TWAS hub - LOC401052

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0240	0.0230	9.1e-03	0.017	0.019	0.006	NA	0.016	4.9e-03	2.7e-03	6.5e-02	NA	5.1e-03
2	TCGA	Prostate Adenocarcinoma	0.0636	0.0411	5.5e-07	0.066	0.063	0.063	NA	0.062	1.9e-07	3.9e-07	3.5e-07	NA	4.3e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Reproduciblity of spirometry measurement using ERS/ATS criteria	7.0	8.4	8.5	-2.9	2.9
Ulcerative Colitis	6.5	9.4	10.5	-3.2	2.9
Leg fat-free mass (right)	5.6	30.0	36.9	4.8	-6.1
Leg predicted mass (right)	5.6	29.9	36.5	4.8	-6.0
Arm predicted mass (left)	5.6	28.5	35.5	4.6	-6.0
Medication: Aspirin	5.5	7.2	10.4	3.2	-2.0
Leg fat-free mass (left)	5.4	28.8	35.8	4.7	-6.0
Leg predicted mass (left)	5.4	28.4	35.2	4.7	-5.9
Weight	5.4	26.6	30.7	4.7	-5.5
Long-standing illness, disability or infirmity	5.2	8.0	12.1	3.5	-1.9
Basal metabolic rate	5.2	28.8	36.6	4.6	-6.0
Arm fat-free mass (left)	5.2	26.5	32.7	4.5	-5.7
Medication: Co-codamol	5.1	5.9	7.4	2.7	-2.1
Hip circumference	5.0	21.5	24.0	4.4	-4.9
Whole body water mass	5.0	28.4	36.5	4.5	-6.0
Whole body fat-free mass	4.9	28.0	36.1	4.5	-6.0
Arm fat-free mass (right)	4.8	24.5	29.8	4.4	-5.5
Arm predicted mass (right)	4.7	24.1	30.0	4.3	-5.5
Illnesses of siblings	4.6	6.5	6.8	-2.6	2.5
Medication: Aspirin	4.4	5.8	7.4	2.7	-2.0
Knee pain experienced in last month	4.3	6.7	7.1	2.5	-2.7
Trunk fat-free mass	4.1	23.5	31.9	3.9	-5.6
Ulcerative Colitis (UC)	3.9	7.3	9.0	-2.4	3.0
Trunk predicted mass	3.9	22.3	30.5	3.7	-5.5
Comparative height size at age 10	3.9	21.5	25.4	4.2	-5.0
Time employed in main current job	3.8	4.4	5.6	-1.8	2.4
Worry too long after embarrassment	3.8	6.4	7.6	-2.3	2.8
Commuting to job workplace: Walk	3.8	4.1	4.5	2.1	-1.9
Bilateral oophorectomy (both ovaries removed)	3.7	4.3	6.3	1.5	-2.5
Smoking Status	3.5	8.4	11.0	2.4	-3.3
Angina	3.5	4.6	6.1	2.5	-1.8
Trunk fat mass	3.5	15.1	15.8	3.8	-4.0
Angina (self-reported)	3.4	4.4	5.8	2.4	-1.8
Heart disease (mother)	3.4	4.2	6.0	1.6	-2.4
Arm fat mass (left)	3.4	14.1	14.3	3.7	-3.8
Leg fat mass (left)	3.4	13.4	14.5	3.8	-3.5
Whole body fat mass	3.2	13.4	13.5	3.7	-3.7
Waist circumference	3.1	11.4	11.8	3.4	-3.3
Alcohol intake versus 10 years previously	3.1	4.7	5.8	2.4	-1.9
Leg fat mass (right)	3.1	11.9	12.8	3.6	-3.3
Pain experienced in last month	3.1	5.2	6.5	-2.6	2.0
BMI	3.0	17.2	20.6	3.7	-4.5
Hayfever/allergic rhinitis (self-reported)	3.0	3.9	6.5	-1.1	2.6
Arm fat mass (right)	3.0	12.4	13.0	3.4	-3.6
Serious illness, injury or assault to yourself	2.8	3.3	4.4	2.1	-1.5
Alcohol drinker status: Never	2.8	3.4	4.0	2.0	-1.7
Body mass index (BMI)	2.7	11.5	13.1	3.6	-3.2
Average weekly red wine intake	2.7	3.9	4.8	2.2	-1.8
Medication: Atorvastatin	2.7	3.4	5.7	-1.0	2.4
Impedance of leg (right)	2.6	12.4	12.5	-3.5	3.5
Sitting height	2.6	18.7	29.4	2.8	-5.4
Migraine (self-reported)	2.6	3.2	3.6	1.7	-1.9
Birth weight	2.5	5.4	6.1	2.2	-2.5
Impedance of leg (left)	2.4	11.4	12.3	-3.2	3.5
