Hub : Genes

CNRIP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1520	0.0390	3.0e-07	0.074	0.058	0.071	0.065	0.067	2.7e-09	1.3e-07	5.5e-09	2.2e-08	1.4e-08
2	GTEx	Artery Tibial	0.0842	0.0342	4.7e-03	-0.002	NA	0.005	NA	-0.002	5.2e-01	NA	1.3e-01	NA	5.2e-01
3	GTEx	Cells Transformed fibroblasts	0.1440	0.0550	2.6e-03	0.133	NA	0.116	NA	0.119	3.7e-10	NA	5.5e-09	NA	3.2e-09
4	METSIM	Adipose	0.1414	0.0272	0.0e+00	0.155	0.151	0.171	0.166	0.170	1.5e-22	7.1e-22	7.4e-25	4.4e-24	1.1e-24
5	NTR	Blood	0.0382	0.0112	9.0e-07	0.026	0.022	0.034	0.027	0.037	6.2e-09	9.9e-08	2.6e-11	2.6e-09	4.7e-12
6	ROSMAP	Brain Pre-frontal Cortex	0.0446	0.0184	3.5e-03	0.026	0.013	0.027	0.021	0.040	2.6e-04	7.0e-03	1.9e-04	8.0e-04	5.9e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.1	-0.1	-0.6	-0.1	-0.3	0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	2.0	0.8	0.1	-0.2	-0.7	1.4	-0.2
Depressed Affect (Nagel 2018)	0.3	0.7	3.0	0.2	-0.5	-1.7	-0.3	0.6	0.6
Depression (Nagel 2018)	0.1	0.2	0.3	0.6	0.4	0.5	0.6	-0.0	0.4
Intelligence (Savage-Jansen 2018)	0.7	2.1	6.5	1.8	0.8	-1.0	0.6	2.6	-0.9
Neuroticism (Nagel 2018)	0.3	0.6	1.7	-1.3	0.1	-0.5	-0.4	1.3	0.4
Schizophrenia (2018)	0.5	1.1	4.1	1.1	0.2	0.2	-0.8	2.0	-0.9
Schizophrenia vs Biploar Disorder	1.0	1.4	2.7	0.1	-0.9	1.6	-0.1	1.6	-1.5
Worry (Nagel 2018)	0.2	0.4	1.5	-1.2	0.4	-0.1	-0.2	0.9	-0.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	0.9	-0.5	0.1	-0.4	0.2	-0.4
Alzheimer’s Disease (in father)	0.6	0.6	3.6	-0.3	-0.0	-0.3	1.9	-0.2	0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	0.5	-1.1	-0.6	0.2	-0.8	0.3
Crohns Disease (2017)	0.5	1.1	2.9	1.0	-0.6	-0.1	-0.5	1.7	-1.5
Irritable Bowel Disease (IBD)	0.5	1.3	3.1	0.8	1.2	-0.2	0.5	1.5	-1.8
Ulcerative Colitis (UC)	1.2	2.3	7.2	0.5	2.7	-1.1	1.6	1.2	-1.0
Major Depression (MDD)	0.8	0.9	2.2	-1.4	0.1	0.4	-1.5	-0.4	1.0
Reaction Time	0.7	1.3	4.3	-0.5	0.2	-0.5	-1.5	-0.7	2.1
Verbal and Numeric Reasoning (VNR)	1.0	2.4	5.5	2.3	1.1	-1.3	0.9	2.3	-0.3
Breast Cancer	0.2	0.4	1.3	-0.2	-1.2	0.4	-0.4	0.6	-0.8
Ovarian Cancer	0.4	0.5	1.9	0.5	-1.4	0.7	0.2	-0.3	-0.7
Prostate Cancer	1.3	1.8	4.6	-0.4	0.8	2.1	1.4	0.3	-1.9
Age at First Birth	0.1	0.1	0.7	-0.8	-0.0	-0.0	0.3	0.3	0.0
Bipolar Disorder (2011)	1.0	1.0	2.7	0.7	-0.4	-1.0	-0.6	-1.6	1.1
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	0.5	1.5	-1.1	0.5	0.5	0.7
Coronary Artery Disease (CAD)	0.7	0.9	2.4	-0.9	0.3	1.3	-0.5	1.6	-0.2
Crohns Disease (2012)	0.6	0.9	2.2	0.6	-1.0	-0.1	0.2	1.5	-1.4
Mean Putamen Volume	2.0	2.3	5.7	0.0	-2.0	-0.4	-1.4	-2.4	1.4
Fasting Glucose	0.3	0.4	1.5	-0.5	-0.3	0.6	-1.2	0.4	0.1
HbA1C	1.2	1.4	2.8	-1.6	-0.9	-0.5	-0.6	1.3	-1.7
HDL Cholesterol	0.8	1.4	3.9	-0.3	-1.3	2.0	-0.3	0.2	-1.5
LDL Cholesterol	1.5	2.4	8.4	-0.8	-2.9	0.2	-1.3	-1.8	0.4
Lupus	0.8	1.3	4.2	1.4	-0.1	-2.0	-0.3	1.1	-0.2
Neuroticism (2016)	0.4	0.6	1.2	0.3	1.1	0.4	1.0	0.6	-1.0
Primary Biliary Cirrhosis	0.6	0.8	3.5	-0.6	-0.0	0.0	0.8	1.9	-0.7
Rheumatoid Arthritis	0.3	0.5	1.1	1.1	0.4	-1.1	-0.2	-0.2	-0.5
Schizophrenia (2014)	0.6	1.2	4.3	1.1	0.5	0.4	-0.3	2.1	-1.2
