TWAS hub

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.064	0.0250	0.0052	0.006	0.031	0.024	0.035	0.019	0.055	0.00011	0.00063	3.8e-05	0.0018
2	GTEx	Nerve Tibial	0.102	0.0392	0.0032	0.005	NA	0.053	NA	0.033	0.130	NA	0.00013	NA	0.0020

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Neck or shoulder pain in last month	4.9	7.0	13.6	3.7	0.5
Health satisfaction	4.6	6.0	7.9	2.8	-2.0
Medication: Aspirin	4.6	6.0	8.1	2.0	-2.8
Arm fat percentage (right)	4.4	17.5	33.0	5.7	-1.4
Chronic bronchitis/emphysema (father)	4.3	5.1	9.0	3.0	-1.1
Medication: Aspirin	4.3	5.6	8.5	1.6	-2.9
Taking other prescription medications	4.0	6.1	8.8	1.9	-3.0
Headache pain in last month	4.0	6.8	12.7	3.6	-1.0
Commuting to job workplace: Walk	4.0	4.3	7.1	-2.7	1.2
Body fat percentage	3.9	15.3	29.0	5.4	-1.3
Arm fat percentage (left)	3.9	15.4	29.1	5.4	-1.3
Medication for pain relief, constipation, heartburn	3.8	6.4	10.7	-3.3	1.5
Medication: Ibuprofen	3.8	4.5	9.0	3.0	-0.2
Pain experienced in last month	3.8	6.3	11.8	-3.4	-0.9
Trunk fat percentage	3.7	15.0	27.1	5.2	-1.7
Bipolar Disorder (2018)	3.5	5.5	10.7	-3.3	-0.5
Leg fat percentage (left)	3.5	12.6	25.1	5.0	-0.5
Leg fat percentage (right)	3.4	12.4	24.5	5.0	-0.5
Whole body fat mass	3.4	14.2	28.0	5.3	-0.7
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.2	8.0	2.8	0.6
Arm fat mass (right)	3.3	13.6	26.7	5.2	-0.6
Arm fat mass (left)	3.3	13.7	27.1	5.2	-0.5
Long-standing illness, disability or infirmity	3.2	4.9	8.7	2.9	-1.0
Trunk fat mass	3.1	13.5	25.8	5.1	-1.0
Supplements: Vitamin C	3.1	3.7	4.6	1.7	2.1
Back pain experienced in last month	3.1	4.5	5.1	2.3	2.0
Leg fat mass (right)	3.0	11.6	23.2	4.8	-0.1
Knee pain experienced in last month	3.0	4.7	5.9	1.9	2.4
Hip circumference	2.9	12.4	22.3	4.7	-1.6
Leg fat mass (left)	2.9	11.5	23.0	4.8	0.0
Number of live births	2.8	4.0	6.3	-2.5	1.3
Past tobacco smoking	2.7	4.9	5.5	-2.1	2.4
Financial difficulties in last 2 years	2.7	3.6	6.2	2.5	1.0
Ever smoked	2.7	4.7	8.1	1.2	-2.8
Depressed Affect (Nagel 2018)	2.6	5.5	11.1	3.3	-0.0
Migraine (self-reported)	2.6	3.3	4.1	2.0	-1.5
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	4.6	1.3	-2.2
Pain type(s) experienced in last month: Hip pain	2.5	3.1	5.9	2.4	0.6
Breast Cancer	2.4	5.9	11.7	0.0	3.4
Other serious medical condition/disability diagnosed by doctor	2.4	3.2	5.3	2.3	-1.0
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	5.0	2.2	0.4
Medication: Lansoprazole	2.4	2.7	3.4	1.9	-1.4
Financial situation satisfaction	2.4	3.0	3.2	1.7	1.8
Depression (Nagel 2018)	2.3	3.5	5.2	2.3	-1.4
Family relationship satisfaction	2.3	2.9	5.6	0.4	2.4
Body mass index (BMI)	2.2	9.6	19.1	4.4	-0.1
Waist circumference	2.2	8.1	15.9	4.0	0.5
Leg pain on walking	2.2	2.8	4.7	2.2	0.9
Neuroticism	2.1	5.1	10.0	3.2	-0.4
Supplements: Zinc	2.1	2.3	4.4	-0.5	2.1
Hayfever, allergic rhinitis or eczema	2.1	4.6	7.7	-1.2	-2.8
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	6.8	2.6	0.2
