TWAS hub - WDR92

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0850	0.0250	5.0e-05	0.084	0.047	0.089	0.081	0.090	1.9e-10	2.1e-06	5.7e-11	4.6e-10	4.5e-11
2	ROSMAP	Brain Pre-frontal Cortex	0.0792	0.0205	7.0e-07	0.095	0.050	0.081	0.071	0.091	3.3e-12	4.8e-07	1.4e-10	1.9e-09	9.9e-12
3	YFS	Blood	0.0547	0.0137	1.4e-11	0.048	0.029	0.031	0.033	0.042	2.8e-15	7.2e-10	1.9e-10	4.9e-11	1.5e-13
4	TCGA	Brain Lower Grade Glioma	0.0358	0.0232	5.0e-03	0.012	0.014	0.007	NA	0.010	1.2e-02	7.9e-03	4.4e-02	NA	2.1e-02
5	TCGA	Prostate Adenocarcinoma	0.0625	0.0287	9.0e-06	0.032	0.050	0.038	NA	0.043	2.4e-04	6.1e-06	6.3e-05	NA	2.6e-05
6	TCGA	Thyroid Carcinoma	0.0330	0.0210	9.1e-03	0.027	0.014	0.008	NA	0.020	1.0e-03	1.5e-02	4.8e-02	NA	4.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication: Aspirin	6.3	8.3	14.5	2.8	2.8	0.7	3.5	3.8	2.7
Medication: Aspirin	5.8	7.5	12.3	2.7	2.7	0.5	3.3	3.5	2.6
Had major operations	4.5	5.3	8.8	2.2	2.2	-0.2	3.0	2.9	2.1
Current tobacco smoking	4.1	6.8	10.2	2.8	3.2	2.0	2.2	1.9	3.2
Smoking status: Current	3.9	6.2	9.4	2.8	3.1	2.0	2.0	1.6	3.1
Hair/balding pattern: Pattern 3	3.7	5.4	8.9	3.0	2.8	1.9	1.0	1.7	3.0
Back pain experienced in last month	3.7	5.4	8.1	-2.4	-2.4	-0.8	-2.4	-2.8	-2.4
Arm fat-free mass (right)	3.5	18.0	43.8	-3.1	-3.4	3.3	-6.6	-4.8	-3.1
Diabetes (self-reported)	3.4	5.2	7.5	2.5	2.7	2.3	1.0	2.0	2.7
Impedance of arm (right)	3.4	15.8	34.3	3.6	3.9	-1.5	5.9	4.1	3.6
Arm predicted mass (right)	3.3	17.0	40.6	-3.1	-3.4	3.0	-6.4	-4.7	-3.1
Medication for hormone replacement therapy	3.2	3.6	5.0	-2.2	-1.9	-1.3	-1.6	-2.1	-2.0
Trunk fat-free mass	3.1	17.9	42.6	-3.3	-3.6	2.1	-6.5	-5.0	-3.4
Trunk predicted mass	3.1	17.4	41.3	-3.3	-3.6	2.0	-6.4	-4.8	-3.4
Verbal and Numeric Reasoning (VNR)	3.0	7.2	11.2	3.4	3.2	0.7	1.8	2.7	3.3
Whole body fat-free mass	2.8	15.8	37.3	-3.1	-3.5	1.9	-6.1	-4.6	-3.2
Whole body water mass	2.8	15.9	37.3	-3.2	-3.5	1.8	-6.1	-4.6	-3.3
Impedance of whole body	2.8	14.2	22.3	3.9	4.3	1.0	4.7	3.5	4.1
High blood pressure (mother)	2.7	3.8	13.0	-1.8	-1.7	-3.6	0.3	-0.5	-1.8
Fluid intelligence score	2.7	5.5	8.5	2.7	2.8	-0.2	1.8	2.4	2.9
Mineral and other dietary supplements	2.7	3.6	6.0	2.0	2.1	2.4	1.2	1.1	2.1
Arm predicted mass (left)	2.7	14.0	36.1	-2.5	-2.8	3.0	-6.0	-4.3	-2.4
Bipolar Disorder (2011)	2.6	2.5	6.2	1.3	1.7	2.5	0.1	0.9	1.9
Impedance of leg (left)	2.6	12.8	16.7	3.8	4.1	3.3	3.4	2.7	4.1
Supplements: Fish oil (including cod liver oil)	2.6	3.4	4.7	-2.2	-2.1	-1.8	-1.6	-1.2	-2.0
Arm fat-free mass (left)	2.6	13.2	33.0	-2.5	-2.8	2.9	-5.7	-4.2	-2.5
Relative age of first facial hair	2.5	5.1	9.4	-2.5	-2.3	-3.1	-1.2	-1.5	-2.5
Impedance of arm (left)	2.5	11.4	25.2	3.1	3.4	-1.2	5.0	3.5	3.0
Breastfed as a baby	2.5	3.1	6.0	1.9	2.0	2.5	-0.1	0.6	2.1
Average weekly champagne plus white wine intake	2.5	3.4	7.1	1.8	1.8	0.2	1.9	2.7	1.8
Waist Hip Ratio (WHR)	2.4	11.0	40.6	2.9	2.7	6.4	-0.2	0.3	3.1
Medication: Blood pressure	2.4	4.2	6.9	2.1	1.9	0.3	2.6	2.6	2.0
Mean Putamen Volume	2.3	2.7	5.4	-1.7	-1.6	0.8	-2.3	-1.6	-1.5
