Hub : Genes

PPP3R1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.2471	0.0627	1.0e-06	0.223	NA	0.230	NA	0.255	2.3e-17	NA	5.4e-18	NA	5.4e-20
2	METSIM	Adipose	0.0752	0.0215	2.3e-06	0.038	0.048	0.048	0.051	0.061	1.7e-06	8.6e-08	9.0e-08	3.3e-08	2.0e-09
3	YFS	Blood	0.2402	0.0282	0.0e+00	0.321	0.310	0.339	0.333	0.335	2.7e-108	4.6e-104	9.1e-116	2.1e-113	6.8e-114
4	TCGA	Brain Lower Grade Glioma	0.1122	0.0544	5.0e-04	0.019	0.022	0.005	NA	0.012	2.5e-03	1.4e-03	7.5e-02	NA	1.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.4	2.2	6.0	-2.5	0.3	-1.5	-0.7
Bipolar Disorder or Schizophrenia	0.4	0.9	2.3	-1.0	-0.4	-0.3	-1.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.2	-0.1	-0.3	-0.5
Depression (Nagel 2018)	0.5	0.7	1.4	-0.5	0.2	-1.1	-1.2
Intelligence (Savage-Jansen 2018)	1.7	5.3	15.1	-2.3	0.1	-0.9	-3.9
Neuroticism (Nagel 2018)	0.5	1.2	1.7	1.1	-0.4	1.3	1.2
Schizophrenia (2018)	0.4	0.9	1.9	0.7	-0.7	0.8	-1.4
Schizophrenia vs Biploar Disorder	1.3	1.7	3.4	1.8	-0.1	1.7	-0.8
Worry (Nagel 2018)	1.1	2.3	4.3	1.3	-0.3	1.8	2.1
Alzheimer’s Disease (in mother)	0.4	0.5	0.8	-0.9	-0.8	0.1	-0.8
Alzheimer’s Disease (in father)	1.1	1.2	3.4	-1.0	1.8	-0.4	0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	-1.4	0.2	-0.5	-0.1
Crohns Disease (2017)	0.4	0.8	1.4	1.2	-0.5	0.8	-0.9
Irritable Bowel Disease (IBD)	0.3	0.6	1.1	1.1	0.8	0.5	-0.7
Ulcerative Colitis (UC)	0.7	1.3	2.6	1.3	1.6	0.7	-0.6
Major Depression (MDD)	0.7	0.9	3.0	-0.1	-1.7	-0.7	0.4
Reaction Time	0.3	0.5	1.1	0.2	-1.1	-0.8	-0.4
Verbal and Numeric Reasoning (VNR)	3.0	7.3	19.9	-2.6	0.8	-1.3	-4.5
Breast Cancer	0.4	0.9	2.2	-1.5	0.3	0.8	0.7
Ovarian Cancer	0.2	0.3	0.8	0.0	-0.6	-0.2	0.9
Prostate Cancer	0.5	0.7	1.3	-1.1	1.0	0.2	0.6
Age at First Birth	0.4	0.5	1.7	-1.3	-0.2	-0.3	-0.5
Bipolar Disorder (2011)	2.4	2.4	8.5	0.0	-0.9	-2.9	0.3
Body Mass Index (BMI) (2010)	0.5	0.7	1.8	1.3	0.2	0.6	-0.9
Coronary Artery Disease (CAD)	0.7	0.9	1.4	0.9	-1.0	1.2	0.6
Crohns Disease (2012)	0.2	0.3	1.0	-0.4	0.1	0.2	-1.0
Mean Putamen Volume	1.1	1.3	2.5	-0.8	-1.6	-1.2	0.7
Fasting Glucose	0.8	1.0	1.8	1.3	-1.2	0.7	0.0
HbA1C	0.9	1.0	1.7	1.3	-0.8	1.3	0.0
HDL Cholesterol	0.5	0.9	3.2	-1.8	-0.3	0.3	0.4
LDL Cholesterol	1.0	1.5	2.3	-1.5	-1.1	-1.1	1.2
Lupus	0.9	1.3	2.3	1.4	0.3	1.5	-0.9
Neuroticism (2016)	0.7	1.0	1.4	0.5	1.1	1.2	0.9
Primary Biliary Cirrhosis	1.8	2.6	5.1	1.2	0.7	1.8	-2.3
Rheumatoid Arthritis	0.3	0.4	0.8	-0.1	-0.8	0.5	-0.9
Schizophrenia (2014)	0.5	1.2	4.0	0.6	-0.4	0.5	-2.0
Triglycerides	0.3	0.5	1.2	0.3	-1.1	-0.6	0.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	6.0	-0.1	0.2	0.3	-2.4
Ulcerative Colitis	0.5	0.8	1.9	0.7	1.4	0.5	-0.7
