TWAS hub - AMAC1L3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Glioblastoma Multiforme	0.1380	0.0830	0.0025	0.119	0.089	0.097	NA	0.119	0.00018	0.0012	0.00072	NA	0.00018
2	TCGA	Brain Lower Grade Glioma	0.0365	0.0215	0.0007	0.019	0.017	0.008	NA	0.009	0.00280	0.0039	0.03400	NA	0.02900

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Height	12.0	230.7	292.4	-17.1	-13.0
Deep venous thrombosis (DVT) (self-reported)	10.6	13.6	14.4	3.6	3.8
Sitting height	10.2	72.7	116.6	-10.8	-5.4
Standing height	10.1	100.7	146.4	-12.1	-7.4
Blood clot in the leg (DVT)	10.0	12.9	13.4	3.5	3.7
Medication: Amlodipine	9.8	13.7	17.8	3.1	4.2
Major Depression (MDD)	9.2	11.2	11.2	3.4	3.3
Alcohol usually taken with meals	8.7	14.1	14.3	-3.7	-3.8
Waist Hip Ratio (WHR)	7.7	34.5	36.5	-5.7	-6.0
Trunk fat-free mass	7.4	42.5	60.1	-7.8	-5.0
Trunk predicted mass	7.4	42.3	59.8	-7.7	-5.0
Medication: Bendroflumethiazide	7.0	10.7	20.9	0.7	4.6
Lung FVC	6.7	34.0	44.5	4.8	6.7
Arm fat percentage (left)	6.7	26.9	38.9	6.2	3.9
Hand grip strength (right)	6.3	17.0	21.9	-4.7	-3.5
Forced expiratory volume in 1-second (FEV1), predicted	6.2	13.0	14.1	-3.8	-3.4
Wears glasses or contact lenses	6.1	7.0	12.5	-1.3	-3.5
Arm fat percentage (right)	6.0	23.5	32.9	5.7	3.8
Medication: Blood pressure	5.4	10.3	11.8	3.0	3.4
Arm fat-free mass (left)	5.3	26.7	39.1	-6.2	-3.8
Length of working week for main job	5.2	5.7	5.9	-2.4	-2.4
Arm predicted mass (left)	5.2	26.4	37.6	-6.1	-3.9
Respiratory disease	5.1	11.2	19.5	-1.7	-4.4
Frequency of tiredness / lethargy in last 2 weeks	5.1	8.3	8.8	2.8	3.0
Arm fat-free mass (right)	4.9	25.3	37.2	-6.1	-3.7
Hand grip strength (left)	4.8	12.6	17.5	-4.2	-2.8
Qualifications: A levels/AS levels or equivalent	4.8	10.7	14.3	-3.8	-2.7
Arm predicted mass (right)	4.8	24.5	34.6	-5.9	-3.8
Whole body fat-free mass	4.7	26.9	38.7	-6.2	-3.9
Prospective memory result	4.6	5.7	7.3	2.0	2.7
Body fat percentage	4.6	18.3	23.3	4.8	3.6
Whole body water mass	4.6	26.0	37.3	-6.1	-3.8
Relative age of first facial hair	4.5	9.2	13.5	3.7	2.2
Hypertension (Self-reported)	4.5	12.4	17.8	2.6	4.2
Mother’s age at death	4.5	5.6	5.9	-2.3	-2.4
Tense / ‘highly strung’	4.4	7.3	10.4	2.0	3.2
Neuroticism	4.3	10.4	16.9	2.0	4.1
High blood pressure	4.3	12.0	19.4	2.2	4.4
Prostate Cancer	4.1	5.8	7.8	-2.8	2.0
Worry (Nagel 2018)	4.0	8.5	12.2	2.2	3.5
Systolic Blood Pressure	4.0	19.8	33.6	2.5	5.8
Illnesses of father: High blood pressure	4.0	5.0	5.7	2.1	2.4
Trunk fat percentage	3.9	15.5	19.4	4.4	3.4
Mean time to correctly identify matches	3.9	7.4	8.2	-2.9	-2.6
Heart disease (siblings)	3.9	4.7	9.5	-0.0	-3.1
High blood pressure (mother)	3.8	5.4	10.7	0.3	3.3
Body Mass Index (BMI) (2010)	3.7	5.1	9.8	3.1	0.7
Tinnitus: Yes, but not now, but have in the past	3.7	4.0	6.1	1.4	-2.5
Qualifications: CSEs or equivalent	3.7	4.9	7.1	1.7	2.7
Leg fat percentage (right)	3.6	13.0	15.7	4.0	3.2
Average weekly red wine intake	3.6	5.3	8.4	-1.4	-2.9
