Hub : Genes

FAM86B3P

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.227	0.0850	1.1e-06	0.074	NA	0.144	NA	0.073	1.1e-04	NA	6.4e-08	NA	1.2e-04
2	GTEx	Adrenal Gland	0.159	0.0794	9.3e-03	0.003	NA	0.034	NA	0.021	2.4e-01	NA	2.2e-02	NA	5.8e-02
3	GTEx	Brain Cerebellar Hemisphere	0.280	0.0790	1.6e-07	0.274	NA	0.255	NA	0.284	1.0e-07	NA	3.1e-07	NA	5.4e-08
4	GTEx	Brain Cerebellum	0.189	0.0650	8.0e-06	0.140	NA	0.149	NA	0.160	6.4e-05	NA	3.6e-05	NA	1.8e-05
5	GTEx	Brain Cortex	0.136	0.0660	3.0e-03	0.049	NA	0.071	NA	0.045	1.7e-02	NA	5.1e-03	NA	2.2e-02
6	GTEx	Brain Frontal Cortex BA9	0.160	0.0617	2.0e-04	0.134	NA	0.103	NA	0.037	2.2e-04	NA	1.1e-03	NA	3.8e-02
7	GTEx	Cells Transformed fibroblasts	0.228	0.0500	0.0e+00	0.330	NA	0.376	NA	0.378	1.9e-25	NA	1.2e-29	NA	8.5e-30
8	GTEx	Colon Transverse	0.129	0.0630	1.0e-03	0.044	NA	0.039	NA	0.042	3.8e-03	NA	5.7e-03	NA	4.4e-03
9	GTEx	Esophagus Mucosa	0.220	0.0660	3.6e-12	0.172	NA	0.172	NA	0.186	1.4e-11	NA	1.3e-11	NA	1.7e-12
10	GTEx	Pituitary	0.127	0.0520	1.2e-03	0.149	NA	0.110	NA	0.132	1.4e-04	NA	1.1e-03	NA	3.5e-04
11	GTEx	Testis	0.153	0.0480	7.6e-07	0.135	NA	0.104	NA	0.130	1.5e-06	NA	2.4e-05	NA	2.2e-06
12	ROSMAP	Brain Pre-frontal Cortex	0.192	0.0409	0.0e+00	0.273	0.24	0.270	0.272	0.269	4.2e-35	1.7e-30	9.7e-35	5.6e-35	1.7e-34

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	3.2	5.0	9.0	3.0	-1.9	-1.9	-2.4	-2.5	-2.0	1.9	2.0	2.1	-2.7	-2.0	-2.4
Bipolar Disorder or Schizophrenia	7.8	19.0	21.7	4.6	-3.7	-4.4	-4.6	-4.5	-4.1	4.3	4.0	4.4	-4.5	-4.7	-4.3
Depressed Affect (Nagel 2018)	3.2	6.6	11.6	-2.6	1.7	2.9	3.4	2.8	3.0	-2.7	-2.1	-2.6	2.4	2.0	2.3
Depression (Nagel 2018)	1.2	1.8	3.4	-0.6	0.8	1.3	1.7	1.3	1.8	-1.5	-1.2	-1.6	1.9	0.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.4	-0.1	0.7	1.0	0.7	0.5	0.0	-0.6	-1.0	-1.1	1.2	0.5	-0.2
Neuroticism (Nagel 2018)	3.1	7.2	10.4	-2.4	2.4	3.0	3.2	3.0	2.8	-3.0	-2.1	-2.8	2.7	2.1	2.3
Schizophrenia (2018)	7.0	14.6	19.4	3.6	-3.3	-4.1	-4.0	-3.9	-3.7	4.0	3.5	3.9	-3.6	-4.4	-3.7
Schizophrenia vs Biploar Disorder	2.6	3.4	5.5	1.4	-1.5	-1.9	-1.9	-1.7	-1.4	2.2	2.4	2.3	-1.4	-2.2	-1.6
Worry (Nagel 2018)	1.6	3.3	4.8	-1.8	1.5	2.0	1.9	2.2	1.1	-2.1	-1.6	-1.9	1.4	1.9	2.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	0.6	-0.4	-0.7	-0.5	-0.1	-0.6	0.6	0.8	0.7	0.3	-0.6	0.3
Alzheimer’s Disease (in father)	0.3	0.3	1.0	0.2	0.2	0.6	0.5	0.5	-0.5	-0.0	-0.6	-0.1	0.7	0.3	1.0
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	0.7	-0.3	-0.2	-0.1	0.0	-0.5	0.2	0.4	0.6	0.7	-0.5	0.6
Crohns Disease (2017)	0.8	1.8	5.5	0.3	-2.4	-1.4	-1.0	-1.1	-1.8	1.3	0.9	1.5	-0.8	-1.2	-1.0
Irritable Bowel Disease (IBD)	0.2	0.5	2.4	0.4	-1.6	-0.7	-0.3	-0.7	-0.8	0.4	0.5	0.7	-0.3	-0.7	-0.6
Ulcerative Colitis (UC)	0.0	0.1	0.2	0.2	-0.1	0.2	0.4	0.0	0.3	-0.5	-0.1	-0.2	0.2	0.1	0.1
Major Depression (MDD)	0.7	0.9	2.1	-1.0	0.9	1.1	0.7	1.3	0.6	-0.5	-0.4	-0.2	1.2	0.7	1.5
Reaction Time	0.7	1.3	2.9	-0.3	1.0	1.1	1.0	1.6	1.5	-0.9	-0.6	-0.8	1.3	1.2	1.7
Verbal and Numeric Reasoning (VNR)	0.7	1.8	4.4	-1.5	0.2	1.5	1.6	1.1	0.5	-1.4	-2.1	-1.7	1.5	1.2	-0.1
Breast Cancer	2.1	5.0	7.6	2.0	0.6	-2.4	-2.8	-1.9	-2.6	2.7	2.4	2.3	-0.8	-2.6	-2.6
Ovarian Cancer	0.7	0.9	2.3	-0.2	-0.8	-0.6	-0.9	-1.2	-1.3	1.3	1.1	0.5	-0.2	-1.5	-1.0
Prostate Cancer	1.3	1.8	3.0	0.9	-1.5	-1.1	-1.3	-1.6	-1.7	1.5	1.4	1.3	-1.2	-1.3	-0.8
Age at First Birth	1.3	1.8	3.6	-1.0	1.6	1.4	1.5	1.3	0.3	-1.5	-1.4	-1.9	0.9	1.6	1.1
Bipolar Disorder (2011)	0.9	0.9	3.0	1.7	-0.5	-0.8	-1.0	-0.9	-0.4	0.5	0.4	0.6	-1.4	-0.7	-1.1
Body Mass Index (BMI) (2010)	3.8	5.2	8.6	2.1	-0.7	-2.6	-2.6	-2.0	-2.6	2.7	2.9	2.6	-1.9	-2.4	-0.9
Coronary Artery Disease (CAD)	0.1	0.2	0.6	-0.3	0.0	0.7	0.6	0.0	0.2	-0.4	-0.3	-0.3	0.4	0.3	0.7
Crohns Disease (2012)	1.2	1.9	5.6	-0.0	-2.4	-1.3	-1.3	-1.6	-1.5	1.2	1.1	1.5	-0.8	-1.3	-1.6
Mean Putamen Volume	0.9	1.0	6.5	1.1	-2.6	-1.0	-0.6	-0.2	-0.2	0.8	0.7	1.1	-0.3	-1.0	-0.1
Fasting Glucose	1.2	1.5	2.5	1.4	-0.1	-1.6	-0.9	-1.0	-1.5	1.3	0.9	1.5	-1.4	-1.1	-1.0
HbA1C	1.2	1.3	3.5	0.3	0.5	-0.6	-0.8	-1.4	-1.7	1.9	1.4	1.1	-1.0	-1.2	0.2
HDL Cholesterol	1.0	1.7	4.9	-2.2	0.2	1.8	1.2	1.0	1.4	-1.5	-1.1	-1.3	1.2	1.1	0.7
LDL Cholesterol	0.4	0.6	1.2	0.1	0.1	-0.3	-0.9	-1.1	-0.9	0.6	0.8	0.6	-1.1	-0.9	-0.8
Lupus	12.5	18.9	25.4	4.8	-3.6	-5.0	-4.3	-4.1	-4.8	4.2	4.1	4.6	-4.2	-4.9	-3.2
Neuroticism (2016)	26.8	38.6	52.1	-6.1	4.0	7.2	7.1	6.5	6.5	-6.1	-5.9	-6.0	6.7	6.2	5.6
