Hub : Genes

MFHAS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.3410	0.0720	2.0e-08	0.232	NA	0.191	NA	0.153	8.6e-11	NA	5.7e-09	NA	2.2e-07
2	GTEx	Heart Left Ventricle	0.1468	0.0542	2.7e-03	-0.005	NA	0.000	NA	0.003	9.9e-01	NA	3.4e-01	NA	2.2e-01
3	GTEx	Muscle Skeletal	0.0692	0.0318	3.6e-04	0.036	NA	0.024	NA	0.037	1.8e-04	NA	1.7e-03	NA	1.4e-04
4	NTR	Blood	0.0207	0.0093	7.7e-05	0.014	0.010	0.006	0.009	0.007	2.2e-05	2.9e-04	3.2e-03	5.1e-04	1.5e-03
5	YFS	Blood	0.0601	0.0144	6.2e-09	0.015	0.025	0.033	0.029	0.029	6.2e-06	9.9e-09	4.3e-11	6.2e-10	5.7e-10
6	TCGA	Pheochromocytoma and Paraganglioma	0.1600	0.0730	1.4e-03	0.007	0.080	0.013	NA	0.017	1.6e-01	4.3e-04	9.6e-02	NA	6.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	2.1	-0.1	0.2	0.6	1.4	0.4	0.6
Bipolar Disorder or Schizophrenia	1.9	4.6	10.6	2.2	1.7	3.2	2.9	0.3	-0.9
Depressed Affect (Nagel 2018)	0.6	1.4	2.8	-0.3	-1.0	-1.4	-1.7	-1.2	0.9
Depression (Nagel 2018)	0.7	1.0	3.4	0.1	0.1	-1.8	-1.1	-0.4	1.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.8	-0.9	-1.9	-1.8	-1.1	1.1	1.2
Neuroticism (Nagel 2018)	1.1	2.5	5.0	0.3	-0.3	-2.0	-2.2	-1.9	1.5
Schizophrenia (2018)	2.8	5.8	13.9	2.8	2.1	3.7	2.6	-0.1	-1.6
Schizophrenia vs Biploar Disorder	1.2	1.6	3.7	1.7	1.1	1.9	0.6	0.3	-1.2
Worry (Nagel 2018)	1.2	2.4	7.3	0.6	0.1	-2.0	-1.6	-2.7	0.7
Alzheimer’s Disease (in mother)	1.5	1.8	5.7	1.4	0.7	0.2	1.0	-2.4	-1.3
Alzheimer’s Disease (in father)	0.3	0.4	1.8	0.4	0.3	0.2	0.0	-0.3	-1.3
Alzheimer’s Disease (including proxy)	1.1	1.6	5.0	1.3	1.1	-0.1	0.3	-2.2	-1.4
Crohns Disease (2017)	0.5	1.2	4.1	2.0	-0.3	0.6	-0.0	-0.5	1.5
Irritable Bowel Disease (IBD)	0.8	1.9	5.2	2.3	0.6	0.6	-0.5	-0.2	2.3
Ulcerative Colitis (UC)	0.6	1.2	3.2	1.8	0.7	0.2	-0.8	0.1	1.7
Major Depression (MDD)	0.6	0.7	1.9	-0.4	0.2	-1.4	-0.8	-0.4	1.1
Reaction Time	0.2	0.4	1.8	0.1	0.3	-0.3	-0.1	0.5	1.3
Verbal and Numeric Reasoning (VNR)	1.3	3.2	7.6	-1.5	-2.8	-2.3	-1.7	0.5	0.9
Breast Cancer	1.4	3.3	8.7	1.0	1.9	1.8	1.8	0.2	-2.9
Ovarian Cancer	1.6	2.1	6.6	0.3	0.0	1.6	1.0	-2.6	-1.6
Prostate Cancer	2.7	3.7	6.2	2.4	2.5	2.0	1.1	-1.1	-1.9
Age at First Birth	1.0	1.4	2.4	-1.3	-1.5	-1.6	-1.2	-0.2	0.8
Bipolar Disorder (2011)	0.4	0.4	1.3	-1.1	-0.4	0.2	0.7	0.0	-0.6
Body Mass Index (BMI) (2010)	3.9	5.3	11.8	2.5	3.4	1.7	1.5	-2.3	-1.9
Coronary Artery Disease (CAD)	0.3	0.4	1.7	0.3	0.1	0.1	-0.3	0.8	1.3
Crohns Disease (2012)	0.8	1.3	5.4	2.3	0.3	0.5	0.3	-1.0	1.1
Mean Putamen Volume	1.2	1.4	2.7	1.7	1.6	0.0	1.4	-0.3	-0.8
Fasting Glucose	0.1	0.1	0.3	-0.5	0.1	0.4	0.5	0.2	-0.3
HbA1C	2.1	2.4	6.0	2.4	1.5	2.0	1.4	0.4	-0.2
HDL Cholesterol	0.7	1.2	3.3	0.8	0.5	-0.5	-1.1	-1.8	-1.3
LDL Cholesterol	0.8	1.3	4.1	-0.1	0.2	2.0	1.7	0.0	-0.9
Lupus	8.3	12.5	19.2	3.1	4.0	3.7	4.4	-1.0	-3.9
Neuroticism (2016)	17.4	25.1	48.3	-4.1	-4.2	-7.0	-6.9	-0.5	4.5
Primary Biliary Cirrhosis	1.3	1.8	3.3	1.8	1.5	0.5	1.0	-1.7	-1.2
Rheumatoid Arthritis	0.7	1.0	4.1	0.7	2.0	0.0	0.6	-0.9	-0.5
Schizophrenia (2014)	2.3	5.0	13.9	1.7	1.7	3.7	3.0	0.9	-1.0
Triglycerides	4.1	6.7	12.5	-2.4	-2.3	-3.5	-3.3	0.3	2.3