Blood Eosinophil Count	0.1	0.4	0.9	-0.4	1.0	-0.8	0.1
Blood Platelet Count	0.8	9.1	22.0	0.1	-4.7	-2.6	2.8
Blood Red Count	0.3	2.8	8.6	0.1	-2.9	-1.0	1.2
Blood White Count	0.2	1.2	2.5	-0.2	0.5	-1.4	1.6
Heel T-Score	0.5	4.0	9.1	-1.0	-3.0	-2.0	-1.4
BMI	0.2	1.1	3.7	-0.0	-1.9	-0.8	0.2
Height	2.3	44.3	123.2	-11.1	-0.2	-7.3	0.4
Waist Hip Ratio (WHR)	2.4	10.9	28.8	-1.8	-2.8	-5.4	1.9
Systolic Blood Pressure	4.7	23.7	47.3	6.9	0.3	6.6	1.8
Smoking Status	1.0	2.3	7.4	-0.7	-0.8	-2.7	-0.8
Allergy or Eczema	0.5	1.4	2.6	0.8	-1.6	1.5	-0.1
Cardiovascular Disease	3.1	10.1	20.7	4.5	-2.2	3.9	-0.2
Hypothyroidism (self reported)	0.2	0.4	0.9	1.0	0.8	0.3	-0.1
Respiratory disease	0.4	0.8	2.2	-0.6	-0.8	0.0	-1.5
Type 2 Diabetes (T2D) (2018)	1.3	2.5	5.4	-0.5	-1.4	-2.3	-1.6
Lung FEV1/FVC ratio	0.5	2.8	7.8	1.4	-0.4	2.8	-1.1
Lung FVC	0.8	3.9	7.8	-1.3	-0.3	-2.8	-2.5
Neuroticism	0.2	0.4	1.2	0.1	-1.1	0.4	0.5
Chronotype (morning person)	0.9	2.1	5.1	2.2	0.7	0.7	1.5
Hair Pigment	0.0	0.7	1.3	1.1	-0.7	0.9	-0.4
Tanning	0.0	0.4	1.7	-0.1	0.0	0.1	-1.3
Hand grip strength (left)	3.4	9.1	27.8	-5.3	-0.3	-2.8	-0.7
Number of treatments/medications taken	0.2	0.4	1.3	0.6	-0.4	0.2	1.1
Average weekly spirits intake	0.9	1.1	2.9	1.2	-0.0	-0.1	1.7
Sensitivity / hurt feelings	0.4	0.7	1.0	1.0	-0.2	0.9	1.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.2
Hearing difficulty/problems: Yes	1.5	2.3	8.2	-1.0	-0.2	0.3	-2.9
Relative age of first facial hair	0.8	1.6	6.3	-0.0	0.3	2.5	0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.6	-1.6	-0.2	-1.0	-0.3
Ever used hormone-replacement therapy (HRT)	1.2	1.6	2.1	-1.5	-1.3	-0.9	-1.3
Ever had hysterectomy (womb removed)	0.9	1.0	2.4	0.8	-1.0	-0.4	-1.6
Systolic blood pressure, automated reading	3.6	10.3	22.6	4.8	0.3	3.9	1.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.2	0.2	-0.8	0.7
Angina	0.9	1.1	2.2	0.9	1.5	1.2	0.3
Medication for hormone replacement therapy	0.4	0.5	1.3	-0.8	0.0	1.1	-0.0
Vitamin and mineral supplements	0.9	1.2	3.2	1.2	1.8	-0.4	-0.3
Supplements: Zinc	0.3	0.3	0.8	-0.6	0.1	-0.3	-0.9
Medication: Co-codamol	0.6	0.7	2.0	-0.8	0.2	-1.4	-0.4
Medication: Metformin	1.4	1.9	4.8	-1.5	-0.9	-2.2	-0.1
Diabetes (father)	0.3	0.4	0.7	-0.5	0.3	-0.9	-0.8
Diabetes (mother)	1.1	1.4	2.9	-0.5	-1.7	-0.4	1.5
Severe depression (siblings)	1.0	1.1	2.6	-1.6	1.1	-0.8	-0.0
Pack years adult smoking proportion	2.4	3.7	7.2	-2.1	-1.6	-2.7	-0.9
Impedance of leg (right)	0.5	2.3	6.1	2.5	0.9	-1.6	-0.2
Leg fat-free mass (left)	1.6	8.6	26.6	-5.2	-1.4	-2.4	0.1
Trunk fat percentage	0.4	1.4	3.5	1.2	-0.8	-1.9	0.1
Hand grip strength (right)	3.6	9.7	30.0	-5.5	-0.4	-3.0	0.1