Primary Biliary Cirrhosis	1.2	1.7	3.5	0.7	-1.9	-1.1	-1.1	-1.5	-1.3	0.8	0.7	0.7	-1.3	-1.7	-1.9
Rheumatoid Arthritis	0.2	0.3	0.6	0.5	0.3	-0.6	-0.6	-0.1	-0.6	0.6	0.7	0.5	-0.3	-0.7	0.3
Schizophrenia (2014)	9.9	21.9	25.4	4.7	-3.9	-5.0	-4.9	-4.6	-4.2	4.8	4.5	5.0	-4.9	-5.0	-4.4
Triglycerides	6.1	9.9	14.2	-2.8	2.2	2.9	3.4	3.7	2.3	-3.3	-3.8	-3.3	3.1	3.3	3.2
Type 2 Diabetes (T2D) (2012)	3.9	4.5	8.6	1.1	-1.5	-2.6	-2.0	-2.2	-2.6	2.0	1.6	1.8	-1.5	-2.9	-2.6
Ulcerative Colitis	1.2	1.7	3.4	-0.5	1.2	1.3	1.2	1.3	1.7	-1.8	-1.2	-1.5	1.6	1.1	0.8
Blood Eosinophil Count	0.1	0.5	1.6	0.2	-0.4	1.3	1.1	-0.4	0.5	-0.6	0.2	-1.1	-0.6	-0.1	0.5
Blood Platelet Count	0.0	0.5	1.9	0.6	-0.0	-0.0	-0.2	-0.0	0.1	1.1	0.4	1.4	0.3	1.0	1.4
Blood Red Count	0.1	1.1	9.9	-0.7	-0.5	-0.3	0.4	1.1	0.2	0.4	-0.1	0.5	3.1	-0.5	-0.1
Blood White Count	0.0	0.3	1.6	0.2	-0.3	0.1	0.8	-0.5	-0.4	0.1	0.4	0.1	-1.3	0.2	0.4
Heel T-Score	0.2	1.8	15.4	0.3	-3.9	-1.0	-0.5	-1.0	0.5	1.2	0.4	1.1	-0.8	-0.5	-0.2
BMI	0.1	0.5	3.9	-0.3	-2.0	0.3	0.5	0.4	-0.3	0.1	0.1	-0.5	0.2	-0.5	0.6
Height	0.1	1.1	4.4	0.1	-0.2	0.5	0.8	0.6	0.4	-1.8	-2.1	-1.1	0.9	0.6	-1.4
Waist Hip Ratio (WHR)	0.2	0.8	3.0	-0.7	-1.2	0.9	0.1	-1.7	-1.1	1.0	0.5	0.8	-0.7	-0.4	-0.7
Systolic Blood Pressure	0.3	1.7	3.5	-1.2	1.5	0.4	1.9	0.7	-0.3	-1.4	-1.7	-1.9	0.8	1.4	1.0
Smoking Status	0.9	2.1	4.8	-1.7	-1.4	1.9	2.2	1.2	1.6	-1.6	-1.5	-1.2	1.2	0.3	0.6
Allergy or Eczema	0.4	1.0	3.7	0.6	0.8	0.2	-0.4	-0.4	-0.1	1.2	1.7	1.1	-1.9	-0.1	0.9
Cardiovascular Disease	0.7	2.2	5.1	-0.7	1.0	0.7	2.2	1.4	1.2	-2.3	-2.1	-1.9	1.1	1.1	0.7
Hypothyroidism (self reported)	3.1	7.2	15.0	-2.0	0.8	3.9	3.5	1.9	2.8	-2.6	-2.4	-2.8	1.9	3.2	2.9
Respiratory disease	1.9	4.2	9.1	1.5	-0.9	-2.2	-1.8	-1.9	-1.9	2.1	1.9	2.2	-3.0	-2.1	-2.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.4	-0.6	-1.2	0.4	0.5	-0.3	0.3	-1.1	-0.5	-0.7	0.5	-0.9	-0.9
Lung FEV1/FVC ratio	0.7	3.5	8.0	-1.4	-2.0	0.7	1.7	1.7	0.7	-2.1	-2.8	-2.7	2.8	1.2	0.5
Lung FVC	0.3	1.7	3.8	-0.1	0.2	-1.1	-1.8	-1.2	-1.3	1.7	2.0	1.6	0.2	-1.5	-1.3
Neuroticism	0.3	0.8	1.9	-0.9	1.0	1.0	0.7	1.2	0.9	-0.9	-0.0	-0.5	1.4	0.6	0.6
Chronotype (morning person)	0.9	2.0	5.7	-0.2	-0.1	-1.0	-1.5	-1.9	-2.4	1.5	0.6	1.1	-1.9	-1.3	-1.5
Hair Pigment	0.0	1.4	4.5	-0.3	1.6	1.8	0.5	1.3	0.4	-0.6	-0.5	-0.5	-0.3	1.9	2.1
Tanning	0.2	1.9	5.9	0.2	-1.0	-1.6	-1.6	-1.5	-0.6	1.1	1.2	1.6	-0.1	-1.6	-2.4
Hand grip strength (left)	0.7	1.7	5.6	0.4	-2.4	-1.3	-1.2	-0.7	-2.1	1.2	0.8	1.2	0.4	-1.6	-0.8
Number of treatments/medications taken	0.6	1.0	3.8	0.6	0.6	-0.7	-0.9	-0.7	-1.9	0.8	1.1	0.7	-1.8	-0.6	0.1
Average weekly spirits intake	1.4	1.7	3.0	-1.7	-0.3	1.5	1.2	1.2	1.5	-1.5	-1.4	-1.6	1.1	1.4	0.4
Sensitivity / hurt feelings	15.3	26.1	36.7	-4.8	4.8	5.5	5.2	5.7	4.5	-5.5	-4.8	-5.2	6.1	4.7	4.3
Frequency of depressed mood in last 2 weeks	8.7	12.1	18.2	-2.8	3.1	3.9	3.6	3.4	4.3	-3.8	-3.2	-3.8	3.6	3.3	2.6
Hearing difficulty/problems: Yes	0.5	0.8	2.9	-0.8	1.7	0.7	0.7	0.7	1.5	-0.8	-0.3	-0.6	0.3	0.8	0.7
Relative age of first facial hair	0.1	0.2	0.7	-0.7	0.0	0.4	0.7	0.1	-0.0	-0.6	-0.9	-0.5	0.2	0.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.5	-0.7	1.6	1.1	0.7	0.7	0.6	-0.8	-0.6	-0.8	0.7	0.7	0.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.9	0.2	-1.6	-1.0	-0.5	-0.9	-0.7	1.4	0.5	1.1	-1.7	-0.0	-0.2
Ever had hysterectomy (womb removed)	4.1	4.7	7.3	2.0	-1.3	-2.7	-2.5	-2.4	-1.9	2.4	1.9	2.3	-2.4	-1.9	-1.9
Systolic blood pressure, automated reading	10.7	30.9	42.4	5.0	-3.6	-6.5	-5.6	-6.2	-6.5	5.9	5.5	5.4	-5.4	-5.6	-5.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	-1.1	-0.1	0.9	0.5	0.5	0.8	-0.7	-0.7	-0.7	0.8	0.9	0.7
Angina	0.4	0.5	2.0	0.3	-0.4	-0.5	-0.4	-1.4	-0.7	0.8	0.8	0.2	-0.7	-0.9	-0.6
Medication for hormone replacement therapy	1.2	1.4	5.6	0.5	-2.4	-1.2	-0.7	-1.4	-1.2	1.4	0.6	1.3	-0.8	-0.4	-0.4
Vitamin and mineral supplements	2.7	3.7	5.6	-1.6	0.9	2.0	2.4	2.1	2.1	-2.4	-2.2	-1.9	2.1	1.2	1.5
Supplements: Zinc	1.9	2.0	4.1	1.9	-1.4	-1.5	-1.5	-1.7	-1.6	1.2	0.8	1.0	-2.0	-0.8	-1.1
Medication: Co-codamol	1.2	1.4	3.0	0.2	-1.0	-1.5	-0.9	-1.1	-1.5	1.5	1.0	1.1	-0.6	-1.7	-1.4
Medication: Metformin	2.9	4.1	6.2	0.8	-2.4	-1.9	-2.0	-2.3	-2.1	2.2	2.1	2.0	-1.2	-2.5	-2.0
Diabetes (father)	4.8	6.0	8.5	1.6	-2.6	-2.4	-2.5	-2.3	-2.6	2.7	2.4	2.7	-2.2	-2.9	-2.1
Diabetes (mother)	0.9	1.1	2.7	1.6	-0.3	-1.5	-1.2	-0.9	-0.5	1.1	1.1	1.3	-0.5	-1.0	-0.5