Vitamin and mineral supplements	2.3	3.2	4.0	1.9	1.8	1.0	1.9	2.0	1.8
Hair/balding pattern: Pattern 4	2.3	5.5	8.2	2.3	2.5	1.0	2.9	2.8	2.2
Suffer from ‘nerves’	2.3	3.6	6.6	-2.0	-2.3	-2.1	-0.5	-1.1	-2.6
LDL Cholesterol	2.2	3.5	6.0	-1.7	-1.8	0.5	-2.4	-2.4	-1.7
Impedance of leg (right)	2.2	10.4	13.6	3.2	3.7	2.9	3.4	2.3	3.7
Hand grip strength (right)	2.2	6.1	17.1	-1.9	-1.9	1.7	-4.1	-2.4	-1.8
Length of working week for main job	2.2	2.4	3.8	1.6	1.9	1.5	1.3	0.8	2.0
Loud music exposure frequency	2.2	2.4	3.5	1.6	1.7	1.9	0.3	1.6	1.7
Qualifications: College or University degree	2.2	7.1	11.4	3.2	3.4	1.6	1.5	2.2	3.3
Family relationship satisfaction	2.2	2.7	4.2	2.0	1.7	0.3	1.6	1.9	1.7
Diabetes diagnosed by doctor	2.2	3.6	4.9	2.2	2.2	1.5	1.2	1.9	2.2
Basal metabolic rate	2.2	11.9	28.9	-2.6	-2.9	2.1	-5.4	-4.0	-2.6
Myopia	2.1	3.0	4.0	1.8	2.0	0.7	1.6	1.9	2.0
Intelligence (Savage-Jansen 2018)	2.0	6.1	10.5	3.0	3.2	0.5	1.8	1.8	3.2
Hearing difficulty/problems: Yes	2.0	3.1	4.0	2.0	2.0	-0.1	1.9	2.0	1.8
Average weekly fortified wine intake	2.0	2.3	4.2	1.2	1.2	-1.4	2.0	1.9	1.1
Supplements: Glucosamine	2.0	2.6	4.3	-1.8	-1.7	-2.1	-0.8	-1.3	-1.7
Medication: Ramipril	2.0	2.5	4.5	1.7	1.4	1.0	2.1	1.6	1.4
Schizophrenia (2014)	1.9	4.1	5.6	2.0	2.1	-0.7	2.3	2.4	2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	8.7	-1.2	-1.4	2.1	-3.0	-2.2	-1.4
Leg fat-free mass (right)	1.9	10.0	24.0	-2.5	-2.9	1.0	-4.9	-3.6	-2.8
Leg predicted mass (right)	1.9	10.2	24.4	-2.5	-2.9	1.0	-4.9	-3.6	-2.8
HDL Cholesterol	1.8	3.0	4.7	-1.7	-1.8	-0.8	-1.9	-2.2	-1.8
Systolic Blood Pressure	1.8	8.9	30.9	-1.7	-1.8	-5.6	2.9	2.0	-2.0
Smoking Status	1.8	4.4	8.4	2.0	2.2	2.9	1.2	1.4	2.4
Lung FVC	1.8	9.2	14.5	3.6	3.6	2.8	1.3	2.2	3.8
Medication: Atenolol	1.8	2.2	4.5	1.4	1.2	0.3	2.1	1.9	1.3
Type 2 Diabetes (T2D) (2018)	1.7	3.2	4.2	1.9	2.0	1.9	0.9	1.7	2.1
Leg fat-free mass (left)	1.7	9.1	21.1	-2.4	-2.7	1.2	-4.6	-3.5	-2.5
Leg predicted mass (left)	1.7	9.0	20.8	-2.4	-2.7	1.2	-4.6	-3.5	-2.6
Time employed in main current job	1.7	1.9	3.2	-1.8	-1.5	-1.3	-0.2	-1.4	-1.5
Number of full sisters	1.7	2.1	3.0	1.7	1.7	1.6	0.6	1.1	1.7
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	5.0	-1.5	-0.7	0.1	-2.2	-1.9	-0.9
Illnesses of siblings: Diabetes	1.7	2.0	5.4	1.0	0.8	-0.6	2.3	2.0	0.9
Diabetes (mother)	1.6	2.0	2.8	-1.6	-1.7	0.6	-1.4	-1.4	-1.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	3.3	-1.7	-1.7	-1.8	0.2	-0.3	-1.8
Heart disease (mother)	1.6	2.0	4.5	0.6	0.6	-1.6	2.0	2.1	0.6
Risk taking	1.6	2.4	9.0	1.0	1.0	3.0	-1.3	-0.3	1.2
Maternal smoking around birth	1.5	2.2	3.1	1.6	1.5	0.6	1.8	1.5	1.7
Leg fat percentage (left)	1.5	5.4	9.4	2.3	2.4	3.1	1.5	1.4	2.7
Fractured/broken bones in last 5 years	1.5	1.9	5.0	-0.8	-1.0	1.4	-2.2	-1.3	-1.0
Vascular/heart problems diagnosed by doctor	1.5	4.0	9.6	-0.4	-0.3	2.9	-3.1	-2.4	-0.3
Height	1.4	26.5	70.1	-2.6	-2.5	5.5	-8.4	-6.3	-2.3
Pack years adult smoking proportion	1.4	2.2	6.9	1.2	1.4	2.6	-0.3	0.1	1.6
Serious illness, injury or assault to yourself	1.4	1.7	3.2	1.8	1.2	0.8	1.2	1.4	1.2
