Hub : Genes

PNO1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1130	0.0320	1.6e-05	0.041	0.037	0.015	0.035	0.028	8.5e-06	2.5e-05	4.9e-03	3.3e-05	2.2e-04
2	GTEx	Cells EBV-transformed lymphocytes	0.3110	0.0990	1.6e-03	0.008	NA	0.000	NA	0.021	1.7e-01	NA	3.1e-01	NA	6.9e-02
3	METSIM	Adipose	0.0997	0.0232	1.6e-12	0.121	0.108	0.120	0.115	0.120	1.2e-17	8.6e-16	1.4e-17	7.2e-17	1.9e-17
4	YFS	Blood	0.1224	0.0199	0.0e+00	0.131	0.123	0.128	0.134	0.131	1.0e-40	6.3e-38	8.6e-40	2.0e-41	1.1e-40
5	TCGA	Esophageal Carcinoma	0.0800	0.0510	7.5e-03	0.071	0.060	0.077	NA	0.064	2.9e-03	5.8e-03	2.0e-03	NA	4.3e-03
6	TCGA	Thyroid Carcinoma	0.0380	0.0210	5.9e-04	0.028	0.039	0.034	NA	0.036	9.4e-04	1.1e-04	2.6e-04	NA	1.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.9	1.4	4.7	0.4	-2.2	-0.3	1.4	1.1	-0.2
Bipolar Disorder or Schizophrenia	0.7	1.7	3.3	-0.1	-1.4	1.5	1.8	-0.2	1.5
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	0.6	-0.8	0.5	0.7	0.2	0.7
Depression (Nagel 2018)	0.8	1.1	3.1	1.2	-0.9	-0.0	1.7	1.2	0.1
Intelligence (Savage-Jansen 2018)	1.3	3.9	9.6	0.3	1.2	2.8	3.1	0.3	2.1
Neuroticism (Nagel 2018)	0.3	0.7	1.5	0.4	0.5	1.2	0.2	-1.0	1.2
Schizophrenia (2018)	1.0	2.1	4.9	-0.4	-0.1	2.2	1.2	-1.2	2.1
Schizophrenia vs Biploar Disorder	2.7	3.6	13.1	-0.9	3.6	1.6	-0.0	-1.5	1.7
Worry (Nagel 2018)	0.8	1.8	5.5	-0.0	2.3	0.9	-1.4	-1.4	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	-0.5	0.9	0.1	-0.5	-0.1	0.1
Alzheimer’s Disease (in father)	0.8	0.9	3.2	1.8	-1.2	-0.4	-0.1	0.4	-0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.0	0.5	-1.0	-0.9	-1.0	0.5	-0.9
Crohns Disease (2017)	0.6	1.3	3.0	0.2	-0.1	1.7	1.2	-0.7	1.7
Irritable Bowel Disease (IBD)	0.6	1.4	2.7	-0.3	-0.8	1.6	1.1	-1.0	1.6
Ulcerative Colitis (UC)	0.7	1.4	1.8	-1.3	-1.1	1.3	0.5	-1.2	1.3
Major Depression (MDD)	0.5	0.6	2.7	1.6	0.5	0.0	0.3	0.7	-0.4
Reaction Time	0.2	0.4	1.0	0.7	0.0	-0.9	0.2	0.2	-1.0
Verbal and Numeric Reasoning (VNR)	1.5	3.6	11.6	0.6	0.4	2.5	3.4	0.8	1.6
Breast Cancer	0.6	1.3	4.3	-1.2	0.0	0.1	-2.1	-1.5	0.3
Ovarian Cancer	0.3	0.4	1.2	-1.1	-1.0	-0.5	0.0	0.1	-0.2
Prostate Cancer	0.9	1.2	5.3	-0.3	2.3	0.1	-1.0	-1.1	0.1
Age at First Birth	0.1	0.1	0.3	0.6	0.3	-0.1	-0.1	-0.3	-0.2
Bipolar Disorder (2011)	3.8	3.7	8.6	1.1	-2.9	-1.2	1.8	2.4	-1.4
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.3	-0.6	0.4	0.6	-0.4	0.6
Coronary Artery Disease (CAD)	1.4	1.7	5.1	-0.1	0.6	2.2	0.7	-0.5	2.0
Crohns Disease (2012)	0.5	0.8	1.8	-0.6	-0.2	1.3	0.8	-0.5	1.3
Mean Putamen Volume	2.6	3.0	6.0	-0.4	-1.9	-2.5	-1.5	1.5	-2.0
Fasting Glucose	0.4	0.5	1.7	0.1	1.3	0.3	0.1	-1.0	0.4
HbA1C	1.3	1.4	2.9	-1.3	1.0	1.0	0.0	-1.7	1.4
HDL Cholesterol	0.6	1.0	2.7	-1.4	-0.5	-0.4	-1.6	-1.0	-0.1
LDL Cholesterol	1.3	2.1	4.4	1.0	0.5	-2.1	-1.7	0.9	-1.8
Lupus	0.8	1.2	3.1	-1.8	-0.4	0.9	-0.2	-1.4	1.1
Neuroticism (2016)	0.5	0.8	2.9	-1.7	-0.0	0.2	-0.7	-0.9	0.6
Primary Biliary Cirrhosis	1.8	2.5	5.2	-1.2	1.5	1.5	0.2	-2.3	1.9
Rheumatoid Arthritis	0.1	0.2	1.2	0.0	0.0	-0.0	-1.1	0.0	0.1
Schizophrenia (2014)	1.4	3.0	6.6	-0.4	0.9	2.6	2.1	-0.8	2.3
