TWAS hub - BRK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0460	0.0210	3.5e-03	0.036	0.011	0.016	0.014	0.030	2.8e-05	0.016	4.3e-03	0.0061	1.2e-04
2	GTEx	Adipose Visceral Omentum	0.1130	0.0480	8.3e-04	0.126	NA	0.021	NA	0.068	4.6e-07	NA	2.9e-02	NA	2.1e-04
3	GTEx	Cells EBV-transformed lymphocytes	0.2010	0.0680	4.9e-04	0.272	NA	0.170	NA	0.262	1.8e-09	NA	3.5e-06	NA	4.2e-09
4	GTEx	Cells Transformed fibroblasts	0.2990	0.0600	1.8e-13	0.291	NA	0.281	NA	0.286	4.0e-22	NA	3.2e-21	NA	1.1e-21
5	GTEx	Esophagus Mucosa	0.1170	0.0540	6.3e-03	0.015	NA	0.035	NA	0.018	3.4e-02	NA	2.1e-03	NA	2.1e-02
6	GTEx	Muscle Skeletal	0.1027	0.0316	9.9e-07	0.123	NA	0.122	NA	0.128	4.4e-12	NA	5.0e-12	NA	1.7e-12
7	GTEx	Pancreas	0.2170	0.0690	2.0e-05	0.198	NA	0.141	NA	0.151	8.8e-09	NA	1.5e-06	NA	6.3e-07
8	GTEx	Skin Sun Exposed Lower leg	0.1290	0.0430	1.5e-05	0.112	NA	0.083	NA	0.102	1.6e-09	NA	2.3e-07	NA	8.6e-09
9	GTEx	Spleen	0.2290	0.1020	4.1e-03	0.071	NA	0.104	NA	0.098	7.1e-03	NA	1.3e-03	NA	1.8e-03
10	GTEx	Thyroid	0.0850	0.0300	2.9e-04	0.047	NA	0.028	NA	0.038	1.7e-04	NA	3.0e-03	NA	6.8e-04
11	GTEx	Whole Blood	0.0810	0.0350	2.1e-03	0.064	NA	0.039	NA	0.041	1.6e-06	NA	1.6e-04	NA	1.2e-04
12	METSIM	Adipose	0.0352	0.0144	1.5e-03	0.022	0.009	0.010	0.010	0.005	2.5e-04	0.014	1.0e-02	0.0089	4.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Ulcerative Colitis	8.2	11.9	13.3	3.5	3.5	3.5	3.5	3.0	3.5	3.5	3.5	3.4	3.7	3.6	3.2
Worry too long after embarrassment	6.1	10.3	12.2	3.5	3.4	3.5	3.5	2.5	3.5	3.4	3.5	2.7	3.0	2.7	3.0
Alcohol drinker status: Never	5.3	6.4	8.9	-2.6	-2.6	-2.6	-2.6	-2.0	-2.6	-2.6	-2.6	-2.2	-2.4	-3.0	-2.3
Weight	4.9	24.1	30.8	-5.1	-5.0	-5.1	-5.1	-1.8	-5.1	-5.3	-5.1	-3.7	-5.5	-5.2	-5.5
Arm predicted mass (left)	4.6	23.6	32.9	-5.1	-4.9	-5.0	-5.0	-2.3	-5.0	-5.2	-5.1	-3.3	-5.5	-5.0	-5.7
Ulcerative Colitis (UC)	4.5	8.4	10.1	2.9	2.6	3.2	2.9	2.3	2.9	3.1	2.9	3.0	3.2	2.6	3.0
Medication: Co-codamol	4.5	5.2	7.6	-2.4	-2.5	-2.4	-2.4	-2.5	-2.4	-2.4	-2.4	-1.5	-2.8	-2.0	-1.6
Hip circumference	4.5	19.4	25.0	-4.6	-4.4	-4.6	-4.6	-1.5	-4.6	-4.7	-4.6	-3.2	-5.0	-4.8	-4.9