Severe depression (siblings)	0.3	0.3	1.1	1.1	-0.2	-0.1	-0.6	-0.6	0.2	0.3	0.6	0.7	-0.3	-0.4	-0.5
Pack years adult smoking proportion	2.6	4.0	10.0	1.2	-3.2	-2.0	-1.8	-1.8	-2.2	2.1	1.6	1.9	-2.2	-1.9	-1.4
Impedance of leg (right)	13.3	64.5	78.1	-7.3	6.5	8.8	8.8	8.8	7.9	-8.6	-7.9	-8.1	7.8	8.5	7.1
Leg fat-free mass (left)	5.2	27.4	32.0	4.5	-5.5	-5.4	-5.5	-5.7	-5.5	5.0	4.4	5.0	-5.3	-5.5	-5.2
Trunk fat percentage	1.5	5.9	9.3	1.9	-3.0	-2.3	-2.3	-2.6	-2.9	2.4	2.1	2.2	-2.6	-2.5	-2.0
Hand grip strength (right)	0.4	1.1	4.1	-0.3	-2.0	-1.0	-0.9	-0.4	-2.0	0.8	0.3	0.8	0.4	-1.1	-0.5
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.3	-0.8	0.5	0.4	0.0	-0.0	-0.2	-0.6	-0.5	0.9	0.7	0.2
Current tobacco smoking	6.7	11.0	19.3	2.4	-4.4	-3.0	-3.0	-3.6	-2.8	2.9	3.1	3.3	-3.5	-3.9	-3.5
Average weekly fortified wine intake	3.1	3.6	5.9	-1.8	-0.5	2.2	1.9	2.1	1.1	-1.7	-2.2	-1.7	1.9	2.4	2.2
Maternal smoking around birth	1.5	2.2	3.1	-0.9	1.7	1.5	1.6	1.8	1.7	-1.5	-1.4	-1.8	0.4	1.4	1.6
Fed-up feelings	20.4	37.2	51.9	-5.0	5.1	6.7	6.5	6.8	7.2	-6.5	-5.4	-5.9	5.6	5.9	6.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	4.9	9.5	-1.4	1.2	2.3	2.6	2.4	3.1	-2.4	-2.1	-1.9	2.8	2.0	1.6
Relative age voice broke	0.2	0.3	1.0	-0.7	-0.2	0.4	0.7	0.2	0.4	-0.6	-1.0	-0.3	0.5	-0.0	-0.5
Taking other prescription medications	0.1	0.2	0.8	-0.9	0.3	0.5	-0.1	-0.0	-0.5	0.2	0.2	-0.1	-0.1	-0.4	0.4
Age when periods started (menarche)	1.3	3.1	6.4	-1.4	2.5	2.2	2.3	1.2	1.8	-2.0	-1.7	-1.8	0.2	1.8	1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.7	0.9	-0.1	-1.3	-1.1	-1.1	-1.3	1.0	0.6	1.2	-1.1	-0.7	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	32.3	73.3	83.4	7.5	-8.2	-8.9	-8.7	-8.9	-8.4	9.1	8.9	9.0	-8.4	-9.0	-7.4
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	4.3	1.2	-1.7	-1.9	-1.3	-1.4	-1.9	1.7	1.4	1.7	-1.1	-2.1	-1.2
Qualifications: CSEs or equivalent	0.3	0.4	1.2	-0.5	-0.1	0.3	0.3	1.1	-0.0	-0.8	-0.8	-0.5	0.6	0.4	1.1
Serious illness, injury or assault to yourself	3.0	3.7	5.4	-2.0	1.8	1.9	1.8	2.3	2.0	-1.9	-1.9	-1.8	1.9	2.1	1.5
High blood pressure	9.4	26.2	34.6	4.7	-3.2	-5.9	-5.3	-5.5	-5.1	5.1	5.0	5.1	-5.1	-5.4	-5.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.9	1.0	0.5	-0.4	-0.9	-1.0	-0.2	1.3	1.7	1.4	-1.6	-0.8	0.2
Multivitamins +/- minerals	0.6	0.8	1.6	0.8	-0.8	-0.8	-1.1	-1.1	-0.5	0.9	1.1	0.6	-1.3	-0.4	-1.0
Stomach or abdominal pain in last month	4.7	5.9	11.6	-2.6	3.1	2.5	1.8	2.9	1.7	-2.3	-1.5	-2.3	1.9	2.5	3.4
Supplements: Glucosamine	0.2	0.3	1.4	-0.4	0.2	-0.3	-0.5	-0.5	-0.9	0.0	0.1	-0.3	0.3	-0.2	-1.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.2	-0.3	0.2	-0.6	-0.1	0.5	-0.2	0.5	-0.2	-0.4	0.2	-0.6
Medication: Atenolol	3.7	4.7	10.5	2.1	-3.2	-2.3	-2.5	-2.1	-2.0	2.1	1.7	1.7	-1.5	-2.2	-2.0
Medication: Levothyroxine sodium	16.4	27.7	36.3	-4.6	3.1	6.0	5.7	5.3	5.4	-5.7	-5.3	-5.8	4.8	5.6	5.2
Sitting height	1.2	8.7	16.6	2.7	-2.8	-2.9	-3.0	-3.3	-3.8	2.2	1.8	2.4	-2.7	-2.9	-4.1
Chronic bronchitis/emphysema (father)	0.2	0.2	1.0	0.7	0.1	0.4	0.2	-0.4	1.0	0.0	-0.1	-0.2	-0.1	0.7	0.1
High blood pressure (mother)	3.7	5.3	10.5	2.7	-1.5	-2.6	-2.2	-2.6	-1.7	1.9	1.8	2.2	-3.2	-1.9	-2.6
Body mass index (BMI)	12.4	53.0	60.4	6.6	-7.2	-7.6	-7.6	-7.6	-7.3	7.8	7.4	7.4	-7.5	-7.7	-5.5
Impedance of leg (left)	14.2	69.0	84.1	-7.6	6.7	9.2	9.1	9.0	8.0	-8.9	-8.2	-8.5	8.0	8.7	7.4
Leg predicted mass (left)	5.1	27.1	31.8	4.5	-5.5	-5.4	-5.4	-5.6	-5.5	5.0	4.3	5.0	-5.3	-5.5	-5.2
Trunk fat mass	2.6	11.0	16.1	2.5	-4.0	-3.2	-3.3	-3.6	-3.9	3.3	2.7	3.1	-3.4	-3.5	-3.0
Waist circumference	1.8	6.5	14.1	1.4	-3.8	-2.0	-2.3	-3.1	-3.1	2.5	2.2	2.2	-2.5	-2.8	-2.2
Number of incorrect matches in round	0.5	0.8	1.5	-0.1	0.9	0.2	0.9	1.2	0.6	-1.0	-1.2	-0.9	1.1	1.0	0.9
Past tobacco smoking	2.4	4.4	7.8	-0.8	2.1	2.2	2.3	1.8	2.2	-2.8	-2.1	-2.6	1.0	2.6	1.6
Alcohol usually taken with meals	2.1	3.4	7.1	2.2	-0.5	-1.9	-2.1	-1.8	-2.1	2.1	1.7	1.8	-2.7	-1.2	-0.8
Nervous feelings	25.6	47.8	56.0	-7.0	5.5	7.5	7.5	7.1	6.2	-7.4	-6.6	-7.3	6.7	7.2	6.8
Frequency of tenseness / restlessness in last 2 weeks	4.0	6.2	11.7	-1.5	2.9	2.9	2.4	2.1	3.4	-2.7	-2.1	-2.5	1.6	2.7	2.3
Hearing difficulty/problems with background noise	1.2	1.9	3.5	-1.6	0.7	1.6	1.5	1.1	1.9	-1.7	-1.2	-1.6	1.2	1.3	0.5
Hair/balding pattern: Pattern 2	0.5	0.7	1.8	0.2	-0.9	-0.8	-1.1	-0.9	-0.3	0.7	0.4	0.8	-0.1	-1.0	-1.3
