Best TWAS P=2.4e-11 · Best GWAS P=2.36e-11 conditioned to 0.0275
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Nerve Tibial | AXIN1 | 0.11 | 0.09 | lasso | 2 | 0.06 | 3.9e-05 | -6.0 | 5.3 | 1.2e-07 | -0.78 | 0.08 | 0.90 | FALSE |
2 | GTEx | Nerve Tibial | PDIA2 | 0.12 | 0.01 | enet | 13 | 0.06 | 4.4e-05 | -5.8 | 6.2 | 7.0e-10 | -0.77 | 0.03 | 0.96 | FALSE |
3 | GTEx | Nerve Tibial | ARHGDIG | 0.13 | 0.07 | lasso | 2 | 0.07 | 8.0e-06 | -6.0 | 5.9 | 3.5e-09 | -0.74 | 0.05 | 0.81 | FALSE |
4 | GTEx | Testis | AXIN1 | 0.36 | 0.29 | lasso | 3 | 0.28 | 4.3e-13 | -6.0 | -5.7 | 1.1e-08 | 0.81 | 0.08 | 0.92 | FALSE |
5 | GTEx | Whole Blood | NME4 | 0.12 | 0.03 | lasso | 5 | 0.04 | 3.0e-04 | 2.9 | 5.7 | 1.0e-08 | -0.62 | 0.02 | 0.96 | FALSE |
6 | ROSMAP | Brain Pre-frontal Cortex | PDIA2 | 0.15 | 0.07 | lasso | 8 | 0.10 | 5.2e-13 | -4.9 | -6.2 | 5.6e-10 | 0.77 | 0.06 | 0.94 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AXIN1 | 0.03 | 0.01 | blup | 88 | 0.01 | 7.7e-03 | -5.9 | 6.7 | 2.4e-11 | -0.80 | 0.01 | 0.74 | TRUE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC100134368 | 0.03 | 0.00 | enet | 5 | 0.01 | 2.8e-02 | -3.6 | -6.4 | 1.7e-10 | 0.58 | 0.01 | 0.57 | FALSE |
9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LOC100134368 | 0.08 | 0.07 | blup | 48 | 0.06 | 1.9e-03 | 2.9 | -5.2 | 2.5e-07 | 0.47 | 0.05 | 0.15 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | blup | 48 | 0.04 | 2.5e-05 | -4.9 | -6.4 | 1.5e-10 | 0.65 | 0.02 | 0.83 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100134368 | 0.06 | 0.05 | blup | 47 | 0.07 | 3.9e-07 | 2.9 | -5.8 | 5.3e-09 | 0.53 | 0.41 | 0.44 | FALSE |