Alcohol usually taken with meals	1.4	2.3	3.3	1.7	1.8	0.6	1.1	1.5	1.8
Qualifications: A levels/AS levels or equivalent	1.4	3.0	5.7	2.1	2.4	-0.3	1.1	1.3	2.2
Illnesses of father: Heart disease	1.4	1.9	4.8	0.5	0.5	-1.6	2.2	1.8	0.3
Illnesses of father: None of the above (group 1)	1.4	1.8	6.0	0.6	0.6	2.4	-1.7	-0.9	0.6
Medication: Lisinopril	1.4	1.9	5.0	0.1	0.3	-1.5	2.2	2.0	-0.0
Depression (Nagel 2018)	1.3	2.0	4.2	2.1	1.7	0.9	0.7	0.8	1.7
High blood pressure	1.3	3.7	8.3	0.8	0.8	-2.5	2.9	2.4	0.8
Sitting height	1.3	9.0	23.7	-0.9	-1.0	3.9	-4.9	-3.6	-0.8
Medication: Ventolin 100micrograms inhaler	1.3	1.7	5.1	-1.4	-1.1	-2.3	-0.2	-0.4	-1.2
High blood pressure (siblings)	1.3	1.9	5.1	-1.6	-1.3	-2.2	0.9	0.2	-1.2
Leg fat percentage (right)	1.3	4.7	8.8	2.1	2.2	3.0	1.5	1.2	2.5
Hypertension (Self-reported)	1.3	3.6	8.2	0.8	0.8	-2.3	2.9	2.4	0.9
Loneliness, isolation	1.3	1.8	4.9	0.9	0.5	-2.2	1.7	1.4	0.2
Hearing aid user	1.3	1.5	2.9	0.8	0.9	-1.1	1.7	1.7	0.9
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.8	-1.1	-1.2	-1.7	-0.7	-1.3	-1.3
Diastolic blood pressure, automated reading	1.3	4.0	6.3	-2.4	-2.4	-2.1	-1.0	-1.1	-2.5
Systolic blood pressure, automated reading	1.2	3.4	10.8	-1.5	-1.7	-3.3	1.0	0.4	-1.8
Medication: Metformin	1.2	1.7	3.2	1.3	1.4	1.8	0.1	1.1	1.5
Townsend deprivation index at recruitment	1.2	1.7	4.0	1.1	1.0	0.1	2.0	1.7	1.1
Standing height	1.2	12.0	31.9	-2.0	-2.0	3.2	-5.7	-4.3	-1.8
Medication: Paracetamol	1.2	1.9	2.4	-1.5	-1.5	-1.2	-1.4	-1.0	-1.5
Medication: Omeprazole	1.2	1.4	2.4	-1.4	-1.2	-0.1	-1.0	-1.5	-1.3
Commuting to job workplace: Car/motor vehicle	1.2	1.3	3.9	-0.8	-0.5	0.6	-1.6	-2.0	-0.5
Medication: Paracetamol	1.2	1.8	2.1	-1.3	-1.4	-1.2	-1.4	-1.3	-1.5
Cholesterol lowering medication	1.2	1.8	4.0	0.9	0.6	-1.5	2.0	1.8	0.4
Breast Cancer	1.1	2.7	3.8	-1.6	-1.3	-1.4	-1.9	-2.0	-1.7
Cardiovascular Disease	1.1	3.6	11.5	-0.3	-0.5	-3.4	2.6	1.6	-0.5
Hand grip strength (left)	1.1	3.0	12.8	-0.8	-0.9	1.4	-3.6	-1.2	-0.7
Chronic bronchitis/emphysema (father)	1.1	1.2	2.1	-1.4	-1.4	-0.8	-0.1	-1.0	-1.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.2	1.5	1.3	0.5	0.5	1.3	1.4
Body fat percentage	1.1	4.4	6.2	2.1	2.2	2.5	1.7	1.5	2.4
Pulse wave peak to peak time	1.1	1.3	2.8	-0.6	-0.7	1.3	-1.7	-1.3	-0.7
Pulse rate, automated reading	1.1	3.4	5.1	-2.0	-1.9	0.7	-2.2	-1.9	-2.0
Ever smoked	1.1	2.0	2.9	1.6	1.7	1.4	0.9	1.0	1.7
Pack years of smoking	1.1	1.6	5.0	0.9	1.2	2.2	-0.2	0.1	1.4
Schizophrenia (2018)	1.0	2.0	3.6	1.1	1.3	-1.1	1.9	1.7	1.2
Trunk fat percentage	1.0	3.9	5.5	2.0	2.1	2.3	1.6	1.4	2.2
Forced vital capacity (FVC)	1.0	3.7	12.2	1.5	1.4	3.5	-1.7	-0.4	1.6
Medication: Simvastatin	1.0	1.4	2.3	1.3	1.2	0.4	1.1	1.5	1.2
Father’s age at death	1.0	1.3	2.4	-1.3	-1.1	0.3	-1.6	-0.9	-1.3
Forced vital capacity (FVC), Best measure	1.0	3.5	11.5	1.1	0.9	3.4	-2.4	-0.9	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.2	1.2	1.4	1.2	0.1	0.3	1.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.4	-1.3	-1.5	-0.6	-0.2	-0.6	-1.5
Medication: Blood pressure	1.0	1.9	3.2	1.3	1.3	-0.6	1.7	1.8	1.2