Had menopause	1.4	1.7	2.8	1.0	-1.3	-1.4	-1.5	-1.4	-1.6	1.7	1.1	1.5	-1.4	-0.9	-0.4
Had other major operations	3.1	3.8	9.8	1.9	-0.1	-2.1	-2.1	-2.0	-1.4	2.1	2.4	1.9	-3.1	-1.4	-1.2
Forced vital capacity (FVC)	2.1	8.0	11.6	-2.6	1.8	2.9	2.9	3.0	2.9	-3.4	-3.1	-2.8	3.4	2.8	1.9
Heel bone mineral density (BMD) T-score, automated (right)	34.2	78.4	89.9	7.6	-7.6	-8.9	-9.2	-9.5	-9.1	9.3	9.5	9.2	-9.0	-9.4	-7.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.1	-0.3	1.4	0.9	0.6	0.8	0.7	-0.0	0.1	-0.1	0.9	0.4	1.4
Qualifications: None of the above	0.1	0.3	1.4	0.2	-1.2	0.1	0.2	-0.1	1.1	-0.2	0.1	-0.2	0.2	0.3	0.8
Financial difficulties in last 2 years	0.3	0.4	1.7	-0.7	-1.3	-0.5	-0.2	-0.3	-0.2	0.3	0.3	0.7	-0.9	-0.9	-0.4
Mouth/teeth dental problems	6.4	9.8	13.2	-3.2	2.9	3.3	3.1	3.3	2.6	-3.0	-2.9	-3.0	3.6	3.5	2.9
Heart attack	0.3	0.4	1.5	-0.6	0.9	0.7	0.1	0.1	-0.6	-0.6	-0.0	-1.2	0.3	0.3	0.8
Allergy	2.9	6.6	13.3	-2.3	0.4	2.1	2.9	2.6	1.7	-3.0	-3.4	-3.2	3.6	2.5	1.5
Pain all over the body in last month	1.4	1.5	2.8	1.1	-0.1	-1.2	-1.4	-1.2	-1.7	1.3	1.3	1.2	-0.8	-1.5	-0.9
Diabetes (self-reported)	1.1	1.6	3.3	0.9	-1.6	-1.2	-1.3	-1.4	-0.8	1.1	1.3	1.2	-0.5	-1.8	-1.7
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	4.5	-2.1	1.8	2.0	1.6	1.2	1.7	-1.3	-1.0	-1.4	1.3	1.5	1.2
Medication: Ramipril	2.3	3.0	7.6	1.2	-2.2	-2.1	-1.2	-1.8	-2.0	1.1	0.8	1.2	-0.9	-2.1	-2.8
Medication: Simvastatin	1.9	2.8	4.5	1.2	-0.4	-1.7	-1.5	-1.8	-2.0	1.5	1.8	1.4	-2.1	-2.1	-1.7
Fluid intelligence score	0.7	1.5	3.1	-1.7	-0.1	1.6	1.4	1.0	0.3	-1.3	-1.8	-1.4	1.2	1.1	0.3
Illnesses of siblings	0.7	0.9	1.9	-0.5	0.7	1.3	0.6	1.1	1.3	-0.7	-0.7	-0.5	0.9	1.4	1.3
Neuroticism score	36.4	75.9	89.9	-8.2	7.3	9.3	9.4	9.5	8.7	-9.3	-8.4	-8.9	8.4	8.8	8.2
Weight	4.6	22.5	28.6	4.2	-5.3	-4.8	-4.8	-5.0	-5.1	4.6	4.2	4.5	-4.8	-5.1	-4.2
Impedance of arm (right)	14.2	66.2	80.0	-7.2	6.7	8.6	8.8	8.5	7.9	-8.9	-8.6	-8.5	8.0	8.9	6.4
Arm fat percentage (right)	5.2	20.7	28.4	3.9	-5.3	-4.6	-4.6	-4.6	-4.9	4.7	4.4	4.5	-4.5	-4.7	-3.5
Trunk fat-free mass	2.0	11.6	18.6	2.4	-4.3	-3.4	-3.4	-3.6	-3.8	3.1	2.5	3.3	-3.0	-3.8	-3.9
Hip circumference	4.5	19.4	26.6	3.9	-5.2	-4.5	-4.5	-4.5	-4.8	4.1	4.0	4.1	-4.1	-4.9	-4.2
Time employed in main current job	2.2	2.5	5.6	-2.1	0.5	2.0	1.8	1.2	0.1	-1.5	-1.5	-2.4	1.5	1.5	1.4
Alcohol intake versus 10 years previously	1.1	1.7	5.9	-1.5	-0.3	1.1	1.2	1.8	0.3	-1.1	-1.5	-1.0	2.4	0.4	1.3
Father’s age at death	10.4	13.9	20.6	-3.9	3.2	3.8	3.8	3.9	3.4	-3.7	-3.5	-3.8	3.3	4.5	3.8
Worrier / anxious feelings	36.7	69.3	95.6	-6.8	7.0	8.8	8.7	9.8	8.2	-8.5	-8.2	-7.5	8.6	8.8	8.5
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.6	7.7	-1.9	1.8	2.8	2.8	2.2	2.5	-2.8	-2.4	-2.4	1.9	2.4	2.3
Falls in the last year	0.1	0.2	1.0	0.4	0.3	0.2	0.2	0.1	-0.1	-0.0	0.4	0.0	-0.7	0.0	1.0
Hair/balding pattern: Pattern 3	0.2	0.2	0.9	-0.1	0.9	0.4	0.3	0.3	-0.5	-0.4	-0.4	-0.7	-0.5	0.3	0.4
Number of live births	0.1	0.2	0.6	0.3	0.2	0.3	0.3	0.1	0.4	-0.2	0.3	0.2	-0.8	0.6	0.5
Forced expiratory volume in 1-second (FEV1)	5.3	17.9	25.2	-4.0	2.3	4.5	4.5	4.5	4.3	-5.0	-4.6	-4.6	4.9	4.0	2.9
Pulse rate	2.5	4.2	5.9	-2.2	1.5	2.2	2.2	2.2	1.4	-2.4	-2.4	-2.2	1.9	2.3	1.4
Happiness	0.5	0.6	1.4	0.4	-0.5	-0.6	-0.6	-0.6	-1.2	1.0	0.9	1.0	0.2	-1.0	-0.9
Noisy workplace	0.5	0.6	1.3	-1.0	0.9	0.8	0.7	1.1	0.7	-0.4	-0.4	-0.5	1.0	0.2	1.0
Qualifications: A levels/AS levels or equivalent	1.7	3.8	7.5	-1.6	0.8	2.4	2.2	1.4	1.9	-2.1	-2.6	-2.3	1.2	2.7	0.8
Serious illness, injury or assault of a close relative in last 2 years	7.0	8.0	11.4	-2.7	2.4	3.1	3.0	2.4	3.4	-2.7	-3.0	-3.0	2.2	3.3	2.5
Mouth/teeth dental problems: Dentures	9.7	16.4	21.3	3.8	-3.4	-4.1	-4.5	-4.1	-3.7	4.4	4.1	4.6	-3.6	-4.6	-3.5
Asthma	4.1	8.0	12.5	3.0	-1.1	-2.6	-3.2	-2.8	-2.2	2.9	3.1	3.1	-3.5	-2.7	-3.0
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	4.7	-1.1	1.1	1.0	1.6	1.8	0.9	-1.4	-1.4	-1.1	1.2	1.5	2.2
Medication: Cholesterol lowering	1.4	2.3	4.6	1.3	0.0	-1.4	-1.3	-1.9	-1.7	1.0	1.4	0.6	-2.1	-1.8	-2.0
Depression (self-reported)	2.2	2.6	4.4	-1.5	-0.2	2.1	2.0	1.8	1.8	-1.6	-1.3	-1.4	1.9	1.3	1.7
Medication: Lansoprazole	0.4	0.4	2.6	-0.2	-0.1	-0.5	-0.6	-0.4	-1.6	0.3	0.3	0.5	-0.9	-0.7	0.3
Prospective memory result	0.1	0.1	0.2	0.0	-0.2	-0.4	0.0	0.2	-0.1	0.2	0.2	0.4	0.1	-0.4	0.3
Lung cancer (father)	0.2	0.2	0.6	-0.3	-0.8	0.4	0.7	-0.2	0.5	-0.1	-0.5	-0.4	-0.4	0.5	0.4