Type 2 Diabetes (T2D) (2012)	2.2	2.5	6.2	0.6	1.4	1.1	1.6	-1.6	-2.5
Ulcerative Colitis	0.7	1.1	2.9	0.2	0.5	-0.9	-1.4	-0.7	1.7
Blood Eosinophil Count	0.1	1.0	2.2	-1.0	-1.2	1.5	0.1	1.3	0.0
Blood Platelet Count	0.1	1.3	5.6	0.4	-1.1	0.1	0.5	2.4	0.8
Blood Red Count	0.2	2.0	5.7	2.4	1.0	1.9	0.5	-1.1	-0.5
Blood White Count	0.0	0.1	0.4	0.6	0.4	0.3	0.2	0.1	0.3
Heel T-Score	0.1	0.4	1.5	0.2	0.3	0.5	0.2	-0.8	1.2
BMI	0.4	2.3	5.2	2.2	2.0	-0.0	0.2	-2.3	0.4
Height	0.2	4.8	10.6	-1.3	-3.3	-1.4	-3.1	1.5	1.6
Waist Hip Ratio (WHR)	0.0	0.2	0.6	0.2	0.1	0.3	0.4	0.8	-0.4
Systolic Blood Pressure	0.1	0.6	1.9	-0.6	-0.7	0.2	0.3	1.4	0.6
Smoking Status	0.7	1.7	4.3	1.6	0.4	-0.4	-1.4	-2.1	0.9
Allergy or Eczema	0.2	0.5	1.6	0.0	-0.1	-0.7	-0.8	0.5	1.3
Cardiovascular Disease	0.2	0.6	2.7	-1.6	-0.5	-0.3	-0.3	-0.6	0.3
Hypothyroidism (self reported)	0.2	0.5	1.4	-0.8	-0.5	0.3	-0.7	0.6	1.2
Respiratory disease	0.3	0.7	1.2	-0.5	0.2	0.7	0.9	-1.1	-1.1
Type 2 Diabetes (T2D) (2018)	1.0	2.0	6.3	0.9	0.7	-0.9	-1.6	-2.5	1.0
Lung FEV1/FVC ratio	0.8	4.0	9.4	3.1	2.3	0.0	-1.3	-2.6	1.0
Lung FVC	0.3	1.6	2.9	1.2	-0.0	-1.0	-1.7	-1.4	1.5
Neuroticism	0.3	0.8	2.0	1.0	0.5	-1.0	-0.5	-1.4	0.3
Chronotype (morning person)	0.1	0.2	1.0	0.0	0.2	1.0	-0.0	-0.5	-0.1
Hair Pigment	0.0	1.1	3.2	-1.0	-0.0	-0.7	-0.7	-1.1	1.8
Tanning	0.1	1.2	3.6	-1.3	-1.9	-0.6	0.6	0.7	1.0
Hand grip strength (left)	1.5	3.9	7.3	2.7	1.7	0.4	1.2	-2.0	-2.7
Number of treatments/medications taken	1.1	1.9	5.6	1.5	0.9	1.3	0.7	-2.4	-0.7
Average weekly spirits intake	0.5	0.6	1.9	-0.4	-0.6	-1.4	-0.9	-0.6	0.2
Sensitivity / hurt feelings	8.6	14.7	31.7	-3.0	-1.9	-5.3	-5.6	-2.9	2.6
Frequency of depressed mood in last 2 weeks	4.0	5.5	13.4	-2.3	-1.5	-3.7	-3.1	-0.4	1.7
Hearing difficulty/problems: Yes	0.8	1.2	3.2	-0.9	0.0	-1.3	-1.2	-0.4	1.8
Relative age of first facial hair	0.1	0.2	0.6	-0.4	0.8	-0.6	-0.1	0.2	-0.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.2	0.6	0.5	0.1	-1.0	-1.1	1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	4.2	0.5	0.6	1.0	2.0	0.9	-0.2
Ever had hysterectomy (womb removed)	2.8	3.1	7.2	0.5	0.5	2.7	2.7	1.2	-1.5
Systolic blood pressure, automated reading	7.5	21.8	36.4	4.6	4.9	5.7	6.0	-0.3	-4.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.4	0.0	-1.0	-0.0	-0.1	-0.5	1.5
Angina	0.7	1.0	2.0	0.4	1.0	0.8	0.8	-1.4	-1.1
Medication for hormone replacement therapy	1.0	1.1	3.9	0.6	0.6	1.3	2.0	0.4	-0.1
Vitamin and mineral supplements	0.9	1.2	3.7	-1.1	-0.3	-1.4	-1.9	-0.1	0.8
Supplements: Zinc	1.6	1.7	5.2	0.9	0.3	2.3	1.9	0.7	-0.5
Medication: Co-codamol	1.5	1.8	3.8	1.9	1.1	1.8	1.3	-0.5	-0.7
Medication: Metformin	1.7	2.4	6.1	2.5	1.7	2.0	1.3	-0.3	0.1
Diabetes (father)	2.9	3.7	5.4	2.1	1.7	2.3	2.3	-1.1	-1.7
Diabetes (mother)	0.7	0.8	2.5	-0.3	0.9	0.8	1.6	1.0	0.3
Severe depression (siblings)	0.9	1.0	1.9	1.4	0.9	0.7	0.5	-0.9	-1.4
Pack years adult smoking proportion	2.3	3.5	7.9	2.8	1.2	2.0	2.0	-0.5	-1.8
Impedance of leg (right)	6.4	30.8	66.7	-5.1	-4.3	-8.2	-7.7	-2.0	3.1
Leg fat-free mass (left)	2.4	12.7	27.9	4.2	2.8	5.3	4.3	0.5	-1.9
Trunk fat percentage	1.5	5.9	12.6	3.6	2.4	2.4	2.4	-1.8	-1.4
