Best TWAS P=2.26e-11 · Best GWAS P=4.06e-12 conditioned to 3.4e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PPP3R1 | 0.25 | 0.22 | lasso | 4 | 0.26 | 5.4e-20 | -6.3 | -6.7 | 2.3e-11 | 0.50 | 0.26 | 0.74 | TRUE |
| 2 | GTEx | Artery Tibial | RP11-474G23.2 | 0.17 | 0.14 | lasso | 3 | 0.12 | 2.3e-09 | -6.3 | -6.6 | 3.4e-11 | 0.45 | 0.26 | 0.74 | FALSE |
| 3 | METSIM | Adipose | PNO1 | 0.10 | 0.12 | enet | 23 | 0.12 | 1.4e-17 | -6.8 | -6.3 | 3.5e-10 | 0.97 | 0.01 | 0.99 | FALSE |
| 4 | NTR | Blood | CNRIP1 | 0.04 | 0.03 | lasso | 4 | 0.04 | 4.7e-12 | -6.9 | -5.8 | 5.9e-09 | 0.92 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | WDR92 | 0.04 | 0.01 | blup | 49 | 0.01 | 7.9e-03 | -6.3 | -6.6 | 3.7e-11 | 0.80 | 0.02 | 0.58 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | PNO1 | 0.04 | 0.03 | blup | 41 | 0.04 | 1.1e-04 | -6.8 | -5.8 | 6.7e-09 | 0.93 | 0.01 | 0.96 | FALSE |