Townsend deprivation index at recruitment	0.8	1.2	3.1	1.8	1.1	0.5	-0.4
Current tobacco smoking	0.8	1.3	2.6	-0.3	0.4	-1.6	-1.5
Average weekly fortified wine intake	1.1	1.3	2.8	1.7	0.3	1.4	-0.6
Maternal smoking around birth	0.7	1.0	3.9	2.0	-0.3	0.0	0.3
Fed-up feelings	0.3	0.5	1.4	0.4	-1.2	0.7	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	0.4	-0.5	-0.6	-0.1
Relative age voice broke	0.2	0.3	1.2	-0.1	-0.0	1.1	-0.3
Taking other prescription medications	0.3	0.5	0.8	-0.7	-0.4	-0.9	0.7
Age when periods started (menarche)	1.4	3.3	11.3	-0.5	-0.4	-1.2	3.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.8	-0.3	-1.9	0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.5	-0.8	-2.1	-1.9	0.3
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	5.4	0.1	-0.5	-1.2	2.3
Qualifications: CSEs or equivalent	0.6	0.7	2.0	0.3	-1.4	0.7	0.5
Serious illness, injury or assault to yourself	0.9	1.2	1.9	-1.4	-0.8	-0.8	-1.2
High blood pressure	2.2	6.0	13.0	3.6	-1.6	2.9	-0.3
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.7	0.5	-2.2	0.9	-0.3
Multivitamins +/- minerals	1.9	2.4	5.8	-1.9	-2.4	-0.0	-0.4
Stomach or abdominal pain in last month	0.3	0.4	0.6	0.1	-0.5	-0.8	0.8
Supplements: Glucosamine	0.5	0.7	2.5	0.3	-0.5	1.6	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	0.5	0.8	0.3	0.6
Medication: Atenolol	1.7	2.1	5.2	1.6	2.3	-0.1	0.6
Medication: Levothyroxine sodium	0.2	0.4	0.9	1.0	-0.1	0.6	-0.5
Sitting height	3.1	22.1	62.3	-7.9	-0.5	-4.9	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	0.6	0.2	1.1	0.6
High blood pressure (mother)	2.9	4.1	12.0	0.7	1.6	3.5	-1.2
Body mass index (BMI)	0.2	0.7	1.3	0.1	-1.2	-1.1	0.5
Impedance of leg (left)	0.5	2.3	4.2	2.0	1.0	-2.0	-0.4
Leg predicted mass (left)	1.6	8.5	26.5	-5.2	-1.3	-2.4	0.2
Trunk fat mass	0.5	2.3	7.6	-0.7	-1.0	-2.8	0.3
Waist circumference	1.0	3.5	10.4	-1.3	-1.4	-3.2	0.2
Number of incorrect matches in round	0.8	1.4	2.6	-0.8	-0.7	-1.6	1.3
Past tobacco smoking	0.5	1.0	2.9	1.0	0.3	1.7	0.0
Alcohol usually taken with meals	1.6	2.5	5.2	-1.9	0.1	-1.1	-2.3
Nervous feelings	1.7	3.2	11.0	1.3	0.2	0.5	3.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	-0.6	0.2	-0.7	0.4
Hearing difficulty/problems with background noise	0.3	0.5	0.8	-0.4	0.6	0.7	-0.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	0.3	-0.8	0.4	0.8
Had menopause	0.4	0.5	0.8	0.9	0.7	0.8	-0.5
Had other major operations	0.6	0.7	1.3	-1.1	0.7	0.9	-0.6
Forced vital capacity (FVC)	3.0	11.4	22.8	-4.8	-0.9	-4.4	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.2	-1.4	-1.7	-2.0	0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.4	0.6	-0.6	-0.6	-0.5