Falls in the last year	2.1	2.8	3.5	1.9	1.5
Angina	2.0	2.6	3.6	1.3	-1.9
Fed-up feelings	2.0	3.7	4.8	1.6	2.2
Loneliness, isolation	2.0	2.8	5.3	2.3	0.5
Osteoporosis (self-reported)	2.0	2.5	4.9	-0.1	-2.2
Number of self-reported non-cancer illnesses	2.0	3.5	4.2	2.0	-1.7
Bipolar Disorder or Schizophrenia	1.9	4.7	8.3	-2.9	-1.1
Medication: Omeprazole	1.9	2.3	4.3	0.5	-2.1
Illnesses of father: None of the above (group 1)	1.9	2.3	4.2	-2.1	0.7
Commuting to job workplace: Public transport	1.9	2.3	3.2	-1.1	1.8
Medication: Paracetamol	1.8	2.9	4.2	2.0	1.3
Shortness of breath walking on level ground	1.8	2.1	3.8	1.9	-0.6
Angina (self-reported)	1.8	2.3	3.5	1.1	-1.9
Overall health rating	1.8	4.0	7.6	2.8	0.6
Friendships satisfaction	1.8	2.2	3.8	0.8	2.0
Mineral and other dietary supplements	1.8	2.4	2.6	-1.5	-1.6
LDL Cholesterol	1.7	2.6	5.1	-2.3	-0.4
Primary Biliary Cirrhosis	1.7	2.4	4.2	0.8	-2.0
Waist Hip Ratio (WHR)	1.7	7.7	12.0	-1.8	3.5
Glaucoma (self-reported)	1.7	1.9	3.7	-1.9	-0.5
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.0	0.1	2.0
Reaction Time	1.6	3.1	5.6	2.4	0.8
Chronotype (morning person)	1.6	3.6	3.9	-2.0	1.8
Number of treatments/medications taken	1.6	2.9	3.0	1.7	-1.6
Average weekly spirits intake	1.6	2.0	3.6	1.9	-0.7
Ever had hysterectomy (womb removed)	1.6	1.8	2.5	1.1	-1.6
Weight	1.6	8.0	16.0	4.0	-0.3
Birth weight	1.6	3.6	5.7	-1.2	-2.4
Wheeze or whistling in the chest in last year	1.6	2.8	3.8	1.9	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.8	2.5	-1.0	-1.6
Supplements: Fish oil (including cod liver oil)	1.6	2.0	2.9	1.1	1.7
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.2	0.8	-1.8
Irritable Bowel Disease (IBD)	1.5	3.6	6.8	0.7	2.6
Allergy or Eczema	1.5	3.9	5.3	-1.5	-2.3
Hearing difficulty/problems: Yes	1.5	2.2	4.1	2.0	0.6
Smoking status: Current	1.5	2.3	2.9	-1.3	-1.7
Current tobacco smoking	1.4	2.3	2.4	-1.5	-1.5
Serious illness, injury or assault to yourself	1.4	1.7	3.4	1.8	0.1
Had other major operations	1.4	1.7	2.0	-1.4	-1.2
Mean time to correctly identify matches	1.4	2.6	4.6	2.1	0.8
Smoking status: Previous	1.4	2.1	2.6	1.6	-1.3
Hearing aid user	1.4	1.5	1.8	1.1	1.3
Medication: Blood pressure	1.4	2.7	4.8	2.2	0.7
Medication: Paracetamol	1.4	2.2	3.2	1.8	1.1
Fasting Glucose	1.3	1.6	2.1	1.4	1.0
Vitamin and mineral supplements	1.3	1.8	2.9	-1.7	-0.8
Severe depression (siblings)	1.3	1.4	1.9	-1.0	1.4
Stomach or abdominal pain in last month	1.3	1.6	3.3	1.8	-0.2
Hearing difficulty/problems with background noise	1.3	2.1	3.2	1.8	1.0
Medication: Ramipril	1.3	1.7	2.6	0.9	-1.6
Had major operations	1.3	1.5	1.5	1.2	-1.2
Ever had bowel cancer screening	1.3	1.5	3.0	1.7	0.1
Medication: Bendroflumethiazide	1.3	2.0	3.3	1.8	0.8
Number of operations (self-reported)	1.3	2.0	2.1	1.3	-1.5
Heart disease (siblings)	1.3	1.6	3.0	1.7	-0.5
Schizophrenia vs Biploar Disorder	1.2	1.5	1.6	1.2	1.3
Crohns Disease (2017)	1.2	2.7	5.4	0.0	2.3