Triglycerides	0.2	0.4	1.2	0.2	-0.6	-1.1	0.3	0.4	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	0.4	0.3	1.1	0.5	-0.8	1.0
Ulcerative Colitis	1.0	1.5	2.4	-1.4	-0.6	1.5	0.8	-1.2	1.5
Blood Eosinophil Count	0.0	0.3	0.8	0.1	0.9	-0.6	0.5	0.2	-0.6
Blood Platelet Count	0.6	6.8	9.9	2.4	-2.5	-3.0	0.9	3.1	-3.1
Blood Red Count	0.1	1.1	3.1	1.8	-0.0	-1.0	0.5	1.1	-1.1
Blood White Count	0.2	1.5	3.1	-0.2	-0.4	-1.7	0.5	1.6	-1.8
Heel T-Score	0.6	4.7	14.1	3.8	-0.6	-0.6	3.2	1.4	-0.9
BMI	0.3	1.8	5.2	-0.7	0.5	-2.3	-1.2	0.5	-1.7
Height	1.3	25.0	56.2	-0.2	0.2	-7.0	-3.1	5.9	-7.5
Waist Hip Ratio (WHR)	4.4	19.6	36.4	3.8	-3.1	-4.7	2.9	6.0	-5.2
Systolic Blood Pressure	3.2	15.9	30.5	-3.5	2.4	4.4	-2.3	-5.5	4.8
Smoking Status	2.0	4.8	7.9	2.7	-1.9	-1.6	2.8	2.1	-1.8
Allergy or Eczema	0.7	1.8	3.3	-0.4	1.8	1.4	-1.0	-1.6	1.3
Cardiovascular Disease	1.6	5.3	11.7	-0.3	0.1	2.9	-0.4	-3.4	3.3
Hypothyroidism (self reported)	0.2	0.4	0.8	0.6	-0.9	-0.9	-0.6	0.3	-0.4
Respiratory disease	0.2	0.5	1.0	-0.8	-0.2	0.7	1.0	-0.3	0.8
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.9	1.1	-1.9	-0.5	2.0	1.8	-0.7
Lung FEV1/FVC ratio	1.1	5.4	11.5	-1.7	-0.8	2.9	-0.1	-3.0	3.4
Lung FVC	1.6	8.2	22.7	2.3	-4.8	0.1	3.7	2.9	-0.2
Neuroticism	0.2	0.5	1.1	0.7	0.5	1.1	0.5	-0.5	0.9
Chronotype (morning person)	0.2	0.4	1.8	-1.4	-0.4	-0.2	-0.3	-0.4	-0.1
Hair Pigment	0.0	0.6	1.1	-0.9	0.6	1.0	0.7	-0.2	1.0
Tanning	0.1	1.3	2.2	-0.2	-1.2	1.0	1.5	-1.0	1.4
Hand grip strength (left)	1.0	2.7	6.5	-0.1	0.5	-2.0	-0.6	2.5	-2.2
Number of treatments/medications taken	0.2	0.3	1.1	1.1	-0.7	-0.4	-0.3	0.1	-0.2
Average weekly spirits intake	0.9	1.1	3.4	0.5	-1.9	-1.2	-0.3	0.4	-1.0
Sensitivity / hurt feelings	0.3	0.5	1.0	0.3	1.0	0.9	0.4	-0.4	0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.4	-0.8	0.3	0.7	0.2	0.4
Hearing difficulty/problems: Yes	1.3	2.0	4.2	0.8	-0.8	1.9	2.0	-0.8	1.4
Relative age of first facial hair	2.1	4.3	9.7	-2.2	1.0	1.2	-2.7	-3.1	1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	4.0	0.1	-2.0	-0.0	0.4	0.6	-0.3
Ever used hormone-replacement therapy (HRT)	0.7	1.0	3.2	1.8	-0.2	-0.4	0.5	1.4	-0.5
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	1.0	0.2	-0.5	0.6	0.7	-0.2
Systolic blood pressure, automated reading	1.9	5.6	10.2	-3.2	1.6	2.0	-2.0	-2.9	2.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.9	1.2	-1.4	-1.0	0.3	0.3	-1.1
Angina	0.5	0.7	1.5	-0.4	0.2	1.1	-0.2	-1.2	1.1
Medication for hormone replacement therapy	0.8	0.8	3.6	-0.1	0.3	-0.2	-1.9	-1.1	0.2
Vitamin and mineral supplements	0.9	1.2	2.9	1.3	0.9	0.5	1.7	1.1	-0.0
Supplements: Zinc	0.1	0.1	0.5	0.2	-0.7	-0.2	0.3	0.3	-0.3
Medication: Co-codamol	1.9	2.2	7.6	2.8	-0.3	-0.9	0.7	1.7	-1.1
Medication: Metformin	1.4	2.0	3.4	1.4	-1.7	-0.8	1.3	1.8	-1.2
Diabetes (father)	0.6	0.8	2.5	0.8	-1.6	-0.6	0.7	0.6	-0.7
Diabetes (mother)	1.3	1.6	3.5	0.8	1.1	-1.9	-1.5	0.2	-1.5
Severe depression (siblings)	0.5	0.6	2.0	0.3	-1.4	0.5	0.9	0.3	0.5
Pack years adult smoking proportion	3.0	4.6	8.4	2.0	-2.9	-1.6	1.7	2.6	-1.6
