Best TWAS P=1.17e-11 · Best GWAS P=4.91e-10 conditioned to 0.0211
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | ERI1 | 0.05 | 0.00 | enet | 10 | 0.00 | 5.5e-01 | 4.3 | -5.6 | 2.3e-08 | -0.48 | 0.11 | 0.67 | FALSE |
2 | GTEx | Adipose Subcutaneous | FAM85A | 0.06 | 0.06 | enet | 10 | 0.07 | 3.3e-06 | -4.4 | 5.3 | 9.3e-08 | 0.39 | 0.08 | 0.84 | FALSE |
3 | GTEx | Adrenal Gland | FAM86B3P | 0.16 | 0.00 | enet | 18 | 0.03 | 2.2e-02 | 3.8 | -5.3 | 1.0e-07 | -0.35 | 0.05 | 0.29 | FALSE |
4 | GTEx | Artery Aorta | ERI1 | 0.11 | 0.08 | lasso | 5 | 0.10 | 5.1e-06 | 5.6 | -5.1 | 2.8e-07 | -0.53 | 0.06 | 0.93 | FALSE |
5 | GTEx | Artery Coronary | AF131215.2 | 0.11 | 0.02 | enet | 27 | 0.05 | 6.5e-03 | -3.9 | 5.3 | 9.4e-08 | 0.67 | 0.07 | 0.70 | FALSE |
6 | GTEx | Artery Tibial | AF131215.2 | 0.07 | 0.03 | enet | 24 | 0.05 | 1.8e-04 | -3.4 | 5.1 | 2.9e-07 | 0.64 | 0.10 | 0.88 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | ERI1 | 0.34 | 0.35 | lasso | 7 | 0.35 | 1.9e-27 | 5.6 | -5.9 | 3.9e-09 | -0.50 | 0.02 | 0.98 | FALSE |
8 | GTEx | Esophagus Gastroesophageal Junction | MSRA | 0.11 | -0.01 | enet | 30 | -0.01 | 8.0e-01 | 6.0 | -5.8 | 6.7e-09 | -0.45 | 0.14 | 0.31 | FALSE |
9 | GTEx | Esophagus Muscularis | ERI1 | 0.12 | 0.09 | enet | 13 | 0.08 | 7.7e-06 | 4.2 | -5.2 | 2.5e-07 | -0.52 | 0.45 | 0.54 | FALSE |
10 | GTEx | Heart Atrial Appendage | MFHAS1 | 0.34 | 0.23 | enet | 56 | 0.19 | 5.7e-09 | -5.2 | 5.6 | 1.8e-08 | 0.36 | 0.03 | 0.97 | FALSE |
11 | GTEx | Nerve Tibial | ERI1 | 0.07 | 0.01 | enet | 16 | 0.01 | 4.2e-02 | -3.8 | -5.6 | 1.8e-08 | -0.50 | 0.13 | 0.64 | FALSE |
12 | GTEx | Prostate | AF131215.2 | 0.18 | 0.02 | lasso | 6 | 0.02 | 9.6e-02 | 3.2 | 5.2 | 2.0e-07 | 0.85 | 0.09 | 0.46 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | FAM85A | 0.09 | 0.04 | enet | 28 | 0.04 | 1.4e-04 | -4.4 | 5.8 | 8.1e-09 | 0.36 | 0.07 | 0.81 | FALSE |
14 | NTR | Blood | MSRA | 0.02 | 0.01 | blup | 833 | 0.01 | 2.3e-05 | 3.9 | -6.8 | 1.2e-11 | -0.66 | 0.32 | 0.68 | TRUE |
15 | ROSMAP | Brain Pre-frontal Cortex | RP11-481A20.11 | 0.06 | 0.04 | blup | 286 | 0.04 | 2.2e-06 | 3.9 | 5.4 | 7.5e-08 | 0.52 | 0.39 | 0.55 | FALSE |
16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ERI1 | 0.05 | 0.01 | blup | 72 | 0.01 | 5.0e-02 | 5.6 | -5.2 | 1.6e-07 | -0.37 | 0.00 | 0.87 | FALSE |
17 | The Cancer Genome Atlas | Lung Adenocarcinoma | ERI1 | 0.06 | 0.04 | blup | 72 | 0.04 | 1.5e-05 | 5.3 | -5.2 | 1.6e-07 | -0.45 | 0.01 | 0.99 | FALSE |