TWAS hub - ERBB3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0689	0.0327	3.7e-06	0.023	0.050	0.042	NA	0.041	0.0012	2.1e-06	1.4e-05	NA	1.7e-05
2	TCGA	Stomach Adenocarcinoma	0.1280	0.0760	3.7e-03	0.010	0.022	0.033	NA	0.013	0.0550	9.9e-03	1.9e-03	NA	3.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Respiratory disease	16.7	37.2	42.1	6.5	-5.7
Allergy or Eczema	16.5	43.4	52.9	7.3	-5.8
Allergy	15.8	36.3	44.6	-6.7	5.3
Asthma (self-reported)	13.5	26.9	35.1	5.9	-4.3
Hayfever, allergic rhinitis or eczema	12.8	27.8	31.7	5.6	-4.9
Asthma	12.2	24.0	31.4	5.6	-4.1
Medication: Levothyroxine sodium	12.1	20.5	24.7	5.0	-4.0
Hypothyroidism (self reported)	11.9	27.4	31.8	5.6	-4.8
Hypothyroidism/myxoedema (self-reported)	11.7	22.8	23.9	4.9	-4.7
Headache pain in last month	9.7	16.7	27.6	-5.2	2.4
Birth weight of first child	9.6	17.4	19.3	4.0	-4.4
Hayfever/allergic rhinitis (self-reported)	9.4	12.4	13.5	3.7	-3.4
Lung FEV1/FVC ratio	8.0	40.6	49.0	-7.0	5.7
Qualifications: College or University degree	7.4	23.2	24.9	4.6	-5.0
Impedance of arm (left)	7.0	32.4	35.0	5.9	-5.5
Average weekly champagne plus white wine intake	6.9	9.5	12.5	2.5	-3.5
Falls in the last year	6.6	9.0	15.7	-1.5	4.0
Blood Eosinophil Count	6.4	49.0	71.7	8.5	-5.1
Impedance of whole body	6.4	32.6	36.2	6.0	-5.4
Body mass index (BMI)	6.3	26.9	36.0	-6.0	4.2
Qualifications: A levels/AS levels or equivalent	6.3	13.9	14.8	3.6	-3.9
Alcohol intake frequency.	6.3	14.6	16.6	-4.1	3.6
Serious illness, injury or assault of a close relative in last 2 years	6.1	7.0	13.2	3.6	-0.9
Wears glasses or contact lenses	6.1	7.1	12.3	3.5	-1.4
Pain experienced in last month	6.1	10.2	15.2	3.9	-2.3
Impedance of arm (right)	5.9	27.7	31.4	5.6	-4.9
Reason for reducing amount of alcohol drunk: Health precaution	5.8	6.7	11.8	1.3	-3.4
BMI	5.7	33.0	42.9	-6.5	4.8
Neck or shoulder pain in last month	5.7	8.1	8.3	-2.8	2.9
Age started oral contraceptive pill	5.6	7.1	8.6	2.9	-2.4
Age at first live birth	5.5	9.8	12.7	2.6	-3.6
Age at First Birth	5.4	7.8	10.7	3.3	-2.2
Medication: Ventolin 100micrograms inhaler	5.4	7.0	8.4	2.9	-2.4
Impedance of leg (left)	5.1	24.9	32.4	5.7	-4.2
Lupus	5.0	7.5	11.4	3.4	-1.9
Impedance of leg (right)	5.0	24.0	31.1	5.6	-4.1
Qualifications: None of the above	5.0	10.8	12.0	-3.1	3.5
Gout (self-reported)	4.9	6.7	8.4	-2.2	2.9
Pulse rate, automated reading	4.9	15.9	18.9	-4.3	3.6
Fractured/broken bones in last 5 years	4.8	6.2	9.8	-3.1	1.6
Medication: Seretide 50 evohaler	4.7	5.5	9.1	3.0	-1.4
Arm fat mass (right)	4.6	18.8	28.8	-5.4	3.0
Medication: Allopurinol	4.6	6.1	6.2	-2.4	2.5
Verbal and Numeric Reasoning (VNR)	4.5	10.7	13.0	2.9	-3.6
Fluid intelligence score	4.5	9.3	13.0	2.4	-3.6
Smoking status: Previous	4.2	6.3	7.3	-2.7	2.3
Arm fat mass (left)	4.2	17.3	27.2	-5.2	2.7
Diastolic blood pressure, automated reading	4.1	12.6	13.2	-3.6	3.5
Loud music exposure frequency	4.0	4.4	6.0	-1.7	2.4
