1 0.0 -1.0 1.1
Friendships satisfaction 0.6 0.7 3.2 0.7 0.5 1.2 -1.8 0.2 0.6 0.0 0.4 -0.8
Qualifications: nursing, teaching 1.7 2.6 5.7 2.4 -0.8 -2.3 1.9 -1.4 0.3 0.0 1.6 -2.0
Commuting to job workplace: Walk 0.7 0.8 3.9 1.1 0.2 0.7 1.0 0.0 0.6 0.0 0.3 -2.0
Eye problems/disorders: Cataract 1.2 1.4 6.0 -0.8 1.4 1.0 -2.5 1.1 1.3 0.0 0.1 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 4.7 -2.2 -0.4 -0.5 -1.7 0.3 -0.7 0.0 0.2 -0.4
Medication for cholesterol 2.5 3.8 8.0 1.6 -2.7 -0.6 1.1 -2.8 -2.3 0.0 2.4 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 1.3 1.1 -0.3 -0.2 0.7 -0.4 -0.4 0.0 -0.5 -0.2
Back pain experienced in last month 0.4 0.5 2.1 1.4 -0.7 -0.9 -0.3 -1.0 -0.3 0.0 0.2 -0.3
Mineral and other dietary supplements 0.8 1.1 8.2 -2.9 -0.6 0.2 -0.1 -0.6 -0.7 0.0 0.5 0.1
Breast cancer (self-reported) 0.4 0.4 1.0 0.2 -0.6 -0.7 1.0 -0.3 -0.0 0.0 0.9 -1.0
Asthma (self-reported) 1.8 3.5 8.9 3.0 -1.8 -1.9 2.5 -2.3 -1.7 0.0 0.9 -0.6
Osteoporosis (self-reported) 0.2 0.3 0.9 0.0 1.0 0.6 -0.1 0.8 0.6 0.0 0.0 -0.1
Osteoarthritis (self-reported) 1.7 2.2 5.8 1.9 1.3 0.1 1.5 0.8 1.8 0.0 -2.4 1.6
Medication: Aspirin 0.8 1.1 3.1 0.1 1.5 0.6 0.3 1.4 1.1 0.0 -1.0 1.8
Medication: Gliclazide 0.6 0.7 2.7 0.7 -0.1 0.0 0.8 0.5 -0.5 0.0 -1.3 1.6
Illnesses of father: None of the above (group 1) 0.2 0.2 1.6 -0.1 0.2 0.4 1.3 -0.3 -0.0 0.0 0.2 0.3
Smoking status: Current 1.1 1.8 8.0 -0.9 1.2 1.2 -2.8 1.6 1.2 0.0 -0.2 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 9.4 -3.1 -0.1 0.1 -2.0 0.0 -0.9 0.0 1.6 -0.0
Whole body water mass 2.9 16.7 38.8 6.2 -4.4 -6.1 1.5 -3.9 -3.1 0.0 2.7 -4.6
Leg predicted mass (right) 1.6 8.7 22.8 4.8 -2.9 -4.4 0.4 -2.4 -2.1 0.0 2.0 -3.6
Arm fat mass (left) 0.9 3.6 9.3 0.3 2.5 1.1 -2.2 3.0 2.3 0.0 -2.1 1.1
Number of self-reported non-cancer illnesses 1.1 1.9 6.0 -1.6 1.2 0.5 -0.3 2.0 1.0 0.0 -2.4 1.5
Average weekly champagne plus white wine intake 0.6 0.9 2.9 0.1 1.1 1.7 0.5 0.9 1.4 0.0 -0.7 -0.5
Miserableness 0.7 1.2 5.5 -2.4 -0.2 -0.2 -2.0 0.3 -0.2 0.0 1.0 -0.4
Guilty feelings 1.0 1.5 3.5 -1.9 1.0 1.0 -1.4 1.5 1.6 0.0 -0.8 1.0
Wears glasses or contact lenses 1.8 2.0 9.2 3.0 -0.7 -0.3 0.8 -1.7 -1.2 0.0 1.2 -1.5
Ever taken oral contraceptive pill 2.4 2.7 6.4 0.1 -2.3 -1.4 -0.6 -2.5 -2.2 0.0 1.9 -1.4
Hearing aid user 1.4 1.6 4.5 0.5 -1.7 -0.7 -0.3 -1.4 -1.7 0.0 1.2 -2.1
Mother’s age at death 1.4 1.8 5.8 2.4 -0.7 -1.6 1.5 -1.6 -0.5 0.0 0.8 -1.1
Financial situation satisfaction 0.3 0.3 2.2 -0.3 0.6 0.1 -1.5 0.3 0.4 0.0 0.4 -0.1
Tinnitus: Yes, now most or all of the time 0.9 1.0 1.9 0.4 -1.0 -1.1 1.2 -1.2 -0.8 0.0 1.4 -1.1
Commuting to job workplace: Public transport 0.3 0.3 1.9 0.7 0.0 1.4 -0.3 -0.4 0.3 0.0 -0.1 -0.5
Eye problems/disorders: Glaucoma 0.4 0.5 1.7 -0.7 -0.2 1.0 -1.3 -0.2 -0.8 0.0 -0.2 0.6
Medication: Blood pressure 6.8 13.0 24.7 -2.9 4.7 2.9 -1.8 5.0 4.2 0.0 -4.3 3.7
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.8 0.6 0.2 0.6 0.1 -0.1 0.5 0.0 -1.3 0.9
Supplements: Fish oil (including cod liver oil) 0.4 0.6 2.5 1.6 0.8 0.3 -0.5 0.7 0.6 0.0 -0.5 0.8
