Best TWAS P=5.99e-18 · Best GWAS P=6.85e-21 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC441454 | 0.05 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | 5.4 | 6.2 | 5.4e-10 | 0.04 | 0.04 | 0.61 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-435O5.5 | 0.09 | 0.04 | lasso | 2 | 0.02 | 7.3e-03 | 8.8 | -8.6 | 6.0e-18 | -0.95 | 0.02 | 0.94 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | CDC14B | 0.16 | 0.02 | enet | 21 | 0.02 | 3.7e-02 | 7.2 | -6.3 | 3.1e-10 | -0.02 | 0.05 | 0.90 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | AAED1 | 0.17 | 0.02 | lasso | 3 | 0.04 | 2.4e-02 | 7.2 | 6.4 | 1.8e-10 | 0.02 | 0.04 | 0.56 | FALSE |
| 5 | GTEx | Nerve Tibial | ZNF367 | 0.10 | 0.05 | lasso | 3 | 0.02 | 7.9e-03 | 7.5 | 6.7 | 2.3e-11 | 0.04 | 0.02 | 0.97 | FALSE |
| 6 | GTEx | Testis | HABP4 | 0.19 | 0.22 | lasso | 9 | 0.21 | 1.1e-09 | 7.2 | 7.3 | 3.9e-13 | 0.04 | 0.04 | 0.96 | FALSE |
| 7 | GTEx | Thyroid | CDC14B | 0.15 | 0.10 | lasso | 5 | 0.08 | 5.3e-07 | 6.8 | -7.0 | 3.3e-12 | -0.04 | 0.19 | 0.81 | FALSE |
| 8 | YFS | Blood | HABP4 | 0.08 | 0.09 | enet | 24 | 0.11 | 5.9e-34 | 7.2 | -7.0 | 3.0e-12 | -0.09 | 0.06 | 0.94 | FALSE |
| 9 | YFS | Blood | PTCH1 | 0.09 | 0.05 | lasso | 8 | 0.05 | 1.2e-15 | 5.9 | 6.7 | 2.0e-11 | 0.42 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDC14B | 0.02 | 0.01 | lasso | 1 | 0.01 | 3.0e-03 | 7.4 | -7.4 | 1.6e-13 | -0.04 | 0.02 | 0.65 | FALSE |
| 11 | The Cancer Genome Atlas | Glioblastoma Multiforme | CDC14B | 0.16 | 0.17 | blup | 41 | 0.19 | 2.6e-06 | 7.2 | -6.5 | 6.2e-11 | -0.01 | 0.03 | 0.94 | FALSE |
| 12 | The Cancer Genome Atlas | Glioblastoma Multiforme | HABP4 | 0.08 | 0.06 | blup | 44 | 0.05 | 1.6e-02 | 6.7 | -7.4 | 1.1e-13 | -0.06 | 0.03 | 0.51 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HABP4 | 0.02 | 0.02 | blup | 44 | 0.02 | 7.1e-03 | 7.2 | 7.4 | 1.9e-13 | 0.04 | 0.02 | 0.71 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDC14B | 0.03 | 0.02 | blup | 42 | 0.02 | 2.1e-03 | 7.2 | -7.3 | 2.3e-13 | -0.04 | 0.03 | 0.73 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CDC14B | 0.05 | 0.06 | lasso | 5 | 0.06 | 6.5e-07 | 7.2 | -6.8 | 1.3e-11 | -0.04 | 0.04 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HABP4 | 0.05 | 0.08 | lasso | 5 | 0.08 | 6.9e-09 | 6.6 | -6.8 | 8.2e-12 | -0.05 | 0.07 | 0.93 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PTCH1 | 0.02 | 0.01 | blup | 54 | 0.02 | 1.1e-03 | 7.4 | -7.3 | 3.2e-13 | -0.86 | 0.02 | 0.72 | FALSE |
| 18 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CDC14B | 0.08 | 0.02 | blup | 41 | 0.04 | 1.0e-03 | 5.4 | -7.6 | 3.7e-14 | -0.08 | 0.02 | 0.63 | TRUE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | CDC14B | 0.05 | 0.07 | blup | 42 | 0.08 | 4.8e-08 | 7.2 | -7.1 | 1.0e-12 | -0.03 | 0.04 | 0.96 | FALSE |