Best TWAS P=2.71e-10 · Best GWAS P=3.68e-10 conditioned to 0.01
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | SF3B1 | 0.04 | 0.02 | lasso | 4 | 0.01 | 5.7e-02 | 4.5 | 5.1 | 2.8e-07 | 0.90 | 0.03 | 0.90 | FALSE |
| 2 | GTEx | Lung | SF3B1 | 0.06 | 0.04 | enet | 23 | 0.02 | 2.2e-02 | 4.5 | 6.3 | 2.7e-10 | 0.70 | 0.29 | 0.51 | TRUE |
| 3 | GTEx | Testis | ANKRD44 | 0.33 | 0.35 | enet | 15 | 0.36 | 6.2e-17 | 6.3 | 5.9 | 3.0e-09 | 0.98 | 0.00 | 1.00 | FALSE |
| 4 | METSIM | Adipose | HSPD1 | 0.02 | 0.00 | blup | 323 | 0.01 | 1.8e-02 | -3.7 | 6.2 | 6.8e-10 | 0.64 | 0.12 | 0.46 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SF3B1 | 0.02 | 0.01 | blup | 336 | 0.01 | 6.2e-03 | 3.8 | 5.3 | 1.2e-07 | 0.82 | 0.28 | 0.55 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | RFTN2 | 0.03 | 0.04 | blup | 351 | 0.03 | 1.5e-04 | 2.7 | -5.2 | 1.7e-07 | -0.76 | 0.40 | 0.56 | FALSE |