High cholesterol (Self-reported) 1.5 2.7 4.9 -1.8 -1.4 -2.2 -1.4 -0.7 -2.1 0.0 1.8 -2.0
Medication: Bendroflumethiazide 6.4 9.8 21.3 -2.8 3.8 2.0 -0.4 4.6 3.1 0.0 -4.5 3.2
Medication: Paracetamol 0.3 0.4 1.2 1.0 -1.1 -0.1 -0.1 -0.8 -1.0 0.0 0.4 0.2
Medication: Lisinopril 2.8 3.6 6.2 -1.3 2.5 1.5 -1.2 2.5 2.4 0.0 -2.5 1.6
Medication: Atorvastatin 0.9 1.1 4.1 0.1 -1.1 -2.0 -0.2 -1.7 -0.6 0.0 1.1 -0.8
Illnesses of father: High blood pressure 2.3 2.9 7.1 -1.0 2.3 1.6 -1.2 2.7 2.2 0.0 -1.7 1.1
Alcohol drinker status: Never 0.8 1.0 4.8 -2.2 0.6 0.6 -0.5 1.3 -0.4 0.0 -0.9 0.8
Ever smoked 0.3 0.6 1.7 1.0 -0.3 -0.8 -1.3 -0.2 0.8 0.0 0.9 -0.6
Basal metabolic rate 2.1 11.7 32.7 5.7 -3.5 -5.1 1.1 -2.9 -2.2 0.0 2.0 -3.9
Leg fat percentage (left) 1.1 4.1 9.3 -2.1 2.4 1.6 -1.7 3.1 2.0 0.0 -2.1 2.0
Arm fat-free mass (left) 3.6 18.1 40.7 6.2 -4.8 -6.4 2.0 -4.2 -3.5 0.0 2.8 -4.2
Number of operations (self-reported) 2.3 3.4 7.2 -2.6 1.9 1.2 -1.1 2.7 2.3 0.0 -1.6 1.3
Average weekly beer plus cider intake 0.4 0.6 2.6 1.6 -0.6 -1.1 0.7 -0.7 -0.1 0.0 0.2 0.4
Irritability 2.0 3.4 8.8 -0.4 -2.4 -1.9 -0.4 -1.4 -2.2 0.0 3.0 -2.4
Risk taking 1.5 2.2 3.9 -0.8 2.0 1.9 -1.9 1.6 1.8 0.0 -0.5 1.5
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.1 -1.0 0.5 0.3 -0.2 0.4 0.3 0.0 -0.0 -1.0
Fractured/broken bones in last 5 years 0.8 1.0 3.2 0.3 0.8 -0.2 1.3 0.8 1.3 0.0 -1.8 1.2
Age started oral contraceptive pill 0.8 1.0 4.0 0.3 0.8 0.6 2.0 0.7 0.4 0.0 -0.9 1.7
Diastolic blood pressure, automated reading 2.7 8.4 20.2 1.8 3.7 1.9 -0.6 4.1 3.6 0.0 -4.5 2.2
Ever depressed for a whole week 0.7 0.9 2.4 -1.3 1.1 0.2 -1.5 1.4 1.0 0.0 0.1 -0.1
Unable to work because of sickness or disability 1.3 1.6 3.7 -0.5 -1.5 -0.9 -1.6 -1.9 -1.5 0.0 1.6 -0.2
Commuting to job workplace: Cycle 0.2 0.3 1.0 -0.6 0.2 -0.4 0.5 -0.2 0.6 0.0 0.5 -1.0
Myopia 1.0 1.5 3.8 -1.3 1.9 1.9 -0.4 1.0 1.6 0.0 -0.1 -0.6
Vascular/heart problems diagnosed by doctor 5.9 16.0 33.2 2.2 -5.0 -3.7 1.1 -5.2 -4.9 0.0 5.8 -3.9
Cholesterol lowering medication 1.4 2.0 4.8 -1.4 2.1 0.0 -0.2 2.2 1.2 0.0 -1.2 1.9
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 1.5 0.4 0.0 -0.5 1.2 -0.2 0.1 0.0 -0.1 -0.4
Pain experienced in last month 0.3 0.5 2.2 -0.9 -0.5 -0.1 1.5 -0.3 -1.2 0.0 -0.3 0.2
Supplements: Calcium 1.9 2.1 5.9 1.5 -1.0 -1.4 -0.8 -0.6 -1.0 0.0 2.3 -2.4
Basal cell carcinoma (self-reported) 0.9 1.1 4.0 -2.0 0.3 0.6 -0.7 1.4 -0.5 0.0 -1.1 1.2
Heart attack/myocardial infarction (self-reported) 1.9 2.4 6.4 0.9 -1.5 -1.8 -1.6 -1.9 -1.0 0.0 2.5 -1.3
Deep venous thrombosis (DVT) (self-reported) 3.5 4.5 6.3 -1.9 2.3 2.4 -2.0 2.5 1.9 0.0 -2.5 2.5
Heart disease (siblings) 0.6 0.7 1.9 0.4 -0.8 -1.2 1.0 -1.4 0.1 0.0 0.6 0.8
Alcohol drinker status: Previous 0.5 0.5 1.7 -1.3 0.2 -1.3 0.1 0.3 0.2 0.0 -0.7 0.9
Pack years of smoking 0.4 0.7 3.3 -1.8 0.5 1.3 -0.2 0.4 0.2 0.0 -0.5 0.3
Impedance of whole body 4.0 20.5 44.9 -2.3 5.8 6.7 -0.4 4.9 6.1 0.0 -4.9 4.0
Leg fat mass (left) 0.3 1.1 3.9 0.4 1.2 0.2 -0.9 2.0 1.4 0.0 -1.3 0.5
Arm predicted mass (left) 3.6 18.1 39.6 6.3 -4.8 -6.3 1.9 -4.3 -3.6 0.0 2.8 -4.2