Illnesses of mother	0.2	0.2	1.0	-0.7	-1.0	0.6	0.2	0.0	-0.6	0.1	-0.2	-0.2	0.4	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	4.3	13.9	21.0	-3.5	2.1	4.0	4.0	3.7	3.7	-4.6	-4.0	-4.3	3.9	3.6	2.4
Pulse wave Arterial Stiffness index	0.7	0.8	3.0	0.2	-1.7	-1.0	-0.4	-0.9	-1.7	0.7	0.3	0.1	-0.2	-1.1	-0.6
Impedance of arm (left)	12.0	55.4	65.8	-7.0	6.4	8.0	8.0	7.5	7.1	-8.1	-7.9	-7.8	7.4	8.1	5.5
Arm fat mass (right)	7.1	29.1	38.8	4.7	-6.2	-5.5	-5.5	-5.6	-5.6	5.5	5.0	5.3	-5.3	-5.7	-4.5
Trunk predicted mass	2.0	11.5	18.7	2.4	-4.3	-3.4	-3.4	-3.5	-3.8	3.1	2.5	3.3	-3.0	-3.8	-3.8
Standing height	2.4	23.7	39.3	-4.7	2.9	5.3	5.4	4.6	4.1	-6.0	-6.3	-5.5	4.9	5.0	2.2
Length of working week for main job	1.9	2.1	3.4	1.4	-1.1	-1.8	-1.6	-1.3	-1.6	1.4	1.5	1.6	-1.2	-1.9	-0.5
Exposure to tobacco smoke at home	0.9	1.0	2.0	0.5	-1.4	-1.1	-1.1	-1.0	-0.4	0.6	0.9	0.9	-1.2	-1.0	-1.4
Breastfed as a baby	0.8	0.9	2.2	-1.0	0.7	1.2	1.5	1.0	0.6	-0.9	-1.4	-0.7	0.8	0.9	0.5
Tense / ‘highly strung’	20.6	34.1	44.2	-5.8	4.8	6.5	6.2	5.9	5.4	-6.3	-5.2	-6.7	5.5	5.8	5.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	6.2	-1.5	1.7	2.0	2.5	2.0	1.7	-2.1	-2.0	-2.0	1.5	1.8	2.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	0.9	-0.1	-0.1	0.4	-0.1	0.8	-0.5	-0.2	-0.2	-0.4	0.3	-0.1
Birth weight of first child	0.7	1.3	3.8	-1.8	0.1	0.8	1.3	1.0	0.6	-0.7	-1.3	-0.7	2.0	0.8	1.0
Peak expiratory flow (PEF)	9.2	21.3	29.6	-4.9	2.5	5.2	5.1	4.8	4.6	-5.4	-5.1	-5.1	5.1	3.9	2.7
Pulse wave reflection index	2.6	3.2	5.6	1.7	-1.7	-2.4	-2.1	-1.6	-2.3	1.9	1.7	1.5	-0.7	-2.1	-0.9
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.9	-1.2	1.7	1.6	1.5	0.9	0.9	-1.1	-1.0	-1.4	1.3	1.4	1.1
Loud music exposure frequency	0.2	0.2	0.7	0.2	-0.1	-0.2	-0.6	0.2	-0.5	0.8	0.1	0.8	0.3	-0.2	0.4
Qualifications: O levels/GCSEs or equivalent	3.6	5.7	8.4	-2.5	2.9	2.8	2.5	2.3	1.1	-2.2	-2.5	-2.8	1.9	2.7	1.8
Mouth/teeth dental problems: Bleeding gums	5.7	7.4	10.4	2.5	-2.4	-2.8	-2.6	-3.2	-2.2	2.5	2.6	2.6	-3.2	-3.1	-2.8
Blood clot in the leg (DVT)	3.1	4.0	6.3	1.8	-1.5	-2.1	-2.3	-2.5	-1.8	2.0	1.7	1.9	-2.0	-1.9	-2.1
Medication: Paracetamol	2.1	3.4	6.5	-1.8	2.5	2.2	2.0	2.1	1.5	-1.8	-0.8	-1.6	0.9	1.6	2.5
Headache pain in last month	5.5	9.5	12.7	-2.4	3.6	3.1	3.5	3.4	3.1	-3.4	-2.5	-2.9	3.1	2.9	2.8
Medication for cholesterol, blood pressure or diabetes	3.5	5.9	10.4	-2.0	0.6	2.5	2.3	2.9	2.7	-2.0	-2.2	-1.7	3.2	2.6	3.2
Glaucoma (self-reported)	0.9	1.0	2.2	1.1	-0.4	-1.2	-1.2	-0.8	-0.7	0.9	1.3	0.9	-0.5	-1.5	-1.2
Gout (self-reported)	0.5	0.6	2.9	0.6	-1.7	-0.0	-0.7	-0.8	-0.1	0.3	0.8	0.4	-0.6	-1.1	-0.8
Hypothyroidism/myxoedema (self-reported)	22.0	42.9	55.2	-6.1	4.2	7.4	7.4	6.2	6.7	-6.8	-6.8	-7.0	6.0	7.0	6.3
Medication: Amlodipine	2.3	3.2	6.4	1.0	-1.7	-1.8	-1.8	-2.1	-1.3	1.7	2.1	1.3	-2.5	-1.9	-1.7
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.7	1.3	-0.6	-1.0	-1.5	-1.4	-1.2	1.7	1.5	1.6	-1.3	-1.9	-1.3
Birth weight	1.3	2.9	5.7	0.6	-2.2	-1.3	-2.0	-2.2	-2.4	1.6	1.4	1.3	-1.6	-1.7	-1.6
Chronic bronchitis/emphysema (mother)	0.6	0.8	4.4	-0.9	1.1	0.7	0.8	0.7	0.0	-0.3	-0.5	-0.5	0.6	0.5	2.1
High blood pressure (siblings)	0.8	1.1	2.0	0.3	-0.7	-1.3	-1.0	-1.1	-1.2	1.2	1.3	1.2	-0.8	-1.4	-0.9
Forced vital capacity (FVC), Best measure	1.3	4.6	7.2	-1.8	1.4	2.2	2.2	2.2	2.5	-2.7	-2.2	-2.2	2.3	2.2	1.5
Body fat percentage	2.8	11.2	14.9	2.9	-3.9	-3.2	-3.3	-3.5	-3.7	3.4	3.2	3.2	-3.6	-3.5	-2.5
Leg fat percentage (right)	4.6	16.8	20.2	3.5	-4.5	-4.1	-4.1	-4.1	-4.4	4.5	4.2	4.2	-4.2	-4.4	-2.7
Arm fat-free mass (right)	4.1	21.0	26.1	3.7	-4.9	-4.6	-4.8	-4.9	-5.0	4.4	4.0	4.5	-4.5	-5.1	-4.5
Exposure to tobacco smoke outside home	0.4	0.6	1.2	-1.0	-0.3	0.6	1.0	0.5	0.9	-1.1	-0.7	-1.1	0.3	0.5	-0.1
Comparative body size at age 10	12.3	34.0	43.1	5.5	-5.4	-5.7	-6.2	-6.6	-5.5	6.0	6.2	5.5	-4.9	-6.5	-5.8
Number of full brothers	4.1	5.1	7.0	2.4	-1.1	-2.4	-2.3	-2.6	-2.1	2.4	2.0	2.5	-2.4	-2.2	-2.3
Worry too long after embarrassment	19.1	32.1	41.4	-5.7	4.8	6.4	6.0	5.8	5.8	-6.0	-5.1	-5.8	6.4	5.3	4.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.9	-0.3	0.3	0.8	0.9	0.9	0.6	-0.9	-1.2	-0.7	1.4	0.6	0.4
Wheeze or whistling in the chest in last year	5.2	9.3	13.8	2.6	-2.2	-3.1	-3.1	-3.1	-2.7	3.2	3.3	3.2	-3.0	-3.7	-3.1
Number of children fathered	2.1	2.3	4.8	1.0	-1.1	-1.8	-1.5	-1.2	-2.2	1.5	1.5	1.5	-2.1	-1.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.7	-1.1	1.3	1.4	1.1	1.9	0.8	-1.2	-1.4	-1.4	1.9	1.6	1.5