Hair/balding pattern: Pattern 4	3.5	8.6	13.4	-3.7	-1.9
Fed-up feelings	3.4	6.2	8.9	1.9	3.0
Stomach or abdominal pain in last month	3.4	4.2	6.4	1.5	2.5
Medication: Blood pressure	3.4	6.0	9.6	1.5	3.1
Systolic blood pressure, automated reading	3.3	9.4	14.6	2.1	3.8
Medication: Allopurinol	3.3	4.4	7.7	1.1	2.8
Miserableness	3.3	5.7	6.6	2.2	2.6
Leg fat percentage (left)	3.3	11.8	13.4	3.7	3.2
Depression (Nagel 2018)	3.2	4.8	6.0	1.9	2.5
Gout (self-reported)	3.2	4.4	8.2	0.7	2.9
Comparative height size at age 10	3.2	17.8	30.1	-5.5	-2.3
Basal metabolic rate	3.2	17.5	25.7	-5.1	-3.1
Neuroticism (Nagel 2018)	3.1	7.3	7.3	2.7	2.7
Neuroticism (2016)	3.1	4.5	5.0	2.2	2.0
Neuroticism score	3.1	6.4	10.6	1.5	3.3
Chest pain or discomfort	3.1	4.5	8.9	0.0	-3.0
Alcohol drinker status: Never	3.1	3.8	7.5	0.1	2.7
Vascular/heart problems diagnosed by doctor	3.1	8.3	12.7	-2.0	-3.6
Eye problems/disorders: Cataract	3.0	3.5	6.6	2.6	-0.5
BMI	2.9	16.8	22.5	4.7	3.3
Smoking Status	2.9	7.0	7.5	2.7	2.5
Time employed in main current job	2.9	3.4	6.4	-2.5	0.6
High blood pressure (siblings)	2.9	4.2	5.7	1.6	2.4
Pulse rate, automated reading	2.9	9.4	14.3	-3.8	-2.1
Guilty feelings	2.9	4.4	5.1	2.3	1.9
Frequency of depressed mood in last 2 weeks	2.8	3.9	6.1	1.3	2.5
Basal cell carcinoma (self-reported)	2.8	3.3	6.4	0.5	2.5
Number of self-reported non-cancer illnesses	2.7	4.7	7.0	1.5	2.6
Depressed Affect (Nagel 2018)	2.6	5.4	6.0	2.4	2.2
Body mass index (BMI)	2.6	11.2	15.2	3.9	2.7
Neck or shoulder pain in last month	2.5	3.6	6.5	2.5	0.8
Asthma (self-reported)	2.5	5.0	10.0	-0.1	-3.2
Financial situation satisfaction	2.5	3.1	6.1	2.5	-0.1
Heel T-Score	2.4	19.4	33.1	5.8	2.4
Cardiovascular Disease	2.4	8.0	13.7	1.5	3.7
Headache pain in last month	2.4	4.1	5.6	1.6	2.4
Number of operations (self-reported)	2.4	3.5	5.3	1.3	2.3
Asthma	2.3	4.6	9.0	-0.3	-3.0
Qualifications: College or University degree	2.3	7.4	7.6	-2.7	-2.8
Mouth/teeth dental problems: Loose teeth	2.3	2.7	5.4	2.3	0.2
Qualifications: nursing, teaching	2.3	3.6	3.8	-1.8	-2.0
Ever depressed for a whole week	2.3	2.8	3.5	1.9	1.4
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	3.6	-1.1	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	3.0	1.7	1.7
Relative age voice broke	2.2	3.3	6.0	2.4	0.8
Chronic bronchitis/emphysema (father)	2.2	2.6	4.8	-0.6	-2.2
Pulse rate	2.2	3.7	7.2	-2.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	4.8	2.2	2.2
Alcohol intake frequency.	2.1	4.8	9.2	-0.7	3.0
Ulcerative Colitis (UC)	2.0	3.8	7.0	2.6	0.8
Breast Cancer	2.0	4.7	7.7	1.3	-2.8
HbA1C	2.0	2.2	3.6	-1.9	-0.9
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.0	-1.7	-1.3
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.4	0.7	2.1
Happiness	2.0	2.4	3.2	1.8	1.3
Mood swings	2.0	3.7	6.2	1.0	2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	2.7	1.6	1.2
Ever used hormone-replacement therapy (HRT)	1.9	2.4	3.3	-1.2	-1.8
Medication: Lansoprazole	1.9	2.2	2.6	1.6	1.3