Lupus	1.2	1.8	2.1	1.5	-1.2
Alcohol intake versus 10 years previously	1.2	1.8	2.7	1.6	-1.0
Comparative body size at age 10	1.2	3.2	4.9	-2.2	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	1.9	0.9	-1.4
Chest pain or discomfort	1.2	1.7	1.9	1.4	-1.3
Hypertension (Self-reported)	1.2	3.4	4.8	2.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.2	0.8	-1.5
Asthma (self-reported)	1.2	2.5	3.3	1.8	-1.3
Neuroticism (Nagel 2018)	1.1	2.5	4.7	2.2	-0.6
Number of incorrect matches in round	1.1	1.8	2.8	-0.9	1.7
Asthma	1.1	2.2	2.5	1.6	-1.4
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.7	1.6	0.3
Exposure to tobacco smoke outside home	1.1	1.5	2.3	1.5	0.9
Medication: Blood pressure	1.1	2.0	3.4	-0.7	-1.8
Medication: Seretide 50 evohaler	1.1	1.3	1.5	1.1	-1.2
Average weekly red wine intake	1.1	1.6	1.7	-1.3	1.3
Wears glasses or contact lenses	1.1	1.3	2.4	-0.5	-1.5
Medication: Lisinopril	1.1	1.5	2.0	1.4	-0.9
Ulcerative Colitis (UC)	1.0	1.9	3.5	0.6	1.9
Prostate Cancer	1.0	1.4	1.8	1.4	-1.0
Triglycerides	1.0	1.6	1.9	-1.4	-1.1
Maternal smoking around birth	1.0	1.5	2.9	-0.3	1.7
Allergy	1.0	2.3	4.4	0.4	2.1
Noisy workplace	1.0	1.2	1.9	0.7	1.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.8	0.9	1.4
Qualifications: College or University degree	1.0	3.1	3.9	-2.0	-1.5
Number of full sisters	1.0	1.2	2.3	1.5	0.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.1	-1.5	0.6
Myopia	1.0	1.4	1.7	-1.0	1.3
Vascular/heart problems diagnosed by doctor	1.0	2.7	3.8	-1.9	1.3
HDL Cholesterol	0.9	1.5	2.9	1.7	0.3
Rheumatoid Arthritis	0.9	1.3	2.5	-0.2	1.6
BMI	0.9	5.1	10.2	3.2	-0.1
Respiratory disease	0.9	2.1	2.3	1.3	-1.5
Fluid intelligence score	0.9	1.8	3.6	-1.9	0.3
Qualifications: A levels/AS levels or equivalent	0.9	1.9	3.8	-2.0	0.3
Emphysema/chronic bronchitis	0.9	1.0	2.1	1.4	0.0
Qualifications: nursing, teaching	0.9	1.5	1.8	-1.4	-1.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.6	1.3	0.7
Age at First Birth	0.8	1.2	2.3	-0.2	-1.5
Mean Putamen Volume	0.8	0.9	1.4	-0.6	-1.2
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.3	1.5	-0.1
Townsend deprivation index at recruitment	0.8	1.2	2.2	0.2	1.5
Multivitamins +/- minerals	0.8	1.0	1.6	0.6	1.3
Supplements: Glucosamine	0.8	1.0	1.4	-1.2	0.8
Alcohol usually taken with meals	0.8	1.3	2.2	-1.5	0.7
Had menopause	0.8	1.0	1.8	0.4	-1.4
Father’s age at death	0.8	1.1	1.6	-0.7	1.3
Happiness	0.8	0.9	1.0	1.0	0.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.5	-0.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.6	0.4	-1.3
Average weekly beer plus cider intake	0.8	1.2	2.3	0.4	1.5
Risk taking	0.8	1.2	1.2	1.1	1.1
Supplements: Calcium	0.8	0.9	1.5	1.2	-0.5
Alzheimer’s Disease (in father)	0.7	0.8	0.9	-1.0	-0.8
Smoking Status	0.7	1.8	3.4	0.3	-1.8
Cardiovascular Disease	0.7	2.5	4.8	2.2	-0.4
High blood pressure	0.7	1.8	3.1	1.8	-0.8
Sitting height	0.7	5.0	9.8	-0.5	-3.1
Neuroticism score	0.7	1.4	2.9	1.7	-0.1