Age at first live birth	4.1	7.3	11.5	-2.9	3.4	2.9	2.3	2.7	2.6	-2.4	-2.4	-2.7	2.7	2.7	2.4
Pulse wave peak to peak time	1.2	1.4	4.2	-0.5	1.9	1.4	0.8	1.2	2.1	-1.1	-0.7	-0.5	0.5	1.5	0.7
Health satisfaction	4.3	5.6	7.7	2.0	-1.3	-2.6	-2.8	-2.7	-1.6	2.4	2.5	2.6	-2.1	-2.4	-2.8
Shortness of breath walking on level ground	0.5	0.6	1.7	0.4	0.0	-0.5	-0.9	-1.1	-0.5	1.0	1.3	0.7	-0.5	-0.7	-0.7
Qualifications: College or University degree	0.1	0.2	0.9	-0.3	0.7	0.4	0.4	-0.4	0.2	0.2	-0.1	-0.4	0.5	0.3	-0.9
Eye problems/disorders: None of the above	1.1	1.2	2.6	-1.5	1.6	1.0	0.9	1.3	1.1	-0.7	-1.0	-0.9	0.5	1.1	1.2
Mouth/teeth dental problems: Loose teeth	5.4	6.4	7.9	2.7	-2.4	-2.6	-2.8	-2.4	-2.1	2.7	2.6	2.7	-2.4	-2.8	-2.0
Emphysema/chronic bronchitis	7.0	7.9	13.6	2.5	-1.5	-3.2	-3.2	-2.6	-3.7	3.1	2.7	3.2	-2.7	-3.0	-1.7
Medication for pain relief, constipation, heartburn	0.6	1.0	3.1	1.0	-0.8	-1.0	-1.1	-1.1	-0.0	1.1	0.4	1.2	-0.1	-0.8	-1.8
Neck or shoulder pain in last month	1.1	1.6	4.0	-0.6	0.8	1.2	1.2	1.2	1.2	-1.2	-1.1	-1.0	1.4	1.6	2.0
Medication: Blood pressure	5.3	9.4	14.5	2.9	-1.2	-3.5	-3.3	-3.4	-3.4	2.8	2.8	2.6	-3.8	-3.0	-3.4
Angina (self-reported)	0.5	0.7	2.3	0.4	-0.3	-0.5	-0.5	-1.5	-0.9	1.0	0.9	0.4	-0.8	-1.1	-0.8
Migraine (self-reported)	0.3	0.4	1.1	-0.3	-0.1	0.9	0.8	0.6	1.0	-0.9	-0.6	-0.6	0.7	0.1	-0.0
Medication: Ibuprofen	1.5	1.9	3.2	-1.3	1.2	1.1	1.7	1.6	0.7	-1.5	-1.4	-1.2	0.9	1.5	1.8
Medication: Allopurinol	1.0	1.3	2.0	1.2	-1.4	-0.8	-1.2	-1.4	-1.0	1.0	1.4	0.9	-1.4	-1.3	-0.3
Medication: Omeprazole	0.3	0.3	1.6	-1.3	-0.0	-0.2	-0.1	0.0	-0.6	0.6	0.5	0.5	0.5	-0.7	-0.6
Medication: Seretide 50 evohaler	1.5	1.7	4.1	2.0	0.3	-1.4	-1.7	-1.2	-1.1	1.3	1.6	0.9	-1.6	-1.0	-0.7
Mean time to correctly identify matches	0.2	0.4	2.8	0.3	1.7	0.3	0.1	0.6	0.7	0.1	0.4	-0.2	0.5	0.2	0.9
Heart disease (mother)	0.4	0.5	2.9	-0.2	1.7	0.2	0.6	0.5	0.3	-0.5	-0.5	-0.7	0.3	0.4	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.7	6.8	8.8	-2.1	2.5	3.0	3.0	2.6	2.6	-2.7	-2.8	-2.6	2.1	2.9	2.2
Whole body fat mass	4.4	18.2	25.1	3.6	-5.0	-4.2	-4.3	-4.5	-4.7	4.3	3.8	4.1	-4.4	-4.5	-3.8
Leg fat mass (right)	7.3	28.1	33.8	4.8	-5.8	-5.3	-5.4	-5.5	-5.6	5.4	5.0	5.2	-5.4	-5.6	-4.2
Arm predicted mass (right)	4.5	22.9	29.4	3.8	-4.9	-4.8	-4.9	-5.0	-5.4	4.7	4.2	4.7	-4.7	-5.3	-4.5
Pulse rate, automated reading	0.1	0.4	1.5	-1.1	0.2	0.1	0.5	0.3	-1.2	-0.3	-0.2	-0.0	-0.5	0.2	0.8
Alcohol intake frequency.	0.1	0.2	1.0	-0.5	0.3	0.8	0.1	0.4	-0.3	-0.3	0.0	-0.2	1.0	-0.3	-0.2
Comparative height size at age 10	0.1	0.6	2.8	0.4	-1.2	-0.5	-0.7	-0.6	-0.9	-0.1	-0.2	0.3	-0.4	-0.6	-1.7
Number of full sisters	4.3	5.2	9.0	1.3	-2.7	-2.3	-1.5	-3.0	-3.0	2.1	2.0	1.8	-2.1	-2.5	-2.6
Suffer from ‘nerves’	18.2	28.6	34.7	-5.1	4.8	5.9	5.7	5.4	5.2	-5.9	-4.9	-5.5	5.3	5.5	4.8
Overall health rating	5.4	11.5	14.4	2.7	-2.9	-3.6	-3.7	-3.8	-2.9	3.6	3.6	3.6	-3.5	-3.6	-3.0
Chest pain or discomfort	0.2	0.3	1.2	-1.1	-0.7	0.3	0.6	0.1	-0.0	-0.4	-0.7	-0.6	0.1	-0.0	-0.3
Had major operations	0.2	0.2	0.6	-0.2	0.5	0.2	0.8	0.4	-0.0	-0.6	-0.4	-0.7	0.1	0.2	0.4
Age at last live birth	6.3	9.1	11.0	-2.9	3.3	3.2	3.1	3.2	2.9	-3.1	-2.8	-3.3	2.7	3.1	2.6
Family relationship satisfaction	0.2	0.2	0.9	-0.5	0.2	0.3	0.2	0.3	0.7	-0.0	0.1	0.1	0.9	0.5	0.6
Leg pain on walking	1.7	2.2	3.3	0.4	-0.4	-1.4	-1.6	-1.6	-1.7	1.4	1.8	1.8	-1.6	-1.6	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.5	-0.1	-0.0	0.2	0.6	0.0	-0.4	-0.1	0.4	-0.5	0.1	0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.1	0.5	-0.9	-0.8	-0.4	-1.0	-1.0	0.7	0.6	0.3	-1.5	-0.8	-0.6
Illness, injury, bereavement, stress in last 2 years	3.4	4.1	6.7	2.6	-1.2	-2.2	-2.2	-1.9	-2.4	1.8	2.0	1.8	-1.6	-2.3	-1.9
Medication: Aspirin	4.1	5.5	9.3	2.6	-1.6	-2.6	-2.2	-2.7	-3.0	2.1	2.3	1.8	-2.2	-2.5	-2.1
Supplements: Vitamin C	4.2	5.0	7.3	2.1	-1.3	-2.4	-2.5	-2.4	-2.7	2.4	2.3	2.1	-2.7	-1.9	-1.7
Knee pain experienced in last month	1.4	2.2	3.4	1.3	-1.7	-1.1	-1.2	-1.8	-1.8	1.4	1.4	1.0	-1.9	-1.6	-1.3
Hypertension (Self-reported)	9.7	27.1	37.0	4.8	-3.2	-6.1	-5.4	-5.5	-5.3	5.3	5.0	5.3	-5.1	-5.4	-5.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.2	-1.1	0.2	-0.1	0.2	0.5	-0.2	0.2	-0.4	0.2	0.7	-0.2	0.2
Illnesses of father: Heart disease	0.2	0.3	2.7	0.3	1.7	-0.5	0.2	0.1	0.2	-0.0	0.1	-0.1	-0.5	0.3	0.6
