Best TWAS P=3.29e-10 · Best GWAS P=2.3e-10 conditioned to 0.000306
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | RPS26 | 0.29 | 0.05 | enet | 37 | 0.12 | 9.4e-07 | -4.5 | -5.7 | 1.0e-08 | 0.52 | 0.66 | 0.33 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | RPS26 | 0.20 | 0.11 | lasso | 3 | 0.10 | 6.6e-04 | -4.4 | -6.3 | 3.3e-10 | 0.52 | 0.05 | 0.23 | TRUE |
| 3 | GTEx | Muscle Skeletal | RAB5B | 0.29 | 0.32 | lasso | 4 | 0.33 | 1.3e-33 | -5.4 | 5.6 | 1.9e-08 | -0.63 | 0.31 | 0.69 | FALSE |
| 4 | GTEx | Muscle Skeletal | AC034102.1 | 0.28 | 0.31 | lasso | 4 | 0.31 | 2.3e-31 | -5.4 | 5.6 | 2.0e-08 | -0.63 | 0.31 | 0.69 | FALSE |
| 5 | GTEx | Prostate | SUOX | 0.22 | 0.04 | enet | 11 | 0.05 | 2.3e-02 | -4.4 | 5.9 | 3.0e-09 | -0.77 | 0.02 | 0.86 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ERBB3 | 0.07 | 0.02 | blup | 29 | 0.05 | 2.1e-06 | -5.7 | -5.4 | 8.1e-08 | 0.79 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RPS26 | 0.28 | 0.15 | lasso | 2 | 0.17 | 3.0e-05 | -5.3 | -5.2 | 2.5e-07 | 0.59 | 0.02 | 0.94 | FALSE |