Hub : Genes

ERBB3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Brain Lower Grade Glioma 0.0689 0.0327 3.7e-06 0.023 0.050 0.042 NA 0.041 0.0012 2.1e-06 1.4e-05 NA 1.7e-05
2 TCGA Stomach Adenocarcinoma 0.1280 0.0760 3.7e-03 0.010 0.022 0.033 NA 0.013 0.0550 9.9e-03 1.9e-03 NA 3.4e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.8 1.2 2.0 1.4 -0.7
Bipolar Disorder or Schizophrenia 0.6 1.5 2.0 1.4 -1.0
Depressed Affect (Nagel 2018) 0.2 0.4 0.6 -0.4 0.8
Depression (Nagel 2018) 0.3 0.5 1.0 -0.1 1.0
Intelligence (Savage-Jansen 2018) 3.0 9.3 11.3 2.7 -3.4
Neuroticism (Nagel 2018) 0.3 0.8 0.9 0.8 0.9
Schizophrenia (2018) 0.2 0.4 0.5 0.6 -0.7
Schizophrenia vs Biploar Disorder 0.7 0.9 1.4 -0.6 1.2
Worry (Nagel 2018) 0.5 1.2 1.8 1.4 0.7
Alzheimer’s Disease (in mother) 1.7 2.0 3.6 -1.9 0.7
Alzheimer’s Disease (in father) 0.8 0.9 1.0 -0.9 1.0
Alzheimer’s Disease (including proxy) 2.4 3.4 5.1 -2.3 1.4
Crohns Disease (2017) 0.3 0.6 1.1 1.0 -0.3
Irritable Bowel Disease (IBD) 0.2 0.4 0.8 0.2 -0.9
Ulcerative Colitis (UC) 0.5 0.9 1.7 -0.4 -1.3
Major Depression (MDD) 0.2 0.2 0.4 0.2 0.6
Reaction Time 2.8 5.4 9.3 -3.1 1.2
Verbal and Numeric Reasoning (VNR) 4.5 10.7 13.0 2.9 -3.6
Breast Cancer 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.8 2.3 4.5 -2.1 0.4
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 5.4 7.8 10.7 3.3 -2.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.5 2.1 3.2 -1.8 1.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.4 0.7 1.2 0.4 1.1
Mean Putamen Volume 0.1 0.1 0.1 0.2 -0.4
Fasting Glucose 0.3 0.3 0.5 -0.7 0.2
HbA1C 0.3 0.3 0.6 -0.1 0.8
HDL Cholesterol 0.5 0.9 1.1 1.1 -0.8
LDL Cholesterol 0.6 1.0 1.7 1.3 0.5
Lupus 5.0 7.5 11.4 3.4 -1.9
Neuroticism (2016) 0.3 0.5 0.9 -1.0 -0.0
Primary Biliary Cirrhosis 3.0 4.2 5.6 -1.7 2.4
Rheumatoid Arthritis 3.0 4.1 8.2 0.1 2.9
Schizophrenia (2014) 0.2 0.4 0.4 0.6 -0.6
Triglycerides 1.4 2.3 2.8 -1.7 1.3
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.1 0.0
Ulcerative Colitis 0.1 0.1 0.2 -0.2 0.4
Blood Eosinophil Count 6.4 49.0 71.7 8.5 -5.1
Blood Platelet Count 0.3 4.0 8.0 2.8 0.2
Blood Red Count 1.6 15.7 16.5 -3.9 4.1
Blood White Count 1.5 11.0 16.3 -2.4 4.0
Heel T-Score 2.1 16.6 33.1 5.8 -0.2
BMI 5.7 33.0 42.9 -6.5 4.8
Height 0.4 7.9 13.9 1.4 -3.7
Waist Hip Ratio (WHR) 0.2 0.7 1.0 0.6 1.0
Systolic Blood Pressure 1.6 8.2 8.4 -2.9 2.8
Smoking Status 3.9 9.4 10.1 -3.0 3.2
Allergy or Eczema 16.5 43.4 52.9 7.3 -5.8
Cardiovascular Disease 3.0 10.0 11.5 -3.4 2.9
Hypothyroidism (self reported) 11.9 27.4 31.8 5.6 -4.8
Respiratory disease 16.7 37.2 42.1 6.5 -5.7
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.1 -1.1 0.2
Lung FEV1/FVC ratio 8.0 40.6 49.0 -7.0 5.7
Lung FVC 0.7 3.5 5.0 -2.2 1.4
Neuroticism 0.3 0.8 1.5 1.2 -0.3
Chronotype (morning person) 0.3 0.7 1.3 1.2 0.1
Hair Pigment 0.3 8.4 13.8 -1.7 3.7
Tanning 0.2 2.6 5.0 -2.2 -0.5
Hand grip strength (left) 0.2 0.4 0.6 -0.4 -0.8