Hand grip strength (right)	0.9	2.6	6.6	2.6	1.4	0.7	0.7	-1.8	-1.6
Townsend deprivation index at recruitment	0.7	1.0	4.4	0.6	-0.1	0.3	0.0	2.1	1.2
Current tobacco smoking	6.8	11.2	18.9	3.8	2.8	4.3	3.9	-1.4	-2.9
Average weekly fortified wine intake	1.6	1.9	4.6	-0.9	-2.1	-1.8	-1.3	-0.7	0.8
Maternal smoking around birth	0.8	1.1	3.3	-1.8	-0.8	-0.6	-1.1	-0.3	1.0
Fed-up feelings	8.0	14.5	29.4	-3.1	-3.2	-4.8	-5.4	-1.6	3.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.4	6.7	0.1	-1.0	-2.6	-2.5	-0.1	2.5
Relative age voice broke	0.7	1.0	2.1	-1.0	-0.1	-1.5	-1.3	-0.3	1.1
Taking other prescription medications	0.7	1.0	4.0	1.2	0.7	-0.0	0.2	-2.0	-0.5
Age when periods started (menarche)	1.3	3.2	6.4	-2.5	-1.5	-1.7	-2.5	0.3	1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.7	0.8	0.6	1.6	1.3	0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	16.3	36.9	64.4	6.5	5.5	8.0	8.0	-0.9	-4.3
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	7.1	2.0	2.7	1.2	1.5	-0.8	-0.8
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.1	-0.5	0.2	-0.2	-0.2	-0.3
Serious illness, injury or assault to yourself	1.3	1.6	3.0	-1.3	-1.4	-1.7	-1.6	-0.4	0.5
High blood pressure	6.3	17.6	35.7	3.4	3.5	6.0	5.6	-0.7	-3.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.8	-0.2	-0.1	-0.4	-0.6	1.0	1.3
Multivitamins +/- minerals	0.3	0.4	2.1	0.1	-0.0	0.5	1.4	0.4	-0.3
Stomach or abdominal pain in last month	2.4	3.0	6.5	-0.6	-0.1	-2.3	-2.4	-2.5	0.5
Supplements: Glucosamine	0.2	0.2	0.7	0.3	-0.6	-0.9	-0.0	-0.4	-0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.6	-0.2	0.0	0.1	0.0	0.0	1.3
Medication: Atenolol	2.0	2.5	6.0	1.5	1.1	2.2	2.5	0.6	-0.0
Medication: Levothyroxine sodium	7.8	13.3	24.2	-2.9	-3.2	-4.5	-4.9	-0.8	4.0
Sitting height	0.6	4.0	12.5	0.6	-2.0	3.5	1.6	2.0	-0.8
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	-0.2	0.2	1.4	0.6	1.4	0.1
High blood pressure (mother)	2.1	2.9	8.0	-0.4	-0.1	2.5	2.8	1.7	-0.8
Body mass index (BMI)	8.2	34.9	55.8	7.1	6.2	7.2	7.5	-0.7	-3.7
Impedance of leg (left)	7.4	35.7	76.4	-5.4	-4.7	-8.7	-8.3	-2.6	3.2
Leg predicted mass (left)	2.4	12.7	28.2	4.2	2.8	5.3	4.3	0.5	-1.8
Trunk fat mass	1.8	7.9	16.5	4.1	2.7	3.2	2.9	-1.5	-1.5
Waist circumference	1.0	3.5	9.1	3.0	2.1	1.7	1.8	-0.9	-0.8
Number of incorrect matches in round	0.2	0.3	0.7	0.9	0.4	-0.5	-0.6	0.4	0.4
Past tobacco smoking	2.5	4.6	7.2	-2.7	-2.4	-1.5	-1.0	2.5	2.3
Alcohol usually taken with meals	1.0	1.6	3.7	-0.5	-0.7	1.9	1.8	0.8	-1.0
Nervous feelings	13.3	24.8	54.1	-3.8	-3.7	-6.8	-7.4	-1.6	4.2
Frequency of tenseness / restlessness in last 2 weeks	3.5	5.5	12.1	-2.1	-1.3	-3.1	-3.5	0.1	2.3
Hearing difficulty/problems with background noise	0.8	1.2	3.0	-0.7	0.3	-1.7	-1.0	-1.0	1.5
Hair/balding pattern: Pattern 2	1.8	2.2	4.2	-0.2	0.9	1.9	2.1	-0.7	-2.1
Had menopause	1.0	1.3	2.4	1.1	1.1	0.8	1.5	-0.6	-1.5
Had other major operations	0.6	0.7	1.5	0.2	1.0	0.7	1.2	1.0	-0.2
Forced vital capacity (FVC)	1.9	7.2	17.9	-2.5	-2.7	-2.8	-4.2	-0.3	2.0