Qualifications: None of the above	3.3	7.1	14.5	3.8	-1.8	0.3	3.3
Financial difficulties in last 2 years	0.5	0.7	2.0	0.8	-1.4	0.0	-0.0
Mouth/teeth dental problems	0.4	0.6	1.7	-1.3	0.2	-0.4	-0.8
Heart attack	0.8	1.0	3.4	0.5	1.8	-0.1	-0.6
Allergy	0.5	1.1	2.9	-0.6	1.7	-0.8	0.6
Pain all over the body in last month	0.1	0.1	0.3	-0.5	-0.5	0.2	0.1
Diabetes (self-reported)	1.6	2.4	5.4	-1.0	-1.1	-2.3	-1.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.8	-0.1	-0.7	-0.4
Medication: Ramipril	0.3	0.3	0.8	-0.1	-0.5	-0.5	-0.9
Medication: Simvastatin	0.4	0.5	1.6	-0.0	0.4	-0.7	-1.3
Fluid intelligence score	2.6	5.4	14.7	-1.6	2.0	-0.4	-3.8
Illnesses of siblings	1.8	2.6	6.3	-2.5	-0.7	-1.9	0.3
Neuroticism score	0.7	1.5	2.4	1.0	-0.5	1.5	1.6
Weight	1.3	6.2	12.3	-3.5	-1.5	-3.2	0.4
Impedance of arm (right)	1.8	8.4	20.6	4.5	1.4	2.5	-2.1
Arm fat percentage (right)	0.5	2.0	7.8	2.8	-0.4	0.3	-0.2
Trunk fat-free mass	2.6	14.8	43.8	-6.6	-1.4	-3.6	0.8
Hip circumference	0.1	0.5	1.2	-0.8	0.3	-1.1	-0.3
Time employed in main current job	1.7	1.9	4.3	2.1	-0.4	1.7	0.5
Alcohol intake versus 10 years previously	0.5	0.8	2.9	-1.7	0.2	-0.5	-0.3
Father’s age at death	0.7	0.9	2.1	-0.8	-0.6	-0.6	1.4
Worrier / anxious feelings	1.1	2.2	4.0	1.7	0.4	2.0	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.1	0.7	0.1	-0.6
Falls in the last year	0.1	0.2	0.3	-0.5	0.2	-0.5	0.5
Hair/balding pattern: Pattern 3	1.7	2.6	4.6	-1.5	-1.1	-2.1	-1.5
Number of live births	1.6	2.2	3.6	1.6	-1.7	0.3	1.9
Forced expiratory volume in 1-second (FEV1)	2.4	8.0	16.0	-4.0	-0.8	-3.0	-2.6
Pulse rate	0.1	0.2	0.4	0.0	-0.7	-0.4	0.5
Happiness	0.8	1.0	3.5	-0.8	1.9	-0.0	-0.0
Noisy workplace	0.9	1.1	3.2	-0.3	0.9	-0.5	-1.8
Qualifications: A levels/AS levels or equivalent	3.4	7.6	15.7	-2.9	2.5	0.0	-4.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.6	0.5	-0.1	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.1	3.2	0.9	-1.8	0.4	0.6
Asthma	0.9	1.8	2.6	-1.2	-1.5	-0.9	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.5	0.4	-0.8	-0.4	1.6
Medication: Cholesterol lowering	0.3	0.5	0.8	-0.5	0.7	-0.9	0.8
Depression (self-reported)	0.3	0.4	0.9	-0.3	0.2	-0.6	1.0
Medication: Lansoprazole	1.8	2.1	5.2	-1.4	0.7	-0.9	-2.3
Prospective memory result	0.2	0.2	0.5	0.6	-0.2	-0.0	0.7
Lung cancer (father)	1.7	2.0	4.7	-1.0	-2.2	-1.2	-0.9
Illnesses of mother	1.4	1.8	4.5	-1.0	1.0	-2.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	16.4	-4.0	-0.9	-2.7	-1.6
Pulse wave Arterial Stiffness index	1.2	1.4	3.1	1.8	0.4	1.5	-0.0
Impedance of arm (left)	1.2	5.4	12.4	3.5	0.9	2.0	-2.0
Arm fat mass (right)	0.1	0.5	1.4	0.1	-0.5	-1.2	0.4