Pulse wave reflection index	1.9	2.3	3.1	1.8	1.3
Medication: Omeprazole	1.9	2.3	3.1	-1.8	-1.2
Handedness (chirality/laterality): Left-handed	1.9	2.2	4.2	0.5	2.1
Leg predicted mass (right)	1.9	9.9	13.4	-3.7	-2.5
Sensitivity / hurt feelings	1.8	3.1	4.6	1.2	2.2
Current tobacco smoking	1.8	3.0	4.2	2.0	1.4
Bilateral oophorectomy (both ovaries removed)	1.8	2.0	2.9	-1.7	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	3.2	1.8	1.0
Birth weight	1.8	3.9	7.3	-2.7	-0.7
Leg fat-free mass (right)	1.8	9.7	13.3	-3.6	-2.5
Medication: Atenolol	1.7	2.1	3.3	0.9	1.8
Number of live births	1.7	2.4	4.4	2.1	0.5
Smoking status: Current	1.7	2.7	3.0	1.7	1.5
Diabetes (father)	1.6	2.0	2.4	-1.5	-1.3
Average weekly fortified wine intake	1.6	1.9	2.0	-1.4	-1.4
Number of full brothers	1.6	2.0	3.4	1.9	-0.7
Ever taken oral contraceptive pill	1.6	1.7	3.3	-0.4	-1.8
Had other major operations	1.5	1.9	3.0	1.7	0.9
Qualifications: None of the above	1.5	3.1	4.4	2.1	1.3
Eye problems/disorders: None of the above	1.5	1.7	3.2	-1.8	0.5
Loneliness, isolation	1.5	2.0	2.7	1.2	1.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.2	-1.8	-0.6
Reaction Time	1.4	2.7	3.8	-2.0	-1.2
Leg fat-free mass (left)	1.4	7.3	9.7	-3.1	-2.2
Impedance of arm (left)	1.4	6.4	9.3	3.0	1.9
Birth weight of first child	1.4	2.6	2.8	-1.7	-1.5
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	2.3	-1.5	-1.5
Medication for cholesterol	1.4	2.1	3.1	-1.8	-1.1
Back pain experienced in last month	1.4	2.0	2.9	1.1	-1.7
Arm fat mass (left)	1.4	5.6	8.0	2.8	1.8
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.8	-1.1	-2.0
Medication: Co-codamol	1.3	1.6	2.9	0.5	1.7
Medication: Metformin	1.3	1.8	3.4	-0.4	-1.8
Pack years adult smoking proportion	1.3	1.9	3.8	2.0	-0.1
Age when periods started (menarche)	1.3	3.1	3.9	-1.5	2.0
Leg predicted mass (left)	1.3	7.1	9.6	-3.1	-2.1
Hair/balding pattern: Pattern 2	1.3	1.6	1.7	1.3	1.2
Heart attack	1.3	1.7	3.2	0.4	-1.8
Impedance of arm (right)	1.3	5.9	6.8	2.6	2.3
Number of full sisters	1.3	1.6	2.5	-1.6	-0.9
Medication: Lisinopril	1.3	1.7	2.9	1.7	0.6
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.1	0.4	-1.8
Had menopause	1.2	1.5	1.5	-1.2	-1.2
Glaucoma (self-reported)	1.2	1.4	1.8	-1.0	-1.4
Long-standing illness, disability or infirmity	1.2	1.8	3.2	1.8	0.7
Ever had bowel cancer screening	1.2	1.4	1.8	-1.0	-1.3
Breast cancer (self-reported)	1.2	1.5	1.8	-1.1	1.4
Fractured/broken bones in last 5 years	1.2	1.6	1.7	-1.3	-1.2
Schizophrenia (2018)	1.1	2.3	2.6	1.6	-1.4
Schizophrenia vs Biploar Disorder	1.1	1.5	3.0	0.1	-1.7
Irritable Bowel Disease (IBD)	1.1	2.7	5.3	2.3	0.1
Number of treatments/medications taken	1.1	2.0	2.8	1.7	1.1
Arm fat mass (right)	1.1	4.4	5.5	2.4	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	2.7	0.5	1.6
Irritability	1.1	1.9	3.4	0.7	1.8
Diastolic blood pressure, automated reading	1.1	3.3	6.4	0.4	2.5
Pack years of smoking	1.1	1.6	3.1	1.8	0.1
Coronary Artery Disease (CAD)	1.0	1.1	1.2	-1.1	-1.0
