TWAS hub - LOXL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0990	0.0390	0.00640	0.003	0.024	0.037	0.027	0.010	1.4e-01	5.3e-04	2.1e-05	0.00027	2.1e-02
2	GTEx	Artery Aorta	0.1980	0.0550	0.00002	0.164	NA	0.157	NA	0.150	2.4e-09	NA	5.3e-09	NA	1.3e-08
3	GTEx	Brain Putamen basal ganglia	0.4750	0.1260	0.00280	0.011	NA	-0.003	NA	-0.012	1.8e-01	NA	3.8e-01	NA	8.5e-01
4	GTEx	Esophagus Muscularis	0.1880	0.0620	0.00099	0.064	NA	0.051	NA	0.068	9.2e-05	NA	4.6e-04	NA	6.0e-05
5	GTEx	Whole Blood	0.0980	0.0370	0.00270	0.069	NA	0.029	NA	0.054	6.2e-07	NA	1.1e-03	NA	1.0e-05
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0623	0.0246	0.00021	0.053	0.044	0.044	NA	0.053	1.1e-06	1.1e-05	1.0e-05	NA	1.3e-06
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1570	0.0550	0.00051	0.033	0.046	0.044	NA	0.046	5.1e-03	1.3e-03	1.4e-03	NA	1.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Mouth/teeth dental problems: Loose teeth	5.7	6.7	11.9	-1.2	3.5	1.7	2.2	-3.1	3.0	2.7
LDL Cholesterol	4.1	6.4	15.4	-0.0	3.9	1.0	1.0	-3.0	3.0	3.1
Trunk fat mass	3.8	16.2	38.1	-1.2	4.4	1.3	3.7	-4.1	4.7	6.2
Prostate Cancer	3.5	4.9	20.9	0.8	-0.6	4.6	1.4	1.0	-1.2	-2.8
Average weekly spirits intake	3.5	4.3	7.0	0.6	2.2	2.6	2.2	-2.3	2.6	1.1
Illnesses of siblings: Diabetes	3.5	4.3	9.8	-0.7	2.7	1.6	1.0	-2.8	3.1	1.3
Whole body fat mass	3.4	14.2	35.0	-1.5	4.3	1.1	2.8	-3.9	4.5	5.9
Arm fat mass (left)	3.4	13.9	34.5	-1.0	4.2	0.9	2.6	-4.1	4.4	5.9
Trunk fat percentage	3.3	13.1	29.4	-1.5	3.9	0.9	2.9	-3.9	4.5	5.4
Birth weight of first child	3.3	5.9	25.9	-2.2	1.7	-0.4	-0.1	-1.2	2.6	5.1
Number of full brothers	3.2	4.0	8.2	-0.0	2.3	0.9	0.7	-2.7	2.9	2.5
Weight	3.1	15.4	38.1	-0.9	4.5	1.7	4.0	-3.6	4.1	6.2
Arm fat mass (right)	3.1	12.8	32.0	-1.3	4.1	0.9	2.6	-3.8	4.2	5.7
Wears glasses or contact lenses	3.1	3.6	7.9	-2.5	1.4	1.0	2.2	-1.1	1.5	2.8
Risk taking	3.0	4.3	11.8	1.0	2.0	3.4	1.6	-2.4	2.2	0.6
Arm fat percentage (left)	2.8	11.0	26.4	-1.2	3.7	0.0	1.6	-3.9	4.2	5.1
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	7.9	-1.0	2.0	0.2	-0.5	-2.8	2.4	1.3
Body fat percentage	2.7	10.8	24.9	-1.7	3.7	0.5	2.1	-3.6	4.1	5.0
Leg fat mass (right)	2.7	10.4	27.9	-1.2	3.7	0.6	2.2	-3.3	3.7	5.3
Leg fat mass (left)	2.7	10.6	29.7	-1.2	3.8	0.8	2.0	-3.2	3.7	5.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	7.1	0.7	2.7	1.7	2.2	-2.3	1.9	0.4
Hip circumference	2.6	11.1	35.0	-0.7	3.5	0.7	1.9	-3.3	3.8	5.9
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.3	11.5	1.5	2.6	3.3	3.4	-1.2	1.1	1.8
Height	2.4	46.7	98.4	0.7	6.2	9.6	9.9	-4.4	5.8	6.6
Frequency of depressed mood in last 2 weeks	2.4	3.4	8.6	0.2	2.9	2.0	0.8	-2.1	2.2	1.0
Waist circumference	2.4	8.6	28.2	-0.4	3.1	0.2	1.5	-2.9	3.4	5.3
Blood Red Count	2.3	21.8	102.0	-0.5	2.8	10.1	3.5	-3.6	3.7	1.9
Arm fat percentage (right)	2.2	8.7	22.6	-1.5	3.1	0.2	1.4	-3.3	3.7	4.8
Arm predicted mass (right)	2.2	11.2	30.1	-0.6	4.1	1.7	3.3	-2.7	3.2	5.5
Loneliness, isolation	2.2	3.0	6.2	0.5	2.5	2.2	0.9	-2.3	2.1	0.3
Basal metabolic rate	2.2	12.1	31.0	-0.4	3.9	2.0	3.9	-2.9	3.2	5.6
Medication: Atenolol	2.1	2.7	8.1	-0.6	-1.9	-2.9	-0.7	2.1	-0.9	1.0
Leg predicted mass (left)	2.1	10.9	27.8	-0.0	3.7	1.7	3.8	-2.9	3.0	5.3
Had other major operations	2.1	2.6	6.1	0.3	1.5	0.8	0.6	-2.2	2.0	2.5