Unable to work because of sickness or disability	1.0	1.3	4.5	-0.3	-0.6	2.1	-1.4	-1.0	-0.6
Medication: Co-codamol	0.9	1.0	2.0	1.1	1.1	1.4	0.3	0.8	1.0
Multivitamins +/- minerals	0.9	1.2	2.0	-1.0	-1.1	-0.6	-1.4	-1.3	-1.1
Hair/balding pattern: Pattern 2	0.9	1.2	1.9	-1.1	-1.0	-0.4	-1.3	-1.4	-1.1
Financial difficulties in last 2 years	0.9	1.2	1.7	1.3	1.2	0.3	1.0	1.3	1.2
Alcohol intake versus 10 years previously	0.9	1.3	2.6	-0.8	-1.4	0.3	-0.9	-1.6	-1.3
Illnesses of mother	0.9	1.2	4.8	0.4	0.8	2.2	-0.7	-0.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.9	1.1	1.1	0.4	1.2	1.7	1.0
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.8	-1.1	-1.0	-0.6	-1.5	-1.7	-1.2
Wears glasses or contact lenses	0.9	1.0	3.1	-0.2	0.1	-1.8	1.5	0.9	0.0
Commuting to job workplace: Cycle	0.9	1.1	1.3	-1.0	-1.1	-1.1	-0.9	-0.9	-1.1
Bipolar Disorder or Schizophrenia	0.8	2.1	3.0	1.5	1.7	-0.1	1.4	1.5	1.7
Rheumatoid Arthritis	0.8	1.2	1.9	-1.4	-1.3	-1.0	-0.9	-0.3	-1.2
Weight	0.8	3.8	9.2	-0.9	-1.1	2.5	-3.0	-2.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.3	1.0	0.5	-0.4	1.3	1.5	0.6
Tense / ‘highly strung’	0.8	1.4	1.9	-1.1	-1.3	-0.7	-1.2	-1.2	-1.4
Birth weight of first child	0.8	1.4	3.6	-0.6	-0.7	1.1	-1.9	-1.5	-0.6
Pulse wave reflection index	0.8	1.0	2.2	0.7	0.7	-0.9	1.2	1.5	0.8
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.2	0.0	0.2	-2.3	1.4	0.9	0.1
Glaucoma (self-reported)	0.8	0.9	1.6	-1.0	-1.2	-0.9	-0.3	-0.7	-1.3
Angina (self-reported)	0.8	1.1	3.6	-0.3	-0.1	-1.0	1.9	1.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	-1.3	-1.2	-0.7	-0.5	-0.8	-1.1
Number of self-reported non-cancer illnesses	0.8	1.4	2.3	1.4	1.5	0.1	1.0	0.9	1.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.6	-1.2	-0.9	-1.3	-0.7	-0.5	-0.9
Medication: Bendroflumethiazide	0.8	1.2	2.8	0.6	0.6	-0.3	1.7	1.6	0.8
Alzheimer’s Disease (including proxy)	0.7	1.0	3.2	-0.8	-0.8	-0.4	-1.8	-0.9	-0.9
Coronary Artery Disease (CAD)	0.7	0.8	1.5	0.7	0.9	-1.2	0.9	0.8	0.7
Angina	0.7	0.9	2.6	-0.5	-0.3	-1.0	1.6	1.1	-0.3
Relative age voice broke	0.7	1.1	2.1	-1.1	-0.9	-1.4	-0.8	-1.0	-0.9
Age when periods started (menarche)	0.7	1.6	3.1	-0.9	-1.1	1.2	-1.8	-1.5	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	6.5	1.0	0.7	2.5	0.2	0.9	0.9
Mouth/teeth dental problems: Dentures	0.7	1.3	2.2	-1.5	-1.5	-0.4	-0.3	-0.9	-1.5
Medication: Lansoprazole	0.7	0.8	1.3	1.1	1.2	0.9	0.4	0.2	1.1
Pulse wave Arterial Stiffness index	0.7	0.9	1.9	0.5	0.5	-1.1	1.4	1.0	0.5
Health satisfaction	0.7	0.9	1.1	-0.9	-1.1	-0.9	-1.0	-0.9	-1.0
Comparative height size at age 10	0.7	3.8	9.9	-1.2	-1.2	1.6	-3.1	-2.5	-1.1
Ever taken oral contraceptive pill	0.7	0.7	1.3	1.1	1.0	0.8	0.1	0.5	1.1
High cholesterol (Self-reported)	0.7	1.2	2.8	1.0	0.7	-0.2	1.7	1.5	0.8
Bipolar Disorder (2018)	0.6	0.9	1.7	0.9	1.1	1.3	-0.1	0.3	1.2
Worry (Nagel 2018)	0.6	1.3	3.0	-0.8	-1.3	-1.7	-0.1	-0.4	-1.5
Crohns Disease (2017)	0.6	1.2	1.7	1.3	1.0	-0.9	1.1	1.2	1.1
Irritable Bowel Disease (IBD)	0.6	1.4	2.3	1.1	1.0	-0.9	1.4	1.5	1.1