Triglycerides	0.3	0.5	0.9	-0.2	-0.9	-0.1	-0.8	-1.0	0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.0	0.7	-0.0	0.7	0.3	1.0	-0.9
Ulcerative Colitis	1.6	2.4	7.1	0.8	2.7	-0.8	1.3	1.4	-1.5
Blood Eosinophil Count	0.1	0.8	2.1	-0.9	-0.1	1.4	1.5	-0.5	-0.2
Blood Platelet Count	0.8	9.5	17.0	-0.7	-1.3	-3.2	-4.1	-3.5	3.9
Blood Red Count	0.6	6.2	17.7	-4.2	-1.6	2.0	-3.0	-1.2	1.6
Blood White Count	0.2	1.2	4.2	0.6	0.5	-0.6	1.3	-2.1	-0.5
Heel T-Score	0.1	0.7	3.6	-0.4	-0.2	0.5	-1.9	-0.4	-0.2
BMI	0.6	3.7	9.0	-1.5	-2.0	0.5	-3.0	-2.0	1.7
Height	0.7	14.2	45.7	0.6	-5.3	1.7	-0.4	-6.8	2.8
Waist Hip Ratio (WHR)	1.9	8.4	26.9	0.9	-2.5	-1.1	-2.0	-5.2	3.4
Systolic Blood Pressure	1.1	5.8	15.5	-1.8	2.7	-1.5	-0.5	3.9	-2.5
Smoking Status	0.3	0.6	1.7	0.6	-1.1	0.0	-0.2	-1.3	0.7
Allergy or Eczema	0.7	2.0	4.7	-1.9	-0.2	1.1	-2.2	1.2	-1.0
Cardiovascular Disease	1.1	3.5	7.9	-2.5	1.0	0.2	-2.4	2.8	0.1
Hypothyroidism (self reported)	0.1	0.3	0.8	0.9	0.5	-0.5	-0.2	-0.5	0.2
Respiratory disease	0.2	0.5	1.6	0.4	-1.3	-0.2	-0.4	0.8	-0.5
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.6	0.2	-0.2	-1.7	-1.9	-0.9	1.7
Lung FEV1/FVC ratio	0.6	2.8	9.4	-1.4	-0.3	0.4	-0.9	3.1	-2.1
Lung FVC	0.6	3.1	8.5	2.8	0.2	-2.9	-0.0	-0.0	1.5
Neuroticism	0.4	0.9	2.0	-0.8	-0.8	-1.4	-0.8	1.1	0.7
Chronotype (morning person)	0.1	0.3	0.8	-0.5	0.9	-0.4	0.3	-0.4	0.3
Hair Pigment	0.0	0.7	1.6	-1.1	-1.3	0.2	-0.4	1.0	0.6
Tanning	0.1	0.7	2.3	1.0	-0.5	-0.1	0.2	1.5	-1.0
Hand grip strength (left)	1.5	3.9	13.1	0.3	-3.6	2.6	-0.1	-1.8	-0.2
Number of treatments/medications taken	0.1	0.3	0.5	-0.7	0.4	-0.5	-0.4	-0.7	0.2
Average weekly spirits intake	0.5	0.6	1.1	1.0	0.7	-0.8	-0.3	-1.0	0.4
Sensitivity / hurt feelings	0.2	0.3	0.9	-1.0	0.4	-0.1	0.2	0.5	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	-0.7	0.3	0.5	-0.1	0.2	-0.1
Hearing difficulty/problems: Yes	0.9	1.4	5.3	0.9	1.4	0.1	0.3	2.3	0.5
Relative age of first facial hair	0.8	1.7	4.5	-1.4	0.8	1.1	0.3	2.1	-1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.3	1.0	1.1	0.4	-0.1	-0.9
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.2	0.2	-1.8	-0.8	-0.9	-0.5	0.7
Ever had hysterectomy (womb removed)	0.6	0.6	1.8	-0.2	0.3	1.1	-1.3	-0.8	-0.2
Systolic blood pressure, automated reading	0.4	1.2	2.7	-0.4	1.4	-0.5	-0.1	1.6	-1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	0.6	0.0	-0.9	-0.6	-0.7	-0.5
Angina	0.5	0.6	2.8	-0.3	0.3	-0.3	0.3	0.8	-1.7
Medication for hormone replacement therapy	0.5	0.6	1.5	-0.3	-0.9	1.2	0.2	0.3	-1.1
Vitamin and mineral supplements	0.6	0.9	2.7	0.8	1.2	0.6	1.6	-0.0	-0.2
Supplements: Zinc	0.4	0.4	1.0	0.8	0.7	-1.0	0.3	-0.2	-0.4
Medication: Co-codamol	0.8	0.9	1.9	-1.4	0.5	0.1	0.2	-1.2	1.4
Medication: Metformin	0.7	1.0	2.5	0.8	-0.4	-1.6	-0.6	-1.0	1.1
Diabetes (father)	0.8	0.9	2.7	1.5	-0.3	-1.6	-0.2	-0.6	0.4
Diabetes (mother)	1.2	1.6	3.4	-1.5	-0.6	0.4	-1.8	-1.8	0.1
Severe depression (siblings)	1.6	1.8	3.8	0.4	1.5	-1.9	1.2	0.4	1.7
Pack years adult smoking proportion	1.5	2.3	8.2	-0.4	-2.9	1.2	-0.8	-1.7	0.3
Impedance of leg (right)	0.5	2.3	6.5	2.5	1.6	-1.6	0.9	-0.6	1.1
