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chr19:9,637,688-11,873,382

Best TWAS P=2.32e-15 · Best GWAS P=3.22e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC147727	0.07	0.02	lasso	2	0.02	5.4e-03	7.8	-7.9	2.3e-15	-0.99	0.01	0.86	TRUE
9	GTEx	Whole Blood	CTD-2369P2.8	0.12	0.11	lasso	3	0.10	9.2e-10	6.7	7.2	8.8e-13	0.06	0.95	0.05	TRUE
7	GTEx	Testis	PDE4A	0.20	0.02	enet	39	0.04	6.4e-03	5.4	5.9	4.4e-09	0.06	0.06	0.04	TRUE
8	GTEx	Vagina	CTD-2369P2.2	0.50	-0.01	lasso	9	0.01	2.0e-01	5.1	5.7	1.4e-08	0.01	0.22	0.11	TRUE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	S1PR2	0.02	0.00	blup	32	0.01	1.5e-02	-5.1	5.5	3.9e-08	0.04	0.00	0.35	TRUE
4	GTEx	Muscle Skeletal	SLC44A2	0.19	0.18	lasso	5	0.19	5.1e-18	6.4	7.0	2.4e-12	0.79	0.82	0.18	FALSE
5	GTEx	Nerve Tibial	ILF3-AS1	0.14	0.04	lasso	3	0.08	3.8e-06	7.7	-6.5	9.8e-11	-0.77	0.01	0.98	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	FDX1L	0.06	0.00	blup	53	0.02	5.1e-03	-4.6	-6.4	2.1e-10	0.05	0.01	0.34	FALSE
3	GTEx	Esophagus Mucosa	ILF3-AS1	0.11	0.00	lasso	4	0.00	2.5e-01	7.8	-6.3	2.4e-10	-0.77	0.02	0.87	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC147727	0.13	0.02	blup	28	0.04	7.2e-05	7.8	-5.8	5.7e-09	-0.76	0.01	0.90	FALSE
2	GTEx	Esophagus Mucosa	SLC44A2	0.13	0.00	lasso	6	0.02	1.4e-02	4.6	-5.8	6.1e-09	-0.46	0.07	0.57	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	SLC44A2	0.32	0.22	enet	14	0.25	3.8e-24	7.3	5.8	7.8e-09	0.85	0.28	0.72	FALSE
1	CommonMind	Brain Pre-frontal Cortex	S1PR2	0.07	0.02	bslmm	369	0.03	5.3e-05	-4.8	5.6	1.8e-08	0.31	0.32	0.14	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FDX1L	0.06	0.02	lasso	3	0.04	2.4e-05	-4.6	-5.4	7.1e-08	-0.04	0.06	0.68	FALSE
10	NTR	Blood	SMARCA4	0.07	0.06	lasso	11	0.06	9.0e-18	4.7	-5.1	2.9e-07	-0.43	1.00	0.00	FALSE
6	GTEx	Skin Sun Exposed Lower leg	SMARCA4	0.15	0.10	enet	25	0.15	1.4e-12	2.5	-5.1	3.0e-07	-0.61	1.00	0.00	FALSE