Osteoarthritis (self-reported)	2.3	3.0	4.0	1.4	-2.0
Standing height	2.2	21.8	34.0	3.1	-5.8
Trunk fat percentage	2.0	7.8	8.6	2.9	-2.7
Age at last live birth	2.0	2.9	3.7	-1.9	1.4
Smoking status: Previous	2.0	2.9	3.3	1.6	-1.8
Number of operations (self-reported)	2.0	3.0	3.6	1.9	-1.6
Impedance of whole body	2.0	10.4	10.4	-3.2	3.2
Height	1.9	36.4	54.3	4.3	-7.4
Headache pain in last month	1.9	3.3	4.4	1.5	-2.1
Breast cancer (self-reported)	1.9	2.3	4.4	-2.1	0.4
Tinnitus: Yes, now most or all of the time	1.8	2.1	2.2	-1.5	1.4
Age started oral contraceptive pill	1.8	2.2	2.3	-1.5	1.5
Supplements: Calcium	1.8	2.0	2.3	-1.3	1.5
Length of working week for main job	1.7	1.9	3.7	0.3	-1.9
Neck or shoulder pain in last month	1.7	2.4	2.5	1.6	-1.5
Alcohol intake frequency.	1.7	3.9	4.2	1.9	-2.1
Had major operations	1.7	2.0	2.4	1.5	-1.3
Schizophrenia (2014)	1.6	3.6	5.6	-2.4	1.2
Number of treatments/medications taken	1.6	2.9	4.8	2.2	-1.0
Medication: Metformin	1.6	2.2	4.0	2.0	-0.7
Pulse wave Arterial Stiffness index	1.6	1.8	3.2	-1.8	0.7
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	2.7	1.2	-1.6
Age at first live birth	1.6	2.8	4.0	-2.0	1.3
Pulse wave peak to peak time	1.6	1.9	3.0	1.7	-0.9
Qualifications: College or University degree	1.6	5.1	9.5	-3.1	0.8
Eye problems/disorders: None of the above	1.6	1.8	3.2	-1.8	0.6
Diabetes diagnosed by doctor	1.6	2.6	4.6	2.1	-0.8
Medication: Blood pressure	1.6	3.1	5.0	2.2	-1.1
Irritable Bowel Disease (IBD)	1.5	3.7	4.4	-1.7	2.1
Bipolar Disorder (2011)	1.5	1.4	2.8	-1.7	0.4
Type 2 Diabetes (T2D) (2018)	1.5	2.9	4.9	2.2	-0.9
Impedance of arm (right)	1.5	7.0	8.9	-3.0	2.2
High blood pressure (siblings)	1.5	2.2	2.2	1.5	-1.5
Body fat percentage	1.5	6.0	7.4	2.7	-2.1
Supplements: Glucosamine	1.4	1.9	2.3	-1.2	1.5
Arm fat percentage (left)	1.4	5.6	6.7	2.6	-2.1
Back pain experienced in last month	1.4	2.1	3.3	1.8	-0.9
Miserableness	1.4	2.3	3.5	1.9	-1.1
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.3	1.8	-0.5
Heart disease (siblings)	1.4	1.7	2.3	1.5	-1.0
Type 2 Diabetes (T2D) (2012)	1.3	1.4	2.0	-1.4	0.9
Lung FEV1/FVC ratio	1.3	6.7	8.4	-2.9	2.2
Financial difficulties in last 2 years	1.3	1.8	1.9	-1.3	1.4
Mouth/teeth dental problems	1.3	2.0	2.4	-1.3	1.6
Heart attack	1.3	1.7	3.0	1.7	-0.6
Pain all over the body in last month	1.3	1.4	1.7	1.3	-1.0
Arm fat percentage (right)	1.3	5.3	5.9	2.4	-2.2
Qualifications: A levels/AS levels or equivalent	1.3	2.8	4.6	-2.1	1.0
Impedance of arm (left)	1.3	6.2	7.0	-2.6	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	5.2	-0.0	-2.3
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.2	1.0	-1.5
Loud music exposure frequency	1.2	1.3	1.9	-0.9	1.4
Mean time to correctly identify matches	1.2	2.2	4.5	0.0	2.1
Taking other prescription medications	1.1	1.6	3.0	1.7	-0.5
Pulse wave reflection index	1.1	1.4	1.6	-1.3	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.5	1.2	-1.1