Impedance of leg (right)	0.9	4.2	11.6	2.3	-2.1	0.2	3.4	1.9	-0.2
Leg fat-free mass (left)	1.0	5.1	12.6	-0.3	0.2	-3.5	-2.4	1.6	-3.1
Trunk fat percentage	0.6	2.2	4.2	1.4	-1.1	-1.2	2.0	1.8	-1.2
Hand grip strength (right)	1.9	5.1	10.7	0.9	1.2	-3.1	-1.6	2.4	-3.3
Townsend deprivation index at recruitment	0.6	0.8	2.2	-0.5	0.5	1.2	1.5	-0.3	0.9
Current tobacco smoking	1.7	2.9	11.6	1.7	-1.3	0.5	3.4	0.9	-0.1
Average weekly fortified wine intake	1.8	2.1	5.5	-0.2	0.3	2.3	1.2	-1.2	2.0
Maternal smoking around birth	0.6	0.9	3.9	0.5	-0.3	0.7	2.0	0.0	0.6
Fed-up feelings	0.4	0.7	1.6	0.4	0.1	1.2	0.7	-0.6	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.1	0.5	-1.8	-0.1	0.8	1.2	0.1
Relative age voice broke	0.8	1.2	1.7	-1.1	1.3	1.1	-1.1	-1.2	0.9
Taking other prescription medications	0.6	1.0	1.8	0.9	-1.4	-0.9	-0.0	1.3	-0.8
Age when periods started (menarche)	1.2	2.8	6.0	0.9	-1.3	-2.2	-1.1	1.5	-2.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	4.2	0.9	-2.0	0.1	0.8	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	8.8	3.0	0.4	-2.0	1.1	1.9	-2.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.6	1.2	-0.6	-1.3	0.3	0.9	-0.9
Qualifications: CSEs or equivalent	0.2	0.2	1.0	0.1	0.2	-0.1	-0.6	-1.0	0.1
Serious illness, injury or assault to yourself	1.2	1.4	4.3	0.7	-2.1	0.2	1.4	1.4	0.1
High blood pressure	2.0	5.6	12.2	-0.1	1.5	3.5	0.9	-2.6	3.5
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.8	-0.3	1.3	1.7	-0.0	-1.3	1.6
Multivitamins +/- minerals	0.5	0.6	1.8	-0.8	-1.3	-0.4	-0.8	-0.8	0.0
Stomach or abdominal pain in last month	1.3	1.6	3.7	0.2	-1.4	-1.9	-0.0	1.1	-1.7
Supplements: Glucosamine	1.3	1.7	2.7	-1.6	0.3	1.0	-1.6	-1.0	1.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.3	0.3	-0.7	-0.6	-0.1	-0.4
Medication: Atenolol	0.3	0.4	1.4	0.3	0.5	0.7	1.2	0.5	0.0
Medication: Levothyroxine sodium	0.3	0.5	1.4	1.2	-1.0	0.4	0.4	-0.3	0.5
Sitting height	1.4	9.9	20.0	1.7	-0.1	-4.5	-0.9	4.0	-4.5
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-1.0	0.6	-0.2	-1.1	-1.0	0.2
High blood pressure (mother)	4.3	6.0	14.5	-1.9	0.6	2.4	-2.0	-3.8	2.9
Body mass index (BMI)	0.3	1.1	3.6	0.0	-0.2	-1.9	-0.0	0.9	-1.5
Impedance of leg (left)	1.0	4.7	14.0	2.5	-1.3	0.3	3.7	2.4	-0.4
Leg predicted mass (left)	1.0	5.1	12.6	-0.3	0.1	-3.5	-2.4	1.6	-3.1
Trunk fat mass	0.9	3.7	6.4	1.2	-1.0	-2.5	1.1	2.5	-2.4
Waist circumference	1.4	5.0	9.2	1.3	-1.1	-2.9	1.3	3.0	-2.8
Number of incorrect matches in round	1.3	2.1	4.5	1.4	0.2	-2.1	-0.3	1.3	-2.1
Past tobacco smoking	1.0	1.9	3.0	-1.7	0.5	1.6	-1.1	-1.5	1.4
Alcohol usually taken with meals	1.1	1.7	4.7	1.6	-0.2	1.4	2.2	0.6	1.0
Nervous feelings	0.6	1.1	5.3	1.1	2.3	0.2	-0.2	0.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	0.7	-1.0	-0.2	0.5	1.2	-0.5
Hearing difficulty/problems with background noise	0.8	1.3	3.7	0.4	-1.9	1.0	1.2	-0.5	1.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	-0.5	0.2	-0.5	-0.9	-0.0	-0.0
Had menopause	0.5	0.6	2.3	-0.3	1.5	0.5	-0.2	-0.8	0.6
Had other major operations	1.0	1.2	3.0	-1.7	0.1	1.1	-0.1	-1.3	1.1