Ulcerative Colitis (UC)	0.6	1.1	2.6	0.4	0.5	-0.9	1.6	1.6	0.6
Neuroticism (2016)	0.6	0.9	1.6	-0.9	-0.8	-1.0	-0.9	-1.3	-0.8
Ulcerative Colitis	0.6	0.9	2.0	0.5	0.7	-0.7	1.2	1.4	0.9
Heel T-Score	0.6	4.5	7.5	2.4	2.4	2.7	0.5	1.0	2.6
Severe depression (siblings)	0.6	0.7	1.5	1.1	1.2	0.5	-0.1	0.1	1.2
Waist circumference	0.6	2.3	9.7	1.0	1.1	3.1	-0.7	-0.1	1.3
Number of incorrect matches in round	0.6	1.0	3.2	-0.4	-0.1	1.8	-1.2	-1.1	-0.3
Hearing difficulty/problems with background noise	0.6	1.0	1.7	1.2	1.0	-0.4	1.3	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	7.0	0.8	0.5	2.6	-0.2	0.3	0.6
Illnesses of siblings	0.6	0.8	2.1	0.5	0.4	1.4	-1.3	-0.7	0.4
Arm fat percentage (right)	0.6	2.3	4.9	1.4	1.3	0.2	2.2	1.8	1.5
Worrier / anxious feelings	0.6	1.2	4.4	-0.7	-0.9	-2.1	0.4	0.4	-1.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.3	1.5	1.3	2.1	-0.9	0.2	1.5
Happiness	0.6	0.7	1.7	-0.6	-0.7	-0.2	-1.3	-1.0	-0.7
Noisy workplace	0.6	0.7	1.2	1.1	1.0	0.7	0.8	0.4	1.0
Lung cancer (father)	0.6	0.8	2.0	0.7	0.9	1.4	0.6	0.3	0.9
Birth weight	0.6	1.3	3.5	-0.8	-0.6	1.3	-1.9	-1.1	-0.5
Exposure to tobacco smoke outside home	0.6	0.8	1.6	-1.3	-1.0	-0.9	0.1	-0.1	-1.2
Number of children fathered	0.6	0.7	2.3	0.4	0.7	1.5	-0.7	0.4	0.8
Medication: Seretide 50 evohaler	0.6	0.7	1.6	-1.0	-0.6	0.2	-0.6	-1.3	-0.9
Leg pain on walking	0.6	0.7	2.1	-0.3	-0.5	-0.1	-1.4	-1.3	-0.4
Arm fat percentage (left)	0.6	2.2	4.2	1.4	1.3	0.5	2.0	1.7	1.5
Commuting to job workplace: Walk	0.6	0.7	1.2	-0.9	-1.0	-1.1	0.2	-0.2	-1.0
Medication for cholesterol	0.6	0.9	4.3	0.2	0.2	2.1	-0.8	-0.6	0.4
Asthma (self-reported)	0.6	1.1	1.9	1.4	1.2	1.0	0.5	0.6	1.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.0	-1.0	-0.7	0.9	-0.9	-1.0	-0.6
Leg fat mass (left)	0.6	2.2	9.1	1.1	1.0	3.0	-0.2	0.1	1.3
Prostate Cancer	0.5	0.7	1.2	-1.1	-0.8	-0.5	-0.7	-0.9	-1.0
Allergy or Eczema	0.5	1.2	3.3	-1.0	-1.2	-1.8	0.6	0.1	-1.2
Diabetes (father)	0.5	0.6	1.5	0.7	0.7	1.2	0.8	0.6	0.6
Fed-up feelings	0.5	0.9	1.8	0.9	0.8	-0.8	1.1	1.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	1.3	0.8	0.6	0.4	0.8	0.7
Qualifications: CSEs or equivalent	0.5	0.7	1.1	-0.9	-0.9	-0.6	-0.4	-1.1	-1.0
Trunk fat mass	0.5	1.9	7.9	1.1	1.0	2.8	-0.2	0.0	1.2
Heart attack	0.5	0.6	1.4	0.7	0.5	-0.1	1.0	1.2	0.6
Pain all over the body in last month	0.5	0.5	0.9	-0.7	-0.7	-0.3	-0.6	-1.0	-0.7
Asthma	0.5	1.0	1.7	1.3	1.1	1.0	0.4	0.5	1.2
Headache pain in last month	0.5	0.8	2.4	0.8	0.9	1.6	0.4	0.1	0.9
Worry too long after embarrassment	0.5	0.8	2.6	-0.4	-0.5	-1.6	1.1	0.2	-0.7
Shortness of breath walking on level ground	0.5	0.6	0.9	0.8	0.9	-0.5	1.0	0.7	0.9
Migraine (self-reported)	0.5	0.6	1.2	1.1	1.1	-0.2	0.7	0.0	1.0
Leg fat mass (right)	0.5	1.9	8.6	0.8	0.9	2.9	-0.3	-0.1	1.1
Alcohol intake frequency.	0.5	1.2	2.5	-1.1	-1.2	-1.6	0.5	0.0	-1.4
Chest pain or discomfort	0.5	0.7	1.8	0.7	0.9	-0.3	1.3	0.8	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	3.1	-0.2	-0.3	-1.8	-0.3	-0.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.7	0.5	0.2	1.6	-0.4	0.0	0.3