Leg predicted mass (right)	4.5	23.8	33.3	-5.1	-5.0	-5.1	-5.1	-1.9	-5.1	-5.3	-5.1	-3.2	-5.7	-4.8	-5.8
Arm fat-free mass (left)	4.5	22.6	31.0	-5.0	-4.8	-5.0	-5.0	-2.3	-5.0	-5.1	-5.0	-3.2	-5.3	-4.8	-5.6
Leg fat mass (left)	4.5	17.4	21.0	-4.4	-4.3	-4.4	-4.4	-1.6	-4.4	-4.5	-4.4	-3.7	-4.3	-4.6	-4.2
Leg fat-free mass (right)	4.4	23.4	33.0	-5.1	-4.9	-5.0	-5.1	-1.9	-5.1	-5.2	-5.1	-3.1	-5.7	-4.8	-5.7
Average weekly red wine intake	4.4	6.5	7.5	-2.7	-2.7	-2.7	-2.7	-2.1	-2.7	-2.7	-2.7	-1.8	-2.7	-2.3	-2.4
Long-standing illness, disability or infirmity	4.4	6.7	9.1	-2.6	-2.7	-2.5	-2.6	-1.3	-2.6	-2.7	-2.6	-2.5	-3.0	-2.9	-2.6
Leg fat-free mass (left)	4.3	22.8	33.9	-5.0	-4.8	-5.0	-5.0	-1.6	-5.0	-5.1	-5.0	-3.1	-5.6	-4.8	-5.8
Arm fat mass (left)	4.3	17.8	20.4	-4.5	-4.4	-4.5	-4.5	-1.5	-4.5	-4.5	-4.5	-3.9	-4.3	-4.5	-4.2
Knee pain experienced in last month	4.2	6.5	8.5	-2.7	-2.5	-2.7	-2.7	-1.4	-2.7	-2.8	-2.7	-2.3	-2.8	-2.9	-2.2
Osteoarthritis (self-reported)	4.2	5.5	7.6	-2.4	-2.4	-2.4	-2.4	-1.4	-2.4	-2.3	-2.4	-2.8	-2.2	-2.4	-2.4
Basal metabolic rate	4.2	23.3	33.9	-5.0	-4.9	-5.0	-5.0	-2.1	-5.0	-5.2	-5.0	-3.1	-5.5	-4.9	-5.8
Leg predicted mass (left)	4.1	22.0	32.9	-4.9	-4.7	-4.8	-4.9	-1.6	-4.9	-5.0	-4.9	-3.1	-5.5	-4.7	-5.7
Trunk fat mass	3.9	16.9	21.0	-4.3	-4.2	-4.3	-4.3	-1.4	-4.3	-4.4	-4.3	-3.6	-4.4	-4.6	-4.0
Arm fat mass (right)	3.9	16.1	18.7	-4.3	-4.2	-4.3	-4.3	-1.2	-4.3	-4.3	-4.3	-3.7	-4.1	-4.3	-3.9
Arm fat-free mass (right)	3.9	20.2	29.9	-4.7	-4.5	-4.7	-4.7	-2.2	-4.7	-4.8	-4.7	-2.8	-5.1	-4.6	-5.5
Whole body water mass	3.9	22.0	34.6	-4.9	-4.7	-4.9	-4.9	-2.1	-4.9	-5.0	-4.9	-2.8	-5.4	-4.7	-5.9
Whole body fat mass	3.8	16.0	19.4	-4.2	-4.1	-4.2	-4.2	-1.4	-4.2	-4.3	-4.2	-3.7	-4.2	-4.4	-3.9
Leg fat mass (right)	3.8	14.7	18.8	-4.0	-3.9	-4.0	-4.0	-1.4	-4.0	-4.1	-4.0	-3.5	-4.0	-4.3	-4.0
Waist circumference	3.7	13.4	16.2	-3.9	-3.8	-3.9	-3.9	-1.3	-3.9	-4.0	-3.9	-3.3	-3.9	-4.0	-3.4
Whole body fat-free mass	3.7	21.2	33.1	-4.8	-4.6	-4.8	-4.8	-2.2	-4.8	-4.9	-4.8	-2.8	-5.4	-4.7	-5.8