Forced vital capacity (FVC)	1.7	6.7	15.5	2.0	-2.7	-2.2	1.5	3.9	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	9.1	3.0	0.4	-2.3	0.9	1.7	-2.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.9	0.7	-0.0	0.8	1.4	0.3	0.3
Qualifications: None of the above	0.7	1.4	4.3	0.7	0.4	-2.1	-0.9	0.3	-1.7
Financial difficulties in last 2 years	0.6	0.8	1.9	1.1	0.1	1.1	1.4	0.2	0.8
Mouth/teeth dental problems	0.3	0.4	0.9	-0.9	0.2	0.6	0.9	0.3	0.5
Heart attack	0.3	0.4	1.0	1.0	0.9	0.4	0.6	0.3	0.2
Allergy	0.4	1.0	2.3	0.2	-0.5	-1.5	-0.4	1.0	-1.5
Pain all over the body in last month	0.4	0.5	1.0	-0.2	-1.0	-0.1	-0.7	-1.0	0.5
Diabetes (self-reported)	2.5	3.9	7.9	1.9	-2.8	-0.6	2.7	1.8	-0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	-0.2	-0.7	0.5	1.0	0.3	0.0
Medication: Ramipril	0.8	1.0	3.2	1.8	-0.2	0.4	1.6	0.3	-0.0
Medication: Simvastatin	0.8	1.1	2.2	1.2	-1.5	0.3	1.4	1.0	0.3
Fluid intelligence score	1.9	3.9	8.9	-0.1	-0.2	3.0	2.9	-0.0	2.5
Illnesses of siblings	0.8	1.2	2.9	0.7	-0.7	-1.2	0.1	1.7	-1.3
Neuroticism score	0.6	1.2	2.6	-0.6	0.6	1.6	-0.5	-1.3	1.4
Weight	1.2	5.7	14.2	0.3	-0.3	-3.8	-0.8	2.7	-3.4
Impedance of arm (right)	2.3	10.5	25.3	0.3	-0.1	5.0	3.4	-2.4	4.5
Arm fat percentage (right)	0.1	0.5	2.4	0.3	-0.5	0.3	1.6	-0.2	0.5
Trunk fat-free mass	2.0	11.4	25.9	-0.4	0.1	-5.1	-3.3	3.1	-4.6
Hip circumference	0.1	0.5	1.2	-0.4	0.7	-1.1	-0.3	0.5	-0.8
Time employed in main current job	0.8	0.9	2.5	-0.5	-0.3	0.1	-1.5	-1.6	0.4
Alcohol intake versus 10 years previously	1.2	1.7	3.0	-1.4	-1.7	-1.5	-1.1	-0.3	-1.3
Father’s age at death	0.6	0.9	2.2	-0.2	-0.7	-1.5	-1.0	0.5	-1.1
Worrier / anxious feelings	0.8	1.5	2.4	-1.0	1.1	1.6	-1.0	-1.5	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	3.5	0.3	-1.9	0.4	0.5	-0.2	0.4
Falls in the last year	0.4	0.5	2.6	0.4	-1.6	-0.1	-0.0	0.4	-0.5
Hair/balding pattern: Pattern 3	1.7	2.5	8.6	0.9	-0.8	0.7	2.9	2.1	0.1
Number of live births	0.9	1.2	3.2	0.8	-1.8	-1.3	-0.8	0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	7.0	1.4	-2.6	-0.9	1.4	2.6	-1.0
Pulse rate	0.6	1.0	1.7	1.0	-1.3	-1.1	-1.1	0.1	-1.0
Happiness	1.3	1.6	5.4	-1.8	-2.3	-0.4	-0.7	-0.6	0.1
Noisy workplace	0.3	0.4	1.0	-0.1	-1.0	0.3	1.0	0.4	0.1
Qualifications: A levels/AS levels or equivalent	2.0	4.4	8.9	-1.4	1.2	3.0	2.3	-1.3	2.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.2	-0.4	-0.0	1.1	0.9	-0.2	0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	2.1	0.6	0.3	-1.1	-1.5	-0.9	-0.7
Asthma	0.2	0.4	1.5	0.5	-0.3	0.2	1.2	0.7	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.9	0.7	-1.4	-1.3	-0.8	1.0	-0.9
Medication: Cholesterol lowering	0.4	0.6	1.2	0.4	-1.1	-1.1	-0.2	0.8	-0.8
Depression (self-reported)	0.8	0.9	2.4	0.1	-1.5	-1.3	-0.4	0.5	-1.1
Medication: Lansoprazole	0.6	0.6	2.2	0.7	0.2	0.6	1.5	0.7	0.4
Prospective memory result	0.4	0.5	1.1	-0.3	0.0	-1.1	-0.6	0.5	-1.0
Lung cancer (father)	0.4	0.5	0.9	0.4	-0.4	-0.5	0.9	0.9	-0.8
Illnesses of mother	2.4	2.9	5.4	0.7	-2.3	-1.9	0.7	2.0	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	6.7	0.6	-0.8	-0.9	0.8	2.6	-1.1