Commuting to job workplace: Car/motor vehicle	2.1	2.5	12.3	-3.5	0.2	0.5	-1.3	-0.3	0.7	1.5
Medication: Atorvastatin	2.1	2.6	4.5	-2.1	1.7	1.5	1.2	-1.2	1.9	1.3
Leg fat-free mass (left)	2.0	10.7	27.2	-0.0	3.6	1.6	3.9	-2.9	3.0	5.2
Maternal smoking around birth	2.0	2.9	5.8	0.0	2.4	0.9	0.1	-2.3	2.4	1.5
Leg fat percentage (right)	2.0	7.2	16.6	-1.9	3.0	-0.0	1.1	-2.9	3.4	4.1
Medication: Omeprazole	2.0	2.4	5.0	1.3	1.5	2.2	0.5	-2.0	1.6	0.9
Number of self-reported non-cancer illnesses	2.0	3.4	7.5	-0.6	2.7	-0.1	1.9	-2.4	2.4	0.9
Happiness	1.9	2.3	6.0	-2.4	1.5	2.1	1.0	-1.1	0.9	-0.2
Standing height	1.9	19.3	44.8	1.2	4.1	6.0	6.7	-2.4	3.2	4.5
Arm fat-free mass (right)	1.9	9.9	28.1	-0.5	3.9	1.7	3.1	-2.4	2.8	5.3
Leg predicted mass (right)	1.9	10.0	25.3	0.2	3.6	1.7	3.8	-2.6	2.7	5.0
Leg fat percentage (left)	1.9	6.8	17.0	-1.7	3.1	0.2	0.9	-2.7	3.2	4.1
Arm fat-free mass (left)	1.9	9.5	28.0	-1.1	3.5	2.0	3.1	-2.2	2.6	5.3
Schizophrenia vs Biploar Disorder	1.8	2.3	5.7	1.7	-1.4	-2.4	-1.1	1.0	-1.8	-0.7
Alzheimer’s Disease (in father)	1.8	1.9	5.1	2.1	-0.3	0.8	2.3	0.8	-0.8	-1.3
Chronotype (morning person)	1.8	4.2	7.4	-2.7	2.7	2.2	2.0	-1.3	1.8	1.0
Stomach or abdominal pain in last month	1.8	2.3	5.1	1.5	-0.4	1.2	2.3	1.2	-1.4	-2.0
Illnesses of siblings	1.8	2.5	6.3	1.1	-2.2	-1.1	-0.6	1.8	-2.5	-0.2
Exposure to tobacco smoke outside home	1.8	2.4	5.1	0.6	2.2	0.3	-0.3	-1.9	2.2	1.8
Medication: Blood pressure	1.8	3.1	9.8	-3.1	0.7	-2.7	-0.1	-1.1	1.7	0.5
Whole body fat-free mass	1.8	10.3	26.1	-0.3	3.6	2.0	3.9	-2.4	2.8	5.1
Leg fat-free mass (right)	1.8	9.8	25.2	0.2	3.5	1.8	3.7	-2.5	2.7	5.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	9.7	-1.5	0.8	1.2	3.1	-0.3	0.6	-0.2
Whole body water mass	1.8	10.4	26.0	-0.3	3.6	2.1	3.9	-2.5	2.8	5.1
Arm predicted mass (left)	1.8	9.3	25.5	-0.9	3.5	2.0	3.4	-2.2	2.6	5.0
Sitting height	1.7	11.9	33.3	1.3	2.6	5.6	5.8	-1.2	1.6	2.5
Leg pain on walking	1.7	2.1	3.5	-0.8	1.5	1.9	1.7	-1.2	1.3	1.5
Ever had prostate specific antigen (PSA) test	1.7	2.0	6.1	-1.1	0.6	2.5	1.4	-1.1	1.5	0.9
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.9	0.9	1.3	1.5	0.8	-2.2	1.8	1.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	3.5	-0.9	1.8	1.3	0.9	-1.3	1.9	1.5
Body mass index (BMI)	1.6	6.7	19.3	-1.5	2.7	-1.0	1.0	-2.7	2.9	4.4
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	5.8	0.7	2.4	2.1	1.3	-1.5	1.4	0.9
Trunk fat-free mass	1.6	9.3	23.8	-0.3	3.4	2.2	3.6	-2.2	2.6	4.9
Number of live births	1.6	2.2	3.8	-1.8	1.4	0.9	2.0	-1.7	1.6	0.5
Trunk predicted mass	1.6	9.2	23.0	-0.3	3.4	2.3	3.6	-2.1	2.6	4.8
Breastfed as a baby	1.6	2.0	3.4	-1.9	-1.6	-0.7	-1.2	1.5	-1.5	-1.2
Comparative height size at age 10	1.6	8.5	23.4	0.7	2.6	3.2	4.8	-1.6	2.0	3.5
Depressed Affect (Nagel 2018)	1.5	3.2	7.0	-0.2	2.5	2.6	0.8	-1.4	1.9	1.7
Hand grip strength (left)	1.5	4.0	10.3	1.8	-1.7	-3.2	-3.0	0.6	-1.5	0.2
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	8.7	0.2	0.8	2.9	1.5	-0.4	-0.1	-0.7
Medication: Lisinopril	1.5	1.9	5.8	-2.4	1.1	0.3	-0.7	-1.3	1.6	1.2
Pain experienced in last month	1.5	2.5	4.0	-1.5	-2.0	-1.3	1.5	1.7	-1.4	-1.7
Coronary Artery Disease (CAD)	1.4	1.6	2.8	-1.0	1.0	1.2	-1.5	-1.0	1.7	1.4
Hearing difficulty/problems: Yes	1.4	2.1	4.9	0.0	0.9	1.5	-0.5	-2.2	2.0	1.5
