Best TWAS P=2.75e-09 · Best GWAS P=4.69e-10 conditioned to 0.129
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HR | 0.06 | 0.01 | bslmm | 452 | 0.03 | 3.8e-05 | -2.6 | 5.2 | 2.3e-07 | -0.01 | 0.03 | 0.90 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -6.2 | 5.9 | 2.7e-09 | -0.86 | 0.00 | 0.99 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | NUDT18 | 0.10 | 0.04 | enet | 6 | 0.03 | 4.7e-03 | 4.7 | 5.2 | 2.1e-07 | -0.05 | 0.02 | 0.89 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | AC091171.1 | 0.15 | 0.06 | lasso | 2 | 0.05 | 2.2e-04 | -5.4 | 5.3 | 1.1e-07 | -0.05 | 0.01 | 0.98 | FALSE |
5 | GTEx | Esophagus Mucosa | AC091171.1 | 0.14 | 0.07 | lasso | 4 | 0.05 | 2.2e-04 | 5.3 | 5.4 | 6.1e-08 | -0.06 | 0.01 | 0.98 | TRUE |
6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NUDT18 | 0.09 | 0.03 | blup | 45 | 0.08 | 1.3e-04 | -5.1 | -5.2 | 1.7e-07 | 0.06 | 0.02 | 0.96 | FALSE |
7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC25A37 | 0.11 | 0.09 | lasso | 5 | 0.09 | 7.8e-10 | -4.7 | -5.2 | 1.8e-07 | 0.59 | 0.84 | 0.16 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOXL2 | 0.16 | 0.03 | lasso | 4 | 0.05 | 1.2e-03 | -4.8 | 5.7 | 1.5e-08 | -0.59 | 0.01 | 0.71 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | NUDT18 | 0.10 | 0.16 | lasso | 2 | 0.16 | 2.3e-09 | -5.1 | -5.1 | 2.9e-07 | 0.05 | 0.02 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NUDT18 | 0.11 | 0.22 | lasso | 6 | 0.22 | 3.6e-24 | -5.4 | -5.2 | 1.5e-07 | 0.06 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NUDT18 | 0.15 | 0.17 | lasso | 4 | 0.12 | 2.3e-04 | -5.2 | -5.4 | 8.2e-08 | 0.05 | 0.01 | 0.96 | FALSE |