Pulse wave Arterial Stiffness index	1.2	1.3	2.8	-1.4	0.1	1.4	0.4	-1.1	1.7
Impedance of arm (left)	1.6	7.5	18.3	0.8	0.2	4.3	2.9	-1.9	3.7
Arm fat mass (right)	0.3	1.1	3.5	0.1	-0.5	-1.9	0.1	1.0	-1.5
Trunk predicted mass	1.9	10.9	24.7	-0.5	0.1	-5.0	-3.3	3.0	-4.5
Standing height	1.0	9.5	19.3	0.4	0.1	-4.3	-2.2	3.8	-4.4
Length of working week for main job	1.3	1.4	3.8	1.6	-1.2	0.3	1.9	0.7	0.1
Exposure to tobacco smoke at home	0.7	0.8	3.8	-0.1	-1.9	-0.8	-0.2	-0.2	-0.5
Breastfed as a baby	2.1	2.6	4.9	2.1	-0.5	-0.4	2.1	2.2	-1.2
Tense / ‘highly strung’	0.4	0.6	2.3	0.1	1.1	-0.2	-1.5	-0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	1.3	0.7	0.7	1.2	-0.5	0.5
Hair/balding pattern: Pattern 4	0.7	1.7	6.8	1.3	0.1	1.1	2.6	0.2	0.6
Birth weight of first child	1.2	2.2	4.5	-0.1	0.3	-2.0	-0.9	1.9	-2.1
Peak expiratory flow (PEF)	0.4	1.0	2.5	-1.1	-1.6	0.8	-0.2	-0.3	1.2
Pulse wave reflection index	1.2	1.4	2.7	-1.6	0.2	1.3	1.1	-0.7	1.6
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.8	0.3	0.4	0.9	0.5	-0.9	0.7
Loud music exposure frequency	2.8	3.0	4.6	2.1	-2.1	-1.1	1.8	1.9	-1.0
Qualifications: O levels/GCSEs or equivalent	3.0	4.7	8.9	-2.2	0.6	3.0	0.4	-2.3	3.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.3	-0.5	0.1	-0.1	-1.8	-1.8	0.2
Blood clot in the leg (DVT)	0.2	0.3	0.7	0.2	-0.3	-0.8	-0.6	0.5	-0.7
Medication: Paracetamol	0.3	0.5	1.8	-0.7	0.7	-0.2	-1.3	-0.2	0.5
Headache pain in last month	0.8	1.3	2.2	0.7	-1.4	-0.9	1.1	1.5	-1.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.7	-1.3	1.3	-0.2	-1.1	-0.7	0.1
Glaucoma (self-reported)	0.3	0.4	1.6	-0.6	-0.3	0.2	-1.3	-0.5	0.0
Gout (self-reported)	0.2	0.3	1.3	-1.1	0.1	0.2	-0.1	-0.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.3	1.1	-0.5	-0.5	-0.6	0.1	-0.3
Medication: Amlodipine	0.4	0.6	1.5	0.7	-1.2	-0.3	-0.6	-1.1	-0.1
Medication: Ventolin 100micrograms inhaler	1.8	2.2	4.2	-1.5	0.4	1.4	-1.6	-2.1	1.5
Birth weight	1.0	2.1	4.4	0.9	0.4	-2.1	-0.7	1.6	-2.1
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.7	-1.3	0.0	1.3	0.2	-0.9	1.3
High blood pressure (siblings)	1.9	2.7	8.1	-1.2	1.1	1.2	-1.0	-2.9	1.7
Forced vital capacity (FVC), Best measure	1.7	6.2	17.8	1.4	-1.6	-2.5	0.9	4.2	-2.8
Body fat percentage	0.7	2.7	5.1	1.4	-1.2	-1.4	2.2	2.0	-1.3
Leg fat percentage (right)	1.0	3.7	6.2	1.4	-1.6	-1.8	2.5	2.4	-1.6
Arm fat-free mass (right)	3.3	16.7	39.4	0.8	0.1	-6.3	-3.0	4.1	-5.8
Exposure to tobacco smoke outside home	0.4	0.6	1.7	0.8	0.3	-0.2	-1.1	-1.3	0.1
Comparative body size at age 10	0.2	0.4	1.3	0.7	1.1	-0.7	-0.4	0.1	-0.6
Number of full brothers	0.4	0.5	1.6	-0.2	-1.3	-0.6	0.5	0.7	-0.6
Worry too long after embarrassment	0.9	1.4	2.4	-0.6	0.9	1.6	-0.7	-1.4	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	1.2	1.0	0.7	0.2	-0.8	0.4
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.9	-0.4	-0.9	0.1	0.6	-0.6
Number of children fathered	1.8	2.0	4.9	1.1	-2.2	-1.3	0.9	1.5	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.1	0.4	-1.8	0.0	1.5	1.0	-0.5
Age at first live birth	0.8	1.3	3.3	-1.7	1.8	1.0	0.2	-0.5	0.7