Friendships satisfaction	1.1	1.4	2.4	-1.5	0.7
Eye problems/disorders: Cataract	1.1	1.3	1.6	1.0	-1.3
Guilty feelings	1.1	1.6	2.6	-0.9	1.6
Financial situation satisfaction	1.1	1.3	2.0	1.4	-0.8
Vascular/heart problems diagnosed by doctor	1.1	3.1	5.1	-2.2	1.0
Heel T-Score	1.0	8.1	11.4	-2.2	3.4
Hearing difficulty/problems: Yes	1.0	1.5	2.2	1.5	-0.9
Diabetes (father)	1.0	1.2	1.5	-1.0	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	1.7	-1.3	0.8
Medication for pain relief, constipation, heartburn	1.0	1.7	2.7	-1.6	0.8
Medication for cholesterol	1.0	1.4	2.3	-1.5	0.8
Medication: Bendroflumethiazide	1.0	1.5	3.1	-0.0	1.7
Leg fat percentage (left)	1.0	3.5	5.4	2.3	-1.3
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	1.5	1.2	-0.6
Vitamin and mineral supplements	0.9	1.2	1.6	1.2	-0.9
Medication: Ramipril	0.9	1.1	1.2	1.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.9	0.4	-1.4
Number of full brothers	0.9	1.2	1.8	1.3	-0.8
Osteoporosis (self-reported)	0.9	1.1	2.0	-0.6	1.4
Ever taken oral contraceptive pill	0.9	1.0	2.1	-0.1	-1.4
Cholesterol lowering medication	0.9	1.4	2.7	-0.3	1.6
Current tobacco smoking	0.8	1.3	2.3	0.6	-1.5
Past tobacco smoking	0.8	1.5	1.7	-1.1	1.3
Had other major operations	0.8	0.9	1.5	-1.2	0.6
Forced vital capacity (FVC)	0.8	3.2	6.4	0.2	-2.5
Tense / ‘highly strung’	0.8	1.4	1.7	-1.3	1.1
Medication: Lisinopril	0.8	1.1	1.6	1.2	-0.7
Risk taking	0.8	1.2	1.7	0.8	-1.3
Commuting to job workplace: Cycle	0.8	1.0	1.9	-0.2	1.4
Prostate Cancer	0.7	0.9	1.7	-1.3	0.4
Primary Biliary Cirrhosis	0.7	1.0	1.9	0.1	-1.4
Rheumatoid Arthritis	0.7	1.0	1.1	1.0	-1.0
Cardiovascular Disease	0.7	2.3	2.8	1.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.6	1.3	-0.6
Age when periods started (menarche)	0.7	1.8	3.2	-1.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.7	1.3	-0.7
Number of live births	0.7	1.0	1.4	-1.2	0.8
Happiness	0.7	0.9	1.5	-0.5	1.2
Forced vital capacity (FVC), Best measure	0.7	2.6	5.1	0.4	-2.3
Leg fat percentage (right)	0.7	2.6	4.0	2.0	-1.1
Medication: Allopurinol	0.7	0.9	1.7	0.5	-1.3
Supplements: Vitamin C	0.7	0.8	1.3	0.4	-1.2
Illnesses of siblings: Diabetes	0.7	0.9	1.2	0.8	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.3	1.1	-1.0
Mineral and other dietary supplements	0.7	0.9	1.5	0.6	-1.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.5	1.6	-0.0
Wears glasses or contact lenses	0.7	0.8	1.2	-1.1	0.5
Illnesses of father: High blood pressure	0.7	0.8	1.6	1.3	-0.2
Ever smoked	0.7	1.3	1.4	1.2	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	0.9	0.9	-0.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-1.1	0.1
Reaction Time	0.6	1.2	2.3	-0.3	1.5
Verbal and Numeric Reasoning (VNR)	0.6	1.3	2.0	-1.4	-0.8
Crohns Disease (2012)	0.6	1.0	2.0	-1.4	0.0
Hypothyroidism (self reported)	0.6	1.4	1.8	-1.4	1.0
Chronotype (morning person)	0.6	1.4	2.4	0.7	-1.5
Sensitivity / hurt feelings	0.6	1.1	1.8	-0.6	1.3
