TWAS hub - FANCD2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.1140	0.0430	3.8e-04	0.015	NA	0.009	NA	0.002	2.4e-02	NA	6.4e-02	NA	2.2e-01
2	YFS	Blood	0.0438	0.0132	1.4e-09	0.040	0.03	0.032	0.033	0.039	3.5e-13	2.8e-10	8.4e-11	6.2e-11	7.7e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Commuting to job workplace: Walk	5.5	5.9	7.8	-2.8	-2.0
Bilateral oophorectomy (both ovaries removed)	5.0	5.7	6.6	-2.2	-2.6
Smoking Status	4.4	10.5	10.7	-3.2	-3.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.1	4.9	6.8	1.8	2.6
Leg fat-free mass (right)	4.1	21.9	35.6	-2.9	-6.0
Ulcerative Colitis	4.0	5.8	8.0	1.9	2.8
Comparative height size at age 10	4.0	22.1	25.1	-4.4	-5.0
Leg predicted mass (right)	4.0	21.6	35.2	-2.8	-5.9
Leg fat-free mass (left)	3.9	20.7	34.3	-2.7	-5.9
Leg predicted mass (left)	3.9	20.5	33.8	-2.7	-5.8
Arm predicted mass (left)	3.9	19.7	34.8	-2.2	-5.9
Basal metabolic rate	3.8	20.9	35.8	-2.5	-6.0
Whole body fat-free mass	3.7	21.1	35.5	-2.6	-6.0
Whole body water mass	3.7	21.3	36.0	-2.6	-6.0
Arm fat-free mass (left)	3.6	18.2	32.3	-2.0	-5.7
Weight	3.4	16.5	29.3	-1.9	-5.4
Illnesses of siblings	3.3	4.7	6.2	1.8	2.5
Trunk fat-free mass	3.3	18.7	32.1	-2.3	-5.7
Arm fat-free mass (right)	3.2	16.5	29.3	-1.9	-5.4
Arm predicted mass (right)	3.2	16.2	28.8	-1.9	-5.4
Knee pain experienced in last month	3.2	5.0	6.3	-1.9	-2.5
Trunk predicted mass	3.1	17.9	30.8	-2.2	-5.6
Sitting height	3.0	21.3	29.1	-3.7	-5.4
Medication: Atorvastatin	3.0	3.7	6.7	0.8	2.6
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	7.1	0.7	2.7
Hip circumference	2.9	12.5	23.4	-1.2	-4.8
Worry too long after embarrassment	2.9	4.8	8.8	0.9	3.0
Ulcerative Colitis (UC)	2.7	5.0	8.7	1.1	2.9
Length of working week for main job	2.7	3.0	3.4	-1.6	-1.9
Heart disease (mother)	2.7	3.3	5.1	-1.2	-2.2
Standing height	2.6	26.1	33.8	-4.3	-5.8
Medication: Seretide 50 evohaler	2.6	3.0	5.3	2.3	0.9
Serious illness, injury or assault to yourself	2.5	3.0	3.3	-1.8	-1.6
Time employed in main current job	2.2	2.5	5.0	-0.2	2.2
Birth weight	2.2	4.8	6.0	-1.9	-2.5
Migraine (self-reported)	2.2	2.7	4.1	-1.1	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	6.2	-1.7	-2.5
Smoking status: Current	2.2	3.5	5.5	-2.4	-1.2
Height	2.1	41.2	51.1	-5.6	-7.2
Supplements: Glucosamine	2.1	2.7	3.0	1.7	1.5
Handedness (chirality/laterality): Left-handed	2.1	2.5	5.0	-2.2	-0.3
Current tobacco smoking	1.9	3.1	4.0	-2.0	-1.5
Past tobacco smoking	1.9	3.4	5.0	2.2	1.4
Eye problems/disorders: Cataract	1.9	2.2	2.5	-1.6	-1.4
Medication: Aspirin	1.9	2.4	4.6	-0.5	-2.1
Primary Biliary Cirrhosis	1.8	2.6	2.9	-1.5	-1.7
BMI	1.8	10.4	20.5	-0.6	-4.5
Trunk fat mass	1.8	7.7	14.2	-1.1	-3.8
Medication: Aspirin	1.8	2.4	4.6	-0.4	-2.1
Long-standing illness, disability or infirmity	1.8	2.8	3.9	-1.3	-2.0
Risk taking	1.8	2.7	3.5	-1.9	-1.4
Alcohol intake versus 10 years previously	1.7	2.5	4.5	-0.7	-2.1