Leg fat-free mass (left)	1.1	5.9	14.4	-2.1	-3.8	2.4	-1.6	-2.8	0.7
Trunk fat percentage	0.4	1.6	5.6	-0.8	-0.1	-0.1	-1.0	-1.5	2.4
Hand grip strength (right)	1.9	5.1	13.3	-0.4	-3.6	3.0	-0.8	-2.7	0.6
Townsend deprivation index at recruitment	0.6	0.8	2.1	1.5	0.3	-1.3	0.6	0.8	-0.2
Current tobacco smoking	0.7	1.1	2.9	1.7	-1.3	0.3	1.0	0.8	-0.3
Average weekly fortified wine intake	1.2	1.5	6.0	0.5	1.2	0.3	1.0	2.4	-0.1
Maternal smoking around birth	0.3	0.4	1.2	0.4	0.7	0.5	-0.5	0.4	1.1
Fed-up feelings	0.5	0.9	1.9	-1.4	0.5	-0.6	-0.9	1.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.1	0.5	-0.2	-0.5	-0.6	0.7
Relative age voice broke	0.9	1.3	2.9	-1.2	0.9	1.7	-0.2	0.9	-1.3
Taking other prescription medications	0.5	0.8	2.6	-0.4	0.1	0.1	-0.2	-1.3	1.6
Age when periods started (menarche)	1.1	2.7	5.8	-0.2	0.6	-2.2	-0.1	-2.4	2.4
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	6.0	0.4	-1.5	-1.5	-2.4	0.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	4.5	-1.8	-1.0	1.6	-2.1	-2.0	1.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.3	-1.3	-1.2	1.5	0.1	-1.2	-0.2
Qualifications: CSEs or equivalent	1.0	1.3	2.8	-1.4	-1.7	1.4	-0.7	0.2	0.1
Serious illness, injury or assault to yourself	2.8	3.3	12.2	2.1	1.1	-3.5	-0.1	-0.1	1.6
High blood pressure	1.0	2.8	8.7	-2.1	0.8	-0.1	-1.5	3.0	-0.7
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.2	-2.1	-0.9	1.6	-2.5	1.6	-1.2
Multivitamins +/- minerals	0.8	1.1	2.5	-1.1	-1.4	-0.5	-1.6	0.3	0.8
Stomach or abdominal pain in last month	0.6	0.8	3.0	-0.6	-0.6	-0.1	0.2	-1.7	0.9
Supplements: Glucosamine	0.4	0.5	1.8	-0.2	1.3	0.2	-0.5	0.5	-0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	-0.4	0.2	1.5	1.1	-0.6	-0.5
Medication: Atenolol	1.1	1.4	5.0	0.0	1.7	0.1	2.2	-0.1	-0.6
Medication: Levothyroxine sodium	0.4	0.7	1.7	0.1	0.8	-1.3	-0.9	0.6	1.0
Sitting height	1.1	7.6	22.4	-0.4	-4.7	2.3	0.3	-3.9	1.4
Chronic bronchitis/emphysema (father)	0.5	0.6	2.6	-0.1	0.5	1.6	-0.4	-0.1	-0.8
High blood pressure (mother)	2.1	2.9	9.3	-1.4	1.8	0.4	1.7	3.0	-0.5
Body mass index (BMI)	0.5	1.9	3.1	-1.1	-1.5	0.7	-1.8	-1.7	1.1
Impedance of leg (left)	0.5	2.3	4.9	2.2	1.9	-1.4	1.2	-0.7	1.3
Leg predicted mass (left)	1.1	5.8	14.2	-2.1	-3.8	2.3	-1.5	-2.8	0.7
Trunk fat mass	0.7	3.0	6.9	-1.2	-1.5	0.8	-1.3	-2.6	2.2
Waist circumference	0.8	3.1	8.8	-0.5	-2.2	0.8	-1.4	-3.0	1.3
Number of incorrect matches in round	1.3	2.2	4.7	-1.0	-1.7	1.7	-1.3	-2.2	0.4
Past tobacco smoking	0.4	0.7	1.8	-1.2	0.2	0.7	-0.2	1.4	0.2
Alcohol usually taken with meals	0.6	0.9	3.2	-0.6	-0.1	1.8	0.8	1.1	-0.3
Nervous feelings	0.2	0.3	1.3	-1.2	0.5	-0.0	0.5	-0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.4	0.4	-0.5	0.4	-0.5	0.1
Hearing difficulty/problems with background noise	0.5	0.8	1.5	1.1	0.7	-0.2	1.2	1.2	-0.5
Hair/balding pattern: Pattern 2	0.2	0.3	1.1	-1.1	-0.3	-0.2	-0.1	-0.7	0.3
Had menopause	0.2	0.3	0.7	0.8	0.1	-0.8	0.2	0.5	0.1
Had other major operations	1.3	1.5	3.5	0.7	0.8	-0.9	1.0	1.6	-1.9
