Best TWAS P=1.93e-10 · Best GWAS P=3.03e-11 conditioned to 0.0104
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PPP3R1 | 0.25 | 0.22 | lasso | 4 | 0.26 | 5.4e-20 | -6.0 | -6.3 | 2.4e-10 | 0.50 | 0.17 | 0.83 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-474G23.2 | 0.17 | 0.14 | lasso | 3 | 0.12 | 2.3e-09 | -6.0 | -6.3 | 2.8e-10 | 0.45 | 0.17 | 0.83 | FALSE |
| 3 | METSIM | Adipose | PNO1 | 0.10 | 0.12 | enet | 23 | 0.12 | 1.4e-17 | -6.5 | -5.9 | 2.8e-09 | 0.97 | 0.01 | 0.99 | FALSE |
| 4 | NTR | Blood | CNRIP1 | 0.04 | 0.03 | lasso | 4 | 0.04 | 4.7e-12 | -6.6 | -5.5 | 3.2e-08 | 0.92 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | WDR92 | 0.04 | 0.01 | blup | 49 | 0.01 | 7.9e-03 | -6.0 | -6.4 | 1.9e-10 | 0.80 | 0.02 | 0.58 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | PNO1 | 0.04 | 0.03 | blup | 41 | 0.04 | 1.1e-04 | -6.5 | -5.4 | 5.5e-08 | 0.93 | 0.01 | 0.96 | FALSE |