Headache pain in last month	1.7	3.0	3.9	-1.4	-2.0
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	3.3	1.8	0.8
Arm fat mass (left)	1.7	7.0	13.4	-0.8	-3.7
Medication: Bendroflumethiazide	1.7	2.6	3.3	1.4	1.8
Medication: Co-codamol	1.6	1.8	3.4	-0.5	-1.8
Average weekly fortified wine intake	1.5	1.8	2.9	1.7	0.8
Waist circumference	1.5	5.7	11.3	-0.3	-3.4
Forced vital capacity (FVC)	1.5	5.9	7.5	-2.1	-2.7
Happiness	1.5	1.9	1.9	1.4	1.4
Arm fat mass (right)	1.5	6.4	12.2	-0.7	-3.5
High blood pressure (siblings)	1.5	2.2	3.2	-1.0	-1.8
Whole body fat mass	1.5	6.4	12.2	-0.8	-3.5
Osteoarthritis (self-reported)	1.5	1.9	3.6	-0.4	-1.9
Leg fat mass (left)	1.5	5.8	11.2	-0.6	-3.3
Impedance of leg (right)	1.4	6.8	12.5	1.0	3.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.5	-1.0	-1.6
Smoking status: Previous	1.4	2.1	3.4	-1.0	-1.8
Coronary Artery Disease (CAD)	1.3	1.5	2.0	1.4	1.0
Number of treatments/medications taken	1.3	2.3	3.0	-1.7	-1.2
Impedance of leg (left)	1.3	6.3	11.9	0.8	3.5
Mouth/teeth dental problems	1.3	2.0	2.8	1.1	1.7
Medication: Lansoprazole	1.3	1.5	1.6	-1.2	-1.3
Forced vital capacity (FVC), Best measure	1.3	4.7	6.0	-1.8	-2.4
Leg fat mass (right)	1.3	5.0	9.8	-0.5	-3.1
Supplements: Vitamin C	1.3	1.5	1.8	-1.4	-1.1
Asthma (self-reported)	1.3	2.6	2.7	1.6	1.6
Ever smoked	1.3	2.3	3.2	-1.8	-1.1
Cholesterol lowering medication	1.3	2.0	3.9	0.1	2.0
Supplements: Calcium	1.3	1.4	1.6	1.1	1.3
Fluid intelligence score	1.2	2.5	2.7	-1.5	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.3	0.7	-1.5
Number of children fathered	1.2	1.4	1.8	1.3	1.0
Mean time to correctly identify matches	1.2	2.2	4.3	0.4	2.1
Back pain experienced in last month	1.2	1.7	2.7	-1.6	-0.8
Pain experienced in last month	1.2	2.1	3.4	0.8	1.9
Irritable Bowel Disease (IBD)	1.1	2.7	4.5	0.9	2.1
Heel T-Score	1.1	8.8	12.0	2.4	3.5
Fed-up feelings	1.1	1.9	2.1	1.4	1.3
Body mass index (BMI)	1.1	4.6	9.2	-0.1	-3.0
Allergy	1.1	2.6	3.6	-1.9	-1.3
Asthma	1.1	2.1	2.3	1.4	1.5
Gout (self-reported)	1.1	1.5	2.0	-1.4	-1.0
Medication: Allopurinol	1.1	1.5	1.7	-1.1	-1.3
Age at last live birth	1.1	1.6	2.9	0.6	1.7
Average weekly red wine intake	1.1	1.6	3.1	-0.3	-1.8
Guilty feelings	1.1	1.7	2.6	0.8	1.6
Ever taken oral contraceptive pill	1.1	1.3	2.5	-0.1	-1.6
Fractured/broken bones in last 5 years	1.1	1.5	2.5	-1.6	-0.7
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.5	-1.9	-0.6
Angina	1.0	1.3	2.6	-0.3	-1.6
Diabetes (mother)	1.0	1.2	2.3	1.5	0.4
Hayfever, allergic rhinitis or eczema	1.0	2.3	2.3	1.5	1.5
Angina (self-reported)	1.0	1.3	2.6	-0.3	-1.6
Mineral and other dietary supplements	1.0	1.3	1.4	-1.1	-1.2
Alcohol drinker status: Never	1.0	1.3	2.1	-0.6	-1.5
Impedance of whole body	1.0	5.3	10.4	0.4	3.2
Bipolar Disorder (2011)	0.9	0.8	1.7	1.3	0.1
Allergy or Eczema	0.9	2.3	3.0	1.7	1.2
Hypothyroidism (self reported)	0.9	2.0	3.1	1.8	0.9
Hearing difficulty/problems: Yes	0.9	1.4	1.4	-1.2	-1.2