Forced vital capacity (FVC)	0.6	2.3	5.2	1.1	-2.3	0.0	-0.6	-2.2	1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	4.0	-1.4	-1.3	1.9	-1.5	-2.0	1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.5	-0.0	0.3	0.5	-0.6	0.4	-1.2
Qualifications: None of the above	0.9	1.9	5.6	-0.6	-0.2	-0.2	-2.4	-2.1	1.0
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.1	0.5	0.3	-0.9	0.6	-0.6
Mouth/teeth dental problems	0.2	0.4	1.0	0.7	0.0	-0.7	1.0	0.5	-0.2
Heart attack	0.7	0.9	1.8	0.3	0.8	-1.3	1.2	0.1	1.1
Allergy	0.4	0.9	2.7	0.6	0.3	-0.1	1.6	-1.3	0.7
Pain all over the body in last month	0.5	0.6	1.3	1.1	0.2	-0.3	-1.1	-0.0	-0.9
Diabetes (self-reported)	0.6	0.9	2.9	0.3	-0.3	-1.3	-0.8	-0.6	1.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	1.1	0.2	-1.0	-0.1	-0.8	0.5	0.0
Medication: Ramipril	0.7	0.9	3.4	-1.9	0.5	0.4	-0.0	0.4	1.1
Medication: Simvastatin	0.1	0.1	0.3	0.5	-0.3	-0.2	0.1	0.1	-0.2
Fluid intelligence score	2.2	4.5	8.0	2.6	2.1	-1.4	2.2	2.8	-1.0
Illnesses of siblings	1.6	2.2	6.1	-1.5	-2.5	0.5	-1.4	-0.9	1.3
Neuroticism score	0.4	0.9	2.0	-1.4	0.0	-1.1	-0.4	1.4	-0.1
Weight	1.2	5.8	12.3	-1.5	-3.4	1.9	-1.7	-3.5	1.4
Impedance of arm (right)	1.4	6.4	20.4	0.2	3.5	0.1	2.2	4.5	-0.7
Arm fat percentage (right)	0.2	0.6	1.4	-1.2	0.2	0.7	-0.8	0.3	1.0
Trunk fat-free mass	1.7	9.5	25.7	-1.1	-5.1	2.3	-1.9	-4.5	0.8
Hip circumference	0.3	1.3	2.9	-1.3	-1.5	1.7	-0.3	-1.1	0.1
Time employed in main current job	0.4	0.4	1.6	-0.6	0.7	0.0	0.1	0.2	-1.3
Alcohol intake versus 10 years previously	0.2	0.3	0.9	0.3	-0.4	-0.9	0.0	-0.8	0.5
Father’s age at death	0.4	0.6	1.9	0.6	-0.7	-0.6	-0.5	-1.4	-0.2
Worrier / anxious feelings	0.5	0.9	2.6	-1.6	0.7	-0.0	0.6	1.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	6.1	1.1	2.5	-1.4	0.3	0.6	0.8
Falls in the last year	0.1	0.1	0.2	-0.5	-0.0	0.1	0.3	0.0	0.5
Hair/balding pattern: Pattern 3	0.6	0.9	2.3	-1.0	0.4	0.8	-1.2	0.3	1.5
Number of live births	1.0	1.4	2.8	-1.1	-0.5	-1.1	-1.7	-1.4	1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	4.9	0.6	-2.2	0.3	-0.9	-0.8	0.5
Pulse rate	0.3	0.6	1.2	0.5	0.4	-1.1	-0.8	-0.8	0.7
Happiness	0.6	0.7	2.1	1.4	-0.1	-0.2	1.4	0.1	0.1
Noisy workplace	0.2	0.2	0.7	0.8	-0.0	-0.5	0.6	0.3	-0.3
Qualifications: A levels/AS levels or equivalent	2.7	6.1	12.3	0.2	1.0	2.1	3.5	3.5	-2.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.9	0.4	0.1	-1.0	0.8	0.9	0.1
Mouth/teeth dental problems: Dentures	0.6	1.1	5.1	-0.0	-0.5	-0.0	-2.2	-0.7	0.8
Asthma	0.3	0.5	1.6	0.7	-1.3	0.0	-1.0	0.3	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	2.7	0.8	1.0	-0.9	-1.0	-1.6	1.4
Medication: Cholesterol lowering	0.4	0.6	1.7	-0.4	0.6	-0.5	0.3	-1.3	1.1
Depression (self-reported)	0.4	0.5	1.5	0.6	0.4	-0.5	0.3	-1.2	-0.6
Medication: Lansoprazole	0.1	0.1	0.4	0.1	0.2	0.2	0.7	0.3	0.2
Prospective memory result	0.4	0.5	1.5	0.3	-0.2	-0.4	0.2	-1.0	1.2
Lung cancer (father)	1.1	1.3	3.3	0.4	-1.8	-0.8	-1.7	-0.6	0.9
Illnesses of mother	1.5	1.9	4.9	2.2	-1.6	-0.6	-0.1	-1.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.0	-0.2	-2.2	1.4	-0.5	-1.1	0.2
Pulse wave Arterial Stiffness index	2.4	2.8	4.4	1.8	2.1	-1.9	1.1	1.5	-1.4