Trunk predicted mass	2.5	14.3	42.2	-6.5	-1.5	-3.4	0.8
Standing height	2.1	20.4	60.8	-7.8	-0.8	-4.5	-0.3
Length of working week for main job	0.8	0.9	2.7	0.2	-0.1	-1.0	-1.6
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.9	-0.5	-0.5	-0.0
Breastfed as a baby	3.6	4.4	8.7	-2.6	0.4	-3.0	-1.4
Tense / ‘highly strung’	1.1	1.8	6.2	0.7	-0.6	0.5	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.0	-0.6	-1.4	-0.4	-0.7
Hair/balding pattern: Pattern 4	0.7	1.7	5.3	2.3	-0.5	0.2	1.1
Birth weight of first child	1.7	3.0	7.6	-2.8	0.9	-1.8	0.7
Peak expiratory flow (PEF)	1.3	2.9	6.7	-2.2	0.5	0.0	-2.6
Pulse wave reflection index	0.3	0.4	0.9	0.8	-0.3	0.9	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	-0.3	0.1	0.2	-0.7
Loud music exposure frequency	1.4	1.5	4.9	-0.2	-0.8	-2.2	-0.6
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	4.7	-0.4	1.5	2.1	-2.2
Mouth/teeth dental problems: Bleeding gums	1.7	2.3	3.6	1.5	1.4	1.9	1.0
Blood clot in the leg (DVT)	0.4	0.5	2.1	0.2	0.1	-0.1	1.4
Medication: Paracetamol	0.8	1.2	2.7	-0.1	-1.2	0.9	1.6
Headache pain in last month	0.4	0.7	1.3	-0.4	0.8	-1.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	-0.9	-0.3	0.5	-0.4
Glaucoma (self-reported)	0.6	0.7	1.5	0.0	0.8	0.9	1.2
Gout (self-reported)	0.1	0.1	0.2	0.2	-0.5	0.4	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.8	0.9	0.3	0.4	-0.0
Medication: Amlodipine	0.3	0.4	0.6	0.7	-0.7	0.8	-0.3
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.4	0.6	-0.8	1.9	0.0
Birth weight	1.4	3.0	7.2	-2.7	-0.2	-2.2	-0.4
Chronic bronchitis/emphysema (mother)	1.4	1.7	2.5	1.6	-1.3	1.4	0.8
High blood pressure (siblings)	2.0	2.9	6.7	2.2	0.2	2.6	0.0
Forced vital capacity (FVC), Best measure	3.3	11.9	26.2	-5.1	-1.2	-4.3	-1.1
Body fat percentage	0.4	1.6	3.8	1.5	-0.6	-1.9	0.2
Leg fat percentage (right)	0.6	2.2	4.9	1.8	-0.4	-2.2	0.6
Arm fat-free mass (right)	3.4	17.4	44.8	-6.7	-1.7	-4.5	1.3
Exposure to tobacco smoke outside home	1.8	2.5	4.5	1.6	-0.8	1.4	2.1
Comparative body size at age 10	0.1	0.3	0.7	0.6	0.4	-0.2	0.8
Number of full brothers	0.1	0.1	0.3	-0.1	0.3	-0.5	0.1
Worry too long after embarrassment	2.4	4.0	6.8	2.6	-1.0	2.2	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.5	1.0	-0.5	-0.8	-0.0	-1.0
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.1	-0.7	-0.8	-0.0
Number of children fathered	1.8	2.0	5.4	0.1	-2.3	-1.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.9	-0.7	0.3	-1.4	-0.3
Age at first live birth	0.9	1.6	5.9	-0.4	2.4	0.6	0.3
Pulse wave peak to peak time	1.7	2.0	4.6	-2.2	-0.3	-1.8	-0.0
Health satisfaction	0.4	0.5	0.8	-0.1	-0.9	0.8	0.8