Impedance of arm (left)	0.7	3.4	6.4	-0.7	-2.5
Number of children fathered	0.7	0.8	1.1	-0.6	1.1
Medication for cholesterol	0.7	1.0	1.6	-0.7	-1.3
Osteoarthritis (self-reported)	0.7	1.0	1.7	0.4	1.3
Guilty feelings	0.7	1.0	1.0	1.0	-1.0
Eye problems/disorders: Glaucoma	0.7	0.9	1.1	-1.0	-0.8
Basal cell carcinoma (self-reported)	0.7	0.8	1.6	1.3	0.1
Arm predicted mass (left)	0.7	3.8	6.6	2.6	1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.2	-1.5	0.4
Relative age of first facial hair	0.6	1.3	1.7	-1.3	0.9
Age when periods started (menarche)	0.6	1.5	2.7	-1.6	0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	-0.1	-1.1
Impedance of arm (right)	0.6	2.9	5.7	0.2	-2.4
Medication: Cholesterol lowering	0.6	1.0	1.9	0.2	-1.4
Tense / ‘highly strung’	0.6	0.9	1.8	0.0	1.4
Blood clot in the leg (DVT)	0.6	0.8	0.9	-0.8	0.9
Medication: Amlodipine	0.6	0.8	1.1	0.7	-1.1
Forced vital capacity (FVC), Best measure	0.6	2.1	4.2	-2.1	0.1
Eye problems/disorders: None of the above	0.6	0.7	1.5	-1.2	0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.3	1.1	0.3
Eye problems/disorders: Cataract	0.6	0.7	1.4	1.2	0.2
Miserableness	0.6	1.1	1.4	1.2	0.9
High cholesterol (Self-reported)	0.6	1.1	1.8	0.6	1.3
Arm fat-free mass (left)	0.6	3.1	5.2	2.3	1.0
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.9	-1.7	0.5
Schizophrenia (2018)	0.5	1.0	1.1	-1.0	-1.0
Coronary Artery Disease (CAD)	0.5	0.6	1.0	-1.0	-0.5
Schizophrenia (2014)	0.5	1.0	1.5	-0.7	-1.2
Hand grip strength (left)	0.5	1.3	2.2	0.7	-1.5
Hand grip strength (right)	0.5	1.3	1.7	-1.0	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.2	1.1	-0.3
Relative age voice broke	0.5	0.8	0.9	-0.8	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.2	1.1	0.5
Qualifications: None of the above	0.5	1.0	1.3	1.1	0.9
Worrier / anxious feelings	0.5	0.9	1.7	-1.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	2.0	-1.4	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.1	-1.8	0.6
Exposure to tobacco smoke at home	0.5	0.6	0.8	0.9	-0.5
Gout (self-reported)	0.5	0.6	0.9	0.6	1.0
Number of full brothers	0.5	0.7	1.3	1.1	0.3
Pulse rate, automated reading	0.5	1.7	3.1	-0.5	-1.8
Medication: Gliclazide	0.5	0.6	0.8	-0.9	0.6
Irritability	0.5	0.8	1.4	1.2	-0.6
Ever depressed for a whole week	0.5	0.6	1.1	-0.4	1.1
Major Depression (MDD)	0.4	0.4	0.9	-0.9	0.0
Diabetes (mother)	0.4	0.5	0.8	-0.9	-0.5
Average weekly fortified wine intake	0.4	0.5	0.7	-0.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	1.0	-0.0
Forced vital capacity (FVC)	0.4	1.6	2.5	-1.6	0.8
Time employed in main current job	0.4	0.5	0.8	0.9	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	0.3	-0.9
Depression (self-reported)	0.4	0.4	0.6	0.5	-0.8
Length of working week for main job	0.4	0.4	0.7	-0.3	0.9
Hair/balding pattern: Pattern 4	0.4	0.9	1.5	-0.5	1.2
Arm fat-free mass (right)	0.4	2.0	2.7	1.6	1.2
Arm predicted mass (right)	0.4	2.2	3.0	1.7	1.2