Impedance of arm (left)	1.0	4.8	14.8	-0.1	3.3	-0.2	1.7	3.9	-0.2
Arm fat mass (right)	0.4	1.6	3.1	-1.0	-1.4	1.0	-1.1	-1.8	1.2
Trunk predicted mass	1.7	9.6	26.2	-1.2	-5.1	2.5	-2.0	-4.4	0.7
Standing height	0.8	7.6	20.1	-0.9	-4.5	2.7	-0.3	-4.1	0.8
Length of working week for main job	0.7	0.8	2.9	0.8	0.4	-1.7	0.2	0.3	1.0
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.4	-0.3	0.1	0.1	-0.3	0.4
Breastfed as a baby	0.2	0.3	0.5	-0.7	-0.4	0.6	0.3	-0.7	0.4
Tense / ‘highly strung’	0.3	0.5	2.1	-1.4	-0.1	0.7	-0.6	-0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.9	-1.0	-1.0	0.1	-1.4	0.7	-0.6
Hair/balding pattern: Pattern 4	0.4	0.9	4.0	-0.9	2.0	-0.1	0.3	0.6	0.5
Birth weight of first child	1.3	2.3	5.7	2.4	1.0	-1.0	1.4	-2.0	0.5
Peak expiratory flow (PEF)	0.3	0.8	3.1	0.3	-0.3	0.5	0.2	1.0	-1.8
Pulse wave reflection index	0.5	0.6	2.0	0.6	0.4	0.0	0.3	1.4	-1.1
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.9	-0.3	-0.7	0.9	0.0	1.3	-1.4
Loud music exposure frequency	1.1	1.2	2.9	1.7	-0.7	-0.5	-1.3	-1.1	-0.8
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	9.2	-0.1	1.5	0.1	2.2	3.0	-1.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.8	-1.0	0.8	1.7	0.5	0.4	-1.5
Blood clot in the leg (DVT)	1.7	2.1	5.6	2.4	0.6	-2.1	-0.7	-0.9	1.1
Medication: Paracetamol	0.7	1.2	2.9	-1.7	-0.9	1.5	-0.5	-0.5	-0.9
Headache pain in last month	0.4	0.7	1.8	0.4	-0.0	-0.6	0.8	-1.1	1.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	0.7	-1.1	0.4	0.1	0.3	-1.1
Glaucoma (self-reported)	0.8	0.9	3.3	-0.3	1.8	-0.6	0.3	0.1	1.3
Gout (self-reported)	0.3	0.5	1.8	0.1	-0.4	0.9	0.1	0.3	-1.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	0.4	0.6	-0.8	-0.5	-0.2	0.6
Medication: Amlodipine	0.7	0.9	2.7	0.2	1.3	-1.7	-0.9	0.2	0.5
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.5	-0.9	1.2	0.7	-0.1	1.6	-1.3
Birth weight	0.4	1.0	3.7	0.5	-1.1	0.6	0.4	-1.9	-0.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	4.8	-2.2	-0.1	0.3	-0.7	0.9	0.2
High blood pressure (siblings)	0.8	1.1	3.6	-0.0	1.9	-0.2	0.8	1.4	-0.8
Forced vital capacity (FVC), Best measure	0.7	2.7	7.6	0.9	-2.3	0.8	-0.3	-2.8	1.2
Body fat percentage	0.4	1.5	4.7	-0.4	-0.1	-0.2	-1.0	-1.7	2.2
Leg fat percentage (right)	0.4	1.5	4.8	0.3	-0.2	-0.5	-0.8	-2.2	1.8
Arm fat-free mass (right)	2.4	12.1	33.9	-0.9	-5.1	1.9	-2.5	-5.8	1.4
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-1.0	0.6	0.6	-0.4	-0.0	-0.9
Comparative body size at age 10	0.2	0.5	0.8	0.8	-0.4	0.5	0.9	-0.7	-0.9
Number of full brothers	2.4	3.0	12.2	3.5	1.2	-1.8	0.7	-0.5	-0.5
Worry too long after embarrassment	0.6	1.1	4.2	-2.1	0.4	0.1	-0.6	1.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.9	-1.0	-0.0	0.2	-0.4	0.5	-0.2
Wheeze or whistling in the chest in last year	0.5	0.8	2.7	0.5	-1.6	-0.7	-0.5	-0.8	0.7
Number of children fathered	1.7	1.9	4.7	0.6	-1.5	1.3	-2.2	-1.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.3	-0.1	-0.5	-1.1	-0.3	-0.0	1.5
Age at first live birth	1.2	2.1	8.2	0.4	0.2	0.7	2.9	1.1	-1.6