Ever had hysterectomy (womb removed)	0.6	0.6	0.8	0.7	-0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.3	1.1	-0.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.2	-0.7	1.5
Hearing difficulty/problems with background noise	0.6	1.0	1.2	-1.1	0.9
Neuroticism score	0.6	1.3	1.7	-0.9	1.3
Wheeze or whistling in the chest in last year	0.6	1.1	1.7	1.3	-0.7
Emphysema/chronic bronchitis	0.6	0.7	0.7	0.8	-0.8
Asthma (self-reported)	0.6	1.3	2.3	-0.5	1.5
Irritability	0.6	1.0	1.2	0.9	-1.1
Fractured/broken bones in last 5 years	0.6	0.8	1.3	1.1	-0.5
Ovarian Cancer	0.5	0.7	1.3	-1.1	-0.3
Mean Putamen Volume	0.5	0.6	1.1	1.0	-0.2
Allergy or Eczema	0.5	1.2	1.9	-0.7	1.4
Neuroticism	0.5	1.1	1.7	-0.7	1.3
Average weekly fortified wine intake	0.5	0.6	0.7	-0.8	0.8
Fed-up feelings	0.5	0.8	1.6	-0.1	1.3
High blood pressure	0.5	1.3	2.5	1.6	-0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	0.5	1.0
Fluid intelligence score	0.5	1.0	1.9	-0.4	-1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.0	-0.8	-1.7
Asthma	0.5	1.1	1.9	-0.5	1.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.6	-1.3	0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.7	0.8	-0.7
Hypertension (Self-reported)	0.5	1.3	2.6	1.6	-0.1
Smoking status: Current	0.5	0.8	1.4	0.4	-1.2
High cholesterol (Self-reported)	0.5	1.0	1.9	-0.0	1.4
Average weekly beer plus cider intake	0.5	0.8	1.3	-0.5	1.1
Basal cell carcinoma (self-reported)	0.5	0.6	0.7	-0.8	0.8
Alcohol drinker status: Previous	0.5	0.6	0.8	-0.9	-0.5
Depressed Affect (Nagel 2018)	0.4	0.9	1.3	0.7	1.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.2	-0.6	-1.5
Neuroticism (Nagel 2018)	0.4	0.9	1.7	-0.1	1.3
Worry (Nagel 2018)	0.4	0.8	1.1	-0.8	1.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.3	-1.1	-0.0
Breast Cancer	0.4	1.0	1.3	0.8	-1.2
Coronary Artery Disease (CAD)	0.4	0.5	0.7	-0.5	0.8
HDL Cholesterol	0.4	0.7	1.3	-0.5	1.1
LDL Cholesterol	0.4	0.6	1.2	-0.1	1.1
Triglycerides	0.4	0.7	0.9	1.0	0.7
Blood Eosinophil Count	0.4	3.2	4.0	-1.6	2.0
Relative age of first facial hair	0.4	0.7	1.5	0.1	-1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.0	1.0	-0.3
Hand grip strength (right)	0.4	1.2	1.4	1.0	-1.2
Stomach or abdominal pain in last month	0.4	0.4	0.9	0.1	-0.9
Number of incorrect matches in round	0.4	0.6	0.7	-0.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	1.1	0.0
Diabetes (self-reported)	0.4	0.6	1.2	1.1	-0.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.1	1.1	-0.2
Medication: Lansoprazole	0.4	0.5	1.0	-0.1	-1.0
Breastfed as a baby	0.4	0.5	0.5	-0.7	0.6
Number of children fathered	0.4	0.4	0.7	0.3	0.8
Medication: Seretide 50 evohaler	0.4	0.5	0.7	-0.5	0.8
Suffer from ‘nerves’	0.4	0.7	0.7	0.8	-0.8
Medication: Gliclazide	0.4	0.4	0.8	0.9	0.3
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.4	0.7	0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	1.2	-1.1	0.4
Depression (Nagel 2018)	0.3	0.5	0.8	0.9	-0.3