Long-standing illness, disability or infirmity	0.5	0.8	1.6	1.2	1.2	0.5	0.3	0.3	1.2
Eye problems/disorders: Cataract	0.5	0.6	1.3	0.5	0.8	0.3	1.1	0.7	0.8
Osteoarthritis (self-reported)	0.5	0.6	0.9	-0.7	-0.9	0.0	-0.8	-1.0	-0.8
Miserableness	0.5	0.8	1.3	1.1	1.1	-0.3	0.7	1.1	0.9
Illnesses of father: High blood pressure	0.5	0.6	1.7	-0.5	-0.6	-1.3	0.9	0.6	-0.5
Number of operations (self-reported)	0.5	0.7	1.2	0.8	0.6	-0.7	1.1	0.9	0.7
Age started oral contraceptive pill	0.5	0.6	2.0	-0.4	-0.7	-1.4	-0.1	-0.4	-0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.4	0.7	0.5	-0.1	1.1	1.2	0.6
Alcohol drinker status: Previous	0.5	0.6	0.9	-0.9	-0.7	0.4	-0.9	-0.9	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.6	2.7	0.3	0.1	-1.6	0.6	0.3	0.1
Body Mass Index (BMI) (2010)	0.4	0.5	1.8	0.6	0.3	-0.4	1.4	0.8	0.5
Primary Biliary Cirrhosis	0.4	0.5	2.1	-0.4	-0.2	-1.4	0.7	-0.5	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	0.2	0.7	-0.6	0.8	0.8	0.5
BMI	0.4	2.0	2.8	-1.4	-1.6	0.5	-1.6	-1.7	-1.4
Lung FEV1/FVC ratio	0.4	2.2	8.9	-0.2	-0.1	-3.0	1.6	1.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.3	0.4	0.4	1.1	-0.7	-0.5	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.7	-0.7	-0.5	0.1	-0.7	-1.3	-0.5
Past tobacco smoking	0.4	0.8	2.6	-0.8	-0.8	-1.6	0.1	-0.3	-1.0
Pulse rate	0.4	0.7	2.3	-0.7	-0.5	0.4	-0.8	-1.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.1	1.0	0.7	1.8	-1.5	-0.3	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	-0.7	-0.9	-0.0	-0.8	-0.6	-0.7
Whole body fat mass	0.4	1.7	7.4	0.9	0.8	2.7	-0.3	-0.0	1.0
Supplements: Vitamin C	0.4	0.5	1.2	-0.5	-0.2	-1.1	0.8	0.7	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.5	0.6	-0.4	0.8	0.7	0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.0	1.0	1.0	0.5	0.3	0.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	1.1	1.0	0.7	-0.1	0.4	1.2
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	-0.7	-1.0	0.2	-0.4	-0.5	-0.9
Pain experienced in last month	0.4	0.7	2.2	0.5	0.7	-0.3	0.9	1.5	0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	1.2	1.0	-0.2	0.2	0.5	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	-0.5	-0.6	-0.5	-0.9	-0.5	-0.6
HbA1C	0.3	0.4	1.8	-0.0	-0.2	-1.3	0.5	0.2	-0.4
Lupus	0.3	0.4	1.7	-0.5	-0.4	-1.3	0.6	-0.1	-0.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	0.4	0.6	0.7	-0.7	-0.8	0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	0.2	0.5	0.8	-0.6	-1.0	0.5
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	0.8	0.6	0.7	0.6	0.2	0.6
Stomach or abdominal pain in last month	0.3	0.4	2.0	0.0	-0.2	1.4	0.2	0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	0.9	0.8	0.7	0.1	0.5	0.6
Had other major operations	0.3	0.3	1.6	-0.1	-0.3	-1.3	-0.1	0.0	-0.3
Mouth/teeth dental problems	0.3	0.4	0.8	0.9	0.9	0.4	0.2	0.4	0.9
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	0.8	0.8	0.6	0.1	-0.0	0.9
Neuroticism score	0.3	0.7	2.9	-0.2	-0.4	-1.7	0.4	0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	1.0	0.7	0.0	0.8	0.6	0.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.6	-0.1	-0.3	-1.3	0.7	0.5	-0.2