Illnesses of siblings: Diabetes	2.7	3.4	4.7	2.1	-1.9	-1.8	-1.8	-2.2	-2.0	1.8	1.8	1.4	-1.8	-1.8	-1.7
Smoking status: Previous	0.7	1.1	2.9	-0.1	-0.5	-1.2	-1.2	-0.6	-1.4	1.7	1.0	1.4	0.1	-1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	8.1	-1.7	0.1	1.9	2.2	1.5	1.5	-2.9	-2.8	-2.3	1.7	1.7	-0.0
Whole body fat-free mass	3.3	19.0	26.0	3.5	-5.1	-4.4	-4.5	-4.6	-4.7	4.1	3.4	4.2	-4.2	-4.8	-4.6
Leg fat-free mass (right)	4.9	26.1	30.9	4.5	-5.4	-5.3	-5.3	-5.6	-5.5	4.8	4.2	4.8	-5.3	-5.4	-5.1
Arm fat percentage (left)	6.0	23.9	28.1	4.1	-5.3	-4.9	-5.0	-5.2	-5.3	5.1	4.7	4.8	-4.9	-5.1	-3.9
Average weekly red wine intake	2.6	3.9	5.7	1.9	-2.0	-2.1	-2.0	-2.0	-1.7	2.3	1.8	2.4	-2.1	-1.5	-1.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	0.7	-0.9	-0.2	-0.6	-0.2	0.5	0.3	0.4	1.1	-0.3	0.1	-0.3
Mood swings	11.8	21.3	30.1	-4.1	3.6	4.5	5.5	5.1	4.6	-4.9	-4.5	-4.8	4.2	4.7	4.6
Loneliness, isolation	3.2	4.4	10.6	-1.9	1.5	2.1	2.2	1.8	3.3	-2.3	-2.2	-1.9	2.4	1.7	1.1
Long-standing illness, disability or infirmity	0.1	0.2	0.9	-0.2	0.7	0.4	-0.5	-0.4	-0.3	0.2	0.4	-0.1	-0.9	0.3	0.4
Ever had bowel cancer screening	1.4	1.7	4.0	-1.1	2.0	1.1	1.1	1.5	0.8	-1.3	-1.2	-1.3	1.2	1.5	1.2
Diabetes diagnosed by doctor	1.6	2.6	4.9	1.1	-1.7	-1.4	-1.6	-1.9	-1.3	1.5	1.7	1.6	-1.0	-2.2	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	4.4	4.7	7.7	1.9	-0.7	-2.1	-2.5	-2.1	-2.7	2.1	2.7	2.0	-2.8	-2.1	-1.5
Friendships satisfaction	0.3	0.4	1.4	0.4	0.0	-0.2	-0.7	-0.3	-0.4	0.5	1.2	0.7	0.4	-1.1	-0.5
Qualifications: nursing, teaching	0.1	0.2	0.5	-0.7	0.1	0.3	0.3	-0.1	-0.2	0.1	-0.4	-0.4	0.4	0.6	-0.6
Commuting to job workplace: Walk	0.3	0.4	2.3	1.5	0.7	-0.1	-0.6	0.2	0.7	0.2	0.4	0.5	0.1	0.3	0.5
Eye problems/disorders: Cataract	0.6	0.7	3.1	0.5	-0.9	-0.7	-0.5	-1.3	-0.6	0.2	0.5	0.5	-0.2	-1.0	-1.8
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	5.8	-1.4	1.6	1.9	2.4	1.8	1.6	-2.1	-1.8	-2.3	1.1	2.1	2.4
Medication for cholesterol	2.3	3.4	5.3	-1.6	2.3	2.0	1.4	1.8	2.1	-2.0	-1.7	-2.2	2.3	1.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.8	0.6	0.1	-0.2	-0.4	-0.1	0.0	0.1	0.4	-0.2	-0.9	-0.1	0.3
Back pain experienced in last month	0.1	0.2	0.7	0.2	-0.0	-0.4	0.1	0.4	-0.4	-0.3	0.3	0.4	-0.1	-0.8	-0.7
Mineral and other dietary supplements	6.5	8.7	13.8	-2.7	2.0	3.3	3.7	3.3	3.2	-3.0	-2.8	-2.8	2.3	2.6	3.2
Breast cancer (self-reported)	0.1	0.1	0.5	0.1	-0.2	-0.3	0.3	-0.4	-0.7	0.6	-0.2	0.3	-0.2	-0.2	-0.4
Asthma (self-reported)	4.6	9.2	13.5	3.1	-1.4	-2.8	-3.4	-3.1	-2.4	3.1	3.3	3.3	-3.7	-3.0	-3.2
Osteoporosis (self-reported)	7.6	9.4	11.4	-2.9	3.2	3.4	3.3	3.1	3.0	-2.7	-3.1	-2.7	3.2	3.4	2.8
Osteoarthritis (self-reported)	1.4	1.8	3.2	0.4	-0.8	-1.0	-1.4	-1.5	-1.3	1.7	1.8	1.5	-1.5	-1.4	-1.3
Medication: Aspirin	3.0	3.9	7.6	2.1	-1.4	-2.1	-1.8	-2.3	-2.8	1.7	2.0	1.5	-1.7	-2.3	-1.8
Medication: Gliclazide	0.8	0.9	1.2	0.7	-0.5	-0.7	-0.9	-1.1	-1.1	0.9	1.1	0.9	-1.1	-1.1	-1.0
Illnesses of father: None of the above (group 1)	0.6	0.8	1.6	-1.2	-0.7	1.2	0.8	0.7	0.6	-1.0	-0.9	-0.9	1.3	0.3	0.1
Smoking status: Current	6.8	10.7	20.1	2.5	-4.5	-3.0	-2.9	-3.6	-2.5	2.8	3.0	3.1	-3.4	-3.9	-3.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.6	7.6	12.0	-3.2	1.6	2.7	2.9	2.6	2.0	-2.9	-3.0	-3.4	3.5	2.5	2.1
Whole body water mass	3.4	19.4	25.7	3.5	-5.1	-4.5	-4.5	-4.7	-4.8	4.1	3.5	4.2	-4.2	-4.8	-4.7
Leg predicted mass (right)	4.9	26.1	31.0	4.5	-5.5	-5.3	-5.3	-5.6	-5.5	4.8	4.2	4.8	-5.3	-5.4	-5.1
Arm fat mass (left)	7.2	29.7	37.9	4.7	-6.2	-5.5	-5.7	-5.7	-5.7	5.5	5.1	5.4	-5.4	-5.8	-4.5
Number of self-reported non-cancer illnesses	0.2	0.4	3.1	-0.8	1.8	0.2	-0.2	-0.2	-0.7	0.1	0.0	-0.2	-0.6	0.0	-0.3
Average weekly champagne plus white wine intake	0.9	1.2	4.0	0.7	0.3	-1.1	-1.0	-1.2	-1.0	1.0	0.8	0.9	-2.0	-0.7	-1.5
Miserableness	19.1	33.1	42.2	-5.8	4.6	6.2	6.5	6.5	5.5	-6.0	-5.4	-5.7	5.2	5.7	5.7
Guilty feelings	14.5	21.9	29.6	-3.4	4.0	4.8	5.3	5.1	5.4	-5.3	-4.8	-4.7	4.7	4.5	3.4
Wears glasses or contact lenses	0.3	0.3	2.1	-0.5	0.2	0.1	0.3	-0.6	0.1	-0.1	-0.3	-0.6	0.6	-0.1	-1.5
Ever taken oral contraceptive pill	0.6	0.7	2.0	-0.7	1.4	1.0	1.0	0.9	1.1	-0.5	-0.4	-0.4	0.2	0.7	1.0
Hearing aid user	0.1	0.1	0.8	-0.1	0.9	-0.2	-0.0	-0.2	0.1	0.1	0.1	-0.1	-0.7	-0.3	-0.2
Mother’s age at death	3.0	3.7	7.4	-1.4	2.0	2.0	1.9	2.0	2.7	-1.5	-1.6	-1.5	2.2	2.1	1.9
Financial situation satisfaction	0.9	1.1	2.1	0.8	0.9	-0.8	-0.9	-1.1	-1.0	1.0	1.0	1.1	-0.9	-1.4	-1.5