Schizophrenia (2014)	1.0	2.2	3.9	0.7	-2.0
Blood Red Count	1.0	9.5	18.8	-0.4	4.3
Ever had hysterectomy (womb removed)	1.0	1.1	1.5	0.8	1.2
Taking other prescription medications	1.0	1.6	3.0	1.7	0.3
Serious illness, injury or assault to yourself	1.0	1.3	2.5	1.6	-0.1
Alcohol intake versus 10 years previously	1.0	1.5	2.4	-0.7	-1.6
Worrier / anxious feelings	1.0	1.9	1.9	1.4	1.4
Pulse wave Arterial Stiffness index	1.0	1.2	2.4	-1.5	-0.1
Medication: Paracetamol	1.0	1.7	2.3	1.5	1.0
Heart disease (mother)	1.0	1.3	1.7	-1.3	-0.9
Commuting to job workplace: Walk	1.0	1.0	1.7	-1.3	0.6
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.5	1.6	0.5
Risk taking	1.0	1.5	3.0	1.7	0.1
Bipolar Disorder or Schizophrenia	0.9	2.3	2.5	1.6	-1.4
Ulcerative Colitis	0.9	1.3	2.3	1.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.0	0.9	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.4	1.9	0.9
Illnesses of siblings	0.9	1.3	2.0	-1.4	-0.7
Wheeze or whistling in the chest in last year	0.9	1.6	2.0	1.1	-1.4
Number of children fathered	0.9	1.0	1.2	-1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.1	-0.1	-1.4
Angina (self-reported)	0.9	1.1	2.1	0.4	-1.4
Whole body fat mass	0.9	3.9	4.5	2.1	1.8
Leg fat mass (right)	0.9	3.5	3.6	1.9	1.8
Suffer from ‘nerves’	0.9	1.5	2.8	0.3	1.7
Knee pain experienced in last month	0.9	1.4	1.4	1.2	1.2
Osteoporosis (self-reported)	0.9	1.1	2.1	1.5	0.0
Blood Eosinophil Count	0.8	6.3	6.4	2.5	2.5
Vitamin and mineral supplements	0.8	1.0	1.9	-1.4	-0.4
Townsend deprivation index at recruitment	0.8	1.2	2.2	1.5	0.3
Trunk fat mass	0.8	3.4	3.9	2.0	1.7
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.0	0.9	1.0
Father’s age at death	0.8	1.0	1.7	-0.6	-1.3
Noisy workplace	0.8	1.0	1.8	1.3	0.6
Forced vital capacity (FVC), Best measure	0.8	3.0	5.9	-2.4	-0.2
Illnesses of father: Heart disease	0.8	1.1	1.3	1.2	0.9
Commuting to job workplace: Public transport	0.8	0.9	1.4	-1.2	-0.7
Cholesterol lowering medication	0.8	1.2	2.3	1.5	0.4
Leg fat mass (left)	0.8	3.3	3.3	1.8	1.8
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.3	-0.2	1.8
Fasting Glucose	0.7	0.8	1.7	-1.3	0.0
Rheumatoid Arthritis	0.7	1.0	1.7	1.3	0.6
Blood White Count	0.7	5.0	7.2	-2.7	-1.7
Multivitamins +/- minerals	0.7	0.9	0.9	1.0	1.0
Forced vital capacity (FVC)	0.7	2.9	5.1	-2.2	-0.8
Medication: Ramipril	0.7	0.9	1.6	0.4	1.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.4	1.2	0.3
Unable to work because of sickness or disability	0.7	0.9	1.6	1.3	-0.5
Pain experienced in last month	0.7	1.2	2.5	-1.6	-0.1
Mean Putamen Volume	0.6	0.7	1.2	-1.1	-0.4
Chronotype (morning person)	0.6	1.4	1.6	1.1	1.3
Number of incorrect matches in round	0.6	1.0	1.1	1.0	1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	-1.2	-0.2
Medication: Cholesterol lowering	0.6	1.0	1.2	-1.1	-0.9
Exposure to tobacco smoke at home	0.6	0.7	1.4	1.2	0.2
Breastfed as a baby	0.6	0.8	1.5	-0.4	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	1.3	0.4
