Best TWAS P=3.49e-09 · Best GWAS P=2.32e-07 conditioned to 0.39
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | GRK4 | 0.38 | 0.25 | lasso | 5 | 0.29 | 5.1e-11 | -4.5 | 5.1 | 2.7e-07 | -0.88 | 0.10 | 0.87 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | NOP14 | 0.12 | 0.06 | enet | 11 | 0.09 | 2.9e-07 | -4.0 | 5.9 | 3.5e-09 | -0.77 | 0.09 | 0.88 | TRUE |
| 3 | GTEx | Colon Transverse | GRK4 | 0.27 | 0.25 | enet | 18 | 0.25 | 2.4e-12 | -4.5 | 5.4 | 7.6e-08 | -0.95 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Whole Blood | HTT | 0.10 | 0.00 | enet | 15 | 0.03 | 1.4e-03 | 5.2 | 5.8 | 8.3e-09 | -0.40 | 0.03 | 0.78 | TRUE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RNF4 | 0.14 | 0.02 | blup | 47 | 0.07 | 3.1e-04 | 3.2 | 5.1 | 2.8e-07 | -0.22 | 0.00 | 0.02 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GRK4 | 0.09 | 0.18 | lasso | 5 | 0.20 | 1.5e-22 | -5.2 | 5.2 | 2.2e-07 | -0.95 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GRK4 | 0.08 | 0.07 | blup | 77 | 0.09 | 4.4e-06 | -4.5 | 5.2 | 2.4e-07 | -0.90 | 0.05 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SH3BP2 | 0.08 | 0.03 | blup | 53 | 0.02 | 2.8e-02 | 4.8 | 5.2 | 1.9e-07 | -0.39 | 0.00 | 0.33 | FALSE |