Number of treatments/medications taken 0.7 1.2 1.5 -1.0 1.2
Average weekly spirits intake 0.3 0.4 0.6 0.3 0.8
Sensitivity / hurt feelings 0.4 0.6 0.8 0.7 0.9
Frequency of depressed mood in last 2 weeks 0.4 0.5 0.9 -0.4 0.9
Hearing difficulty/problems: Yes 0.0 0.1 0.1 -0.3 0.3
Relative age of first facial hair 2.6 5.4 7.0 2.6 -2.0
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.7 1.3 -0.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.2 0.5 -0.4
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.5 -0.2
Systolic blood pressure, automated reading 2.0 5.7 7.3 -2.0 2.7
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 2.1 1.4 -1.3
Angina 1.7 2.3 4.2 2.0 0.6
Medication for hormone replacement therapy 1.5 1.7 2.2 1.5 -1.1
Vitamin and mineral supplements 0.9 1.2 2.3 0.3 -1.5
Supplements: Zinc 0.1 0.1 0.2 0.1 0.4
Medication: Co-codamol 0.7 0.8 1.1 0.7 1.1
Medication: Metformin 0.0 0.0 0.0 0.0 -0.0
Diabetes (father) 0.9 1.1 1.6 -1.3 -0.8
Diabetes (mother) 1.0 1.2 2.0 -1.4 0.7
Severe depression (siblings) 0.8 0.9 1.7 1.3 -0.4
Pack years adult smoking proportion 0.7 1.1 1.1 -1.0 1.1
Impedance of leg (right) 5.0 24.0 31.1 5.6 -4.1
Leg fat-free mass (left) 3.4 18.0 27.7 -5.3 2.9
Trunk fat percentage 0.9 3.5 6.7 -2.6 0.6
Hand grip strength (right) 0.5 1.4 1.4 -1.2 -1.2
Townsend deprivation index at recruitment 1.9 2.6 4.1 -1.1 2.0
Current tobacco smoking 1.4 2.4 4.3 -0.7 2.1
Average weekly fortified wine intake 2.0 2.4 3.4 1.9 -1.2
Maternal smoking around birth 3.9 5.7 11.3 -3.4 0.0
Fed-up feelings 1.6 2.9 3.5 -1.9 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.6 4.1 -2.0 1.1
Relative age voice broke 2.7 4.2 6.2 2.5 -1.5
Taking other prescription medications 1.0 1.5 2.2 1.5 -0.8
Age when periods started (menarche) 1.6 3.8 5.2 1.5 -2.3
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.4 1.2 0.2
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.5 6.3 2.5 1.6
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.5 -1.6 0.6
Qualifications: CSEs or equivalent 2.1 2.7 3.1 -1.8 1.6
Serious illness, injury or assault to yourself 0.5 0.6 1.2 1.1 0.0
High blood pressure 2.5 6.9 7.2 -2.7 2.6
Hayfever, allergic rhinitis or eczema 12.8 27.8 31.7 5.6 -4.9
Multivitamins +/- minerals 0.5 0.7 1.3 -0.2 1.1
Stomach or abdominal pain in last month 2.0 2.5 3.0 -1.4 1.7
Supplements: Glucosamine 0.5 0.7 1.2 1.1 -0.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.4 0.6 0.7
Medication: Atenolol 1.6 2.0 4.0 2.0 -0.4
Medication: Levothyroxine sodium 12.1 20.5 24.7 5.0 -4.0
Sitting height 0.4 2.7 5.3 -0.2 -2.3
Chronic bronchitis/emphysema (father) 0.7 0.9 1.3 0.7 -1.1
High blood pressure (mother) 1.8 2.5 5.1 -2.3 0.1
Body mass index (BMI) 6.3 26.9 36.0 -6.0 4.2
Impedance of leg (left) 5.1 24.9 32.4 5.7 -4.2
Leg predicted mass (left) 3.3 17.7 27.1 -5.2 2.9
Trunk fat mass 1.7 7.3 13.0 -3.6 1.3
Waist circumference 3.8 13.8 17.7 -4.2 3.2
Number of incorrect matches in round 0.8 1.3 1.3 -1.1 1.1