Shortness of breath walking on level ground	0.2	0.3	0.5	0.7	-0.2	0.7	-0.3
Qualifications: College or University degree	2.4	7.5	18.3	-2.6	1.2	-1.9	-4.3
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.9	0.7	-0.2	0.5
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.6	1.4	-0.3	0.6	2.4
Emphysema/chronic bronchitis	2.1	2.4	7.1	2.7	-0.5	1.1	0.8
Medication for pain relief, constipation, heartburn	1.3	2.2	5.1	-0.2	1.7	0.8	-2.3
Neck or shoulder pain in last month	0.4	0.6	0.9	-0.5	-0.9	-0.9	0.8
Medication: Blood pressure	0.2	0.4	1.6	1.3	-0.0	-0.0	-0.1
Angina (self-reported)	0.9	1.1	1.9	1.0	1.4	1.2	0.1
Migraine (self-reported)	1.2	1.5	5.1	-1.0	0.2	0.2	-2.2
Medication: Ibuprofen	0.8	1.0	2.5	-0.4	-0.5	-1.0	1.6
Medication: Allopurinol	0.4	0.5	1.5	-0.2	-1.2	-0.7	0.2
Medication: Omeprazole	1.8	2.1	4.9	-0.2	-2.2	0.0	1.9
Medication: Seretide 50 evohaler	0.2	0.3	0.5	-0.6	-0.7	-0.2	0.4
Mean time to correctly identify matches	0.5	1.0	2.8	0.8	-1.7	-0.6	0.3
Heart disease (mother)	1.6	2.0	4.8	2.2	0.3	1.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	9.5	0.7	-1.0	0.1	3.1
Whole body fat mass	0.5	2.0	7.0	-0.6	-0.8	-2.6	0.4
Leg fat mass (right)	0.5	2.1	7.5	-0.3	-0.7	-2.7	0.7
Arm predicted mass (right)	3.0	15.4	40.1	-6.3	-1.7	-4.1	1.4
Pulse rate, automated reading	1.1	3.6	6.7	-0.5	-2.5	-1.3	2.6
Alcohol intake frequency.	0.4	0.9	1.6	-0.1	1.3	1.3	-0.4
Comparative height size at age 10	1.0	5.2	16.2	-4.0	-0.4	-2.1	-0.6
Number of full sisters	0.8	1.0	2.1	-0.6	-1.2	-1.5	0.4
Suffer from ‘nerves’	4.5	7.0	15.9	2.7	-0.6	2.2	4.0
Overall health rating	0.5	1.1	1.6	0.8	-0.8	-1.1	1.3
Chest pain or discomfort	0.6	0.8	1.7	0.1	-1.1	0.5	-1.3
Had major operations	0.5	0.6	1.9	0.5	0.3	0.1	-1.4
Age at last live birth	0.1	0.1	0.3	-0.5	0.2	-0.2	0.3
Family relationship satisfaction	1.1	1.4	3.5	-0.5	1.9	-0.2	-1.3
Leg pain on walking	0.4	0.6	1.6	-0.6	-1.3	-0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.1	-0.7	-0.3	1.1	-0.1
Commuting to job workplace: Car/motor vehicle	1.3	1.5	5.6	0.2	0.3	-0.3	2.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.2	-0.8	1.1	-0.5	0.6
Medication: Aspirin	0.2	0.3	0.5	0.7	-0.4	-0.6	-0.5
Supplements: Vitamin C	0.4	0.5	0.9	0.9	0.4	1.0	-0.0
Knee pain experienced in last month	1.2	1.9	2.7	1.6	-1.1	1.1	1.5
Hypertension (Self-reported)	2.2	6.1	14.0	3.7	-1.7	2.7	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.2	-1.1	-1.2	-1.8	0.6
Illnesses of father: Heart disease	1.9	2.6	4.3	2.0	1.4	2.1	0.4
Illnesses of siblings: Diabetes	0.7	0.9	2.5	1.6	0.5	0.8	-0.4
Smoking status: Previous	0.7	1.0	2.8	-0.2	-0.3	-1.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.1	16.2	-4.0	-0.6	-2.6	1.0