Overall health rating	0.3	0.6	3.0	0.7	0.4	1.7	0.0	0.2	0.5
Smoking status: Previous	0.3	0.4	2.3	-0.1	-0.0	1.5	-0.5	0.0	0.2
Qualifications: nursing, teaching	0.3	0.4	0.6	0.8	0.7	-0.3	0.2	0.8	0.8
Breast cancer (self-reported)	0.3	0.3	1.8	-0.0	-0.2	1.3	0.0	-0.4	-0.2
Medication: Gliclazide	0.3	0.3	0.4	0.6	0.6	0.3	0.0	0.6	0.7
Commuting to job workplace: Public transport	0.3	0.4	1.2	0.8	0.5	-0.2	-0.1	1.1	0.4
Alcohol drinker status: Never	0.3	0.4	1.6	0.1	0.1	-1.3	0.8	0.2	0.1
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.6	-0.6	0.8	-0.6	-0.6	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	1.3	-0.2	-0.0	0.1	-1.1	-0.2	-0.2
Major Depression (MDD)	0.2	0.3	0.5	0.6	0.5	0.7	0.2	0.6	0.5
Reaction Time	0.2	0.4	1.3	0.3	0.2	1.2	0.0	-1.0	0.2
Crohns Disease (2012)	0.2	0.3	0.5	0.6	0.7	-0.5	-0.2	-0.1	0.7
Blood Platelet Count	0.2	1.8	9.5	0.6	0.7	3.1	-0.2	0.2	0.7
Respiratory disease	0.2	0.5	0.9	0.9	0.9	0.3	0.7	0.2	1.0
Neuroticism	0.2	0.5	1.1	0.8	0.4	-0.6	0.8	1.0	0.2
Sensitivity / hurt feelings	0.2	0.3	1.0	0.3	0.2	-0.4	1.0	0.6	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.7	0.5	0.2	0.6	0.5	0.2
Taking other prescription medications	0.2	0.3	0.6	-0.0	0.0	0.8	-0.7	-0.8	0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.6	0.6	0.1	-0.2	-0.4	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.7	0.0	-0.0	-1.3	0.6	0.5	-0.1
Medication: Levothyroxine sodium	0.2	0.3	0.6	0.6	0.6	-0.1	0.7	0.8	0.5
Qualifications: None of the above	0.2	0.5	0.9	-0.8	-1.0	0.4	0.5	-0.1	-0.8
Allergy	0.2	0.4	1.3	-0.6	-0.5	0.7	-1.1	-0.4	-0.4
Falls in the last year	0.2	0.3	1.2	0.5	0.3	0.1	0.3	1.1	0.1
Number of live births	0.2	0.3	0.6	-0.6	-0.7	0.1	-0.3	-0.3	-0.8
Depression (self-reported)	0.2	0.3	0.4	-0.5	-0.6	0.7	-0.5	-0.5	-0.5
Prospective memory result	0.2	0.2	0.4	-0.6	-0.5	0.3	-0.4	-0.5	-0.5
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.2	-0.5	0.4	-0.5	-0.8	-0.5
Gout (self-reported)	0.2	0.2	0.8	-0.4	-0.2	-0.4	-0.3	-0.9	-0.3
Medication: Amlodipine	0.2	0.2	0.5	-0.6	-0.5	-0.2	-0.2	-0.7	-0.5
Number of full brothers	0.2	0.2	0.6	0.5	0.3	0.5	0.3	0.7	0.4
Age at first live birth	0.2	0.3	0.6	0.4	0.0	-0.8	0.5	0.8	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.7	0.0	0.1	-0.7	0.8	0.0	0.0
Medication: Ibuprofen	0.2	0.2	0.7	0.1	-0.1	0.7	-0.8	-0.4	-0.0
Medication: Allopurinol	0.2	0.3	0.7	-0.5	-0.2	0.5	-0.7	-0.9	-0.2
Age at last live birth	0.2	0.3	0.7	0.7	0.4	0.1	0.3	0.8	0.6
Knee pain experienced in last month	0.2	0.2	0.7	0.3	0.1	-0.7	0.8	0.4	-0.0
Average weekly red wine intake	0.2	0.3	0.5	0.7	0.5	0.6	-0.2	0.2	0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.4	-0.3	0.5	-0.7	-0.5	-0.3
Mood swings	0.2	0.3	1.4	-0.3	-0.3	0.2	-1.2	-0.2	-0.4
Friendships satisfaction	0.2	0.3	0.8	-0.4	-0.4	-0.9	-0.4	-0.5	-0.3
Osteoporosis (self-reported)	0.2	0.3	0.7	-0.5	-0.5	-0.8	-0.1	-0.4	-0.4
Medication: Atorvastatin	0.2	0.2	0.5	-0.3	-0.2	-0.6	0.6	0.7	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.6	-0.5	0.3	-0.7	-0.2	-0.3
Ever depressed for a whole week	0.2	0.3	0.4	0.7	0.5	-0.6	0.4	0.5	0.6