Arm predicted mass (left)	4.0	20.5	29.1	-5.4	3.4
Smoking Status	3.9	9.4	10.1	-3.0	3.2
Maternal smoking around birth	3.9	5.7	11.3	-3.4	0.0
Waist circumference	3.8	13.8	17.7	-4.2	3.2
Past tobacco smoking	3.8	7.0	9.2	2.2	-3.0
Leg fat mass (left)	3.8	15.0	23.1	-4.8	2.6
Pulse rate	3.7	6.3	8.9	-3.0	1.9
Leg fat mass (right)	3.7	14.5	21.6	-4.6	2.7
Weight	3.6	17.5	29.1	-5.4	2.5
Exposure to tobacco smoke outside home	3.6	4.8	7.4	-1.5	2.7
Arm fat-free mass (left)	3.6	18.5	27.1	-5.2	3.1
Number of full sisters	3.5	4.2	5.3	-1.8	2.3
Loneliness, isolation	3.5	4.8	9.4	-0.4	3.1
Leg fat-free mass (left)	3.4	18.0	27.7	-5.3	2.9
Medication: Atorvastatin	3.4	4.2	6.2	-1.5	2.5
Leg predicted mass (left)	3.3	17.7	27.1	-5.2	2.9
Qualifications: O levels/GCSEs or equivalent	3.3	5.2	7.1	1.8	-2.7
Leg fat-free mass (right)	3.3	17.4	26.2	-5.1	2.9
Leg predicted mass (right)	3.3	17.4	26.3	-5.1	2.9
Medication: Paracetamol	3.3	5.1	7.1	-2.7	1.8
Qualifications: nursing, teaching	3.2	4.9	5.5	2.1	-2.4
Basal metabolic rate	3.2	17.9	26.9	-5.2	3.0
Average weekly beer plus cider intake	3.2	4.7	6.6	-1.6	2.6
Pain all over the body in last month	3.1	3.3	4.1	-2.0	1.6
Arm fat percentage (right)	3.1	12.3	18.6	-4.3	2.4
Emphysema/chronic bronchitis	3.1	3.5	5.2	2.3	-1.3
Arm predicted mass (right)	3.1	15.8	21.0	-4.6	3.3
Intelligence (Savage-Jansen 2018)	3.0	9.3	11.3	2.7	-3.4
Primary Biliary Cirrhosis	3.0	4.2	5.6	-1.7	2.4
Rheumatoid Arthritis	3.0	4.1	8.2	0.1	2.9
Cardiovascular Disease	3.0	10.0	11.5	-3.4	2.9
Medication: Omeprazole	3.0	3.5	5.2	-2.3	1.4
Mean time to correctly identify matches	3.0	5.8	10.3	-3.2	1.1
Number of live births	2.9	4.1	8.0	-2.8	-0.4
Migraine (self-reported)	2.9	3.6	6.4	-2.5	0.9
Overall health rating	2.9	6.2	11.9	-0.7	3.4
Whole body fat-free mass	2.9	16.4	24.1	-4.9	3.0
Whole body water mass	2.9	16.4	24.6	-5.0	2.9
Reaction Time	2.8	5.4	9.3	-3.1	1.2
Alcohol drinker status: Previous	2.8	3.2	5.3	-2.3	1.1
Relative age voice broke	2.7	4.2	6.2	2.5	-1.5
Alcohol usually taken with meals	2.7	4.4	7.1	2.7	-1.3
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	4.8	-2.2	2.0
Arm fat-free mass (right)	2.7	13.8	19.5	-4.4	2.9
Relative age of first facial hair	2.6	5.4	7.0	2.6	-2.0
Whole body fat mass	2.6	11.0	18.2	-4.3	1.9
Smoking status: Current	2.6	4.2	7.9	-0.7	2.8
High blood pressure	2.5	6.9	7.2	-2.7	2.6
Angina (self-reported)	2.5	3.3	6.5	2.5	0.3
Arm fat percentage (left)	2.5	9.8	15.5	-3.9	2.0
Alzheimer’s Disease (including proxy)	2.4	3.4	5.1	-2.3	1.4
Financial difficulties in last 2 years	2.4	3.2	4.9	-2.2	1.2
Trunk fat-free mass	2.4	13.6	19.5	-4.4	2.8
Hip circumference	2.4	10.4	17.8	-4.2	1.7
Trunk predicted mass	2.4	13.8	19.8	-4.5	2.8
Medication: Paracetamol	2.4	4.0	6.1	-2.5	1.4
Hypertension (Self-reported)	2.4	6.6	7.1	-2.7	2.5
Mouth/teeth dental problems	2.3	3.5	7.0	0.1	-2.6
Forced expiratory volume in 1-second (FEV1)	2.3	7.7	15.3	-3.9	0.2