Heel bone mineral density (BMD) T-score, automated (right)	19.0	43.5	64.0	7.3	7.0	8.0	8.0	-1.6	-5.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	-0.7	-1.1	-0.5	-0.8	-0.3	0.5
Qualifications: None of the above	0.4	0.8	1.5	0.7	1.2	1.1	0.9	-0.7	0.2
Financial difficulties in last 2 years	1.0	1.4	3.6	1.9	0.8	1.0	-0.4	-1.5	-0.7
Mouth/teeth dental problems	4.7	7.2	10.3	-2.8	-2.6	-3.2	-3.0	1.2	2.9
Heart attack	1.2	1.5	5.8	-0.1	0.9	0.5	-0.4	-2.4	-1.4
Allergy	0.6	1.4	2.7	-0.8	-1.0	-1.7	-1.6	-0.7	0.9
Pain all over the body in last month	1.2	1.3	4.0	1.6	2.0	0.9	0.3	0.5	-0.2
Diabetes (self-reported)	1.0	1.6	3.3	1.8	1.2	1.6	0.7	-1.3	-0.4
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	7.9	-2.8	-1.6	-2.2	-1.3	1.1	1.5
Medication: Ramipril	2.3	2.9	7.0	2.6	1.5	2.4	1.6	0.3	-0.4
Medication: Simvastatin	0.9	1.3	2.9	1.1	1.1	1.5	0.7	-1.7	-0.0
Fluid intelligence score	1.3	2.7	6.7	-0.6	-2.6	-2.2	-1.7	0.3	1.0
Illnesses of siblings	1.6	2.3	4.2	-1.5	-1.2	-1.7	-1.6	0.7	2.0
Neuroticism score	17.9	37.2	75.2	-4.8	-5.0	-8.1	-8.7	-1.8	5.7
Weight	2.6	12.8	22.8	4.8	3.6	4.5	4.0	-0.5	-2.1
Impedance of arm (right)	8.1	37.9	67.5	-6.1	-6.7	-7.9	-8.2	-0.4	3.9
Arm fat percentage (right)	4.5	17.9	31.7	5.6	4.2	4.9	4.9	-1.5	-2.7
Trunk fat-free mass	0.9	5.1	12.5	2.6	1.9	3.5	2.5	0.6	-1.2
Hip circumference	2.4	10.5	20.3	4.5	3.2	3.9	3.7	-0.9	-1.7
Time employed in main current job	2.6	3.0	4.3	-1.5	-2.1	-2.0	-2.0	-1.8	0.7
Alcohol intake versus 10 years previously	1.4	2.1	6.0	1.3	1.0	-1.4	-1.1	-2.5	-1.0
Father’s age at death	6.9	9.3	16.1	-3.6	-3.3	-4.0	-3.1	0.9	2.4
Worrier / anxious feelings	21.1	39.9	79.7	-5.2	-5.2	-8.9	-8.7	-2.0	5.1
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	6.2	-1.1	-0.9	-2.4	-2.5	-0.5	2.1
Falls in the last year	0.7	0.9	2.1	0.7	1.4	0.1	0.5	-1.4	-0.6
Hair/balding pattern: Pattern 3	0.4	0.7	1.2	-0.5	-0.7	-1.1	-1.0	-0.2	0.9
Number of live births	0.5	0.6	2.3	-1.1	0.1	0.2	0.5	0.2	1.5
Forced expiratory volume in 1-second (FEV1)	3.5	12.0	31.8	-2.5	-2.6	-4.3	-5.6	-1.4	2.5
Pulse rate	1.2	2.1	4.2	-0.9	-2.0	-1.3	-1.7	1.2	1.2
Happiness	0.3	0.4	0.7	0.4	-0.7	0.4	-0.3	-0.8	-0.8
Noisy workplace	1.6	1.9	4.3	-0.6	0.8	-1.6	-0.5	-1.9	-2.1
Qualifications: A levels/AS levels or equivalent	4.0	8.9	16.0	-4.0	-3.5	-3.2	-2.4	2.5	1.6
Serious illness, injury or assault of a close relative in last 2 years	3.9	4.4	7.2	-2.7	-2.2	-2.1	-1.6	1.7	2.2
Mouth/teeth dental problems: Dentures	6.6	11.1	16.6	3.5	2.5	4.1	3.9	-1.4	-3.8
Asthma	1.4	2.7	6.3	0.3	0.5	2.4	2.5	1.0	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	-0.7	-0.5	-1.0	-1.0	-0.4	1.0
Medication: Cholesterol lowering	0.8	1.2	2.9	0.6	1.3	1.4	0.2	-1.7	-0.4
Depression (self-reported)	1.3	1.6	4.8	-0.9	-0.7	-2.2	-1.5	-0.9	0.7
Medication: Lansoprazole	0.6	0.7	2.5	-0.3	-0.9	0.0	0.2	-1.6	-0.7
Prospective memory result	0.4	0.5	2.1	0.3	0.5	-0.2	-0.7	-1.4	-0.5
Lung cancer (father)	0.2	0.2	0.5	-0.1	-0.6	0.4	0.7	0.2	0.3
Illnesses of mother	0.6	0.8	1.6	0.7	-1.1	-0.6	-1.0	0.1	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.3	10.6	27.6	-1.9	-2.3	-4.3	-5.3	-1.0	2.8
Pulse wave Arterial Stiffness index	1.7	1.9	4.3	1.6	0.6	1.0	2.1	-0.9	-1.6