Pulse wave peak to peak time	1.6	1.8	3.9	1.5	-0.1	-1.7	-0.5	1.3	-2.0
Health satisfaction	1.1	1.4	4.0	-2.0	-1.7	0.0	-0.8	-0.9	0.5
Shortness of breath walking on level ground	1.3	1.5	2.5	-0.6	1.5	1.6	1.1	-0.7	1.5
Qualifications: College or University degree	0.8	2.6	9.8	0.6	-0.7	1.5	3.1	1.3	1.0
Eye problems/disorders: None of the above	0.2	0.3	1.3	-1.1	-0.2	0.2	0.1	0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.4	0.3	0.3	-1.1	-1.6	-0.7	-1.1
Emphysema/chronic bronchitis	0.4	0.5	1.0	-0.4	-0.7	0.6	0.0	-0.8	1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	2.1	-0.8	0.0	0.9	-0.1	-1.5	0.8
Neck or shoulder pain in last month	0.4	0.6	1.7	0.4	0.2	-0.8	0.4	1.3	-0.8
Medication: Blood pressure	0.8	1.4	3.6	1.3	-0.3	1.4	1.9	0.2	0.9
Angina (self-reported)	0.7	1.0	2.0	-0.3	0.7	1.4	0.1	-1.2	1.3
Migraine (self-reported)	0.7	0.8	1.6	0.8	-0.5	1.2	0.9	-0.6	1.3
Medication: Ibuprofen	1.2	1.5	2.6	1.6	-0.9	-1.4	-0.4	1.5	-1.0
Medication: Allopurinol	0.2	0.2	0.6	0.1	-0.3	-0.8	-0.3	0.5	-0.6
Medication: Omeprazole	0.5	0.6	1.5	-0.2	0.7	-0.8	-1.2	0.4	-0.8
Medication: Seretide 50 evohaler	0.6	0.7	1.9	0.5	1.4	-0.8	-0.8	-0.5	-0.8
Mean time to correctly identify matches	0.2	0.3	0.8	0.4	-0.2	-0.8	-0.3	0.2	-0.9
Heart disease (mother)	2.1	2.5	6.2	0.3	1.5	2.3	0.5	-1.0	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.0	1.0	-0.9	-0.7	0.7	-1.0
Whole body fat mass	0.9	3.7	7.2	1.0	-1.0	-2.7	0.9	2.4	-2.5
Leg fat mass (right)	1.1	4.2	8.2	1.1	-1.1	-2.9	1.2	2.6	-2.6
Arm predicted mass (right)	2.9	14.9	35.3	0.5	0.2	-5.9	-3.1	3.8	-5.4
Pulse rate, automated reading	1.3	4.1	8.3	1.2	-1.1	-2.9	-2.4	1.0	-2.6
Alcohol intake frequency.	0.4	1.0	2.8	-1.1	0.3	0.5	-1.1	-1.7	0.7
Comparative height size at age 10	0.4	2.3	4.6	-0.3	-0.5	-2.1	-1.1	2.0	-2.0
Number of full sisters	1.2	1.5	3.0	1.7	-1.3	-0.4	1.7	1.1	-0.7
Suffer from ‘nerves’	1.0	1.6	7.3	0.0	0.6	-0.1	-2.7	-1.4	0.1
Overall health rating	1.7	3.7	10.1	1.1	-3.2	-2.1	0.5	1.6	-1.8
Chest pain or discomfort	0.9	1.3	2.5	1.6	0.2	1.3	0.7	-1.1	1.3
Had major operations	2.2	2.6	5.7	1.3	-1.2	2.4	1.9	0.2	1.7
Age at last live birth	0.2	0.3	1.0	-0.1	1.0	0.5	0.6	0.3	0.0
Family relationship satisfaction	1.8	2.2	5.9	-0.7	-2.4	1.4	1.7	-0.4	1.3
Leg pain on walking	0.3	0.4	1.6	-0.6	-1.3	-0.4	-0.3	0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.8	-0.4	0.7	1.7	-0.2	-1.0	1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.2	0.2	-2.1	-1.2	-0.5	0.8	-0.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.1	-0.9	-1.4	-1.1	-1.1	0.2	-0.9
Medication: Aspirin	1.6	2.2	6.6	1.6	0.2	1.7	2.6	0.2	1.0
Supplements: Vitamin C	0.6	0.7	2.2	-0.9	0.2	0.8	-0.2	-1.5	0.9
Knee pain experienced in last month	0.3	0.5	1.3	-1.2	0.3	0.6	0.1	-0.8	0.8
Hypertension (Self-reported)	1.7	4.8	10.8	0.2	1.2	3.3	0.9	-2.4	3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	4.3	2.0	0.6	-1.6	0.2	2.1	-1.9
Illnesses of father: Heart disease	2.7	3.7	10.3	-0.0	3.2	2.0	0.2	-2.1	1.9
Illnesses of siblings: Diabetes	0.5	0.6	2.0	0.2	-0.3	1.4	0.9	-0.4	0.8