Birth weight	2.3	5.1	8.9	1.1	-3.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	13.1	-3.6	1.0
Age at last live birth	2.2	3.2	6.5	-0.1	-2.5
Medication: Aspirin	2.2	2.9	5.0	0.9	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	7.8	-2.8	1.2
Heel T-Score	2.1	16.6	33.1	5.8	-0.2
Qualifications: CSEs or equivalent	2.1	2.7	3.1	-1.8	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	3.7	-1.9	1.1
Medication: Aspirin	2.1	2.7	5.1	0.5	2.3
Systolic blood pressure, automated reading	2.0	5.7	7.3	-2.0	2.7
Average weekly fortified wine intake	2.0	2.4	3.4	1.9	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	6.3	2.5	1.6
Stomach or abdominal pain in last month	2.0	2.5	3.0	-1.4	1.7
High cholesterol (Self-reported)	2.0	3.5	4.8	-1.5	2.2
Leg fat percentage (left)	2.0	7.4	10.6	-3.3	2.0
Townsend deprivation index at recruitment	1.9	2.6	4.1	-1.1	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	4.1	-2.0	1.1
Had other major operations	1.9	2.4	4.2	-0.7	-2.0
Alcohol intake versus 10 years previously	1.9	2.8	2.9	-1.7	1.6
Lung cancer (father)	1.9	2.2	3.4	-1.8	1.1
Leg fat percentage (right)	1.9	6.9	9.7	-3.1	2.1
Illnesses of father: Heart disease	1.9	2.6	5.0	2.2	-0.3
Financial situation satisfaction	1.9	2.4	2.5	-1.6	1.5
Ever smoked	1.9	3.4	4.8	-1.4	2.2
Ovarian Cancer	1.8	2.3	4.5	-2.1	0.4
High blood pressure (mother)	1.8	2.5	5.1	-2.3	0.1
Medication: Cholesterol lowering	1.8	2.8	5.2	0.5	2.3
Peak expiratory flow (PEF)	1.8	4.2	4.7	-2.2	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.1	-2.0	0.6
Alzheimer’s Disease (in mother)	1.7	2.0	3.6	-1.9	0.7
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	2.1	1.4	-1.3
Angina	1.7	2.3	4.2	2.0	0.6
Trunk fat mass	1.7	7.3	13.0	-3.6	1.3
Medication for pain relief, constipation, heartburn	1.7	2.8	3.2	1.8	-1.6
Medication: Blood pressure	1.7	3.3	3.7	-1.7	1.9
Vascular/heart problems diagnosed by doctor	1.7	4.6	5.6	1.9	-2.4
Blood Red Count	1.6	15.7	16.5	-3.9	4.1
Systolic Blood Pressure	1.6	8.2	8.4	-2.9	2.8
Fed-up feelings	1.6	2.9	3.5	-1.9	1.5
Age when periods started (menarche)	1.6	3.8	5.2	1.5	-2.3
Medication: Atenolol	1.6	2.0	4.0	2.0	-0.4
Breastfed as a baby	1.6	2.0	2.0	1.4	-1.4
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.5	-0.8	1.9
Commuting to job workplace: Cycle	1.6	1.9	3.4	1.8	-0.6
Body Mass Index (BMI) (2010)	1.5	2.1	3.2	-1.8	1.0
Blood White Count	1.5	11.0	16.3	-2.4	4.0
Medication for hormone replacement therapy	1.5	1.7	2.2	1.5	-1.1
Hearing difficulty/problems with background noise	1.5	2.4	3.1	-1.8	1.3
Medication: Bendroflumethiazide	1.5	2.3	4.0	-2.0	0.7
Triglycerides	1.4	2.3	2.8	-1.7	1.3
Current tobacco smoking	1.4	2.4	4.3	-0.7	2.1
Prospective memory result	1.4	1.7	2.9	1.7	0.7
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.7	-0.7	-1.6
Body fat percentage	1.4	5.7	9.7	-3.1	1.3
Eye problems/disorders: Glaucoma	1.4	1.7	3.1	-0.5	-1.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.5	-1.6	0.6
Depression (self-reported)	1.3	1.6	3.0	-1.7	0.3