Hand grip strength (right)	1.4	3.9	7.7	2.1	-1.6	-2.8	-2.8	1.2	-1.8	0.3
Depression (self-reported)	1.4	1.7	3.0	0.7	1.6	1.1	1.2	-1.7	1.5	1.1
Hair/balding pattern: Pattern 4	1.4	3.5	7.8	0.8	-2.0	-2.8	-0.6	1.7	-2.3	-1.9
Headache pain in last month	1.4	2.5	5.0	0.9	1.8	2.0	-0.5	-2.2	1.8	0.9
Medication: Amlodipine	1.4	1.9	3.8	-1.8	0.5	-1.3	-1.9	-1.4	1.5	0.2
Breast cancer (self-reported)	1.4	1.7	3.3	-1.4	1.3	-0.0	1.7	-1.2	1.8	0.9
Fractured/broken bones in last 5 years	1.4	1.9	4.5	-0.4	1.4	1.1	0.0	-2.1	2.0	1.1
Major Depression (MDD)	1.3	1.5	4.9	-0.3	0.9	2.2	2.0	-0.1	0.2	-1.0
Hypothyroidism (self reported)	1.3	3.0	5.3	-0.3	-1.7	-2.0	-0.9	2.3	-2.3	1.7
Fed-up feelings	1.3	2.4	6.7	-0.3	2.6	1.2	-0.8	-1.4	1.6	1.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.6	0.5	-1.7	-0.3	-0.8	1.9	-1.6	-0.7
Serious illness, injury or assault to yourself	1.3	1.6	3.1	0.8	1.3	1.7	1.1	-1.4	1.4	0.7
Hearing difficulty/problems with background noise	1.3	2.1	4.8	1.1	0.4	0.2	-1.4	-1.8	1.8	2.2
Overall health rating	1.3	2.7	6.5	-0.2	2.2	-0.0	2.6	-1.8	1.9	0.4
Myopia	1.3	1.9	5.7	0.2	-2.4	0.6	-1.9	1.2	-1.6	0.0
Cholesterol lowering medication	1.3	1.9	3.7	-1.5	1.9	1.1	0.9	-0.4	1.6	1.6
Heart disease (siblings)	1.3	1.6	3.2	1.7	1.8	1.4	-0.3	-0.9	1.3	0.9
Depression (Nagel 2018)	1.2	1.9	3.1	1.4	1.6	1.8	1.5	-1.2	1.1	0.7
Breast Cancer	1.2	3.0	11.7	-1.2	-0.2	-3.4	0.4	0.9	-1.3	-2.3
Age at First Birth	1.2	1.8	4.5	1.6	-0.8	-0.7	-0.9	1.0	-1.5	-2.1
Respiratory disease	1.2	2.6	6.7	0.2	-1.1	1.0	0.4	1.9	-2.4	-2.6
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	7.4	0.4	0.6	0.5	2.7	-0.8	0.7	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	7.2	-1.0	2.7	1.5	0.1	-1.1	1.4	0.6
Medication: Cholesterol lowering	1.2	1.8	5.3	-0.3	1.1	-0.7	1.2	-1.9	2.3	0.6
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.1	1.9	-0.6	2.0	-0.8	1.0	-1.8	-0.7
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.0	1.4	-1.4	-0.4	-0.3	1.0	-1.7	-1.7
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.6	2.1	0.1	-1.2	-0.2	-0.3	-0.1	-1.8
Heart disease (mother)	1.2	1.5	3.8	-0.5	1.9	0.8	0.1	-1.4	1.7	0.9
Osteoporosis (self-reported)	1.2	1.5	3.4	1.3	-1.3	0.4	0.6	1.2	-1.2	-1.9
Ever depressed for a whole week	1.2	1.5	5.2	1.3	-0.6	2.3	0.9	0.4	-1.3	-0.9
Irritable Bowel Disease (IBD)	1.1	2.5	4.2	2.0	-1.7	-1.2	-2.0	1.5	-1.4	1.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.5	-0.7	-1.0	-1.9	0.0	1.8	-0.9	0.1
Sensitivity / hurt feelings	1.1	1.9	5.9	-0.3	2.4	1.7	-0.3	-1.4	1.4	0.2
Supplements: Zinc	1.1	1.2	2.7	-0.1	1.0	0.7	-0.4	-1.5	1.7	1.3
Diabetes (father)	1.1	1.4	4.6	-0.5	1.5	0.9	2.1	-0.8	0.8	0.6
Pack years adult smoking proportion	1.1	1.7	3.9	-2.0	1.6	0.8	1.6	-0.7	1.3	0.4
Medication: Lansoprazole	1.1	1.3	4.4	-1.6	-0.2	-2.1	1.0	0.3	0.2	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.7	1.4	1.6	-0.9	-1.0	-1.1	1.2	0.0
Mood swings	1.1	1.9	9.7	1.3	1.0	3.1	0.3	-0.3	0.5	0.8
Ever had bowel cancer screening	1.1	1.3	5.5	-2.3	0.6	-0.3	1.6	0.4	0.4	0.5
Commuting to job workplace: Walk	1.1	1.2	2.2	1.3	-0.9	0.4	0.2	1.2	-1.5	-1.5
Guilty feelings	1.1	1.6	4.1	1.1	0.4	2.0	0.9	0.9	-1.1	-1.7
Mother’s age at death	1.1	1.4	6.6	-0.4	-0.1	1.3	2.6	0.6	-0.3	0.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.4	1.0	0.3	-0.5	1.2	-2.1	1.4	-0.2