Smoking status: Previous	1.6	2.4	5.3	1.3	-1.0	-2.3	0.2	1.9	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	9.4	0.2	1.0	-2.9	-1.4	2.2	-3.1
Whole body fat-free mass	1.7	9.9	23.3	-0.4	0.1	-4.8	-3.2	2.8	-4.3
Leg fat-free mass (right)	0.9	5.1	11.4	-0.6	0.7	-3.4	-2.6	1.6	-3.0
Arm fat percentage (left)	0.1	0.5	2.4	0.8	-0.4	-0.0	1.6	0.1	0.1
Average weekly red wine intake	0.3	0.5	1.8	0.7	-1.3	-0.2	0.8	0.2	-0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.2	-0.8	-0.8	-0.3	0.9	-0.9
Mood swings	0.4	0.7	2.0	-0.2	-1.4	-0.9	-0.5	0.6	-0.7
Loneliness, isolation	2.7	3.7	8.9	-1.4	0.9	2.8	0.5	-1.5	3.0
Long-standing illness, disability or infirmity	1.0	1.5	4.3	1.5	-2.1	0.4	1.2	0.8	0.2
Ever had bowel cancer screening	0.3	0.4	0.7	-0.5	0.8	0.9	0.2	-0.4	0.7
Diabetes diagnosed by doctor	1.4	2.3	5.6	1.4	-2.4	0.0	2.2	1.2	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	0.9	-0.9	-0.9	0.9	0.4	-0.9	0.9
Friendships satisfaction	1.6	2.0	5.3	-2.3	-1.8	0.7	-0.3	-1.2	1.2
Qualifications: nursing, teaching	0.3	0.5	0.8	-0.7	-0.9	0.9	0.5	0.0	0.7
Commuting to job workplace: Walk	1.0	1.1	2.2	-1.2	1.5	0.5	-0.9	-1.0	0.9
Eye problems/disorders: Cataract	0.2	0.3	0.8	0.3	0.7	0.1	0.9	-0.5	0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.6	0.2	-0.0	0.6	0.9	1.3	0.1
Medication for cholesterol	1.4	2.1	4.3	-0.1	-0.4	-2.1	0.3	1.9	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	-0.2	-0.8	-0.4	-1.0	-0.6	-0.2
Back pain experienced in last month	1.3	2.0	5.8	-1.1	-0.9	-1.8	-2.4	0.1	-0.9
Mineral and other dietary supplements	1.8	2.4	4.5	2.0	-0.8	-0.8	2.1	1.6	-1.4
Breast cancer (self-reported)	1.5	1.8	4.0	0.3	-2.0	-1.7	-0.3	0.9	-1.7
Asthma (self-reported)	0.2	0.4	1.6	0.3	-0.2	0.4	1.3	0.6	0.1
Osteoporosis (self-reported)	0.4	0.4	0.9	-1.0	0.2	0.6	-0.1	-0.6	1.0
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.7	-0.6	-0.9	-0.9	0.4	-0.6
Medication: Aspirin	1.7	2.2	6.4	1.5	-0.0	1.8	2.5	0.2	1.2
Medication: Gliclazide	0.1	0.2	0.4	0.2	-0.7	-0.2	0.6	0.1	-0.2
Illnesses of father: None of the above (group 1)	4.2	5.2	7.8	1.3	-2.7	-2.5	0.2	2.8	-2.8
Smoking status: Current	1.8	2.8	10.7	1.9	-1.2	0.4	3.3	0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.8	0.7	-1.7	0.4	1.2	1.2	0.0
Whole body water mass	1.7	9.7	22.6	-0.5	0.3	-4.8	-3.2	2.6	-4.2
Leg predicted mass (right)	1.0	5.2	11.6	-0.5	0.8	-3.4	-2.7	1.6	-3.0
Arm fat mass (left)	0.3	1.3	3.2	0.6	-0.3	-1.8	0.4	1.2	-1.5
Number of self-reported non-cancer illnesses	0.9	1.6	2.9	1.7	-1.1	1.3	1.5	0.5	1.2
Average weekly champagne plus white wine intake	1.1	1.5	3.4	0.9	1.2	1.6	1.9	0.2	0.7
Miserableness	0.3	0.5	0.8	0.3	-0.9	0.9	0.9	-0.0	0.7
Guilty feelings	0.7	1.1	5.5	0.7	-2.4	0.5	-0.0	0.0	0.6
Wears glasses or contact lenses	1.8	2.1	4.1	-1.0	0.6	1.8	0.1	-2.0	2.0
Ever taken oral contraceptive pill	1.2	1.3	5.3	-0.5	-2.3	0.2	1.3	0.7	0.1
Hearing aid user	1.9	2.2	5.2	-0.0	0.9	2.3	1.0	-1.6	1.8
Mother’s age at death	0.3	0.3	1.4	-0.6	1.2	0.2	-0.4	-0.2	0.3
Financial situation satisfaction	0.3	0.4	1.5	-0.7	-1.2	0.5	-0.4	-0.2	0.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.7	-1.6	-0.4	0.9	-0.4	-1.0	1.2