Illnesses of siblings	3.6	5.0	7.3	2.3	2.2	2.3	2.3	0.4	2.3	2.4	2.3	2.1	2.7	2.5	2.3
Arm predicted mass (right)	3.6	18.2	27.7	-4.4	-4.3	-4.4	-4.4	-2.1	-4.4	-4.6	-4.4	-2.6	-5.0	-4.4	-5.3
Body mass index (BMI)	3.5	15.0	17.2	-4.1	-4.0	-4.1	-4.1	-1.2	-4.1	-4.2	-4.1	-3.6	-4.0	-4.1	-3.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.1	8.0	1.9	1.9	1.9	1.9	1.2	1.9	2.1	1.9	1.3	2.8	1.9	2.7
Medication: Metformin	3.2	4.5	6.1	-2.3	-2.4	-2.4	-2.3	-1.0	-2.3	-2.3	-2.3	-2.5	-2.1	-1.9	-1.1
Alcohol intake frequency.	3.2	7.4	10.1	-2.8	-2.8	-2.8	-2.8	-3.1	-2.8	-2.8	-2.8	-2.1	-2.5	-3.2	-2.1
Medication: Aspirin	3.0	3.9	6.9	-1.9	-1.9	-1.9	-1.9	-1.0	-1.9	-2.1	-1.9	-1.8	-2.6	-2.0	-2.4
BMI	2.9	16.7	20.0	-4.3	-4.3	-4.3	-4.3	-1.2	-4.3	-4.5	-4.3	-3.5	-4.5	-4.2	-4.2
Impedance of leg (right)	2.9	14.2	17.1	4.1	4.0	4.1	4.1	1.2	4.1	4.1	4.1	2.9	4.1	3.2	4.1
Trunk fat-free mass	2.9	16.6	28.4	-4.2	-4.1	-4.2	-4.2	-2.2	-4.2	-4.3	-4.2	-2.2	-4.7	-4.1	-5.3
Neck or shoulder pain in last month	2.9	4.1	5.6	-2.2	-2.4	-2.2	-2.2	0.0	-2.2	-2.2	-2.2	-1.1	-1.9	-2.3	-2.0
Trunk predicted mass	2.8	16.2	27.2	-4.1	-4.0	-4.1	-4.1	-2.3	-4.1	-4.3	-4.1	-2.1	-4.6	-4.1	-5.2
Risk taking	2.8	4.1	5.9	-2.4	-2.4	-2.4	-2.4	-0.5	-2.4	-2.3	-2.4	-1.6	-1.5	-1.8	-0.8
Schizophrenia (2014)	2.7	6.0	7.0	2.5	2.5	2.5	2.5	1.2	2.5	2.5	2.5	2.5	2.6	2.6	2.4
Pain experienced in last month	2.7	4.5	6.7	2.1	2.2	2.1	2.1	0.2	2.1	2.2	2.1	1.6	2.6	2.3	2.6
Trunk fat percentage	2.6	10.6	13.8	-3.5	-3.4	-3.5	-3.5	-1.0	-3.5	-3.5	-3.5	-3.3	-3.3	-3.7	-2.6
Arm fat percentage (right)	2.6	10.1	12.0	-3.4	-3.3	-3.4	-3.4	-0.9	-3.4	-3.4	-3.4	-3.4	-2.9	-3.5	-2.5
Time employed in main current job	2.6	3.0	4.4	1.7	1.9	1.7	1.7	1.2	1.7	1.8	1.7	1.8	2.1	1.7	1.6
Arm fat percentage (left)	2.6	10.4	12.7	-3.5	-3.4	-3.5	-3.5	-0.9	-3.5	-3.5	-3.5	-3.4	-3.0	-3.6	-2.7
Irritable Bowel Disease (IBD)	2.5	6.0	9.1	2.6	2.4	2.7	2.6	1.7	2.6	2.7	2.6	3.0	2.4	1.8	1.9
Hearing difficulty/problems: Yes	2.5	3.8	5.7	-1.9	-2.1	-1.9	-2.0	-0.2	-1.9	-1.9	-1.9	-2.2	-1.6	-2.4	-2.2