Whole body fat-free mass	2.3	13.2	39.3	-6.3	-1.4	-3.3	0.7
Leg fat-free mass (right)	1.8	9.4	30.8	-5.5	-1.3	-2.3	0.2
Arm fat percentage (left)	0.3	1.3	4.8	2.2	-0.6	-0.1	-0.2
Average weekly red wine intake	0.5	0.7	1.9	-0.6	0.0	-0.8	-1.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	-0.8	-0.3	-0.6	-0.2
Mood swings	0.3	0.5	0.8	-0.8	-0.5	-0.7	0.9
Loneliness, isolation	1.8	2.5	4.2	1.7	0.0	2.1	-1.8
Long-standing illness, disability or infirmity	0.4	0.6	1.6	-0.4	-1.3	-0.7	-0.6
Ever had bowel cancer screening	0.3	0.4	0.6	-0.8	0.6	0.5	-0.7
Diabetes diagnosed by doctor	0.9	1.5	2.7	-0.9	-0.7	-1.6	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.7	-0.1	0.4	0.1
Friendships satisfaction	0.8	1.1	3.7	-0.3	1.9	0.5	-0.3
Qualifications: nursing, teaching	1.2	1.9	3.3	-1.8	0.8	-0.5	-1.8
Commuting to job workplace: Walk	0.5	0.6	1.2	0.2	0.5	0.9	-1.1
Eye problems/disorders: Cataract	0.7	0.8	1.8	0.5	-1.1	-0.1	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.1	0.5	-0.6	0.4
Medication for cholesterol	1.5	2.3	5.8	-0.9	0.6	-2.4	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.7	0.6	-1.0	0.5	1.3
Back pain experienced in last month	0.7	1.0	2.7	-0.6	0.8	0.5	1.6
Mineral and other dietary supplements	0.7	0.9	3.6	-0.2	-0.0	-1.9	0.2
Breast cancer (self-reported)	0.4	0.4	1.1	-0.3	0.7	-1.1	-0.2
Asthma (self-reported)	0.8	1.5	2.3	-1.2	-1.3	-0.9	-1.5
Osteoporosis (self-reported)	0.8	1.0	1.5	1.2	-0.0	1.1	1.1
Osteoarthritis (self-reported)	0.4	0.6	1.4	0.0	-1.2	0.2	1.0
Medication: Aspirin	0.2	0.3	0.6	0.8	-0.6	-0.4	-0.5
Medication: Gliclazide	0.2	0.3	0.7	-0.1	-0.2	-0.6	-0.8
Illnesses of father: None of the above (group 1)	2.9	3.6	7.2	-2.1	-1.5	-2.7	0.8
Smoking status: Current	1.0	1.6	3.4	-0.6	0.1	-1.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	0.9	-0.6	-0.8	-0.9	-0.5
Whole body water mass	2.2	12.8	38.6	-6.2	-1.4	-3.2	0.6
Leg predicted mass (right)	1.8	9.5	30.7	-5.5	-1.4	-2.3	0.2
Arm fat mass (left)	0.2	0.7	2.0	-0.1	-0.8	-1.4	0.2
Number of self-reported non-cancer illnesses	0.4	0.6	1.5	0.1	-1.2	-0.2	-1.0
Average weekly champagne plus white wine intake	0.3	0.4	1.3	-0.1	1.2	-0.2	0.0
Miserableness	0.1	0.2	0.7	0.8	-0.1	0.0	-0.3
Guilty feelings	0.5	0.8	1.8	0.9	-0.2	0.7	1.4
Wears glasses or contact lenses	1.8	2.1	3.2	0.8	-1.6	1.8	-1.3
Ever taken oral contraceptive pill	0.6	0.7	1.8	-1.4	0.1	-1.0	-0.3
Hearing aid user	0.7	0.8	2.0	0.4	-0.2	1.0	-1.4
Mother’s age at death	0.3	0.3	1.0	-0.3	1.0	0.5	0.1
Financial situation satisfaction	0.6	0.7	2.2	0.7	0.4	0.1	1.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.8	-0.5	0.0	1.0	-1.3