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.0	1.4	0.1
Medication: Ramipril	0.9	1.2	1.8	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	4.0	-1.4	-2.0
Qualifications: College or University degree	0.9	3.0	5.6	2.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	1.5	-1.1	-1.2
Osteoporosis (self-reported)	0.9	1.1	2.1	0.5	1.4
Number of operations (self-reported)	0.9	1.4	2.7	0.1	-1.7
Age started oral contraceptive pill	0.9	1.1	2.0	0.5	1.4
Ovarian Cancer	0.8	1.1	2.0	-1.4	-0.5
Prostate Cancer	0.8	1.1	2.0	1.4	0.4
Trunk fat percentage	0.8	3.1	6.0	-0.5	-2.5
Had other major operations	0.8	1.0	1.7	1.3	0.6
Financial difficulties in last 2 years	0.8	1.1	1.7	0.8	1.3
Heart attack	0.8	1.0	1.4	-1.2	-0.7
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.7	1.3	0.5
Exposure to tobacco smoke outside home	0.8	1.0	1.3	-1.1	-0.9
Shortness of breath walking on level ground	0.8	1.0	1.6	1.3	0.6
Neck or shoulder pain in last month	0.8	1.1	2.0	0.5	-1.4
Alcohol intake frequency.	0.8	1.9	3.8	-0.0	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.5	-0.7	-1.2
Pain type(s) experienced in last month: Hip pain	0.8	1.1	2.0	0.3	-1.4
Reaction Time	0.7	1.3	2.0	0.8	1.4
Breast Cancer	0.7	1.6	2.3	-1.5	-0.9
Chronotype (morning person)	0.7	1.7	3.1	-0.5	-1.8
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	-1.2	0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.1	1.5	0.9
Tense / ‘highly strung’	0.7	1.1	1.8	0.6	1.3
Pulse wave reflection index	0.7	0.8	1.1	0.7	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	-1.3	0.5
Medication: Omeprazole	0.7	0.9	1.7	1.3	-0.2
Had major operations	0.7	0.8	1.5	-0.3	-1.2
Miserableness	0.7	1.1	1.2	-1.0	-1.1
Wears glasses or contact lenses	0.7	0.9	1.5	1.2	0.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.1	0.7	1.1
Commuting to job workplace: Cycle	0.7	0.8	1.6	-0.2	1.2
Neuroticism (Nagel 2018)	0.6	1.3	2.4	-0.5	1.5
Sensitivity / hurt feelings	0.6	1.0	1.9	0.1	1.4
Diabetes (father)	0.6	0.7	1.1	0.6	1.1
Taking other prescription medications	0.6	0.9	1.4	-1.2	-0.6
Stomach or abdominal pain in last month	0.6	0.8	1.3	0.5	-1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-1.2	-0.1
Medication: Levothyroxine sodium	0.6	1.0	1.1	-0.9	-1.1
Hearing difficulty/problems with background noise	0.6	0.9	1.4	1.2	0.7
Pain all over the body in last month	0.6	0.7	1.3	-0.2	-1.2
Arm fat percentage (right)	0.6	2.3	4.5	-0.3	-2.1
Pulse rate	0.6	1.1	1.5	1.2	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	2.0	-1.3	-1.4
Impedance of arm (left)	0.6	2.6	5.1	-0.3	2.2
Breastfed as a baby	0.6	0.7	0.8	0.9	0.8
Age at first live birth	0.6	1.1	1.9	0.6	1.4
Illnesses of siblings: Diabetes	0.6	0.7	0.9	-0.7	-1.0
Diabetes diagnosed by doctor	0.6	0.9	1.7	-1.3	-0.4
Friendships satisfaction	0.6	0.7	0.9	1.0	0.7
Breast cancer (self-reported)	0.6	0.8	1.3	-1.2	0.4