Neuroticism (Nagel 2018)	1.0	2.2	8.6	0.2	2.2	2.9	0.3	-0.8	1.1	0.2
Primary Biliary Cirrhosis	1.0	1.4	4.1	-1.5	-0.2	-2.0	-1.0	1.4	-0.3	0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.9	6.3	2.5	-1.5	-0.4	1.3	1.1	-1.2	-0.8
Lung FEV1/FVC ratio	1.0	5.2	10.3	-1.3	1.8	-1.9	0.9	-3.1	2.8	3.2
Townsend deprivation index at recruitment	1.0	1.4	6.0	1.6	0.5	2.4	0.2	-0.7	0.4	0.2
Average weekly fortified wine intake	1.0	1.2	2.9	-1.2	-0.5	-1.7	1.2	1.0	-0.5	1.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.5	1.4	-0.5	1.9	1.2	-0.5	-0.5	-0.7
Lung cancer (father)	1.0	1.1	3.1	-1.0	0.8	1.8	1.4	0.8	-0.2	-0.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.8	0.0	-0.5	2.2	-0.4	-1.1	1.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.2	-0.7	0.8	-0.7	0.0	-1.8	1.8	0.1
Medication: Ibuprofen	1.0	1.2	3.4	1.0	-1.6	1.8	-0.8	0.3	-0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.2	-0.7	1.3	-1.2	-1.2	-0.7	0.7	1.5
Suffer from ‘nerves’	1.0	1.5	6.8	0.6	1.1	2.6	1.2	-0.7	0.5	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	3.4	-1.5	-0.2	-1.6	-1.8	0.7	-0.5	-0.0
Long-standing illness, disability or infirmity	1.0	1.5	2.7	-0.9	1.4	0.2	0.9	-1.3	1.6	1.6
Smoking status: Current	1.0	1.6	5.2	-0.7	2.3	1.1	-0.9	-1.5	0.9	0.4
Commuting to job workplace: Cycle	1.0	1.2	5.7	0.2	0.8	-0.1	2.4	-1.0	0.8	0.7
Pack years of smoking	1.0	1.5	3.7	-1.9	1.2	0.4	1.8	-0.5	1.2	0.2
Crohns Disease (2017)	0.9	1.9	4.5	1.1	-1.6	-2.1	-1.8	0.5	-1.3	0.3
Ulcerative Colitis (UC)	0.9	1.8	4.5	2.1	-1.3	-0.1	-1.1	1.5	-1.0	1.3
Medication: Co-codamol	0.9	1.0	4.3	1.5	-0.2	0.2	2.1	-0.4	0.6	-0.3
Severe depression (siblings)	0.9	1.0	2.7	-0.9	1.1	1.3	0.3	-0.9	1.6	0.0
Current tobacco smoking	0.9	1.5	5.3	-0.3	2.3	0.7	-1.0	-1.4	1.0	0.5
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	3.2	0.2	1.1	-0.1	1.0	-1.8	1.0	0.0
Nervous feelings	0.9	1.6	5.8	2.4	-0.7	1.2	0.2	0.9	-0.9	-1.3
Financial difficulties in last 2 years	0.9	1.2	3.7	0.6	0.5	0.6	-1.9	-0.8	0.8	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.7	0.8	-1.6	1.9	-0.7	0.6	-0.7	0.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	3.4	0.1	-1.7	-1.1	-0.6	1.8	-1.9	0.7
Neck or shoulder pain in last month	0.9	1.3	7.9	0.4	-0.5	-0.3	-2.8	0.2	-0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	2.3	0.0	-1.1	-1.0	0.7	0.9	-1.5	-1.1
Asthma (self-reported)	0.9	1.8	5.0	0.6	-1.0	-0.0	-0.7	1.3	-2.2	-2.0
Commuting to job workplace: Public transport	0.9	1.1	4.1	2.0	-0.0	-1.0	0.6	0.5	-1.0	-1.1
Mean Putamen Volume	0.8	0.9	2.1	-0.7	-0.2	-0.1	-1.0	1.5	-1.3	-1.1
Relative age of first facial hair	0.8	1.7	3.7	1.0	1.9	0.1	0.6	-1.9	1.9	0.4
Ever had hysterectomy (womb removed)	0.8	0.9	4.2	2.0	-0.1	-0.0	-0.2	0.8	-0.9	-0.7
High blood pressure	0.8	2.1	4.9	-2.2	1.3	-2.0	1.3	-0.8	1.2	-0.6
Alcohol usually taken with meals	0.8	1.2	5.1	0.6	0.9	-0.3	2.3	-0.8	0.9	0.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.9	5.9	1.2	1.7	2.4	1.3	-1.3	1.6	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.5	0.9	1.7	2.0	0.7	-1.3	1.4	2.6
Gout (self-reported)	0.8	1.1	3.2	-1.8	0.1	0.7	1.6	1.0	-0.7	0.4
Wheeze or whistling in the chest in last year	0.8	1.3	6.3	0.0	1.2	2.5	0.6	-0.7	0.2	-0.8
Eye problems/disorders: None of the above	0.8	0.9	1.7	-0.6	-0.8	-0.9	-1.3	1.1	-1.2	-0.4
Medication: Allopurinol	0.8	1.1	2.2	-1.0	-0.8	-0.3	1.3	1.5	-1.5	-0.3