Past tobacco smoking 3.8 7.0 9.2 2.2 -3.0
Alcohol usually taken with meals 2.7 4.4 7.1 2.7 -1.3
Nervous feelings 1.1 2.1 3.7 1.9 -0.7
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.1 -0.2 1.8
Hearing difficulty/problems with background noise 1.5 2.4 3.1 -1.8 1.3
Hair/balding pattern: Pattern 2 0.3 0.3 0.6 0.8 0.1
Had menopause 0.0 0.0 0.0 0.1 0.0
Had other major operations 1.9 2.4 4.2 -0.7 -2.0
Forced vital capacity (FVC) 0.9 3.3 4.2 -2.0 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 3.1 1.8 1.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.1 1.0 -0.6
Qualifications: None of the above 5.0 10.8 12.0 -3.1 3.5
Financial difficulties in last 2 years 2.4 3.2 4.9 -2.2 1.2
Mouth/teeth dental problems 2.3 3.5 7.0 0.1 -2.6
Heart attack 0.5 0.6 1.1 1.1 0.3
Allergy 15.8 36.3 44.6 -6.7 5.3
Pain all over the body in last month 3.1 3.3 4.1 -2.0 1.6
Diabetes (self-reported) 0.0 0.0 0.0 -0.1 -0.1
Hayfever/allergic rhinitis (self-reported) 9.4 12.4 13.5 3.7 -3.4
Medication: Ramipril 0.2 0.3 0.6 -0.0 0.8
Medication: Simvastatin 0.1 0.1 0.2 0.1 0.4
Fluid intelligence score 4.5 9.3 13.0 2.4 -3.6
Illnesses of siblings 0.7 1.0 1.0 1.0 -0.9
Neuroticism score 0.2 0.5 0.8 0.9 0.4
Weight 3.6 17.5 29.1 -5.4 2.5
Impedance of arm (right) 5.9 27.7 31.4 5.6 -4.9
Arm fat percentage (right) 3.1 12.3 18.6 -4.3 2.4
Trunk fat-free mass 2.4 13.6 19.5 -4.4 2.8
Hip circumference 2.4 10.4 17.8 -4.2 1.7
Time employed in main current job 0.3 0.4 0.4 0.7 -0.5
Alcohol intake versus 10 years previously 1.9 2.8 2.9 -1.7 1.6
Father’s age at death 0.6 0.8 1.3 -1.1 -0.5
Worrier / anxious feelings 1.0 1.9 2.2 1.5 -1.3
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 4.8 -2.2 2.0
Falls in the last year 6.6 9.0 15.7 -1.5 4.0
Hair/balding pattern: Pattern 3 0.5 0.8 1.1 -1.0 -0.7
Number of live births 2.9 4.1 8.0 -2.8 -0.4
Forced expiratory volume in 1-second (FEV1) 2.3 7.7 15.3 -3.9 0.2
Pulse rate 3.7 6.3 8.9 -3.0 1.9
Happiness 0.1 0.1 0.2 -0.5 -0.2
Noisy workplace 0.9 1.2 2.2 -1.5 0.4
Qualifications: A levels/AS levels or equivalent 6.3 13.9 14.8 3.6 -3.9
Serious illness, injury or assault of a close relative in last 2 years 6.1 7.0 13.2 3.6 -0.9
Mouth/teeth dental problems: Dentures 0.8 1.3 2.6 0.0 1.6
Asthma 12.2 24.0 31.4 5.6 -4.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.4 -1.2 0.1
Medication: Cholesterol lowering 1.8 2.8 5.2 0.5 2.3
Depression (self-reported) 1.3 1.6 3.0 -1.7 0.3
Medication: Lansoprazole 1.2 1.3 2.5 -1.6 0.4
Prospective memory result 1.4 1.7 2.9 1.7 0.7
Lung cancer (father) 1.9 2.2 3.4 -1.8 1.1
Illnesses of mother 0.6 0.8 1.1 1.1 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 7.1 13.1 -3.6 1.0
Pulse wave Arterial Stiffness index 0.3 0.4 0.7 -0.3 0.8
Impedance of arm (left) 7.0 32.4 35.0 5.9 -5.5
Arm fat mass (right) 4.6 18.8 28.8 -5.4 3.0
Trunk predicted mass 2.4 13.8 19.8 -4.5 2.8
Standing height 0.6 6.0 11.4 0.7 -3.4