High cholesterol (Self-reported)	0.6	1.1	2.1	0.4	1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	0.7	0.8	-0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.2	-1.1	-0.6
Heart disease (siblings)	0.6	0.7	0.7	-0.8	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.6	0.7	-0.7	0.9
HbA1C	0.5	0.6	1.0	-1.0	-0.4
HDL Cholesterol	0.5	0.8	1.3	0.6	1.1
Neuroticism (2016)	0.5	0.7	1.3	-1.1	0.3
Rheumatoid Arthritis	0.5	0.7	1.0	0.7	-1.0
Schizophrenia (2014)	0.5	1.0	1.1	1.0	1.0
Blood Eosinophil Count	0.5	3.7	3.7	1.9	1.9
Respiratory disease	0.5	1.0	1.6	1.3	0.6
Lung FEV1/FVC ratio	0.5	2.8	4.7	0.9	2.2
Neuroticism	0.5	1.1	2.2	0.3	1.5
Relative age of first facial hair	0.5	1.1	1.9	-0.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.9	-1.0	0.5
Medication: Metformin	0.5	0.8	1.4	-1.2	-0.3
Neuroticism score	0.5	1.1	1.9	0.6	1.4
Impedance of arm (right)	0.5	2.5	4.7	-0.4	2.2
Number of live births	0.5	0.6	0.8	0.9	0.7
Loud music exposure frequency	0.5	0.6	1.1	-0.1	1.1
Body fat percentage	0.5	1.9	3.8	-0.1	-2.0
Wheeze or whistling in the chest in last year	0.5	0.8	1.1	1.0	-0.8
Eye problems/disorders: None of the above	0.5	0.6	0.7	0.8	0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	-1.1	-0.3
Arm fat percentage (left)	0.5	2.1	4.2	-0.2	-2.0
Loneliness, isolation	0.5	0.6	0.7	0.8	0.8
Medication for cholesterol	0.5	0.8	1.2	1.1	0.6
Average weekly beer plus cider intake	0.5	0.7	1.3	0.4	1.1
Basal cell carcinoma (self-reported)	0.5	0.5	0.8	0.9	0.6
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	-0.1	1.3
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.5	-0.4	-1.6
Verbal and Numeric Reasoning (VNR)	0.4	0.8	1.5	-0.4	-1.2
Age at First Birth	0.4	0.6	0.8	0.7	-0.9
LDL Cholesterol	0.4	0.7	1.0	-0.6	1.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	-0.2	1.0
Medication for hormone replacement therapy	0.4	0.5	0.6	-0.6	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.6	1.3	-0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	0.1	1.0
Father’s age at death	0.4	0.6	0.7	-0.9	-0.7
Emphysema/chronic bronchitis	0.4	0.4	0.5	0.6	-0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	0.9	-0.6	1.0
Medication: Ibuprofen	0.4	0.5	0.6	-0.6	-0.8
Family relationship satisfaction	0.4	0.5	0.6	0.6	0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.6	0.8	0.7
Illnesses of father: High blood pressure	0.4	0.5	0.9	1.0	-0.2
Irritability	0.4	0.6	1.1	-0.4	-1.0
Worry (Nagel 2018)	0.3	0.6	1.3	-0.0	1.1
Fasting Glucose	0.3	0.4	0.6	0.5	0.8
Waist Hip Ratio (WHR)	0.3	1.4	1.5	1.1	1.2
Cardiovascular Disease	0.3	1.1	1.5	-0.8	-1.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.2	-0.8
Vitamin and mineral supplements	0.3	0.3	0.6	-0.3	-0.8
Hand grip strength (right)	0.3	0.8	1.0	-0.8	-1.0
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.9	0.0
Maternal smoking around birth	0.3	0.4	0.7	0.4	0.8
Alcohol usually taken with meals	0.3	0.6	1.1	-1.0	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	-1.0	0.2