Impedance of arm (left)	8.1	37.4	63.4	-6.2	-6.7	-7.8	-8.0	0.1	4.1
Arm fat mass (right)	4.7	19.5	31.1	5.6	4.3	5.5	5.5	-0.7	-2.7
Trunk predicted mass	0.9	5.1	12.6	2.6	1.9	3.6	2.5	0.6	-1.2
Standing height	2.1	20.5	44.1	-4.4	-5.1	-4.9	-6.6	0.7	3.1
Length of working week for main job	2.6	2.8	5.5	1.9	2.1	0.7	1.0	-1.6	-2.3
Exposure to tobacco smoke at home	1.0	1.2	3.2	1.2	0.8	0.7	0.3	1.1	1.8
Breastfed as a baby	2.1	2.7	4.1	-1.4	-1.7	-1.5	-2.0	1.1	1.8
Tense / ‘highly strung’	7.3	12.1	29.6	-1.2	-1.7	-4.9	-5.4	-1.5	3.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	7.5	-0.9	-0.5	-2.7	-2.3	-1.4	0.8
Hair/balding pattern: Pattern 4	0.6	1.5	3.8	-0.8	-0.6	-0.6	-0.4	1.9	2.0
Birth weight of first child	0.6	1.0	2.3	1.0	-0.8	-0.7	-1.1	-0.6	1.5
Peak expiratory flow (PEF)	6.4	14.9	36.5	-2.6	-1.9	-5.6	-6.0	-2.6	2.0
Pulse wave reflection index	3.8	4.7	8.7	1.6	2.2	1.1	2.8	-1.7	-2.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.3	-1.5	-1.2	-1.3	-1.0	-1.1	-0.1
Loud music exposure frequency	0.5	0.6	1.9	-0.6	-0.1	-0.2	1.0	1.4	-0.2
Qualifications: O levels/GCSEs or equivalent	5.7	9.1	16.7	-2.6	-3.1	-4.0	-4.1	0.7	2.3
Mouth/teeth dental problems: Bleeding gums	3.4	4.4	9.6	1.7	3.1	2.1	2.6	-0.3	-1.6
Blood clot in the leg (DVT)	4.3	5.6	11.7	1.0	2.0	3.3	3.4	0.5	-2.4
Medication: Paracetamol	0.9	1.4	4.6	0.3	0.9	-1.5	-2.1	-0.6	0.7
Headache pain in last month	4.2	7.1	18.4	-2.3	-1.3	-4.3	-3.7	-0.8	1.8
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	6.8	-1.0	-1.1	-2.6	-1.5	0.9	1.0
Glaucoma (self-reported)	0.5	0.5	2.0	0.8	0.6	-0.1	0.0	-1.4	-0.5
Gout (self-reported)	0.9	1.3	5.0	1.0	2.2	0.5	0.7	-0.8	-0.7
Hypothyroidism/myxoedema (self-reported)	11.6	22.6	39.9	-4.5	-4.5	-5.4	-6.3	0.3	5.1
Medication: Amlodipine	2.8	4.0	9.8	2.1	2.2	3.1	1.7	-1.2	-0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.3	0.6	0.6	1.5	0.7	0.0	-1.2
Birth weight	0.7	1.5	3.4	1.0	1.1	1.3	1.0	-1.0	-1.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.2	0.9	0.0	-0.4	-0.2	-0.9
High blood pressure (siblings)	2.0	2.9	4.8	2.2	1.7	1.9	1.1	-1.2	-1.9
Forced vital capacity (FVC), Best measure	1.1	4.2	11.8	-1.4	-1.8	-2.4	-3.4	-0.4	1.4
Body fat percentage	2.6	10.2	20.4	4.5	3.4	3.3	3.4	-1.9	-1.9
Leg fat percentage (right)	4.7	17.2	34.7	5.9	4.9	3.9	4.2	-2.2	-2.6
Arm fat-free mass (right)	1.9	9.5	19.3	3.5	3.0	4.4	3.6	0.0	-1.8
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.0	-0.3	-0.4	-0.6	0.8	1.1
Comparative body size at age 10	8.4	23.1	43.5	5.4	4.4	6.1	6.6	0.7	-3.0
Number of full brothers	2.1	2.7	5.1	0.3	1.7	2.3	2.2	1.4	-1.0
Worry too long after embarrassment	10.9	18.3	36.1	-3.4	-3.0	-6.0	-5.9	-0.5	4.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.7	-0.8	-0.1	-0.8	-0.2	0.7	0.5
Wheeze or whistling in the chest in last year	3.9	7.0	10.3	2.7	2.3	2.9	3.2	-0.8	-3.2
Number of children fathered	1.6	1.8	4.9	0.9	0.4	0.6	1.1	-2.2	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.5	-1.1	-1.6	-0.7	-1.1	0.7	1.4
Age at first live birth	4.6	8.2	14.0	-3.0	-3.4	-3.4	-3.7	0.6	1.5