Alcohol intake versus 10 years previously	2.5	3.8	5.3	-2.0	-2.1	-2.0	-2.0	-0.4	-2.0	-2.1	-2.0	-2.3	-2.3	-1.6	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	3.6	1.8	1.8	1.8	1.8	1.5	1.8	1.8	1.8	1.9	1.5	1.7	1.2
Qualifications: College or University degree	2.5	7.7	13.0	2.9	2.9	2.9	2.9	0.8	2.9	2.9	2.9	2.3	2.7	3.6	2.8
Type 2 Diabetes (T2D) (2012)	2.4	2.8	5.1	1.6	1.5	2.1	1.6	0.2	1.6	2.1	1.6	2.3	1.7	1.0	1.9
Asthma	2.4	4.7	8.1	2.4	2.3	2.4	2.4	1.7	2.4	2.2	2.4	1.9	1.4	2.8	1.3
Body fat percentage	2.4	9.4	12.3	-3.3	-3.1	-3.3	-3.3	-0.9	-3.3	-3.3	-3.3	-3.3	-3.0	-3.5	-2.5
Commuting to job workplace: Walk	2.4	2.6	8.1	-1.4	-1.2	-1.3	-1.3	-1.2	-1.3	-1.5	-1.4	-1.6	-1.9	-1.9	-2.8
Asthma (self-reported)	2.4	4.8	8.3	2.4	2.3	2.4	2.4	1.5	2.4	2.3	2.4	1.7	1.4	2.9	1.4
Number of operations (self-reported)	2.4	3.5	8.6	-1.9	-1.7	-1.9	-1.9	-1.0	-1.9	-2.0	-1.9	-1.3	-2.0	-1.6	-2.9
Impedance of leg (left)	2.3	11.1	16.6	3.5	3.5	3.5	3.5	0.7	3.5	3.6	3.5	2.5	3.8	2.9	4.1
Comparative height size at age 10	2.3	12.6	19.3	-3.8	-3.6	-3.7	-3.7	-1.4	-3.7	-3.9	-3.8	-1.7	-4.4	-3.7	-4.0
Schizophrenia vs Biploar Disorder	2.2	2.9	6.0	1.6	1.8	1.6	1.6	2.3	1.6	1.5	1.6	2.4	1.0	2.0	0.4
Serious illness, injury or assault to yourself	2.2	2.7	4.1	-1.8	-1.8	-1.7	-1.8	-0.6	-1.8	-1.8	-1.8	-1.5	-2.0	-1.6	-0.8
Smoking Status	2.1	5.0	7.1	-2.3	-2.4	-2.3	-2.3	-0.3	-2.3	-2.5	-2.3	-1.4	-2.7	-2.3	-2.5
Pain all over the body in last month	2.1	2.3	4.3	-1.5	-1.6	-1.5	-1.5	-1.0	-1.5	-1.5	-1.5	-1.6	-1.1	-2.1	-1.4
Pulse wave peak to peak time	2.0	2.3	3.3	-1.4	-1.7	-1.5	-1.5	-1.6	-1.5	-1.5	-1.4	-1.6	-1.7	-1.8	-0.9
Migraine (self-reported)	2.0	2.4	3.3	-1.7	-1.7	-1.7	-1.7	-1.1	-1.7	-1.8	-1.7	-0.8	-1.7	-1.2	-1.4
Heart disease (mother)	2.0	2.4	4.2	-1.7	-1.7	-1.7	-1.7	-0.7	-1.7	-1.7	-1.7	-0.8	-2.0	-1.3	-1.2
Leg fat percentage (left)	2.0	7.3	9.9	-2.9	-2.8	-2.9	-2.9	-1.0	-2.9	-2.9	-2.9	-2.9	-2.5	-3.1	-2.2
Impedance of whole body	2.0	10.4	14.8	3.4	3.4	3.4	3.4	1.2	3.4	3.5	3.4	2.2	3.6	2.8	3.9
Eye problems/disorders: None of the above	1.9	2.2	3.6	1.4	1.4	1.4	1.4	1.0	1.4	1.5	1.4	1.9	1.5	1.4	1.9
Medication: Aspirin	1.9	2.4	4.9	-1.4	-1.5	-1.5	-1.4	-0.8	-1.4	-1.7	-1.4	-1.5	-2.2	-1.5	-2.0