Eye problems/disorders: Cataract	0.8	1.0	2.2	0.6	0.6	1.5	1.1	-0.5	0.9	-1.3
Miserableness	0.8	1.5	2.6	0.2	1.6	1.6	0.0	-0.8	1.4	1.6
Ever taken oral contraceptive pill	0.8	0.9	2.6	0.6	-1.1	-1.6	-0.2	1.1	-0.8	0.3
Illnesses of father: High blood pressure	0.8	1.0	3.3	1.2	-0.6	-0.1	-0.4	0.9	-0.9	-1.8
Vascular/heart problems diagnosed by doctor	0.8	2.2	5.4	2.3	-1.3	2.2	-1.4	0.6	-1.2	0.2
Schizophrenia (2018)	0.7	1.5	4.4	0.5	-0.5	0.2	0.2	1.5	-1.8	-2.1
Alzheimer’s Disease (in mother)	0.7	0.8	3.3	0.2	-0.2	0.3	-1.8	-0.1	0.0	1.6
Bipolar Disorder (2011)	0.7	0.7	1.5	0.6	-1.0	-0.7	-0.1	1.2	-1.0	-0.7
Neuroticism (2016)	0.7	1.0	2.5	-0.7	1.0	0.9	0.7	-0.5	1.2	1.6
Ulcerative Colitis	0.7	1.0	4.3	2.1	-0.8	0.6	-0.7	0.8	-0.3	0.7
Systolic blood pressure, automated reading	0.7	1.9	7.4	-2.7	0.8	-1.5	0.8	-0.5	1.2	-1.0
Vitamin and mineral supplements	0.7	0.9	2.2	-0.5	-1.2	-1.5	-0.2	1.1	-0.9	0.5
Medication: Metformin	0.7	1.0	4.9	0.3	-0.3	0.4	2.2	0.4	-0.5	-1.3
Relative age voice broke	0.7	1.1	2.5	1.5	1.2	0.0	0.0	-1.6	1.4	0.2
Qualifications: None of the above	0.7	1.5	3.1	-1.2	1.8	1.4	1.3	-0.5	1.5	0.5
Heart attack	0.7	0.9	1.9	-1.4	0.2	-1.0	-0.8	-0.3	1.2	1.0
Allergy	0.7	1.5	4.0	-2.0	1.1	-0.5	-0.1	-1.1	2.0	0.5
Alcohol intake versus 10 years previously	0.7	1.0	2.3	-1.2	-0.5	-0.9	1.2	0.3	0.6	1.5
Father’s age at death	0.7	1.0	3.0	-0.8	0.3	1.0	1.7	0.3	-0.1	1.4
Pulse rate	0.7	1.2	3.1	-0.6	-1.1	-0.7	0.4	1.0	-1.5	-1.8
Noisy workplace	0.7	0.9	4.0	-0.0	-0.8	2.0	0.1	-0.8	0.0	1.0
Asthma	0.7	1.4	3.8	0.5	-0.8	-0.1	-0.7	1.0	-2.0	-1.9
Birth weight	0.7	1.6	5.1	0.8	-1.3	-0.8	-1.0	1.0	-1.1	2.3
Alcohol intake frequency.	0.7	1.7	4.6	-0.8	1.2	-1.3	1.2	-0.5	1.4	2.1
Number of full sisters	0.7	0.8	1.8	0.2	-1.2	1.2	-1.3	0.8	-0.6	0.2
Chest pain or discomfort	0.7	1.0	2.6	-0.7	1.2	1.2	0.0	-0.4	0.6	1.6
Knee pain experienced in last month	0.7	1.1	2.2	0.7	1.1	1.4	0.7	-1.5	0.9	0.9
Smoking status: Previous	0.7	1.0	3.2	1.5	-1.8	-0.8	-1.1	0.2	0.1	-0.3
Friendships satisfaction	0.7	0.8	2.1	-1.2	-0.6	-1.4	-1.3	-0.3	-0.2	0.5
Osteoarthritis (self-reported)	0.7	0.9	2.3	-1.3	-1.0	-1.5	-0.7	-0.3	0.3	0.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.8	-0.6	-0.1	-0.9	-0.4	-1.3	1.3	1.1
High cholesterol (Self-reported)	0.7	1.2	2.3	-1.3	0.6	-1.2	0.4	-0.4	1.5	1.4
Average weekly beer plus cider intake	0.7	1.0	3.9	-1.4	0.0	-0.1	-2.0	-0.5	0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.8	1.7	-1.2	0.2	-0.9	-0.9	-0.3	1.3	1.1
Worry (Nagel 2018)	0.6	1.3	4.8	1.4	0.9	2.2	0.5	0.1	-0.3	-1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.6	0.5	-1.9	-0.6	-1.3	1.0	-1.3	-1.0
Fasting Glucose	0.6	0.7	3.0	-0.1	0.2	0.2	-0.7	-0.9	0.7	1.7
BMI	0.6	3.3	12.9	-0.8	1.2	-2.1	0.4	-1.5	1.1	3.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.8	-1.1	-0.5	-0.4	-0.6	1.7	-0.9	0.1
Medication: Levothyroxine sodium	0.6	1.1	2.2	-1.2	-0.9	-1.5	-0.6	0.9	-0.6	1.1
High blood pressure (mother)	0.6	0.8	1.6	-1.1	0.8	-0.9	-0.6	-1.1	1.3	-0.0
Forced vital capacity (FVC)	0.6	2.2	8.5	1.1	1.3	2.9	1.2	-0.3	0.8	1.4
Neuroticism score	0.6	1.3	4.5	0.3	1.7	2.1	0.2	-0.9	0.8	0.4
Illnesses of mother	0.6	0.8	4.2	0.0	0.1	0.7	2.0	0.2	-0.3	-0.7
Exposure to tobacco smoke at home	0.6	0.7	2.5	-0.4	-0.2	-1.4	-1.6	0.4	-0.2	-0.0