Commuting to job workplace: Public transport	0.8	1.0	5.0	0.6	2.2	0.7	0.3	0.1	0.3
Eye problems/disorders: Glaucoma	0.6	0.7	1.0	-0.2	-1.0	-1.0	-1.0	0.2	-1.0
Medication: Blood pressure	0.8	1.5	3.8	0.5	0.3	1.9	1.4	-0.8	1.6
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.4	-1.6	0.1	0.7	-1.4	-1.0	1.1
Supplements: Fish oil (including cod liver oil)	1.7	2.2	6.8	-2.6	0.2	0.0	-2.1	-1.3	0.7
High cholesterol (Self-reported)	0.3	0.5	1.1	0.8	-1.1	0.6	0.7	-0.3	0.8
Medication: Bendroflumethiazide	0.2	0.3	0.9	0.2	0.4	1.0	0.6	-0.0	0.6
Medication: Paracetamol	0.4	0.5	1.8	-0.8	0.8	-0.0	-1.3	-0.2	0.5
Medication: Lisinopril	0.9	1.2	3.0	-0.5	-0.3	1.7	-0.1	-1.3	1.5
Medication: Atorvastatin	0.6	0.7	2.4	-0.2	1.5	0.3	-0.3	-1.1	0.6
Illnesses of father: High blood pressure	0.7	0.9	1.5	-1.2	-0.3	1.0	-0.3	-1.1	1.2
Alcohol drinker status: Never	1.0	1.2	3.1	-1.0	-0.5	1.1	0.1	-1.2	1.8
Ever smoked	0.7	1.2	3.4	1.5	-0.1	-0.5	1.9	0.9	-0.6
Basal metabolic rate	1.6	9.0	21.8	-0.2	0.1	-4.7	-2.6	2.8	-4.2
Leg fat percentage (left)	1.0	3.7	7.0	1.4	-1.1	-1.7	2.6	2.5	-1.6
Arm fat-free mass (left)	2.4	12.0	29.2	0.4	-0.0	-5.4	-2.4	3.6	-4.9
Number of operations (self-reported)	0.7	1.0	2.0	-0.0	-1.4	1.4	0.6	-0.2	1.3
Average weekly beer plus cider intake	0.6	0.9	2.5	0.1	-0.7	-1.6	-0.5	-0.5	-1.4
Irritability	0.3	0.4	2.0	0.3	-1.4	0.4	0.2	0.6	0.2
Risk taking	3.2	4.6	10.8	1.1	-1.6	-2.3	1.1	3.3	-2.6
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.0	0.5	-1.4	-1.0	-0.5	0.7	-1.1
Fractured/broken bones in last 5 years	2.9	3.7	7.3	1.1	-1.3	-2.7	-1.2	2.0	-2.6
Age started oral contraceptive pill	1.4	1.7	5.5	-1.1	2.4	0.8	-1.0	-1.2	0.8
Diastolic blood pressure, automated reading	1.0	3.2	10.0	-3.2	0.0	-0.1	-2.6	-1.6	0.4
Ever depressed for a whole week	0.5	0.6	1.8	-0.5	-1.4	0.7	0.4	-0.2	0.7
Unable to work because of sickness or disability	3.5	4.5	10.5	0.2	-1.8	-3.2	-0.7	2.1	-2.9
Commuting to job workplace: Cycle	0.4	0.5	0.8	-0.9	0.4	0.3	-0.8	-0.9	0.6
Myopia	0.9	1.3	3.1	1.7	-0.5	0.9	1.8	0.7	0.5
Vascular/heart problems diagnosed by doctor	2.3	6.2	13.0	0.7	-1.6	-3.6	-0.4	2.9	-3.6
Cholesterol lowering medication	1.0	1.5	4.1	0.4	0.0	2.0	0.6	-1.2	1.8
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.1	0.4	0.4	-1.5	-0.5	1.4	-1.4
Pain experienced in last month	0.6	1.0	2.1	0.5	1.5	1.5	0.5	-0.7	0.9
Supplements: Calcium	1.3	1.4	3.0	-0.6	1.7	1.5	-0.0	-0.9	1.4
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	0.9	0.5	0.3	0.9	-0.1	0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	1.1	1.1	0.3	0.6	0.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.2	-0.2	-0.7	-0.7	0.4	-0.5
Heart disease (siblings)	0.2	0.2	0.7	0.8	0.0	-0.6	-0.1	0.4	-0.5
Alcohol drinker status: Previous	0.4	0.5	1.0	-0.2	-0.8	-1.0	-0.5	0.2	-0.9
Pack years of smoking	2.3	3.4	5.8	1.9	-2.4	-1.4	1.5	2.3	-1.3
Impedance of whole body	1.0	5.1	14.3	1.9	-0.6	2.8	3.8	0.1	2.1
Leg fat mass (left)	1.1	4.2	7.5	1.3	-0.8	-2.7	1.4	2.6	-2.5
Arm predicted mass (left)	2.5	12.5	30.1	0.2	-0.3	-5.5	-2.4	3.7	-5.0