Pulse wave peak to peak time	2.5	3.0	4.8	-1.8	-2.2	2.0	-1.0	-1.7	1.4
Health satisfaction	0.4	0.5	2.2	-0.7	0.3	-1.5	-0.1	0.5	-0.1
Shortness of breath walking on level ground	0.3	0.4	2.0	0.0	-0.1	0.0	0.1	1.4	-0.4
Qualifications: College or University degree	0.5	1.6	3.5	1.9	0.2	-0.8	1.5	1.5	-0.7
Eye problems/disorders: None of the above	0.5	0.5	1.7	0.3	-0.8	-0.5	1.3	-0.1	-0.7
Mouth/teeth dental problems: Loose teeth	2.5	3.0	8.2	-2.1	0.3	2.9	-0.2	-0.8	-2.1
Emphysema/chronic bronchitis	0.4	0.5	2.4	-0.4	1.6	-0.5	-0.1	0.4	-0.2
Medication for pain relief, constipation, heartburn	0.8	1.4	2.9	1.7	0.5	-0.2	1.1	1.5	-1.3
Neck or shoulder pain in last month	0.6	0.9	3.3	-1.8	-0.1	-0.1	-0.4	-1.2	-0.2
Medication: Blood pressure	0.2	0.3	0.8	-0.9	0.6	0.2	-0.0	0.8	0.0
Angina (self-reported)	0.5	0.6	2.5	-0.2	0.4	-0.3	0.2	1.0	-1.6
Migraine (self-reported)	0.6	0.7	2.4	-0.6	-0.0	0.4	-0.8	1.6	0.9
Medication: Ibuprofen	0.8	0.9	3.1	0.6	0.5	-0.4	-0.4	-1.8	1.2
Medication: Allopurinol	0.4	0.5	0.9	0.4	-1.0	0.4	-0.6	-0.9	-0.9
Medication: Omeprazole	1.7	2.0	8.7	-1.3	-0.6	0.2	-3.0	-1.1	-0.2
Medication: Seretide 50 evohaler	0.4	0.5	1.3	-0.4	-1.0	1.1	-0.8	-0.3	0.3
Mean time to correctly identify matches	1.0	1.8	4.8	-0.6	0.2	-1.3	-1.8	-0.8	2.2
Heart disease (mother)	1.1	1.3	2.4	-1.1	1.4	-0.2	-0.3	1.4	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	4.2	-2.1	-1.1	1.3	-1.2	-1.1	0.8
Whole body fat mass	0.6	2.6	7.5	-0.9	-1.5	0.7	-1.2	-2.7	1.8
Leg fat mass (right)	0.7	2.7	8.5	-0.5	-1.6	0.8	-1.2	-2.9	1.7
Arm predicted mass (right)	2.2	11.2	30.6	-1.0	-5.0	2.0	-2.3	-5.5	1.3
Pulse rate, automated reading	1.0	3.1	7.1	-0.5	0.2	-1.0	-2.5	-2.7	1.9
Alcohol intake frequency.	0.4	1.0	2.7	-0.2	1.0	0.4	1.6	0.9	-1.2
Comparative height size at age 10	0.3	1.7	4.9	-0.4	-2.2	1.1	-0.3	-1.9	0.2
Number of full sisters	0.5	0.6	1.7	-1.3	-0.7	0.5	-1.0	-0.3	0.4
Suffer from ‘nerves’	0.5	0.8	2.1	-1.4	1.2	-1.0	-0.5	-0.4	0.2
Overall health rating	1.2	2.5	8.4	-0.2	0.5	-1.3	-0.9	-1.9	2.9
Chest pain or discomfort	0.6	0.9	2.3	-0.6	0.4	-0.5	-1.5	1.3	-0.8
Had major operations	0.8	0.9	2.6	-0.5	1.5	-0.2	0.6	1.6	0.2
Age at last live birth	0.3	0.4	0.9	-0.9	-0.5	0.2	0.8	0.5	-0.5
Family relationship satisfaction	1.2	1.5	4.3	0.9	2.1	-0.4	1.2	1.4	-0.4
Leg pain on walking	1.1	1.4	3.0	0.5	-1.3	-1.4	-1.2	-0.1	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.9	-1.0	-0.1	-0.2	-0.4	1.7	-0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.2	0.8	-1.0	-1.2	-0.4	-1.2	1.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.6	-0.2	-0.9	1.6	0.6	-0.5	-0.1
Medication: Aspirin	0.5	0.6	1.4	-0.4	0.7	-1.2	-0.3	1.1	0.7
Supplements: Vitamin C	0.4	0.5	1.0	-0.5	0.8	-0.6	0.5	1.0	-0.5
Knee pain experienced in last month	0.8	1.3	4.4	-2.1	0.8	0.8	-0.7	0.7	1.1
Hypertension (Self-reported)	0.9	2.4	7.2	-2.0	0.8	-0.4	-1.6	2.7	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.2	-0.2	-1.5	0.3	-1.5	-1.9	2.1
Illnesses of father: Heart disease	2.0	2.7	8.0	-0.8	2.8	1.4	1.0	1.9	-1.1
Illnesses of siblings: Diabetes	1.2	1.4	4.8	0.0	2.2	-1.3	0.7	0.9	0.8