Mood swings	0.4	0.7	1.0	0.6	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.2	1.1	-0.4
Basal metabolic rate	0.4	2.5	4.5	2.1	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	-0.5	0.8
Ovarian Cancer	0.3	0.3	0.7	0.1	-0.8
Blood Eosinophil Count	0.3	2.2	3.2	1.1	-1.8
Blood Red Count	0.3	3.1	4.0	2.0	1.5
Lung FVC	0.3	1.6	2.8	-1.7	-0.7
Sensitivity / hurt feelings	0.3	0.5	0.7	-0.9	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	-0.1	-0.9
Leg fat-free mass (left)	0.3	1.6	3.0	1.7	0.4
High blood pressure (mother)	0.3	0.5	0.9	-0.9	-0.2
Leg predicted mass (left)	0.3	1.6	3.1	1.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.2	-1.1	-0.0
Diabetes (self-reported)	0.3	0.5	1.0	-0.1	-1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.6	-0.5	-0.8
Medication: Simvastatin	0.3	0.5	0.6	-0.8	-0.5
Trunk fat-free mass	0.3	1.7	2.1	1.4	1.1
Trunk predicted mass	0.3	1.7	2.4	1.5	1.1
Birth weight of first child	0.3	0.5	1.0	0.1	-1.0
Loud music exposure frequency	0.3	0.4	0.7	0.8	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	-0.9	0.3
Age at first live birth	0.3	0.5	0.9	0.3	-0.9
Whole body fat-free mass	0.3	1.7	2.5	1.6	0.9
Whole body water mass	0.3	1.6	2.4	1.6	0.9
Mother’s age at death	0.3	0.4	0.5	0.7	-0.5
Medication: Atorvastatin	0.3	0.4	0.8	0.9	0.2
Illnesses of father: High blood pressure	0.3	0.3	0.6	0.7	0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.7	-0.3	-0.9
Diastolic blood pressure, automated reading	0.3	1.0	1.2	0.9	-1.1
Cholesterol lowering medication	0.3	0.5	0.6	-0.6	0.8
Impedance of whole body	0.3	1.5	2.7	-0.6	-1.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.4	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.1	-1.0	-0.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.3	-0.6
Blood Platelet Count	0.2	2.8	3.8	-1.9	1.4
Blood White Count	0.2	1.5	2.8	1.7	-0.5
Height	0.2	3.2	5.1	1.1	-2.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.3	0.5	-0.5
Medication for hormone replacement therapy	0.2	0.2	0.2	-0.4	-0.4
Qualifications: CSEs or equivalent	0.2	0.2	0.4	0.2	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	0.3	0.7
Mouth/teeth dental problems	0.2	0.4	0.7	-0.8	-0.1
Pain all over the body in last month	0.2	0.2	0.3	0.0	0.6
Illnesses of siblings	0.2	0.3	0.7	-0.1	0.8
Pulse rate	0.2	0.4	0.6	0.5	-0.8
Prospective memory result	0.2	0.2	0.3	-0.3	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.0	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.2	0.7
Pulse wave peak to peak time	0.2	0.3	0.5	-0.0	0.7
Medication: Allopurinol	0.2	0.3	0.4	0.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	-0.9	0.3
Leg fat-free mass (right)	0.2	1.1	2.0	1.4	0.4
Leg predicted mass (right)	0.2	1.0	2.0	1.4	0.3
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.7	-0.1
Age started oral contraceptive pill	0.2	0.2	0.3	0.4	-0.6
Unable to work because of sickness or disability	0.2	0.3	0.6	0.8	-0.0