Peak expiratory flow (PEF)	0.6	1.3	2.0	-0.3	1.2	-1.4	0.6	-1.4	1.1	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.9	2.0	0.5	0.9	-0.7	0.4	0.1	0.0
Medication: Seretide 50 evohaler	0.6	0.7	1.8	1.2	-0.5	1.1	-1.3	0.1	-0.3	0.1
Had major operations	0.6	0.7	1.3	0.8	-0.9	0.7	1.1	0.9	-0.7	-0.5
Hypertension (Self-reported)	0.6	1.6	4.6	-2.1	1.1	-1.5	1.0	-0.8	1.0	-0.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.4	0.0	-1.1	-1.2	-1.6	-0.1	-0.1	0.2
Diabetes diagnosed by doctor	0.6	1.0	4.5	1.4	-0.3	0.3	2.1	-0.4	0.4	-0.1
Financial situation satisfaction	0.6	0.8	2.1	-0.5	0.8	0.5	-0.8	-1.5	0.9	0.7
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.3	-0.8	-1.5	0.3	0.4	1.6	-1.8	-1.2
Body Mass Index (BMI) (2010)	0.5	0.7	2.9	-0.4	-1.2	0.2	0.3	-0.1	0.0	1.7
Number of incorrect matches in round	0.5	0.8	1.9	1.0	0.2	-0.8	1.2	-0.4	0.3	-1.4
Diabetes (self-reported)	0.5	0.7	2.5	1.2	-0.3	0.3	1.6	-0.4	0.7	-0.2
Tense / ‘highly strung’	0.5	0.9	4.5	0.7	0.5	2.1	0.7	-0.5	0.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.9	1.0	-0.3	0.6	-1.4	0.8	-0.8	0.2
Pulse wave reflection index	0.5	0.6	1.7	0.4	0.5	0.2	-0.7	-0.6	1.2	1.3
Loud music exposure frequency	0.5	0.6	2.1	-0.2	0.1	-1.5	0.4	0.1	0.4	1.2
Blood clot in the leg (DVT)	0.5	0.7	3.4	1.9	0.4	-0.3	0.5	-0.1	-0.1	1.0
Medication: Paracetamol	0.5	0.8	3.3	1.8	-0.5	0.4	-0.6	0.8	-0.8	-0.5
Forced vital capacity (FVC), Best measure	0.5	2.0	8.5	0.8	1.2	2.9	0.8	-0.1	0.4	1.5
Age at first live birth	0.5	0.8	2.6	-0.0	-0.5	-1.6	0.4	0.3	-0.6	-1.5
Pulse rate, automated reading	0.5	1.6	2.9	1.6	-1.3	-0.4	-0.3	0.8	-1.7	-1.7
Age at last live birth	0.5	0.7	2.6	0.4	0.3	0.3	1.6	-1.0	0.5	-1.0
Qualifications: nursing, teaching	0.5	0.8	1.8	-1.4	0.8	-0.1	-0.1	-1.0	1.1	0.8
Hearing aid user	0.5	0.6	1.7	1.3	-0.2	0.6	1.3	-0.2	0.1	-0.6
Medication: Bendroflumethiazide	0.5	0.8	2.9	-1.7	1.1	-0.7	0.5	-0.6	0.8	-0.0
Alcohol drinker status: Never	0.5	0.6	2.2	0.2	0.3	-0.5	1.5	-0.5	1.1	0.3
Diastolic blood pressure, automated reading	0.5	1.6	6.5	-0.5	-0.8	-1.5	0.7	0.3	-0.9	-2.6
Unable to work because of sickness or disability	0.5	0.6	1.3	-0.3	0.6	0.8	0.6	-0.7	1.0	1.1
Basal cell carcinoma (self-reported)	0.5	0.7	2.2	-0.4	1.5	0.3	-0.1	-0.6	1.3	-0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	1.5	1.1	-0.4	0.8	0.5	1.1	-1.2	-1.2
Ovarian Cancer	0.4	0.6	2.1	0.2	0.7	-0.4	-1.4	-0.6	0.9	-0.2
Blood Eosinophil Count	0.4	3.2	12.3	0.4	-3.5	-2.2	-0.8	0.6	-0.6	2.0
Blood Platelet Count	0.4	4.7	11.6	-1.2	-3.4	-3.0	-2.3	1.3	-1.1	1.5
Systolic Blood Pressure	0.4	1.8	6.8	-2.6	1.1	-0.6	-0.3	-0.8	1.9	-0.1
Allergy or Eczema	0.4	1.1	3.7	1.1	-0.8	1.9	1.2	0.6	-0.7	-0.1
Cardiovascular Disease	0.4	1.4	6.6	-0.5	-0.3	-2.6	0.2	0.9	-0.4	-1.4
Diabetes (mother)	0.4	0.5	2.2	0.7	-0.2	1.5	-0.9	-0.1	-0.1	0.1
Qualifications: CSEs or equivalent	0.4	0.6	2.8	-0.1	0.4	0.1	-0.5	-0.9	0.3	1.7
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	1.0	-0.5	-0.2	-0.9	-0.3	0.2	-1.2
Had menopause	0.4	0.5	1.0	-1.0	-0.4	-0.5	0.1	0.9	-0.6	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.2	-1.2	0.8	-0.4	0.8	-0.5	1.1	1.5
Pain all over the body in last month	0.4	0.5	1.4	-1.2	0.6	1.0	0.2	0.7	0.1	0.4
Medication: Ramipril	0.4	0.5	2.2	-0.3	0.2	-1.5	0.5	0.4	0.3	0.8
Medication: Simvastatin	0.4	0.5	2.5	-0.2	-0.2	-1.6	-0.5	-0.0	0.7	0.7