Hair/balding pattern: Pattern 4	1.3	3.0	3.4	1.6	-1.8
Blood clot in the leg (DVT)	1.3	1.6	2.8	-1.7	0.7
Worry too long after embarrassment	1.3	2.2	4.3	2.1	-0.2
Mood swings	1.3	2.3	2.9	-1.7	1.3
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	2.6	-1.6	0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	3.1	1.8	1.5
Medication: Lansoprazole	1.2	1.3	2.5	-1.6	0.4
Number of full brothers	1.2	1.4	2.7	-0.4	1.7
Commuting to job workplace: Car/motor vehicle	1.2	1.3	1.4	-1.1	1.2
Hearing aid user	1.2	1.4	2.7	1.6	0.2
Nervous feelings	1.1	2.1	3.7	1.9	-0.7
Glaucoma (self-reported)	1.1	1.3	2.6	-0.0	-1.6
High blood pressure (siblings)	1.1	1.6	1.7	-1.3	1.2
Average weekly red wine intake	1.1	1.6	2.3	1.5	-1.0
Medication: Gliclazide	1.1	1.2	1.7	-0.9	1.3
Diabetes (mother)	1.0	1.2	2.0	-1.4	0.7
Taking other prescription medications	1.0	1.5	2.2	1.5	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.1	-0.2	1.8
Worrier / anxious feelings	1.0	1.9	2.2	1.5	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.3	-1.1	1.1
Heart disease (siblings)	1.0	1.2	2.2	-0.5	1.5
Vitamin and mineral supplements	0.9	1.2	2.3	0.3	-1.5
Diabetes (father)	0.9	1.1	1.6	-1.3	-0.8
Trunk fat percentage	0.9	3.5	6.7	-2.6	0.6
Forced vital capacity (FVC)	0.9	3.3	4.2	-2.0	-1.6
Noisy workplace	0.9	1.2	2.2	-1.5	0.4
Tense / ‘highly strung’	0.9	1.5	2.8	-0.4	1.7
Suffer from ‘nerves’	0.9	1.3	2.6	0.4	1.6
Family relationship satisfaction	0.9	1.1	1.7	-1.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.3	-0.8	1.2
Eye problems/disorders: Cataract	0.9	1.0	2.0	1.4	0.1
Back pain experienced in last month	0.9	1.3	2.5	0.1	1.6
Ever taken oral contraceptive pill	0.9	1.0	2.0	0.3	-1.4
Bipolar Disorder (2018)	0.8	1.2	2.0	1.4	-0.7
Alzheimer’s Disease (in father)	0.8	0.9	1.0	-0.9	1.0
Severe depression (siblings)	0.8	0.9	1.7	1.3	-0.4
Number of incorrect matches in round	0.8	1.3	1.3	-1.1	1.1
Mouth/teeth dental problems: Dentures	0.8	1.3	2.6	0.0	1.6
Exposure to tobacco smoke at home	0.8	0.9	1.7	-1.3	0.0
Wheeze or whistling in the chest in last year	0.8	1.4	2.8	1.7	-0.3
Supplements: Vitamin C	0.8	1.0	1.3	1.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.5	-0.3	1.6
Illnesses of father: High blood pressure	0.8	1.0	1.2	-0.9	1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	1.4	-0.6	1.2
Lung FVC	0.7	3.5	5.0	-2.2	1.4
Number of treatments/medications taken	0.7	1.2	1.5	-1.0	1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	1.3	-0.1
Medication: Co-codamol	0.7	0.8	1.1	0.7	1.1
Pack years adult smoking proportion	0.7	1.1	1.1	-1.0	1.1
Chronic bronchitis/emphysema (father)	0.7	0.9	1.3	0.7	-1.1
Illnesses of siblings	0.7	1.0	1.0	1.0	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.2	0.0	-1.5
Medication: Ibuprofen	0.7	0.9	1.6	-1.3	-0.5
Medication for cholesterol	0.7	1.1	1.3	1.0	-1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.5	-1.2	-0.4
Myopia	0.7	1.1	1.1	1.0	1.0