Supplements: Calcium	0.2	0.2	1.1	0.2	0.1	-1.0	0.3	-0.0	-0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.5	0.3	0.1	0.7	0.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.3	-0.6	0.2	-0.5	-0.8	-0.6
Neuroticism (Nagel 2018)	0.1	0.3	1.2	0.4	0.1	-1.1	0.6	0.3	-0.1
Triglycerides	0.1	0.2	0.8	-0.0	0.2	0.9	-0.1	0.4	0.3
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.5	-0.5	-0.1	-0.4	-0.4	-0.5
Average weekly spirits intake	0.1	0.1	0.4	-0.3	-0.1	0.6	-0.4	-0.3	0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.6	0.3	0.3	0.8	-0.1	0.3	0.3
Supplements: Zinc	0.1	0.1	0.2	0.3	0.3	0.4	0.3	0.2	0.2
Body mass index (BMI)	0.1	0.3	0.9	-0.3	-0.4	0.9	-0.7	-0.4	-0.2
Nervous feelings	0.1	0.3	1.1	0.1	-0.1	-0.2	0.6	1.1	-0.4
Had menopause	0.1	0.1	0.3	-0.1	0.1	-0.4	0.5	-0.3	0.0
Hip circumference	0.1	0.3	0.8	-0.5	-0.4	0.5	-0.9	-0.7	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.3	-0.6	0.3	-0.5	-0.3	-0.5
Medication: Cholesterol lowering	0.1	0.1	0.4	-0.3	-0.3	0.6	-0.1	0.4	-0.0
Arm fat mass (right)	0.1	0.3	1.3	0.0	-0.1	1.1	-0.4	-0.3	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.1	-0.1	0.4	-0.6	-0.3	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.5	0.4	-0.4	0.1	0.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	-0.5	-0.4	-0.1	-0.4	-0.4	-0.5
Comparative body size at age 10	0.1	0.2	0.6	-0.2	-0.2	0.3	-0.6	-0.8	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.1	0.1	0.7	-0.5	-0.6	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.5	-0.0	-0.1	0.1	-0.7	-0.5	-0.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	-0.1	-0.0	-0.6	0.0	-0.5	-0.1
Neck or shoulder pain in last month	0.1	0.2	0.5	0.5	0.2	0.7	0.1	0.6	0.3
Mean time to correctly identify matches	0.1	0.3	1.0	-0.2	-0.2	0.7	-0.2	-1.0	-0.1
Arm fat mass (left)	0.1	0.4	1.9	0.3	0.2	1.4	-0.2	-0.0	0.4
Guilty feelings	0.1	0.1	0.2	0.4	0.1	-0.5	0.3	0.2	0.0
Mother’s age at death	0.1	0.1	0.2	-0.5	-0.3	-0.4	-0.1	-0.3	-0.3
Financial situation satisfaction	0.1	0.1	0.3	0.0	-0.1	-0.5	0.0	0.4	-0.2
Irritability	0.1	0.2	1.1	0.1	0.1	0.2	-1.1	-0.4	0.1
Heart disease (siblings)	0.1	0.1	0.2	-0.3	-0.5	0.0	-0.3	0.1	-0.4
Ovarian Cancer	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.1	-0.4	-0.0
Age at First Birth	0.0	0.1	0.2	-0.4	0.1	0.2	-0.5	-0.1	0.0
Fasting Glucose	0.0	0.1	0.1	-0.0	0.0	-0.3	0.4	0.2	-0.0
Blood Eosinophil Count	0.0	0.2	0.5	0.3	0.3	0.7	0.5	0.1	0.3
Blood Red Count	0.0	0.4	1.8	0.3	0.3	1.3	-0.5	-0.5	0.4
Blood White Count	0.0	0.4	2.0	-0.1	-0.0	1.4	0.1	0.3	0.0
Chronotype (morning person)	0.0	0.1	0.2	-0.5	-0.3	-0.3	0.2	0.4	-0.2
Hair Pigment	0.0	0.7	1.7	0.7	0.4	-0.8	0.9	1.3	0.5
Tanning	0.0	0.6	1.3	0.3	1.1	-0.1	1.0	0.4	1.1
Number of treatments/medications taken	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.0	-0.4	-0.3
Peak expiratory flow (PEF)	0.0	0.1	0.4	0.2	-0.2	-0.7	-0.1	-0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.0	0.1	-0.1
Ever had bowel cancer screening	0.0	0.0	0.2	0.0	-0.0	-0.5	-0.2	0.1	0.1

Hub : Genes

WDR92

Models

Trait associations