Smoking status: Previous	0.8	1.2	6.1	0.3	0.5	-0.9	-0.0	-2.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	9.1	-0.8	-1.8	1.2	-0.0	-3.0	1.3
Whole body fat-free mass	1.5	8.8	23.6	-1.5	-4.9	2.4	-1.9	-4.2	0.7
Leg fat-free mass (right)	1.1	5.8	14.3	-2.2	-3.8	2.5	-1.4	-2.7	0.6
Arm fat percentage (left)	0.2	0.8	1.6	-1.3	0.3	0.6	-1.0	-0.1	1.2
Average weekly red wine intake	0.2	0.4	1.0	0.4	-0.9	1.0	-0.4	0.1	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.4	-0.7	-0.3	-0.9	-0.9	0.1
Mood swings	0.5	0.9	2.0	0.2	-1.3	-1.4	-0.9	-0.7	0.8
Loneliness, isolation	1.1	1.6	5.8	-0.3	0.6	-1.7	-0.3	2.4	-0.4
Long-standing illness, disability or infirmity	0.4	0.6	1.1	-0.8	1.0	0.7	-0.3	0.3	1.0
Ever had bowel cancer screening	0.4	0.5	1.0	-0.5	-0.8	-0.1	0.9	1.0	0.3
Diabetes diagnosed by doctor	0.4	0.7	2.1	-0.0	-0.1	-1.5	-0.7	0.1	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.8	0.0	0.6	-2.0	-1.3	1.0	-0.3
Friendships satisfaction	1.6	1.9	3.6	1.4	1.9	-1.7	1.2	1.0	-0.7
Qualifications: nursing, teaching	0.3	0.5	1.1	-0.4	-0.2	0.1	1.0	1.0	-0.9
Commuting to job workplace: Walk	0.6	0.7	2.0	0.0	1.2	-0.2	1.4	0.3	-0.7
Eye problems/disorders: Cataract	0.5	0.5	1.4	-0.7	-0.3	1.2	-0.9	0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.0	1.0	0.3	-0.8	0.8	-0.2	0.1
Medication for cholesterol	1.0	1.5	5.1	-0.4	-0.3	1.6	0.7	-2.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.2	-1.6	-1.8	0.6	-1.0	-0.1	0.9
Back pain experienced in last month	0.4	0.5	2.0	0.8	-0.2	-0.1	0.6	-1.4	-0.3
Mineral and other dietary supplements	0.4	0.6	1.5	0.3	-1.2	1.1	-0.2	-0.8	-0.3
Breast cancer (self-reported)	3.2	3.8	11.6	1.8	1.2	-3.4	0.0	-1.6	2.1
Asthma (self-reported)	0.2	0.3	0.7	0.6	-0.9	0.1	-0.8	0.4	-0.3
Osteoporosis (self-reported)	0.3	0.4	1.9	0.2	-0.2	0.2	-0.2	0.6	-1.4
Osteoarthritis (self-reported)	0.7	0.9	2.9	-0.4	-0.2	-0.2	-1.7	-1.1	1.0
Medication: Aspirin	0.4	0.5	1.4	-0.1	0.4	-1.1	-0.5	1.2	0.5
Medication: Gliclazide	0.1	0.1	0.7	-0.0	-0.0	-0.0	-0.4	0.1	0.8
Illnesses of father: None of the above (group 1)	3.0	3.7	10.0	0.0	-3.2	-0.4	-1.6	-2.3	2.0
Smoking status: Current	0.6	1.0	2.3	1.5	-1.4	0.4	0.8	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.9	0.6	-1.0	-1.4	-0.4	0.2	0.8
Whole body water mass	1.5	8.5	22.6	-1.5	-4.8	2.3	-1.9	-4.1	0.7
Leg predicted mass (right)	1.1	6.1	14.7	-2.4	-3.8	2.5	-1.5	-2.7	0.6
Arm fat mass (left)	0.4	1.8	2.9	-1.1	-1.3	1.0	-1.3	-1.7	1.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.9	-0.7	-0.2	-0.3	-1.0	0.9	0.5
Average weekly champagne plus white wine intake	1.2	1.6	4.7	1.0	2.2	-1.2	1.1	1.1	0.2
Miserableness	0.3	0.5	1.5	0.2	-0.2	-1.2	-0.3	1.0	-0.2
Guilty feelings	0.4	0.6	1.5	-0.9	1.2	-0.2	-0.9	0.1	0.4
Wears glasses or contact lenses	1.1	1.3	4.9	-0.1	-0.5	0.7	-0.5	2.2	-1.3
Ever taken oral contraceptive pill	3.2	3.5	11.4	3.1	0.2	-3.4	-0.2	0.3	0.2
Hearing aid user	1.8	2.1	5.2	0.8	1.8	-0.3	-0.1	2.3	-1.8
Mother’s age at death	0.4	0.5	1.2	-1.1	-0.6	0.1	1.1	0.3	-0.5
Financial situation satisfaction	0.4	0.5	1.7	-0.3	1.3	-0.8	-0.5	0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-0.2	0.4	-0.9	0.6	0.8	-1.0