Time employed in main current job	0.4	0.5	2.0	1.4	-0.1	0.8	-0.3	-0.5	0.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.0	-0.1	-0.6	0.8	-1.4	0.3	-0.5	-0.1
Glaucoma (self-reported)	0.4	0.4	1.1	0.1	1.0	0.5	-0.4	-0.8	0.4	0.8
High blood pressure (siblings)	0.4	0.6	1.4	-0.8	0.6	0.3	0.5	-0.8	1.2	-1.0
Worry too long after embarrassment	0.4	0.7	2.7	-0.3	1.6	0.7	-0.9	-0.6	0.6	-0.6
Health satisfaction	0.4	0.5	1.3	-1.0	1.2	0.7	0.4	-0.5	0.1	0.7
Qualifications: College or University degree	0.4	1.4	3.8	1.4	-1.0	1.9	1.3	0.4	-0.7	-0.5
Family relationship satisfaction	0.4	0.4	0.9	-0.9	-0.0	0.6	0.7	-0.9	0.5	-0.5
Medication: Aspirin	0.4	0.6	1.9	-0.5	-1.4	-1.0	-0.5	0.2	-0.0	-0.8
Illnesses of father: Heart disease	0.4	0.6	1.3	0.1	0.6	0.3	1.2	-0.9	1.0	0.7
Back pain experienced in last month	0.4	0.6	1.4	1.2	0.0	-0.5	-1.2	-0.3	0.4	1.0
Mineral and other dietary supplements	0.4	0.6	2.1	0.2	-0.1	-0.4	1.0	0.0	-0.7	-1.4
Illnesses of father: None of the above (group 1)	0.4	0.4	1.5	-1.2	0.7	-0.4	-0.7	-0.4	0.3	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	0.6	0.9	0.2	-0.5	-1.0	0.8	0.7
Medication: Blood pressure	0.4	0.8	2.6	-1.4	0.0	-1.6	-0.5	0.3	-0.1	-0.8
Medication: Paracetamol	0.4	0.6	1.5	1.1	-0.4	-0.5	-1.2	0.9	-0.7	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	3.3	1.8	0.2	-0.3	0.3	0.1	-0.2	0.7
HDL Cholesterol	0.3	0.5	1.5	-1.1	0.3	-0.6	-1.2	-0.2	0.6	0.1
Rheumatoid Arthritis	0.3	0.4	0.8	-0.5	-0.6	-0.9	0.6	0.7	-0.7	-0.2
Triglycerides	0.3	0.5	2.3	0.8	-0.2	-0.7	-0.4	-0.2	-0.0	1.5
Blood White Count	0.3	2.0	8.6	0.7	-1.6	-2.9	0.8	-0.5	-0.5	-1.0
Waist Hip Ratio (WHR)	0.3	1.2	4.0	2.0	0.4	-0.4	-1.0	-0.5	0.7	1.6
Lung FVC	0.3	1.5	3.6	-0.1	-0.3	1.9	-1.4	1.5	-0.8	-1.3
Neuroticism	0.3	0.8	3.1	-0.0	1.6	1.8	-0.2	-0.0	0.0	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.1	1.4	-0.5	1.2	0.3	0.1	-0.8	0.2
Multivitamins +/- minerals	0.3	0.3	1.3	1.1	-0.1	0.7	-0.4	-0.1	-0.3	-0.6
Impedance of leg (left)	0.3	1.3	3.3	-0.3	-0.5	1.8	-0.9	1.0	-0.6	-1.7
Past tobacco smoking	0.3	0.6	1.5	-1.2	1.2	0.0	1.1	0.3	-0.3	0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	-0.2	0.5	1.0	0.3	-0.7	0.3	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-1.1	-0.5	0.2	0.1	0.9	-0.4	0.6
Impedance of arm (right)	0.3	1.5	7.1	0.5	-0.2	2.7	1.3	-0.1	0.4	-1.1
Worrier / anxious feelings	0.3	0.5	1.9	1.4	0.7	0.4	-0.9	0.2	-0.5	-0.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	0.2	-1.0	0.2	-1.1	0.8	-0.2	0.2
Impedance of arm (left)	0.3	1.6	4.1	0.9	0.7	2.0	1.5	-1.1	1.3	-0.6
Length of working week for main job	0.3	0.3	0.7	-0.0	0.9	-0.5	0.7	0.1	-0.1	-0.7
Comparative body size at age 10	0.3	0.7	3.7	-1.9	-0.1	-0.7	0.3	0.4	-0.1	0.8
Number of children fathered	0.3	0.3	1.2	0.0	0.7	-0.5	-0.6	-0.3	0.2	-1.1
Medication for pain relief, constipation, heartburn	0.3	0.6	1.1	-0.8	0.2	-1.1	-0.1	0.8	-1.0	-0.7
Migraine (self-reported)	0.3	0.4	0.7	0.2	-0.0	-0.7	-0.7	-0.8	0.8	0.5
Supplements: Vitamin C	0.3	0.3	1.2	-0.0	0.6	0.6	-0.4	-0.2	0.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.6	1.3	-0.2	-1.1	-0.3	0.9	0.8	-0.9	0.1
Medication: Aspirin	0.3	0.4	1.1	-0.5	-0.9	-1.1	-0.6	-0.2	0.4	-0.4
Medication: Gliclazide	0.3	0.4	1.7	-1.3	0.2	-0.4	0.8	-0.0	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.5	0.5	1.0	1.2	0.1	-0.7	0.6	1.2