Pulse wave peak to peak time	2.6	3.0	6.1	-2.1	-1.2	-1.4	-2.5	1.0	1.9
Health satisfaction	1.9	2.5	7.7	0.7	0.5	2.8	2.1	1.4	-0.5
Shortness of breath walking on level ground	1.5	1.7	4.4	0.4	0.4	2.1	1.9	0.7	-1.3
Qualifications: College or University degree	1.2	3.9	8.1	-2.2	-2.9	-1.2	-0.9	2.6	1.2
Eye problems/disorders: None of the above	1.4	1.6	6.8	-2.6	-0.5	-1.1	-0.6	0.8	-0.7
Mouth/teeth dental problems: Loose teeth	6.1	7.2	11.0	3.3	3.1	2.1	2.4	-1.1	-3.3
Emphysema/chronic bronchitis	6.4	7.2	11.0	3.3	2.5	2.9	3.2	-0.9	-2.5
Medication for pain relief, constipation, heartburn	0.9	1.6	5.2	-0.9	-1.2	0.5	1.1	2.3	-0.6
Neck or shoulder pain in last month	0.4	0.5	1.4	-0.9	-0.1	-0.7	-0.6	0.0	1.2
Medication: Blood pressure	2.7	4.7	15.3	1.3	1.3	3.9	2.9	0.5	-1.1
Angina (self-reported)	0.9	1.1	2.2	0.4	1.1	0.9	0.9	-1.5	-1.3
Migraine (self-reported)	0.4	0.5	1.5	-0.1	0.7	-1.2	-0.7	-0.7	0.4
Medication: Ibuprofen	0.4	0.5	1.0	-0.6	-0.5	-1.0	-0.7	-0.9	0.4
Medication: Allopurinol	1.0	1.3	3.9	1.3	2.0	1.2	1.0	0.0	-0.4
Medication: Omeprazole	1.5	1.8	5.6	1.9	0.8	0.9	0.1	-2.4	0.3
Medication: Seretide 50 evohaler	0.6	0.7	2.4	-0.1	0.1	0.6	1.3	1.5	0.3
Mean time to correctly identify matches	0.3	0.6	2.2	0.6	1.5	0.5	0.6	0.6	0.5
Heart disease (mother)	0.4	0.5	1.1	-1.0	0.2	-0.7	-0.1	-0.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	5.3	-2.3	-2.0	-2.3	-2.0	0.4	0.4
Whole body fat mass	2.9	12.1	21.5	4.6	3.4	4.2	4.1	-1.2	-2.0
Leg fat mass (right)	5.2	20.0	35.0	5.9	4.8	5.1	5.1	-1.6	-2.7
Arm predicted mass (right)	2.2	11.1	21.1	3.9	3.5	4.6	3.8	-0.2	-1.9
Pulse rate, automated reading	0.4	1.4	3.8	1.0	0.3	1.0	0.4	-2.0	-1.5
Alcohol intake frequency.	0.3	0.8	2.6	0.4	0.8	-0.4	-1.0	-1.6	0.0
Comparative height size at age 10	0.1	0.6	2.2	1.5	0.7	0.5	-0.1	0.4	-0.8
Number of full sisters	3.0	3.6	5.9	2.4	2.3	2.0	1.9	-0.8	-1.6
Suffer from ‘nerves’	7.8	12.3	32.6	-2.1	-1.9	-4.4	-5.7	-1.8	3.2
Overall health rating	3.3	7.2	11.2	3.1	2.6	3.3	3.2	-0.6	-2.2
Chest pain or discomfort	0.2	0.3	1.3	0.5	0.1	-0.3	0.1	-1.2	-0.1
Had major operations	0.7	0.9	3.3	-0.0	0.8	-0.9	-0.4	-1.8	-0.5
Age at last live birth	6.1	8.8	15.8	-3.1	-3.2	-3.7	-4.0	-0.5	1.9
Family relationship satisfaction	0.3	0.4	1.0	-0.6	-0.5	-0.2	0.6	0.3	-1.0
Leg pain on walking	0.9	1.2	3.5	1.0	1.1	1.9	0.7	-0.8	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.9	1.3	1.4	0.1	-0.3	-0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.8	0.6	0.3	0.9	0.7	-2.0	0.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.5	1.6	1.5	0.8	1.3	-1.0	-1.1
Medication: Aspirin	3.9	5.1	8.3	2.2	2.9	2.4	2.6	-1.3	-1.8
Supplements: Vitamin C	2.7	3.2	6.6	1.4	1.2	1.9	2.0	-1.2	-2.6
Knee pain experienced in last month	0.8	1.2	3.2	1.5	0.8	1.8	0.9	0.4	0.5
Hypertension (Self-reported)	6.8	18.8	37.6	3.6	3.6	6.1	5.9	-0.7	-3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	0.5	-1.0	-0.2	-1.3	-0.3	0.8
Illnesses of father: Heart disease	0.4	0.6	1.7	-1.3	-0.1	-0.8	-0.3	0.8	-0.7
Illnesses of siblings: Diabetes	1.2	1.5	4.4	0.4	0.6	1.5	2.1	1.2	-0.5