Commuting to job workplace: Public transport	1.2	1.4	2.4	-1.3	-1.2	-0.6	-1.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.6	0.5	0.9	0.1	1.3
Medication: Blood pressure	0.5	0.9	2.1	0.5	-0.8	0.7	-1.4
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.3	-0.8	1.8	1.2	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.6	-0.5	1.0	1.3	0.2
High cholesterol (Self-reported)	0.4	0.8	1.4	0.9	0.4	0.8	-1.2
Medication: Bendroflumethiazide	0.5	0.7	2.3	1.5	-0.6	0.4	-0.5
Medication: Paracetamol	0.8	1.3	2.6	0.3	-1.2	1.0	1.6
Medication: Lisinopril	1.9	2.4	5.9	2.4	0.7	1.8	0.0
Medication: Atorvastatin	0.3	0.4	0.9	0.5	0.4	0.9	0.6
Illnesses of father: High blood pressure	0.8	0.9	1.8	1.4	0.3	1.3	-0.3
Alcohol drinker status: Never	1.8	2.1	3.1	1.7	0.8	1.4	-1.7
Ever smoked	0.5	0.8	1.5	-1.1	-0.0	-1.2	-0.7
Basal metabolic rate	2.1	11.4	31.9	-5.7	-1.5	-3.3	0.6
Leg fat percentage (left)	0.6	2.0	5.5	1.5	-0.2	-2.3	0.5
Arm fat-free mass (left)	2.5	12.8	32.3	-5.7	-1.6	-3.9	0.9
Number of operations (self-reported)	0.4	0.6	1.7	-0.7	-0.3	0.2	-1.3
Average weekly beer plus cider intake	0.4	0.6	0.9	-1.0	-0.9	-0.7	0.2
Irritability	0.5	0.9	2.9	-1.7	-0.1	-0.5	0.5
Risk taking	4.9	7.2	14.2	-3.4	-1.6	-3.8	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.9	-0.5	-0.7	-1.0	-0.2
Fractured/broken bones in last 5 years	2.9	3.8	8.0	-2.8	0.9	-2.2	1.2
Age started oral contraceptive pill	1.2	1.5	2.7	1.4	-0.0	1.6	1.1
Diastolic blood pressure, automated reading	1.0	3.2	5.6	2.4	-0.4	2.2	1.6
Ever depressed for a whole week	1.0	1.3	4.2	2.0	-0.4	0.6	0.6
Unable to work because of sickness or disability	1.1	1.5	3.8	-0.6	-0.1	-2.0	1.3
Commuting to job workplace: Cycle	1.0	1.2	2.4	-0.9	-1.6	0.6	-1.1
Myopia	0.5	0.7	1.1	-0.4	-1.0	-0.6	-1.1
Vascular/heart problems diagnosed by doctor	2.4	6.4	13.7	-3.7	0.9	-3.3	0.3
Cholesterol lowering medication	1.1	1.6	3.0	1.1	0.2	1.7	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	5.0	-0.8	-2.2	-1.0	1.7
Pain experienced in last month	0.5	0.8	3.2	-0.4	-0.0	0.0	-1.8
Supplements: Calcium	0.9	1.0	2.3	-0.3	0.8	1.0	-1.5
Basal cell carcinoma (self-reported)	0.9	1.1	2.7	0.6	-1.6	0.2	-1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.9	0.6	1.7	-0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.0	0.3	0.4	0.0	1.4
Heart disease (siblings)	0.9	1.1	2.7	-0.2	1.6	-0.3	1.3
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.6	0.4	-0.6	0.9
Pack years of smoking	1.8	2.7	5.3	-1.8	-1.2	-2.3	-0.8
Impedance of whole body	0.6	3.2	9.5	3.1	1.1	0.2	-1.5
Leg fat mass (left)	0.6	2.3	8.2	-0.6	-0.6	-2.9	0.4
Arm predicted mass (left)	2.7	13.6	33.5	-5.8	-1.7	-4.1	1.0