Qualifications: None of the above	0.3	0.6	1.0	-1.0	0.5
Diabetes (self-reported)	0.3	0.4	0.7	-0.9	0.2
Depression (self-reported)	0.3	0.3	0.4	-0.6	0.5
Lung cancer (father)	0.3	0.3	0.6	-0.8	0.1
Birth weight of first child	0.3	0.6	1.1	-1.1	-0.3
Number of full brothers	0.3	0.4	0.7	-0.8	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.5	0.5	0.7
Pulse wave peak to peak time	0.3	0.4	0.7	-0.3	-0.8
Overall health rating	0.3	0.6	0.9	0.9	0.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	-0.1	0.8
Medication: Gliclazide	0.3	0.3	0.5	0.3	0.7
Medication: Blood pressure	0.3	0.6	1.0	-0.5	-1.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	0.9	0.9	1.0
Bipolar Disorder (2018)	0.2	0.3	0.6	0.7	-0.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.6	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.2	-0.5	0.4
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	-0.7	0.3
Blood Platelet Count	0.2	2.4	4.8	2.2	0.4
Tanning	0.2	2.8	4.8	-0.9	-2.2
Supplements: Zinc	0.2	0.2	0.3	-0.5	0.3
Severe depression (siblings)	0.2	0.3	0.3	0.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.3	-0.4	-0.6
Age when periods started (menarche)	0.2	0.6	0.9	0.5	-0.9
Had menopause	0.2	0.2	0.2	0.5	0.4
Falls in the last year	0.2	0.3	0.4	-0.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	-0.4	-0.6
Illnesses of mother	0.2	0.2	0.4	-0.1	0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.0	0.6
Peak expiratory flow (PEF)	0.2	0.5	1.0	-0.1	-1.0
Glaucoma (self-reported)	0.2	0.3	0.4	0.3	0.6
Medication: Amlodipine	0.2	0.3	0.5	0.4	0.7
Leg fat percentage (right)	0.2	0.8	0.9	0.8	-0.9
Suffer from ‘nerves’	0.2	0.3	0.6	-0.0	-0.8
Mother’s age at death	0.2	0.2	0.3	-0.6	-0.4
Financial situation satisfaction	0.2	0.3	0.5	-0.2	-0.7
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.2	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.6	0.3
Medication: Paracetamol	0.2	0.3	0.5	-0.7	-0.2
Medication: Lisinopril	0.2	0.3	0.4	-0.4	-0.6
Leg fat percentage (left)	0.2	0.9	1.3	0.7	-1.1
Diastolic blood pressure, automated reading	0.2	0.5	0.8	-0.9	-0.5
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.7	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	0.6	0.3
Depression (Nagel 2018)	0.1	0.1	0.2	-0.5	-0.1
Schizophrenia (2018)	0.1	0.2	0.3	0.1	0.5
Crohns Disease (2017)	0.1	0.1	0.3	0.0	0.5
Major Depression (MDD)	0.1	0.1	0.2	-0.5	-0.1
Triglycerides	0.1	0.2	0.4	-0.2	0.6
Blood Red Count	0.1	0.7	1.4	1.2	0.2
Systolic Blood Pressure	0.1	0.4	0.8	-0.9	0.3
Lung FVC	0.1	0.7	0.8	-0.9	-0.7
Hair Pigment	0.1	3.0	4.1	-1.4	-2.0
Hand grip strength (left)	0.1	0.3	0.4	-0.3	-0.6
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	0.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.1	-0.4
Systolic blood pressure, automated reading	0.1	0.2	0.4	-0.6	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.2	-0.4	-0.4
