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chr19:32,209,988-34,959,979

Best TWAS P=2.33e-15 · Best GWAS P=2.81e-14 conditioned to 0.135

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DPY19L3	0.07	0.05	lasso	2	0.06	8.7e-08	-5.5	-5.6	1.7e-08	-0.01	0.01	0.99	TRUE
2	GTEx	Adipose Subcutaneous	PEPD	0.30	0.25	lasso	6	0.26	2.5e-21	5.8	5.3	1.2e-07	0.73	1.00	0.00	FALSE
3	GTEx	Breast Mammary Tissue	PEPD	0.16	0.06	lasso	4	0.04	3.5e-03	5.8	6.1	1.0e-09	0.78	0.42	0.53	FALSE
4	GTEx	Cells Transformed fibroblasts	DPY19L3	0.19	0.12	lasso	6	0.10	9.4e-08	-5.3	-5.2	2.3e-07	-0.03	0.01	0.99	FALSE
5	GTEx	Colon Transverse	PEPD	0.14	0.16	lasso	2	0.13	1.2e-06	5.8	5.7	1.3e-08	0.71	0.63	0.22	FALSE
6	GTEx	Esophagus Mucosa	PEPD	0.37	0.32	enet	20	0.39	9.5e-28	5.8	7.1	1.1e-12	0.87	0.02	0.98	FALSE
7	METSIM	Adipose	CHST8	0.22	0.17	lasso	4	0.17	3.7e-25	5.8	6.0	1.5e-09	0.73	1.00	0.00	FALSE
8	METSIM	Adipose	PEPD	0.19	0.18	lasso	5	0.17	2.3e-24	5.8	5.8	5.6e-09	0.73	1.00	0.00	FALSE
9	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PEPD	0.06	0.01	blup	114	0.04	2.6e-04	7.5	7.1	1.6e-12	0.84	0.01	0.96	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	PEPD	0.13	0.06	blup	113	0.10	1.2e-06	5.2	7.9	2.3e-15	0.86	0.02	0.98	TRUE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PEPD	0.04	0.05	blup	113	0.03	1.9e-04	-5.1	5.5	3.7e-08	0.53	0.51	0.24	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPY19L3	0.04	0.03	blup	60	0.02	2.2e-03	-5.2	-5.2	2.0e-07	-0.03	0.02	0.92	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF507	0.04	0.02	blup	38	0.03	1.0e-04	-5.2	-5.1	2.8e-07	-0.04	0.01	0.98	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	DPY19L3	0.05	0.06	blup	62	0.05	1.3e-06	-5.2	-5.2	2.2e-07	-0.02	0.01	0.98	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF507	0.05	0.03	blup	39	0.05	1.3e-06	-5.1	-5.5	4.3e-08	-0.04	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PEPD	0.16	0.07	lasso	3	0.05	3.1e-03	7.5	7.4	1.1e-13	0.95	0.01	0.96	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DPY19L3	0.04	0.04	lasso	1	0.03	7.5e-05	-5.2	-5.2	2.5e-07	-0.02	0.02	0.98	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	DPY19L3	0.05	0.04	enet	9	0.05	2.1e-05	-5.3	-5.5	3.0e-08	-0.02	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF507	0.14	0.14	lasso	5	0.18	2.4e-17	-5.2	-5.5	3.8e-08	-0.04	0.01	0.99	FALSE