Had major operations	1.8	2.1	3.6	-1.4	-1.5	-1.4	-1.5	-0.3	-1.4	-1.5	-1.4	-1.2	-1.7	-1.4	-1.9
Fractured/broken bones in last 5 years	1.8	2.4	3.8	-1.7	-1.6	-1.7	-1.7	0.1	-1.7	-1.7	-1.7	-2.0	-1.1	-1.4	-1.2
Age started oral contraceptive pill	1.8	2.2	4.0	1.4	1.4	1.5	1.4	1.1	1.4	1.5	1.4	1.4	1.7	1.3	2.0
Vitamin and mineral supplements	1.7	2.3	4.1	-1.4	-1.5	-1.5	-1.5	-1.1	-1.4	-1.5	-1.4	-1.4	-1.4	-1.9	-2.0
Qualifications: CSEs or equivalent	1.7	2.3	3.1	1.7	1.8	1.7	1.7	1.6	1.7	1.6	1.7	1.2	1.0	1.5	0.8
Pulse wave Arterial Stiffness index	1.7	2.0	2.7	1.3	1.6	1.3	1.4	1.5	1.4	1.4	1.3	1.6	1.6	1.6	0.7
Medication: Atorvastatin	1.7	2.1	3.6	1.5	1.5	1.5	1.5	1.1	1.5	1.6	1.5	0.7	1.4	1.3	1.9
Number of treatments/medications taken	1.6	2.9	3.8	-1.9	-1.9	-1.9	-1.9	-0.2	-1.9	-1.9	-1.9	-1.1	-2.0	-1.8	-1.3
Angina	1.6	2.1	4.3	-1.3	-1.4	-1.3	-1.3	-0.8	-1.3	-1.5	-1.3	-1.9	-2.1	-1.5	-1.5
Angina (self-reported)	1.6	2.2	4.3	-1.3	-1.4	-1.3	-1.3	-0.9	-1.3	-1.5	-1.3	-1.8	-2.1	-1.5	-1.5
Age at last live birth	1.6	2.4	3.3	1.6	1.5	1.6	1.6	0.7	1.6	1.7	1.6	1.8	1.7	1.5	1.5
Diabetes diagnosed by doctor	1.6	2.6	4.0	-1.7	-1.9	-1.7	-1.7	-0.8	-1.7	-1.8	-1.7	-0.7	-2.0	-1.7	-1.5
High cholesterol (Self-reported)	1.6	2.9	3.9	1.9	1.8	1.9	1.9	2.0	1.9	1.7	1.9	1.3	0.9	1.8	1.2
Crohns Disease (2012)	1.5	2.5	3.5	1.8	1.9	1.8	1.8	0.6	1.8	1.8	1.8	1.7	1.2	1.3	0.3
Impedance of arm (right)	1.5	6.9	10.0	2.8	2.7	2.8	2.8	1.1	2.8	2.9	2.8	1.7	3.1	2.3	3.2
Impedance of arm (left)	1.5	6.8	8.7	2.7	2.7	2.8	2.8	1.2	2.8	2.8	2.7	1.9	2.9	2.3	3.0
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	2.6	-1.3	-1.3	-1.3	-1.3	-1.2	-1.3	-1.4	-1.3	-1.6	-1.5	-1.3	-1.6
Wears glasses or contact lenses	1.5	1.7	5.1	1.3	1.3	1.3	1.3	-0.1	1.3	1.3	1.3	-0.2	1.2	1.5	2.3
Sitting height	1.4	9.9	17.8	-3.1	-3.1	-3.1	-3.1	-1.5	-3.1	-3.3	-3.1	-1.6	-3.9	-3.5	-4.2
Illnesses of mother	1.4	1.7	2.2	1.5	1.4	1.5	1.5	1.3	1.5	1.3	1.5	0.2	1.1	1.2	1.2
Tense / ‘highly strung’	1.4	2.3	2.9	1.6	1.6	1.6	1.6	1.4	1.6	1.6	1.6	1.7	1.3	1.3	1.6