Schizophrenia (2018)	0.3	0.6	1.0	-1.0	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	-0.3	0.8
Lupus	0.3	0.4	0.7	0.8	-0.5
Waist Hip Ratio (WHR)	0.3	1.5	2.2	-0.9	1.5
Tanning	0.3	3.3	4.9	1.3	-2.2
Medication for hormone replacement therapy	0.3	0.3	0.6	-0.3	0.8
Maternal smoking around birth	0.3	0.4	0.9	0.0	0.9
Allergy	0.3	0.6	1.3	-0.0	-1.1
Father’s age at death	0.3	0.4	0.4	0.6	-0.6
Illnesses of mother	0.3	0.4	0.6	-0.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.4	-0.5	-1.2
Peak expiratory flow (PEF)	0.3	0.7	0.9	-0.9	-0.7
Gout (self-reported)	0.3	0.4	0.7	0.0	-0.9
Health satisfaction	0.3	0.4	0.6	0.8	-0.4
Medication: Omeprazole	0.3	0.4	0.6	0.8	-0.4
Family relationship satisfaction	0.3	0.4	0.5	-0.6	0.7
Loneliness, isolation	0.3	0.4	0.4	-0.6	0.7
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.9	0.2
Age at First Birth	0.2	0.3	0.5	-0.2	-0.7
Fasting Glucose	0.2	0.2	0.5	-0.0	0.7
Blood White Count	0.2	1.5	2.2	1.5	-0.9
Respiratory disease	0.2	0.4	0.6	0.8	0.4
Hair Pigment	0.2	5.9	7.8	2.8	-2.0
Hand grip strength (left)	0.2	0.6	0.7	0.6	-0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.4	0.6
Diabetes (mother)	0.2	0.3	0.6	0.7	0.1
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.6	0.2
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.1	-0.8
Medication: Simvastatin	0.2	0.4	0.6	0.8	-0.3
Falls in the last year	0.2	0.3	0.3	-0.5	0.6
Pulse rate	0.2	0.3	0.3	-0.5	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	-0.3	-0.5
Medication: Cholesterol lowering	0.2	0.4	0.7	0.9	0.1
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.9	-0.2
Blood clot in the leg (DVT)	0.2	0.2	0.2	0.5	-0.4
Glaucoma (self-reported)	0.2	0.3	0.4	-0.3	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.7	0.4
Exposure to tobacco smoke outside home	0.2	0.3	0.3	0.5	-0.5
Medication: Blood pressure	0.2	0.3	0.6	0.7	-0.2
Medication: Ibuprofen	0.2	0.3	0.6	0.0	-0.8
Overall health rating	0.2	0.3	0.6	0.8	0.3
Leg pain on walking	0.2	0.3	0.4	0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	-0.8	0.4
Commuting to job workplace: Public transport	0.2	0.3	0.5	-0.3	0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.2	0.7
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.5	0.0
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.2	0.5
Crohns Disease (2017)	0.1	0.2	0.2	-0.4	0.4
Major Depression (MDD)	0.1	0.2	0.2	0.4	0.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	-0.5	0.2
HbA1C	0.1	0.2	0.2	0.3	-0.4
Neuroticism (2016)	0.1	0.1	0.1	-0.3	0.4
Average weekly spirits intake	0.1	0.1	0.2	0.5	-0.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.4	0.1
Severe depression (siblings)	0.1	0.1	0.3	0.1	-0.5
Pack years adult smoking proportion	0.1	0.1	0.2	0.4	-0.2
Relative age voice broke	0.1	0.1	0.3	0.5	-0.0
Multivitamins +/- minerals	0.1	0.1	0.2	-0.4	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.4	0.2