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.4	-0.6
Pack years of smoking	0.2	0.3	0.5	0.7	-0.1
Worry (Nagel 2018)	0.1	0.3	0.5	0.7	0.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.5	-0.2
HbA1C	0.1	0.1	0.2	-0.4	-0.0
Neuroticism (2016)	0.1	0.1	0.3	0.5	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.3	-0.3
Heel T-Score	0.1	1.1	1.6	0.8	-1.3
Systolic Blood Pressure	0.1	0.4	0.5	0.5	-0.7
Hypothyroidism (self reported)	0.1	0.2	0.3	0.6	-0.3
Hair Pigment	0.1	2.6	4.8	2.2	-0.6
Tanning	0.1	0.9	1.8	0.0	1.3
Systolic blood pressure, automated reading	0.1	0.3	0.5	0.7	-0.3
Medication: Co-codamol	0.1	0.2	0.3	-0.5	0.3
Diabetes (father)	0.1	0.1	0.1	0.2	-0.4
Impedance of leg (right)	0.1	0.6	1.1	-1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	-0.8	-0.0
Medication: Atenolol	0.1	0.2	0.2	0.4	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.1	-0.4
Impedance of leg (left)	0.1	0.5	0.7	-0.9	-0.5
Nervous feelings	0.1	0.2	0.3	-0.6	0.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.5	-0.0
Heart attack	0.1	0.1	0.3	-0.0	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	0.2	-0.5
Illnesses of mother	0.1	0.1	0.1	-0.3	0.2
Breastfed as a baby	0.1	0.1	0.2	0.4	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.3	-0.6	0.4
Pulse wave reflection index	0.1	0.1	0.2	0.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	0.1	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.3	-0.5
High blood pressure (siblings)	0.1	0.2	0.3	-0.6	0.2
Age at last live birth	0.1	0.2	0.2	-0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	0.6	0.2
Illnesses of father: Heart disease	0.1	0.2	0.3	0.5	0.3
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.1	-0.6
Breast cancer (self-reported)	0.1	0.1	0.2	0.5	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.0	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.2	0.5	-0.2
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.0	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	-0.1	0.0
Ulcerative Colitis	0.0	0.0	0.1	0.1	0.3
Lung FEV1/FVC ratio	0.0	0.2	0.3	0.4	-0.5
Medication: Metformin	0.0	0.0	0.0	0.0	-0.1
Pack years adult smoking proportion	0.0	0.1	0.1	0.4	0.1
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.1	-0.1
Lung cancer (father)	0.0	0.0	0.0	0.0	-0.1
Standing height	0.0	0.3	0.5	-0.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.2	0.3
Worry too long after embarrassment	0.0	0.1	0.1	0.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.0	-0.1
Heart disease (mother)	0.0	0.0	0.1	-0.2	-0.2
Alcohol intake frequency.	0.0	0.1	0.2	0.1	0.4
Comparative height size at age 10	0.0	0.2	0.3	-0.5	-0.3
Suffer from ‘nerves’	0.0	0.0	0.0	-0.2	-0.0
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	0.1
Illnesses of siblings: Diabetes	0.0	0.1	0.1	-0.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.0	0.1
Alcohol drinker status: Never	0.0	0.0	0.0	-0.2	0.0

Hub : Genes

HR

Models

Trait associations