Average weekly champagne plus white wine intake	0.3	0.4	1.7	0.0	0.2	1.3	-0.4	0.1	-0.4	-0.6
Ever smoked	0.3	0.5	1.7	1.0	-0.5	0.5	-1.3	-0.5	0.4	0.2
Alcohol drinker status: Previous	0.3	0.4	0.9	-1.0	0.4	0.7	0.1	0.2	0.6	-0.7
Bipolar Disorder (2018)	0.2	0.3	1.2	0.6	0.1	1.1	0.4	-0.0	0.3	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	1.0	-0.1	0.5	0.4	0.2	-0.0	0.6
Reaction Time	0.2	0.4	2.4	1.5	-0.2	0.3	0.3	-0.2	-0.6	-0.5
Crohns Disease (2012)	0.2	0.2	0.8	0.1	-0.7	-0.9	-0.5	0.1	-0.4	0.1
HbA1C	0.2	0.2	0.8	-0.1	0.9	0.4	0.6	0.3	-0.5	0.3
Lupus	0.2	0.4	0.5	0.7	0.1	-0.7	-0.7	0.6	-0.6	0.6
Schizophrenia (2014)	0.2	0.4	1.5	0.1	-0.2	-0.2	0.6	0.8	-1.2	-0.4
Smoking Status	0.2	0.5	0.9	1.0	0.9	0.8	-0.8	-0.7	0.5	-0.1
Number of treatments/medications taken	0.2	0.4	0.7	-0.5	0.2	0.2	0.6	-0.8	0.8	0.6
Angina	0.2	0.2	0.7	-0.5	0.3	-0.1	0.7	-0.1	0.8	-0.3
Impedance of leg (right)	0.2	0.9	2.8	-0.5	-0.5	1.6	-0.5	0.5	-0.2	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	-0.1	-0.8	-0.8	0.7	0.9	-0.4	-0.0
Falls in the last year	0.2	0.3	1.6	0.4	-0.4	1.2	0.4	-0.3	0.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.0	0.2	-1.4	-0.3	-0.2	0.4	-0.9	-0.1
Prospective memory result	0.2	0.3	0.7	0.3	0.3	0.9	0.5	-0.7	0.5	0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	-0.7	0.3	0.1	-0.2	0.0	0.4	0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-1.0	-0.0	-0.3	-0.4	-0.1	0.5	0.7
Pulse wave peak to peak time	0.2	0.2	0.7	0.8	0.0	0.3	0.6	-0.1	-0.3	-0.6
Shortness of breath walking on level ground	0.2	0.2	0.6	0.4	0.1	0.5	0.4	0.8	-0.7	-0.0
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.7	-0.2	-0.3	0.7	0.3	-0.1	-0.8
Angina (self-reported)	0.2	0.2	0.8	-0.4	0.3	0.2	0.6	-0.2	0.9	-0.2
Mean time to correctly identify matches	0.2	0.4	2.3	1.5	-0.4	-0.1	-0.2	-0.0	-0.4	-0.5
Average weekly red wine intake	0.2	0.3	0.8	0.9	-0.3	-0.3	0.7	0.5	-0.5	-0.0
Medication for cholesterol	0.2	0.4	1.7	1.3	-0.7	0.4	0.1	-0.2	-0.4	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	0.6	-0.5	0.2	0.3	0.4	-0.1	-0.7
Irritability	0.2	0.3	0.7	0.7	0.4	0.8	-0.4	0.1	-0.2	-0.8
Age started oral contraceptive pill	0.2	0.3	0.9	-0.3	-0.3	0.6	0.3	0.5	-0.1	1.0
Supplements: Calcium	0.2	0.2	0.9	-0.1	-0.1	0.9	0.2	0.7	-0.3	0.1
Impedance of whole body	0.2	1.1	5.5	0.3	0.3	2.4	0.5	-0.3	0.6	-1.1
Heel T-Score	0.1	0.8	2.8	-1.0	-0.0	-1.7	1.0	0.4	0.7	0.7
Hair Pigment	0.1	2.2	5.8	1.5	-0.9	-2.4	-1.7	0.7	-1.2	-1.4
Tanning	0.1	1.7	5.4	2.0	-0.0	0.4	-2.3	0.6	-0.6	-1.2
Medication for hormone replacement therapy	0.1	0.1	0.3	0.0	0.2	-0.1	0.5	-0.5	0.4	0.4
Taking other prescription medications	0.1	0.2	0.7	-0.8	-0.1	0.3	0.7	0.2	0.0	-0.4
Age when periods started (menarche)	0.1	0.3	1.3	0.3	0.1	0.2	-1.1	-0.3	-0.3	0.8
Supplements: Glucosamine	0.1	0.2	0.4	0.2	-0.5	0.5	-0.2	0.4	-0.4	0.6
Mouth/teeth dental problems	0.1	0.2	0.5	0.4	0.2	-0.7	-0.5	0.2	-0.7	-0.0
Fluid intelligence score	0.1	0.2	0.7	0.1	-0.5	0.2	0.2	0.4	-0.7	-0.8
Mouth/teeth dental problems: Dentures	0.1	0.1	0.7	-0.1	0.0	-0.8	0.2	0.3	0.1	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.3	-0.4	0.2	0.5	-0.1	-0.2	-0.1
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	-0.1	0.2	0.5	0.3	-0.1	0.3

Hub : Genes

LOXL2

Models

Trait associations