Nervous feelings	0.1	0.1	0.2	0.4	0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	-0.6	0.2
Had menopause	0.1	0.1	0.1	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.5	0.3
Qualifications: None of the above	0.1	0.3	0.3	0.5	0.5
Noisy workplace	0.1	0.1	0.2	-0.2	0.4
Depression (self-reported)	0.1	0.1	0.2	-0.1	0.5
Prospective memory result	0.1	0.1	0.2	-0.5	0.2
Lung cancer (father)	0.1	0.1	0.1	-0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.3	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	-0.2	-0.4
Medication: Paracetamol	0.1	0.2	0.4	0.1	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	-0.6	0.3
Medication: Amlodipine	0.1	0.2	0.3	0.2	0.5
Comparative body size at age 10	0.1	0.2	0.4	0.7	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.1	0.4
Shortness of breath walking on level ground	0.1	0.1	0.1	0.1	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.5	-0.2
Number of full sisters	0.1	0.1	0.3	-0.5	-0.1
Chest pain or discomfort	0.1	0.2	0.3	0.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.3	-0.1	0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.0	0.5
Illnesses of father: Heart disease	0.1	0.1	0.1	-0.2	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	-0.3
Mood swings	0.1	0.1	0.2	0.5	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	-0.1	-0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.3	0.3
Hearing aid user	0.1	0.1	0.1	0.4	-0.1
Mother’s age at death	0.1	0.1	0.2	-0.5	-0.1
Medication: Paracetamol	0.1	0.1	0.2	0.5	-0.1
Diastolic blood pressure, automated reading	0.1	0.3	0.3	0.5	-0.5
Myopia	0.1	0.1	0.2	0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.3	-0.4
Pack years of smoking	0.1	0.1	0.3	0.5	-0.2
Blood Platelet Count	0.0	0.3	0.3	0.5	0.5
Blood Red Count	0.0	0.4	0.7	0.9	0.2
Systolic Blood Pressure	0.0	0.1	0.1	0.2	0.3
Lung FVC	0.0	0.1	0.2	0.0	-0.5
Systolic blood pressure, automated reading	0.0	0.0	0.1	0.2	0.1
Supplements: Zinc	0.0	0.0	0.1	-0.2	0.2
Townsend deprivation index at recruitment	0.0	0.0	0.0	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.2	-0.2
Medication: Atenolol	0.0	0.0	0.0	0.2	0.0
High blood pressure (mother)	0.0	0.0	0.0	0.2	-0.1
Alcohol usually taken with meals	0.0	0.0	0.1	0.2	-0.0
Worrier / anxious feelings	0.0	0.1	0.2	-0.4	0.1
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	-0.3	-0.1
Exposure to tobacco smoke at home	0.0	0.0	0.1	-0.3	0.1
Birth weight of first child	0.0	0.0	0.0	-0.1	-0.2
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.1	0.1	0.3
Pulse rate, automated reading	0.0	0.1	0.1	0.4	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.1	-0.2
Qualifications: nursing, teaching	0.0	0.1	0.1	-0.4	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.1	-0.3
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.0	-0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.1	0.2
Ever depressed for a whole week	0.0	0.1	0.1	-0.2	0.2

Hub : Genes

LOC401052

Models

Trait associations