Ever highly irritable/argumentative for 2 days	0.6	0.7	0.9	1.0	0.7
Loud music exposure frequency	0.6	0.6	1.2	1.1	0.1
Comparative body size at age 10	0.6	1.5	1.8	1.3	1.1
Medication for pain relief, constipation, heartburn	0.6	1.1	1.6	-0.8	-1.3
Migraine (self-reported)	0.6	0.7	1.3	-0.4	1.1
Overall health rating	0.6	1.3	2.2	1.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.0	0.7	1.0
Illnesses of siblings: Diabetes	0.6	0.7	1.4	1.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.4	0.6	1.2
Alcohol drinker status: Previous	0.6	0.7	1.2	0.3	1.1
Alzheimer’s Disease (in father)	0.5	0.6	0.9	-0.5	-0.9
Lupus	0.5	0.8	1.0	-0.7	1.0
Primary Biliary Cirrhosis	0.5	0.8	1.0	-0.7	-1.0
Angina	0.5	0.7	1.2	0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.6	1.3	-0.8
Nervous feelings	0.5	0.9	1.5	1.2	0.5
Hearing difficulty/problems with background noise	0.5	0.9	1.5	0.5	-1.2
Medication: Simvastatin	0.5	0.7	1.0	0.7	1.0
Falls in the last year	0.5	0.6	1.2	1.1	0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.7	0.8	-0.8
Worry too long after embarrassment	0.5	0.8	1.4	-1.2	-0.6
Medication: Aspirin	0.5	0.6	0.8	0.9	0.7
Alzheimer’s Disease (in mother)	0.4	0.4	0.5	0.6	-0.7
Age at First Birth	0.4	0.6	1.0	-0.5	-1.0
Allergy or Eczema	0.4	1.1	1.1	-1.0	-1.0
Medication for hormone replacement therapy	0.4	0.5	1.0	0.1	-1.0
Mouth/teeth dental problems: Dentures	0.4	0.6	0.8	0.9	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.7	-1.6	0.2
Peak expiratory flow (PEF)	0.4	0.9	1.3	-0.7	-1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	-0.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.2	-0.2	-1.1
Shortness of breath walking on level ground	0.4	0.4	0.5	0.6	-0.7
Mineral and other dietary supplements	0.4	0.5	0.9	-1.0	-0.2
Medication: Aspirin	0.4	0.6	0.9	0.9	0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.1	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.4	-0.9
Age started oral contraceptive pill	0.4	0.4	0.6	-0.8	-0.5
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.2	0.9
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.2	-1.1	0.7
Bipolar Disorder (2011)	0.3	0.3	0.5	0.7	0.5
LDL Cholesterol	0.3	0.4	0.7	0.4	-0.8
Triglycerides	0.3	0.5	0.5	-0.7	0.7
Hypothyroidism (self reported)	0.3	0.7	1.4	-0.1	-1.2
Severe depression (siblings)	0.3	0.3	0.4	0.5	0.7
Supplements: Glucosamine	0.3	0.3	0.5	-0.7	-0.4
Impedance of leg (left)	0.3	1.6	2.3	-1.5	0.9
Financial difficulties in last 2 years	0.3	0.4	0.7	0.1	-0.8
Fluid intelligence score	0.3	0.5	1.0	0.0	1.0
Weight	0.3	1.6	2.6	-1.6	-0.8
Hip circumference	0.3	1.4	1.7	1.1	1.3
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.0	-1.4	-0.0
Pulse wave peak to peak time	0.3	0.3	0.6	0.7	-0.3
Leg pain on walking	0.3	0.4	0.6	-0.4	-0.7
Supplements: Vitamin C	0.3	0.3	0.6	0.2	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	-0.8	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.4	0.7	-0.4
Impedance of whole body	0.3	1.7	2.2	1.1	1.5