Length of working week for main job 0.4 0.4 0.5 0.7 0.6
Exposure to tobacco smoke at home 0.8 0.9 1.7 -1.3 0.0
Breastfed as a baby 1.6 2.0 2.0 1.4 -1.4
Tense / ‘highly strung’ 0.9 1.5 2.8 -0.4 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.5 -0.1
Hair/balding pattern: Pattern 4 1.3 3.0 3.4 1.6 -1.8
Birth weight of first child 9.6 17.4 19.3 4.0 -4.4
Peak expiratory flow (PEF) 1.8 4.2 4.7 -2.2 -1.9
Pulse wave reflection index 0.0 0.1 0.1 0.3 -0.0
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 0.7 -0.0
Loud music exposure frequency 4.0 4.4 6.0 -1.7 2.4
Qualifications: O levels/GCSEs or equivalent 3.3 5.2 7.1 1.8 -2.7
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 3.5 -0.8 1.9
Blood clot in the leg (DVT) 1.3 1.6 2.8 -1.7 0.7
Medication: Paracetamol 2.4 4.0 6.1 -2.5 1.4
Headache pain in last month 9.7 16.7 27.6 -5.2 2.4
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 2.2 0.0 -1.5
Glaucoma (self-reported) 1.1 1.3 2.6 -0.0 -1.6
Gout (self-reported) 4.9 6.7 8.4 -2.2 2.9
Hypothyroidism/myxoedema (self-reported) 11.7 22.8 23.9 4.9 -4.7
Medication: Amlodipine 0.5 0.7 1.3 -1.2 0.1
Medication: Ventolin 100micrograms inhaler 5.4 7.0 8.4 2.9 -2.4
Birth weight 2.3 5.1 8.9 1.1 -3.0
Chronic bronchitis/emphysema (mother) 1.4 1.6 2.7 -0.7 -1.6
High blood pressure (siblings) 1.1 1.6 1.7 -1.3 1.2
Forced vital capacity (FVC), Best measure 0.5 1.9 3.6 -1.9 -0.4
Body fat percentage 1.4 5.7 9.7 -3.1 1.3
Leg fat percentage (right) 1.9 6.9 9.7 -3.1 2.1
Arm fat-free mass (right) 2.7 13.8 19.5 -4.4 2.9
Exposure to tobacco smoke outside home 3.6 4.8 7.4 -1.5 2.7
Comparative body size at age 10 0.2 0.7 1.2 -1.1 0.4
Number of full brothers 1.2 1.4 2.7 -0.4 1.7
Worry too long after embarrassment 1.3 2.2 4.3 2.1 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 -0.9 0.1
Wheeze or whistling in the chest in last year 0.8 1.4 2.8 1.7 -0.3
Number of children fathered 0.3 0.3 0.6 -0.1 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 5.8 6.7 11.8 1.3 -3.4
Age at first live birth 5.5 9.8 12.7 2.6 -3.6
Pulse wave peak to peak time 0.5 0.6 1.0 0.5 -1.0
Health satisfaction 0.3 0.3 0.5 -0.4 0.7
Shortness of breath walking on level ground 0.5 0.6 1.0 -1.0 0.4
Qualifications: College or University degree 7.4 23.2 24.9 4.6 -5.0
Eye problems/disorders: None of the above 0.6 0.7 1.2 -1.1 -0.3
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 0.3 0.7
Emphysema/chronic bronchitis 3.1 3.5 5.2 2.3 -1.3
Medication for pain relief, constipation, heartburn 1.7 2.8 3.2 1.8 -1.6
Neck or shoulder pain in last month 5.7 8.1 8.3 -2.8 2.9
Medication: Blood pressure 0.3 0.5 1.0 -0.2 1.0
Angina (self-reported) 2.5 3.3 6.5 2.5 0.3
Migraine (self-reported) 2.9 3.6 6.4 -2.5 0.9
Medication: Ibuprofen 0.7 0.9 1.6 -1.3 -0.5
Medication: Allopurinol 4.6 6.1 6.2 -2.4 2.5
Medication: Omeprazole 3.0 3.5 5.2 -2.3 1.4
Medication: Seretide 50 evohaler 4.7 5.5 9.1 3.0 -1.4
Mean time to correctly identify matches 3.0 5.8 10.3 -3.2 1.1