Bipolar Disorder or Schizophrenia	0.6	1.5	2.0	1.4	-1.0
LDL Cholesterol	0.6	1.0	1.7	1.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.4	1.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.1	1.0	-0.6
Father’s age at death	0.6	0.8	1.3	-1.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.4	-1.2	0.1
Illnesses of mother	0.6	0.8	1.1	1.1	0.6
Standing height	0.6	6.0	11.4	0.7	-3.4
Eye problems/disorders: None of the above	0.6	0.7	1.2	-1.1	-0.3
Leg pain on walking	0.6	0.8	1.6	0.1	1.3
Commuting to job workplace: Public transport	0.6	0.8	1.0	0.7	-1.0
Medication: Lisinopril	0.6	0.8	1.7	-1.3	0.0
Number of operations (self-reported)	0.6	0.8	1.3	-1.1	-0.6
Worry (Nagel 2018)	0.5	1.2	1.8	1.4	0.7
Ulcerative Colitis (UC)	0.5	0.9	1.7	-0.4	-1.3
HDL Cholesterol	0.5	0.9	1.1	1.1	-0.8
Hand grip strength (right)	0.5	1.4	1.4	-1.2	-1.2
Serious illness, injury or assault to yourself	0.5	0.6	1.2	1.1	0.0
Multivitamins +/- minerals	0.5	0.7	1.3	-0.2	1.1
Supplements: Glucosamine	0.5	0.7	1.2	1.1	-0.4
Heart attack	0.5	0.6	1.1	1.1	0.3
Hair/balding pattern: Pattern 3	0.5	0.8	1.1	-1.0	-0.7
Medication: Amlodipine	0.5	0.7	1.3	-1.2	0.1
Forced vital capacity (FVC), Best measure	0.5	1.9	3.6	-1.9	-0.4
Pulse wave peak to peak time	0.5	0.6	1.0	0.5	-1.0
Shortness of breath walking on level ground	0.5	0.6	1.0	-1.0	0.4
Heart disease (mother)	0.5	0.6	1.0	1.0	-0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.9	-0.5	-0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.2	0.2	-1.1
Long-standing illness, disability or infirmity	0.5	0.8	0.9	0.9	0.8
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	1.3	-0.0
Guilty feelings	0.5	0.8	1.1	0.6	1.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	0.2	-1.1
Ever depressed for a whole week	0.5	0.6	0.8	0.7	-0.9
Crohns Disease (2012)	0.4	0.7	1.2	0.4	1.1
Height	0.4	7.9	13.9	1.4	-3.7
Sensitivity / hurt feelings	0.4	0.6	0.8	0.7	0.9
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	-0.4	0.9
Sitting height	0.4	2.7	5.3	-0.2	-2.3
Length of working week for main job	0.4	0.4	0.5	0.7	0.6
Chest pain or discomfort	0.4	0.5	0.8	-0.9	0.5
Breast cancer (self-reported)	0.4	0.4	0.4	-0.6	-0.7
Mother’s age at death	0.4	0.5	0.8	0.9	0.5
Unable to work because of sickness or disability	0.4	0.5	0.8	0.4	0.9
Cholesterol lowering medication	0.4	0.6	0.7	-0.8	0.8
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	0.9	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	1.0	0.1
Pack years of smoking	0.4	0.5	0.7	-0.6	0.8
Depression (Nagel 2018)	0.3	0.5	1.0	-0.1	1.0
Neuroticism (Nagel 2018)	0.3	0.8	0.9	0.8	0.9
Crohns Disease (2017)	0.3	0.6	1.1	1.0	-0.3
Fasting Glucose	0.3	0.3	0.5	-0.7	0.2
HbA1C	0.3	0.3	0.6	-0.1	0.8
Neuroticism (2016)	0.3	0.5	0.9	-1.0	-0.0
Blood Platelet Count	0.3	4.0	8.0	2.8	0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.1	-1.1	0.2
Neuroticism	0.3	0.8	1.5	1.2	-0.3
Chronotype (morning person)	0.3	0.7	1.3	1.2	0.1