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.2	-1.3	1.3	1.5	1.4	1.4	0.9	-1.1	-1.1	-1.1	1.8	0.7	1.0
Commuting to job workplace: Public transport	4.8	5.7	8.7	-1.9	2.9	2.7	2.3	2.5	2.9	-2.3	-2.2	-2.0	2.3	2.5	1.9
Eye problems/disorders: Glaucoma	1.5	1.8	2.9	1.6	-0.9	-1.5	-1.5	-1.0	-1.2	1.2	1.6	1.5	-0.7	-1.7	-1.1
Medication: Blood pressure	7.9	15.0	19.9	3.8	-3.4	-4.5	-3.9	-4.0	-3.9	4.0	3.7	3.9	-4.3	-3.8	-3.3
Pain type(s) experienced in last month: Hip pain	2.7	3.4	6.0	1.5	-2.5	-1.7	-1.5	-1.8	-2.1	1.6	1.8	1.7	-1.7	-1.9	-2.0
Supplements: Fish oil (including cod liver oil)	8.8	11.5	17.5	2.5	-3.0	-3.8	-4.2	-3.4	-3.5	3.6	3.4	3.6	-2.6	-3.5	-3.3
High cholesterol (Self-reported)	1.2	2.1	5.1	1.5	-0.3	-1.4	-1.2	-1.5	-1.5	1.0	1.4	0.9	-1.7	-2.3	-1.8
Medication: Bendroflumethiazide	11.6	17.6	24.3	4.5	-2.5	-4.9	-4.0	-4.2	-4.0	4.2	4.2	4.2	-4.5	-4.7	-4.0
Medication: Paracetamol	1.8	2.7	6.5	-1.7	2.2	1.9	1.9	1.8	1.2	-1.4	-0.5	-1.2	0.8	1.5	2.5
Medication: Lisinopril	2.4	3.1	5.1	0.8	-0.7	-1.9	-1.9	-1.8	-2.0	2.1	2.2	1.9	-2.3	-1.6	-1.1
Medication: Atorvastatin	0.2	0.2	0.5	0.6	-0.7	-0.0	0.1	-0.6	-0.1	-0.3	0.2	-0.4	-0.6	-0.4	-0.6
Illnesses of father: High blood pressure	1.3	1.6	3.0	0.9	-1.2	-1.5	-1.2	-0.9	-1.7	1.3	1.5	0.9	-1.5	-1.4	-0.6
Alcohol drinker status: Never	1.0	1.2	2.4	-0.5	1.5	1.1	1.1	1.0	1.1	-1.0	-1.3	-1.1	1.1	1.4	0.7
Ever smoked	0.8	1.4	4.0	0.0	-2.0	-1.1	-1.0	-0.5	-1.1	1.6	1.0	1.8	-0.1	-1.6	-0.4
Basal metabolic rate	3.8	20.9	28.5	3.8	-5.3	-4.6	-4.7	-4.8	-5.0	4.3	3.7	4.3	-4.4	-5.0	-4.7
Leg fat percentage (left)	4.8	17.3	21.5	3.5	-4.5	-4.2	-4.2	-4.1	-4.6	4.5	4.2	4.1	-4.3	-4.5	-2.7
Arm fat-free mass (left)	3.7	18.6	24.7	3.7	-5.0	-4.4	-4.4	-4.3	-4.7	4.1	3.7	4.3	-4.2	-4.8	-4.1
Number of operations (self-reported)	4.0	5.9	9.5	2.3	-1.5	-2.6	-2.5	-2.3	-2.9	2.6	2.6	2.4	-3.1	-2.2	-1.6
Average weekly beer plus cider intake	12.4	17.9	23.4	-4.2	3.3	4.7	4.8	4.2	4.3	-4.7	-4.1	-4.5	3.0	3.9	4.5
Irritability	30.2	51.1	63.2	-7.1	6.0	7.6	7.9	7.8	7.1	-8.0	-6.9	-7.5	6.8	6.9	5.9
Risk taking	4.5	6.5	10.3	2.5	-2.6	-3.1	-2.2	-2.3	-3.2	2.4	2.5	2.5	-2.5	-2.8	-1.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	-0.1	-0.1	-0.4	-0.5	-0.4	-0.7	0.8	0.8	0.8	-0.2	-0.7	-0.3
Fractured/broken bones in last 5 years	1.1	1.4	9.6	-0.4	3.1	0.6	1.0	0.9	0.4	-1.0	-1.0	-0.9	0.5	1.0	1.0
Age started oral contraceptive pill	1.9	2.4	4.7	-1.3	2.2	1.3	1.6	1.6	1.6	-1.6	-1.7	-1.6	1.2	1.7	1.2
Diastolic blood pressure, automated reading	12.6	39.2	49.4	5.8	-4.5	-7.0	-6.4	-6.7	-7.0	6.7	6.2	6.3	-6.5	-6.2	-5.1
Ever depressed for a whole week	2.9	3.5	5.7	-1.8	1.3	2.4	2.2	2.0	1.5	-1.5	-1.6	-1.6	1.9	2.0	2.3
Unable to work because of sickness or disability	2.7	3.5	5.2	1.4	-1.0	-1.7	-1.9	-2.2	-2.2	2.1	2.3	2.2	-1.7	-2.0	-1.4
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.5	0.6	0.4	-0.2	0.6	0.2	-0.3	-0.2	-0.2	0.4	0.4	0.2
Myopia	1.9	2.8	4.7	-2.1	1.1	2.2	2.0	1.1	1.8	-1.8	-1.8	-2.0	1.4	1.4	0.7
Vascular/heart problems diagnosed by doctor	7.9	21.4	28.4	-4.2	2.7	5.3	4.7	5.2	4.7	-4.6	-4.6	-4.4	5.0	4.7	4.8
Cholesterol lowering medication	0.2	0.3	1.8	-0.5	-0.5	0.4	0.7	0.6	-0.4	-0.1	-0.2	-0.0	0.0	0.0	1.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	3.7	-1.9	0.5	0.6	0.6	0.6	0.2	-0.3	-0.1	-0.5	0.8	0.1	0.3
Pain experienced in last month	0.1	0.1	0.6	0.1	0.0	-0.3	-0.4	-0.4	-0.3	0.8	0.2	0.4	-0.2	0.0	-0.1
Supplements: Calcium	0.2	0.2	0.5	-0.2	0.7	0.6	0.3	-0.1	0.1	-0.3	-0.6	-0.6	-0.3	0.6	0.2
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	0.7	-0.1	-0.6	-0.5	-0.7	-0.8	0.8	0.6	0.6	-0.7	-0.7	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	-0.7	1.1	0.7	0.0	0.1	-0.8	-0.5	0.0	-1.2	0.3	0.3	1.0
Deep venous thrombosis (DVT) (self-reported)	3.9	5.0	7.6	2.1	-1.5	-2.3	-2.6	-2.8	-2.1	2.3	1.8	2.1	-2.1	-2.2	-2.5
Heart disease (siblings)	0.2	0.3	0.7	-0.7	-0.5	0.4	0.9	-0.3	-0.6	-0.3	-0.3	-0.8	-0.8	-0.3	-0.0
Alcohol drinker status: Previous	0.1	0.1	0.4	-0.4	-0.1	0.4	-0.0	-0.1	-0.7	0.2	0.2	0.0	0.1	-0.7	-0.3
Pack years of smoking	1.9	2.8	8.2	0.8	-2.9	-1.7	-1.4	-1.4	-1.9	1.8	1.3	1.5	-1.7	-1.6	-1.3
Impedance of whole body	14.5	74.0	88.7	-7.9	7.2	9.4	9.3	9.1	8.3	-9.3	-8.8	-8.8	8.4	9.2	7.1
Leg fat mass (left)	7.1	27.6	33.7	4.7	-5.8	-5.2	-5.4	-5.4	-5.6	5.4	5.0	5.2	-5.5	-5.6	-4.1
Arm predicted mass (left)	4.0	20.4	26.4	3.9	-5.1	-4.6	-4.6	-4.6	-4.9	4.3	3.9	4.6	-4.4	-5.0	-4.1