Bipolar Disorder (2018)	0.2	0.3	0.3	0.5	-0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.3	-0.7
HDL Cholesterol	0.2	0.4	0.7	0.8	-0.0
Blood Platelet Count	0.2	2.3	4.4	-0.5	2.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.8	0.1
Supplements: Zinc	0.2	0.2	0.3	-0.3	0.5
Maternal smoking around birth	0.2	0.3	0.6	0.8	-0.1
Allergy	0.2	0.4	0.8	-0.1	0.9
Pain all over the body in last month	0.2	0.2	0.3	0.6	0.1
Diabetes (self-reported)	0.2	0.3	0.5	0.2	-0.7
Family relationship satisfaction	0.2	0.3	0.5	0.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	-0.5	-0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.0	0.6
Diabetes diagnosed by doctor	0.2	0.4	0.7	-0.3	-0.8
Friendships satisfaction	0.2	0.2	0.4	0.6	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.2	-0.5	0.4
Hearing aid user	0.2	0.2	0.4	-0.6	0.3
Medication: Atorvastatin	0.2	0.3	0.4	0.4	-0.6
Ever smoked	0.2	0.4	0.5	-0.7	-0.6
Myopia	0.2	0.3	0.7	0.1	-0.8
Crohns Disease (2017)	0.1	0.2	0.3	0.5	-0.5
Ovarian Cancer	0.1	0.1	0.1	0.3	0.3
Lung FEV1/FVC ratio	0.1	0.6	0.6	0.7	0.8
Tanning	0.1	0.7	1.0	-1.0	0.6
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.6	0.0
Diabetes (mother)	0.1	0.1	0.1	-0.0	-0.4
Impedance of leg (right)	0.1	0.7	0.9	-0.7	0.9
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.6	-0.2
Past tobacco smoking	0.1	0.1	0.2	-0.2	0.4
Mouth/teeth dental problems	0.1	0.1	0.3	-0.5	0.1
Depression (self-reported)	0.1	0.2	0.3	0.3	0.5
Lung cancer (father)	0.1	0.1	0.2	0.2	0.4
Age at first live birth	0.1	0.3	0.4	-0.6	0.4
Medication: Ibuprofen	0.1	0.1	0.2	0.2	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.1	0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	-0.5	-0.1
Had major operations	0.1	0.1	0.3	-0.0	0.5
Smoking status: Previous	0.1	0.2	0.3	-0.2	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.1	0.3	0.3
Medication: Gliclazide	0.1	0.1	0.3	0.5	0.0
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.3	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.2	0.6
Medication: Paracetamol	0.1	0.2	0.2	0.5	-0.3
Supplements: Calcium	0.1	0.2	0.2	0.3	-0.4
Crohns Disease (2012)	0.0	0.0	0.0	0.1	0.1
Hair Pigment	0.0	1.1	2.0	-1.4	-0.4
Average weekly spirits intake	0.0	0.0	0.1	0.1	0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.1	-0.4
Waist circumference	0.0	0.2	0.3	0.0	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.1	-0.1
Illnesses of mother	0.0	0.0	0.1	0.1	-0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	0.1	-0.0
Exposure to tobacco smoke outside home	0.0	0.1	0.1	-0.0	-0.3
Health satisfaction	0.0	0.0	0.1	0.0	-0.3
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.0	0.1
Age at last live birth	0.0	0.1	0.1	-0.2	-0.3
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.1	-0.3
Average weekly beer plus cider intake	0.0	0.0	0.1	0.2	-0.2
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.2	0.2

Hub : Genes

AMAC1L3

Models

Trait associations