Heart disease (mother) 0.5 0.6 1.0 1.0 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 -0.3 -0.3
Whole body fat mass 2.6 11.0 18.2 -4.3 1.9
Leg fat mass (right) 3.7 14.5 21.6 -4.6 2.7
Arm predicted mass (right) 3.1 15.8 21.0 -4.6 3.3
Pulse rate, automated reading 4.9 15.9 18.9 -4.3 3.6
Alcohol intake frequency. 6.3 14.6 16.6 -4.1 3.6
Comparative height size at age 10 0.3 1.7 3.2 -1.8 -0.4
Number of full sisters 3.5 4.2 5.3 -1.8 2.3
Suffer from ‘nerves’ 0.9 1.3 2.6 0.4 1.6
Overall health rating 2.9 6.2 11.9 -0.7 3.4
Chest pain or discomfort 0.4 0.5 0.8 -0.9 0.5
Had major operations 0.1 0.1 0.1 -0.4 0.0
Age at last live birth 2.2 3.2 6.5 -0.1 -2.5
Family relationship satisfaction 0.9 1.1 1.7 -1.3 0.6
Leg pain on walking 0.6 0.8 1.6 0.1 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 1.3 -1.1 1.1
Commuting to job workplace: Car/motor vehicle 1.2 1.3 1.4 -1.1 1.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 0.9 -0.5 -0.9
Medication: Aspirin 2.2 2.9 5.0 0.9 2.2
Supplements: Vitamin C 0.8 1.0 1.3 1.1 -0.8
Knee pain experienced in last month 0.1 0.2 0.3 0.2 0.5
Hypertension (Self-reported) 2.4 6.6 7.1 -2.7 2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.4 3.7 -1.9 1.1
Illnesses of father: Heart disease 1.9 2.6 5.0 2.2 -0.3
Illnesses of siblings: Diabetes 0.5 0.6 1.2 0.2 -1.1
Smoking status: Previous 4.2 6.3 7.3 -2.7 2.3
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.8 0.1 -0.9
Whole body fat-free mass 2.9 16.4 24.1 -4.9 3.0
Leg fat-free mass (right) 3.3 17.4 26.2 -5.1 2.9
Arm fat percentage (left) 2.5 9.8 15.5 -3.9 2.0
Average weekly red wine intake 1.1 1.6 2.3 1.5 -1.0
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.3 0.5 0.2
Mood swings 1.3 2.3 2.9 -1.7 1.3
Loneliness, isolation 3.5 4.8 9.4 -0.4 3.1
Long-standing illness, disability or infirmity 0.5 0.8 0.9 0.9 0.8
Ever had bowel cancer screening 0.1 0.2 0.3 0.0 0.6
Diabetes diagnosed by doctor 0.3 0.4 0.9 -0.9 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.3 -0.8 1.2
Friendships satisfaction 0.1 0.1 0.2 -0.4 -0.0
Qualifications: nursing, teaching 3.2 4.9 5.5 2.1 -2.4
Commuting to job workplace: Walk 0.2 0.2 0.3 0.3 0.6
Eye problems/disorders: Cataract 0.9 1.0 2.0 1.4 0.1
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 2.5 -0.3 1.6
Medication for cholesterol 0.7 1.1 1.3 1.0 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.2 -0.4 0.5
Back pain experienced in last month 0.9 1.3 2.5 0.1 1.6
Mineral and other dietary supplements 0.1 0.1 0.2 -0.4 0.2
Breast cancer (self-reported) 0.4 0.4 0.4 -0.6 -0.7
Asthma (self-reported) 13.5 26.9 35.1 5.9 -4.3
Osteoporosis (self-reported) 0.3 0.4 0.6 0.4 0.8
Osteoarthritis (self-reported) 0.2 0.3 0.5 -0.4 0.7
Medication: Aspirin 2.1 2.7 5.1 0.5 2.3
Medication: Gliclazide 1.1 1.2 1.7 -0.9 1.3
Illnesses of father: None of the above (group 1) 0.3 0.4 0.8 -0.9 -0.1
Smoking status: Current 2.6 4.2 7.9 -0.7 2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.6 7.8 -2.8 1.2