Smoking status: Previous	0.6	0.9	2.5	1.6	0.9	0.2	0.0	-1.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	8.8	-1.3	-1.7	-2.2	-3.0	-1.1	-0.1
Whole body fat-free mass	1.5	8.7	19.8	3.4	2.5	4.5	3.4	0.5	-1.6
Leg fat-free mass (right)	2.0	10.9	25.5	3.9	2.5	5.1	4.0	0.5	-1.7
Arm fat percentage (left)	4.3	17.0	29.1	5.4	4.1	5.0	4.9	-1.0	-2.3
Average weekly red wine intake	1.7	2.4	8.5	0.2	0.5	1.2	2.9	0.3	-2.1
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.3	-0.9	0.0	-0.2	0.6	0.0	-1.1
Mood swings	5.9	10.7	20.1	-2.9	-3.4	-4.0	-4.5	-0.1	2.9
Loneliness, isolation	1.1	1.5	3.8	-0.4	-0.3	-1.4	-1.7	0.3	1.9
Long-standing illness, disability or infirmity	0.4	0.5	1.2	1.1	0.6	0.4	-0.4	-1.0	0.5
Ever had bowel cancer screening	1.8	2.1	4.8	-0.7	-0.6	-2.2	-2.2	-1.1	1.0
Diabetes diagnosed by doctor	1.6	2.6	4.2	2.0	1.9	1.7	1.0	-1.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	5.7	1.1	1.0	2.4	1.5	-0.9	-1.3
Friendships satisfaction	0.6	0.8	2.6	0.5	0.6	-0.3	0.3	-1.6	-1.1
Qualifications: nursing, teaching	1.0	1.6	2.9	-1.6	-1.7	-1.3	-1.4	0.5	0.3
Commuting to job workplace: Walk	1.1	1.2	6.2	-0.7	-0.0	0.5	0.2	2.5	0.5
Eye problems/disorders: Cataract	0.3	0.3	1.0	1.0	-0.1	0.3	0.1	-0.3	0.9
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.6	-1.4	-1.1	-1.5	-1.9	0.6	1.8
Medication for cholesterol	4.8	7.2	14.0	-2.8	-2.5	-3.7	-3.2	1.3	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.4	0.2	1.5	-0.4	-0.7	-0.1	0.7
Back pain experienced in last month	1.0	1.5	4.4	1.4	0.4	0.2	-1.3	-2.1	0.8
Mineral and other dietary supplements	3.3	4.4	10.9	-1.8	-0.3	-2.9	-3.3	-0.5	1.8
Breast cancer (self-reported)	0.5	0.5	1.5	0.3	-0.8	-0.7	-0.1	1.2	0.7
Asthma (self-reported)	1.6	3.1	7.2	0.6	0.7	2.7	2.6	0.9	-1.7
Osteoporosis (self-reported)	3.3	4.1	6.3	-2.5	-2.0	-2.5	-2.4	0.8	1.4
Osteoarthritis (self-reported)	1.0	1.4	2.1	0.3	1.1	1.4	1.3	-1.1	-1.5
Medication: Aspirin	4.2	5.5	10.4	2.3	3.2	2.5	2.5	-1.8	-1.5
Medication: Gliclazide	0.3	0.3	0.9	-0.2	0.4	0.9	0.8	-0.5	-0.2
Illnesses of father: None of the above (group 1)	1.0	1.2	2.6	0.6	-0.1	-1.6	-1.3	-1.1	1.3
Smoking status: Current	6.6	10.4	18.6	3.7	2.9	4.3	3.7	-1.1	-2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.9	12.8	-1.0	-1.7	-3.3	-3.6	-1.1	2.5
Whole body water mass	1.5	8.6	19.5	3.4	2.5	4.4	3.4	0.5	-1.6
Leg predicted mass (right)	2.0	10.9	24.9	3.9	2.5	5.0	3.9	0.4	-1.7
Arm fat mass (left)	4.5	18.7	29.4	5.4	4.3	5.4	5.3	-0.7	-2.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.1	-0.4	0.2	-0.6	-0.7	-0.2
Average weekly champagne plus white wine intake	0.6	0.8	1.7	-0.4	-0.3	1.3	1.0	1.3	-0.6
Miserableness	10.1	17.6	32.1	-4.3	-3.6	-5.5	-5.7	-1.5	3.0
Guilty feelings	8.8	13.2	20.7	-3.4	-3.8	-4.0	-4.6	1.0	3.9
Wears glasses or contact lenses	0.6	0.7	2.3	-1.5	-0.3	-1.3	-0.5	-0.2	-0.1
Ever taken oral contraceptive pill	0.7	0.8	1.7	-0.8	-0.4	-0.8	-1.3	1.2	0.5
Hearing aid user	0.1	0.1	0.3	-0.6	-0.0	-0.0	0.3	-0.2	-0.3
Mother’s age at death	1.1	1.4	3.5	-1.1	-1.0	-1.6	-1.9	0.1	0.5
Financial situation satisfaction	0.2	0.3	0.8	0.3	-0.1	0.7	-0.2	-0.4	-0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.5	0.5	-0.2	-1.1	-1.9	-0.5	0.4