Pack years adult smoking proportion	0.1	0.2	0.4	0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	0.2	-0.6
High blood pressure	0.1	0.2	0.3	-0.5	-0.4
Multivitamins +/- minerals	0.1	0.1	0.2	0.3	-0.4
High blood pressure (mother)	0.1	0.1	0.2	0.4	0.1
Number of incorrect matches in round	0.1	0.2	0.5	-0.1	0.7
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.5	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.1	-0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.6	-0.3
Noisy workplace	0.1	0.1	0.2	0.2	0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.7	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.4	-0.5
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.5	-0.1
Medication: Paracetamol	0.1	0.1	0.3	0.1	0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.3	0.4
Health satisfaction	0.1	0.1	0.2	0.4	-0.3
Medication: Blood pressure	0.1	0.1	0.2	-0.2	-0.4
Pulse rate, automated reading	0.1	0.3	0.4	-0.7	0.4
Number of full sisters	0.1	0.2	0.3	0.6	0.1
Chest pain or discomfort	0.1	0.1	0.2	0.2	-0.5
Leg pain on walking	0.1	0.1	0.2	-0.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	0.1	-0.6
Illnesses of father: Heart disease	0.1	0.2	0.3	0.2	-0.6
Ever had bowel cancer screening	0.1	0.1	0.2	0.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.5	-0.1
Qualifications: nursing, teaching	0.1	0.1	0.1	0.3	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	-0.3	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.7	-0.0
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	0.3	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	-0.6	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.1	-0.5
Pack years of smoking	0.1	0.1	0.2	0.4	-0.0
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.1	0.2
Crohns Disease (2012)	0.0	0.1	0.1	-0.3	-0.0
Mean Putamen Volume	0.0	0.0	0.0	0.2	-0.1
Lupus	0.0	0.0	0.0	0.1	-0.1
Blood White Count	0.0	0.4	0.7	-0.2	-0.8
Average weekly spirits intake	0.0	0.0	0.0	0.2	-0.0
Relative age voice broke	0.0	0.0	0.0	0.2	0.1
Qualifications: CSEs or equivalent	0.0	0.1	0.1	0.3	0.3
Medication: Atenolol	0.0	0.0	0.0	-0.1	-0.1
Nervous feelings	0.0	0.1	0.1	0.3	0.2
Medication: Simvastatin	0.0	0.1	0.1	-0.0	-0.3
Worrier / anxious feelings	0.0	0.1	0.1	-0.2	0.2
Medication: Cholesterol lowering	0.0	0.0	0.0	0.1	0.0
Prospective memory result	0.0	0.0	0.0	-0.1	0.2
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.3	-0.0
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	0.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.0	0.2
Comparative body size at age 10	0.0	0.1	0.1	0.3	-0.4
Hypertension (Self-reported)	0.0	0.1	0.2	-0.4	-0.0
Mood swings	0.0	0.1	0.1	-0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	0.3	0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.1	0.0	0.3
Hearing aid user	0.0	0.0	0.0	-0.1	-0.1
Ever depressed for a whole week	0.0	0.0	0.0	0.1	0.2
Myopia	0.0	0.0	0.1	0.1	-0.3

Hub : Genes

FANCD2

Models

Trait associations