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chr5:41,726,855-43,577,190

Best TWAS P=2.52e-20 · Best GWAS P=1.49e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	YFS	Blood	CCDC152	0.07	0.06	enet	16	0.06	2.0e-19	9.0	9.2	2.5e-20	0.47	0.03	0.97	TRUE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC152	0.15	0.12	lasso	6	0.12	1.0e-12	8.7	-8.7	3.7e-18	-0.46	0.11	0.89	TRUE
9	GTEx	Esophagus Muscularis	CCDC152	0.13	0.09	lasso	8	0.10	7.9e-07	7.9	7.7	1.4e-14	0.48	0.05	0.95	TRUE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEPP1	0.01	0.00	enet	7	0.01	1.5e-03	8.7	-7.1	1.3e-12	-0.39	0.02	0.58	TRUE
11	GTEx	Stomach	SERBP1P6	0.12	0.03	enet	16	0.01	6.7e-02	-4.1	6.9	4.7e-12	0.24	0.08	0.13	TRUE
10	GTEx	Nerve Tibial	CCDC152	0.16	0.06	enet	25	0.06	2.9e-05	8.9	6.1	9.8e-10	0.19	0.05	0.94	TRUE
7	GTEx	Brain Frontal Cortex BA9	GHR	0.14	0.02	lasso	9	0.06	9.9e-03	7.4	-6.0	1.8e-09	-0.31	0.13	0.05	TRUE
8	GTEx	Breast Mammary Tissue (Female)	SEPP1	0.15	0.00	enet	29	0.02	1.0e-01	-1.5	-5.2	2.4e-07	-0.23	0.06	0.12	TRUE
2	GTEx	Adipose Subcutaneous	CCDC152	0.09	0.04	lasso	4	0.02	6.4e-03	9.0	9.1	1.0e-19	0.46	0.03	0.96	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	SEPP1	0.18	0.19	lasso	11	0.21	1.3e-26	8.5	-9.0	1.8e-19	-0.48	0.03	0.97	FALSE
12	GTEx	Thyroid	CCDC152	0.10	0.07	lasso	4	0.04	4.2e-04	8.9	9.0	2.7e-19	0.45	0.03	0.96	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC152	0.06	0.06	blup	40	0.07	1.6e-08	8.4	-9.0	3.1e-19	-0.43	0.03	0.97	FALSE
5	GTEx	Artery Coronary	CCDC152	0.20	0.13	lasso	2	0.12	7.7e-05	8.9	9.0	3.3e-19	0.46	0.04	0.95	FALSE
3	GTEx	Adipose Visceral Omentum	CCDC152	0.09	0.06	lasso	9	0.05	1.9e-03	8.9	8.5	2.6e-17	0.45	0.04	0.79	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	GHR	0.12	0.11	enet	6	0.13	2.5e-13	-7.5	-8.3	6.6e-17	-0.26	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEPP1	0.06	0.02	blup	38	0.04	5.2e-05	7.9	-8.3	1.2e-16	-0.40	0.12	0.85	FALSE
4	GTEx	Artery Aorta	CCDC152	0.31	0.24	lasso	8	0.24	2.5e-13	8.9	8.2	2.3e-16	0.45	0.04	0.96	FALSE
6	GTEx	Artery Tibial	CCDC152	0.22	0.17	enet	35	0.18	1.8e-14	8.9	7.0	2.9e-12	0.43	0.04	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GHR	0.25	0.07	bslmm	382	0.13	2.6e-15	-6.0	6.2	6.6e-10	0.20	0.19	0.81	FALSE