Hair Pigment	0.3	8.4	13.8	-1.7	3.7
Average weekly spirits intake	0.3	0.4	0.6	0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.4	0.6	0.7
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	0.8	0.1
Time employed in main current job	0.3	0.4	0.4	0.7	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	-0.3	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.9	0.1
Number of children fathered	0.3	0.3	0.6	-0.1	-0.8
Health satisfaction	0.3	0.3	0.5	-0.4	0.7
Medication: Blood pressure	0.3	0.5	1.0	-0.2	1.0
Comparative height size at age 10	0.3	1.7	3.2	-1.8	-0.4
Diabetes diagnosed by doctor	0.3	0.4	0.9	-0.9	0.2
Osteoporosis (self-reported)	0.3	0.4	0.6	0.4	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.9	-0.1
Irritability	0.3	0.6	1.0	0.3	-1.0
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	-0.4	0.8
Schizophrenia (2018)	0.2	0.4	0.5	0.6	-0.7
Irritable Bowel Disease (IBD)	0.2	0.4	0.8	0.2	-0.9
Major Depression (MDD)	0.2	0.2	0.4	0.2	0.6
Schizophrenia (2014)	0.2	0.4	0.4	0.6	-0.6
Waist Hip Ratio (WHR)	0.2	0.7	1.0	0.6	1.0
Tanning	0.2	2.6	5.0	-2.2	-0.5
Hand grip strength (left)	0.2	0.4	0.6	-0.4	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.2	0.5	-0.4
Medication: Ramipril	0.2	0.3	0.6	-0.0	0.8
Neuroticism score	0.2	0.5	0.8	0.9	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.7	-0.0
Comparative body size at age 10	0.2	0.7	1.2	-1.1	0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	0.1	-0.9
Commuting to job workplace: Walk	0.2	0.2	0.3	0.3	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.2	-0.4	0.5
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.4	0.7
Risk taking	0.2	0.2	0.4	0.6	0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.2	0.5	-0.4
Supplements: Calcium	0.2	0.3	0.5	0.7	-0.0
Mean Putamen Volume	0.1	0.1	0.1	0.2	-0.4
Ulcerative Colitis	0.1	0.1	0.2	-0.2	0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.5	-0.2
Supplements: Zinc	0.1	0.1	0.2	0.1	0.4
Medication: Simvastatin	0.1	0.1	0.2	0.1	0.4
Happiness	0.1	0.1	0.2	-0.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	-0.3	-0.3
Had major operations	0.1	0.1	0.1	-0.4	0.0
Knee pain experienced in last month	0.1	0.2	0.3	0.2	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	0.5	0.2
Ever had bowel cancer screening	0.1	0.2	0.3	0.0	0.6
Friendships satisfaction	0.1	0.1	0.2	-0.4	-0.0
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	0.2
Miserableness	0.1	0.2	0.3	0.6	-0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.1	0.0
Hearing difficulty/problems: Yes	0.0	0.1	0.1	-0.3	0.3
Medication: Metformin	0.0	0.0	0.0	0.0	-0.0
Had menopause	0.0	0.0	0.0	0.1	0.0
Diabetes (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Pulse wave reflection index	0.0	0.1	0.1	0.3	-0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	-0.1	0.2
Alcohol drinker status: Never	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

ERBB3

Models

Trait associations