Whole body water mass 2.9 16.4 24.6 -5.0 2.9
Leg predicted mass (right) 3.3 17.4 26.3 -5.1 2.9
Arm fat mass (left) 4.2 17.3 27.2 -5.2 2.7
Number of self-reported non-cancer illnesses 0.5 0.9 1.8 1.3 -0.0
Average weekly champagne plus white wine intake 6.9 9.5 12.5 2.5 -3.5
Miserableness 0.1 0.2 0.3 0.6 -0.4
Guilty feelings 0.5 0.8 1.1 0.6 1.1
Wears glasses or contact lenses 6.1 7.1 12.3 3.5 -1.4
Ever taken oral contraceptive pill 0.9 1.0 2.0 0.3 -1.4
Hearing aid user 1.2 1.4 2.7 1.6 0.2
Mother’s age at death 0.4 0.5 0.8 0.9 0.5
Financial situation satisfaction 1.9 2.4 2.5 -1.6 1.5
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.2 0.2 -1.1
Commuting to job workplace: Public transport 0.6 0.8 1.0 0.7 -1.0
Eye problems/disorders: Glaucoma 1.4 1.7 3.1 -0.5 -1.8
Medication: Blood pressure 1.7 3.3 3.7 -1.7 1.9
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.5 -1.2 -0.4
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.0 -0.1 0.2
High cholesterol (Self-reported) 2.0 3.5 4.8 -1.5 2.2
Medication: Bendroflumethiazide 1.5 2.3 4.0 -2.0 0.7
Medication: Paracetamol 3.3 5.1 7.1 -2.7 1.8
Medication: Lisinopril 0.6 0.8 1.7 -1.3 0.0
Medication: Atorvastatin 3.4 4.2 6.2 -1.5 2.5
Illnesses of father: High blood pressure 0.8 1.0 1.2 -0.9 1.1
Alcohol drinker status: Never 0.0 0.0 0.0 -0.1 -0.1
Ever smoked 1.9 3.4 4.8 -1.4 2.2
Basal metabolic rate 3.2 17.9 26.9 -5.2 3.0
Leg fat percentage (left) 2.0 7.4 10.6 -3.3 2.0
Arm fat-free mass (left) 3.6 18.5 27.1 -5.2 3.1
Number of operations (self-reported) 0.6 0.8 1.3 -1.1 -0.6
Average weekly beer plus cider intake 3.2 4.7 6.6 -1.6 2.6
Irritability 0.3 0.6 1.0 0.3 -1.0
Risk taking 0.2 0.2 0.4 0.6 0.3
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.2 0.5 -0.4
Fractured/broken bones in last 5 years 4.8 6.2 9.8 -3.1 1.6
Age started oral contraceptive pill 5.6 7.1 8.6 2.9 -2.4
Diastolic blood pressure, automated reading 4.1 12.6 13.2 -3.6 3.5
Ever depressed for a whole week 0.5 0.6 0.8 0.7 -0.9
Unable to work because of sickness or disability 0.4 0.5 0.8 0.4 0.9
Commuting to job workplace: Cycle 1.6 1.9 3.4 1.8 -0.6
Myopia 0.7 1.1 1.1 1.0 1.0
Vascular/heart problems diagnosed by doctor 1.7 4.6 5.6 1.9 -2.4
Cholesterol lowering medication 0.4 0.6 0.7 -0.8 0.8
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 4.1 -2.0 0.6
Pain experienced in last month 6.1 10.2 15.2 3.9 -2.3
Supplements: Calcium 0.2 0.3 0.5 0.7 -0.0
Basal cell carcinoma (self-reported) 0.4 0.4 0.8 0.9 0.2
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.0 1.0 0.1
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 2.6 -1.6 0.8
Heart disease (siblings) 1.0 1.2 2.2 -0.5 1.5
Alcohol drinker status: Previous 2.8 3.2 5.3 -2.3 1.1
Pack years of smoking 0.4 0.5 0.7 -0.6 0.8
Impedance of whole body 6.4 32.6 36.2 6.0 -5.4
Leg fat mass (left) 3.8 15.0 23.1 -4.8 2.6
Arm predicted mass (left) 4.0 20.5 29.1 -5.4 3.4