Commuting to job workplace: Public transport	3.0	3.6	6.8	-2.6	-2.1	-2.3	-1.9	1.2	-0.4
Eye problems/disorders: Glaucoma	1.2	1.5	2.6	1.6	0.7	0.8	1.3	-1.4	-1.1
Medication: Blood pressure	8.0	15.2	30.8	4.1	2.9	5.5	4.7	-0.8	-3.4
Pain type(s) experienced in last month: Hip pain	2.5	3.1	6.1	2.5	2.1	2.2	1.4	-0.9	-1.0
Supplements: Fish oil (including cod liver oil)	5.2	6.8	11.5	3.2	1.9	3.0	3.4	-0.7	-2.5
High cholesterol (Self-reported)	1.6	2.8	4.3	1.2	1.9	2.1	1.2	-1.3	-2.0
Medication: Bendroflumethiazide	8.8	13.3	28.2	4.3	3.2	5.3	4.0	-0.9	-2.6
Medication: Paracetamol	0.7	1.0	2.9	0.7	1.1	-0.9	-1.7	-0.7	0.4
Medication: Lisinopril	1.9	2.4	4.5	1.4	1.4	1.8	2.1	-0.8	-1.4
Medication: Atorvastatin	0.7	0.9	1.6	0.2	1.0	0.7	1.0	-1.1	-1.3
Illnesses of father: High blood pressure	1.4	1.8	4.1	1.5	1.4	2.0	1.5	0.1	0.1
Alcohol drinker status: Never	2.3	2.7	3.7	-1.9	-1.8	-1.4	-1.9	0.7	1.9
Ever smoked	2.2	3.9	9.0	2.1	2.2	0.9	0.1	-3.0	-2.1
Basal metabolic rate	1.8	10.0	20.6	3.9	2.8	4.5	3.6	0.2	-1.8
Leg fat percentage (left)	4.7	17.0	34.1	5.8	4.7	3.9	4.2	-2.5	-2.7
Arm fat-free mass (left)	2.1	10.7	19.3	3.9	3.2	4.4	3.7	-0.3	-2.3
Number of operations (self-reported)	1.8	2.6	4.1	1.2	1.8	1.9	2.0	-0.3	-1.8
Average weekly beer plus cider intake	5.2	7.6	22.8	-2.1	-1.3	-3.4	-4.8	-0.8	2.0
Irritability	16.2	27.3	64.0	-3.7	-3.2	-7.4	-8.0	-2.1	4.2
Risk taking	8.1	11.9	15.7	3.8	3.3	3.5	3.8	-2.1	-4.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.3	0.7	-0.6	-0.3	0.2	0.7
Fractured/broken bones in last 5 years	0.6	0.7	1.6	-0.8	-0.4	-1.3	-1.1	0.0	0.8
Age started oral contraceptive pill	3.3	4.1	9.0	-2.3	-3.0	-2.4	-2.2	-0.0	0.3
Diastolic blood pressure, automated reading	9.2	28.6	53.7	4.7	5.3	6.4	7.3	-0.8	-5.1
Ever depressed for a whole week	3.5	4.4	7.9	-2.2	-2.8	-2.4	-2.0	0.5	1.8
Unable to work because of sickness or disability	2.8	3.7	5.8	1.5	2.4	1.8	1.6	-1.8	-2.2
Commuting to job workplace: Cycle	0.6	0.7	1.7	-1.3	-1.0	-0.5	-0.0	0.7	0.7
Myopia	1.7	2.5	7.5	-1.5	-0.7	-2.1	-2.7	-0.1	0.5
Vascular/heart problems diagnosed by doctor	4.9	13.4	29.2	-2.9	-2.9	-5.4	-5.0	0.9	3.0
Cholesterol lowering medication	1.5	2.2	8.1	1.1	1.3	0.7	0.8	-2.8	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.3	1.8	0.8	0.2	-0.6	-2.1	1.2
Pain experienced in last month	0.6	0.9	1.8	-1.3	-1.1	0.2	1.0	0.5	-1.2
Supplements: Calcium	1.0	1.1	2.4	-1.4	-1.6	-0.3	-0.9	-0.2	1.0
Basal cell carcinoma (self-reported)	0.4	0.5	2.2	0.2	0.2	0.6	-0.1	1.5	0.7
Heart attack/myocardial infarction (self-reported)	1.5	1.9	7.2	0.1	1.2	0.5	-0.4	-2.7	-1.5
Deep venous thrombosis (DVT) (self-reported)	4.3	5.6	12.0	1.1	1.6	3.5	3.4	0.6	-2.4
Heart disease (siblings)	0.2	0.2	0.7	0.7	0.1	-0.2	0.2	-0.4	-0.8
Alcohol drinker status: Previous	0.7	0.8	2.2	0.9	1.5	-0.1	-0.6	-0.9	-0.3
Pack years of smoking	1.9	2.8	6.8	2.6	1.1	1.6	1.7	-0.6	-1.8
Impedance of whole body	8.1	41.3	77.3	-6.3	-6.2	-8.8	-8.7	-1.4	3.8
Leg fat mass (left)	5.0	19.6	34.1	5.8	4.7	5.0	5.0	-1.8	-2.7
Arm predicted mass (left)	2.3	11.6	20.6	3.9	3.5	4.5	3.9	-0.3	-2.5