Best TWAS P=1.29e-09 · Best GWAS P=6.63e-08 conditioned to 0.396
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | RABEP1 | 0.13 | 0.03 | lasso | 13 | 0.02 | 7.2e-02 | -4.3 | -5.2 | 1.6e-07 | -0.80 | 0.04 | 0.81 | FALSE |
2 | GTEx | Brain Putamen basal ganglia | AC012146.7 | 0.30 | 0.03 | enet | 23 | 0.03 | 7.6e-02 | 4.2 | -6.1 | 1.3e-09 | -0.45 | 0.08 | 0.24 | TRUE |
3 | GTEx | Esophagus Gastroesophageal Junction | DHX33 | 0.12 | 0.08 | lasso | 5 | 0.07 | 1.8e-03 | 5.4 | -5.2 | 1.7e-07 | -0.96 | 0.02 | 0.96 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | RABEP1 | 0.19 | -0.01 | lasso | 13 | 0.00 | 4.2e-01 | 4.4 | -5.3 | 1.3e-07 | -0.82 | 0.04 | 0.76 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | GP1BA | 0.35 | 0.16 | lasso | 11 | 0.18 | 5.9e-07 | 4.3 | 5.8 | 6.8e-09 | 0.56 | 0.12 | 0.78 | FALSE |
6 | GTEx | Esophagus Muscularis | RABEP1 | 0.13 | 0.09 | lasso | 10 | 0.10 | 2.1e-06 | 5.4 | -5.2 | 2.2e-07 | -0.94 | 0.02 | 0.97 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | AC012146.7 | 0.21 | 0.07 | enet | 17 | 0.18 | 1.3e-14 | 2.8 | -5.3 | 1.5e-07 | -0.45 | 0.90 | 0.02 | FALSE |
8 | METSIM | Adipose | SLC52A1 | 0.07 | 0.02 | lasso | 7 | 0.05 | 1.8e-07 | 4.1 | -5.1 | 3.0e-07 | -0.20 | 0.45 | 0.49 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | RABEP1 | 0.20 | 0.22 | bslmm | 546 | 0.20 | 7.4e-25 | 4.4 | -5.3 | 9.0e-08 | -0.75 | 0.29 | 0.68 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | RPAIN | 0.06 | 0.06 | lasso | 3 | 0.06 | 3.1e-08 | 5.3 | -5.7 | 1.2e-08 | -0.98 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | NUP88 | 0.12 | 0.07 | enet | 12 | 0.09 | 1.2e-03 | 4.4 | -5.2 | 1.9e-07 | -0.78 | 0.02 | 0.66 | FALSE |
12 | The Cancer Genome Atlas | Glioblastoma Multiforme | RABEP1 | 0.23 | 0.13 | blup | 79 | 0.15 | 3.4e-05 | 4.5 | -5.8 | 7.8e-09 | -0.77 | 0.05 | 0.84 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GP1BA | 0.02 | 0.02 | blup | 49 | 0.02 | 9.3e-03 | 4.2 | 5.3 | 8.6e-08 | 0.33 | 0.01 | 0.62 | FALSE |
14 | The Cancer Genome Atlas | Soft Tissue Sarcoma | INCA1 | 0.06 | 0.00 | enet | 11 | 0.00 | 1.7e-01 | 4.3 | 5.4 | 7.8e-08 | 0.30 | 0.00 | 0.34 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | RABEP1 | 0.04 | 0.03 | enet | 5 | 0.03 | 1.5e-03 | -4.4 | -5.6 | 1.8e-08 | -0.67 | 0.08 | 0.82 | TRUE |