Commuting to job workplace: Public transport	1.0	1.2	2.6	-1.2	-1.2	1.6	-0.8	0.7	-0.8
Eye problems/disorders: Glaucoma	1.2	1.4	3.2	0.4	1.8	-1.0	0.2	-1.0	1.7
Medication: Blood pressure	0.7	1.3	3.9	0.5	0.6	-2.0	-0.7	1.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.2	0.2	1.6	0.4	1.8	0.9	-0.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.6	1.0	0.7	-1.6	1.2	0.3	-0.1
High cholesterol (Self-reported)	0.2	0.4	2.0	-0.0	1.4	-0.3	0.4	0.5	-0.3
Medication: Bendroflumethiazide	0.5	0.8	3.0	0.7	-0.1	-1.7	-0.3	0.5	1.0
Medication: Paracetamol	0.7	1.1	2.2	-1.5	-1.1	1.1	-0.5	-0.3	-1.2
Medication: Lisinopril	1.1	1.4	3.0	-0.1	1.7	-0.7	1.4	1.4	-0.9
Medication: Atorvastatin	0.3	0.4	1.0	0.1	1.0	-0.2	1.0	0.3	0.4
Illnesses of father: High blood pressure	1.8	2.3	5.2	1.4	2.1	-0.8	1.0	0.6	-2.3
Alcohol drinker status: Never	0.5	0.6	2.1	0.7	0.6	0.6	0.6	1.4	-0.3
Ever smoked	0.3	0.6	2.0	1.4	-0.4	-0.8	0.7	-0.1	-0.3
Basal metabolic rate	1.5	8.2	20.2	-1.5	-4.5	2.2	-1.9	-4.1	1.1
Leg fat percentage (left)	0.4	1.5	4.5	0.2	0.1	-0.5	-0.6	-2.1	1.9
Arm fat-free mass (left)	2.0	10.2	26.0	-0.9	-5.1	2.0	-2.1	-5.0	1.2
Number of operations (self-reported)	0.5	0.8	1.7	0.4	1.1	-0.3	0.2	1.3	-1.2
Average weekly beer plus cider intake	0.7	1.0	2.3	0.1	-1.5	0.2	-1.2	-0.7	1.2
Irritability	0.2	0.3	1.4	-0.6	-1.2	0.4	-0.4	-0.0	-0.1
Risk taking	1.8	2.6	6.2	0.1	-2.2	0.3	-1.6	-2.5	1.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.2	-0.2	0.2	-0.2	-0.0	-0.9	1.1
Fractured/broken bones in last 5 years	1.0	1.3	5.7	0.3	-1.1	-0.1	0.7	-2.4	0.8
Age started oral contraceptive pill	0.8	1.1	3.0	-0.1	1.7	0.4	0.8	0.9	-1.3
Diastolic blood pressure, automated reading	0.1	0.2	0.8	-0.4	-0.2	-0.4	-0.9	-0.2	-0.4
Ever depressed for a whole week	0.4	0.5	1.6	0.2	1.3	-1.0	-0.3	0.7	-0.0
Unable to work because of sickness or disability	2.6	3.4	10.4	1.5	0.1	-0.8	-0.3	-3.2	2.7
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.2	-0.9	0.4	-1.2	0.7	-0.8
Myopia	0.3	0.4	1.0	0.4	-1.0	0.1	-0.2	0.5	-1.0
Vascular/heart problems diagnosed by doctor	0.9	2.5	8.9	1.7	-1.3	0.5	1.0	-3.0	0.6
Cholesterol lowering medication	1.0	1.5	3.8	0.7	1.5	-1.0	-0.1	1.9	-1.2
Medication: Omeprazole (e.g. Zanprol)	2.1	2.6	6.6	-1.3	-1.7	1.2	-2.6	-1.7	-0.2
Pain experienced in last month	0.4	0.7	1.8	0.9	-0.5	-0.8	-0.4	1.3	-0.5
Supplements: Calcium	1.5	1.7	2.9	-0.9	1.7	0.8	1.4	1.3	-1.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	-0.2	-1.1	1.1	-1.1	0.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.2	0.5	0.7	-1.5	1.1	0.1	1.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	5.2	2.3	0.8	-1.8	-0.6	-0.8	0.8
Heart disease (siblings)	1.4	1.7	4.9	1.1	1.8	-0.2	2.2	-0.7	-0.2
Alcohol drinker status: Previous	0.4	0.5	1.2	-0.3	-0.2	-0.2	1.1	-0.7	1.0
Pack years of smoking	1.1	1.6	6.1	-0.2	-2.5	1.1	-0.4	-1.5	-0.0
Impedance of whole body	0.5	2.8	7.7	1.2	2.8	-0.6	1.7	2.0	0.3
Leg fat mass (left)	0.7	2.6	7.8	-0.7	-1.5	1.0	-1.1	-2.8	1.8
Arm predicted mass (left)	2.0	10.2	25.7	-0.7	-5.1	1.8	-2.1	-5.1	1.3