Best TWAS P=1.65e-10 · Best GWAS P=4.95e-12 conditioned to 0.000335
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CRELD1 | 0.46 | 0.16 | enet | 51 | 0.27 | 2.2e-22 | -5.3 | -5.4 | 6.4e-08 | 0.07 | 0.06 | 0.94 | FALSE |
2 | GTEx | Adipose Visceral Omentum | CRELD1 | 0.19 | 0.12 | lasso | 4 | 0.10 | 4.1e-06 | -5.3 | -5.1 | 2.8e-07 | -0.02 | 0.06 | 0.80 | FALSE |
3 | GTEx | Artery Aorta | CRELD1 | 0.30 | 0.07 | lasso | 7 | 0.12 | 2.4e-07 | -5.3 | -5.2 | 1.7e-07 | 0.03 | 0.06 | 0.92 | FALSE |
4 | GTEx | Artery Aorta | RP11-1020A11.1 | 0.15 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | -5.3 | -5.9 | 3.7e-09 | -0.03 | 0.03 | 0.54 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | CRELD1 | 0.39 | 0.19 | enet | 39 | 0.28 | 4.5e-21 | -5.3 | -5.8 | 7.0e-09 | 0.04 | 0.06 | 0.94 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | HRH1 | 0.20 | 0.00 | lasso | 3 | 0.01 | 1.1e-01 | 6.9 | -6.0 | 1.8e-09 | -0.77 | 0.00 | 0.95 | TRUE |
7 | GTEx | Cells Transformed fibroblasts | RP11-1020A11.1 | 0.20 | 0.10 | enet | 67 | 0.09 | 1.9e-07 | -5.3 | -5.2 | 2.3e-07 | 0.01 | 0.06 | 0.93 | FALSE |
8 | GTEx | Esophagus Muscularis | CRELD1 | 0.21 | 0.10 | lasso | 1 | 0.08 | 1.7e-05 | -5.3 | -5.3 | 1.1e-07 | -0.02 | 0.06 | 0.87 | FALSE |
9 | GTEx | Skin Not Sun Exposed Suprapubic | AC034193.5 | 0.15 | 0.09 | enet | 11 | 0.08 | 3.3e-05 | 4.9 | 5.2 | 2.5e-07 | 0.02 | 0.33 | 0.58 | FALSE |
10 | GTEx | Testis | CRELD1 | 0.22 | 0.22 | lasso | 8 | 0.26 | 1.1e-11 | 4.9 | -6.4 | 1.6e-10 | 0.00 | 0.13 | 0.87 | TRUE |
11 | METSIM | Adipose | BRK1 | 0.04 | 0.02 | bslmm | 559 | 0.01 | 8.9e-03 | 4.4 | -5.3 | 1.4e-07 | -0.04 | 0.15 | 0.68 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | AC022007.5 | 0.05 | 0.02 | blup | 515 | 0.03 | 2.8e-04 | 5.5 | 5.3 | 9.2e-08 | 0.02 | 0.04 | 0.96 | FALSE |
13 | YFS | Blood | FANCD2 | 0.04 | 0.04 | lasso | 1 | 0.04 | 7.7e-13 | 5.4 | -5.4 | 7.7e-08 | -0.06 | 0.03 | 0.97 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CIDECP | 0.04 | 0.02 | blup | 33 | 0.03 | 3.8e-04 | 4.9 | 5.4 | 7.1e-08 | 0.00 | 0.04 | 0.90 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC401052 | 0.06 | 0.07 | enet | 6 | 0.06 | 3.5e-07 | 5.6 | -5.5 | 4.3e-08 | -0.05 | 0.01 | 0.99 | FALSE |