Leg fat percentage (right)	1.4	5.0	7.7	-2.3	-2.2	-2.3	-2.3	-0.6	-2.3	-2.3	-2.3	-2.6	-2.1	-2.8	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.5	-1.5	-1.6	-1.4	-1.5	-0.7	-1.5	-1.5	-1.5	-1.1	-1.4	-0.7	-0.6
Friendships satisfaction	1.4	1.7	2.3	1.4	1.5	1.4	1.4	0.5	1.4	1.5	1.4	0.9	1.3	1.4	1.1
Supplements: Glucosamine	1.3	1.7	2.1	1.4	1.4	1.4	1.4	0.1	1.4	1.4	1.4	1.3	1.3	1.2	1.4
Financial difficulties in last 2 years	1.3	1.8	2.4	1.4	1.3	1.4	1.4	1.2	1.4	1.4	1.4	1.1	1.6	1.4	1.1
Mouth/teeth dental problems	1.3	1.9	3.4	1.4	1.4	1.4	1.4	1.0	1.4	1.5	1.4	1.9	1.4	1.3	1.1
Qualifications: A levels/AS levels or equivalent	1.3	3.0	3.6	1.8	1.7	1.8	1.8	0.9	1.8	1.9	1.8	1.4	1.9	1.9	1.9
Age at first live birth	1.3	2.3	3.1	1.6	1.6	1.6	1.6	0.8	1.6	1.7	1.6	1.5	1.8	1.6	1.1
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.1	-1.6	-1.7	-1.6	-1.6	-0.8	-1.6	-1.7	-1.6	-0.3	-2.0	-1.5	-1.1
Fed-up feelings	1.2	2.1	2.8	1.7	1.6	1.7	1.7	1.2	1.7	1.5	1.7	1.2	1.0	1.2	1.2
Neuroticism score	1.2	2.6	3.1	1.7	1.7	1.8	1.7	1.3	1.7	1.7	1.7	1.5	1.4	1.1	1.6
Breastfed as a baby	1.2	1.4	2.7	1.3	1.2	1.2	1.3	0.4	1.3	1.2	1.3	1.4	0.9	1.6	0.7
Loneliness, isolation	1.2	1.7	2.5	1.4	1.4	1.4	1.4	1.6	1.4	1.4	1.4	1.1	0.8	1.4	1.0
Eye problems/disorders: Cataract	1.2	1.4	2.2	-1.1	-1.1	-1.1	-1.1	-1.5	-1.1	-1.1	-1.1	-1.5	-1.1	-1.0	-1.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.7	1.2	1.0	1.2	1.2	0.9	1.2	1.3	1.2	0.6	1.7	1.2	1.1
Prostate Cancer	1.1	1.6	2.2	1.3	1.4	1.3	1.3	0.6	1.3	1.3	1.3	1.4	1.4	1.5	0.8
Height	1.1	21.1	36.2	-4.6	-4.6	-4.6	-4.6	-2.5	-4.6	-4.8	-4.6	-1.4	-5.7	-5.0	-6.0
Medication for hormone replacement therapy	1.1	1.2	2.0	1.1	1.2	1.1	1.1	1.2	1.1	1.0	1.1	1.4	0.9	1.3	0.7
Taking other prescription medications	1.1	1.7	2.3	-1.4	-1.5	-1.4	-1.5	0.5	-1.5	-1.5	-1.4	-1.0	-1.4	-1.2	-1.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	4.4	-1.0	-0.9	-1.0	-1.0	-0.3	-1.0	-1.2	-1.0	-0.5	-1.6	-0.8	-2.1
Pulse wave reflection index	1.1	1.4	3.2	1.1	1.1	1.1	1.1	1.8	1.1	1.1	1.1	0.8	1.3	1.4	1.1
Birth weight	1.1	2.4	7.3	-1.5	-1.5	-1.4	-1.5	-0.2	-1.5	-1.6	-1.5	-0.3	-2.2	-0.9	-2.7
High blood pressure (siblings)	1.1	1.6	2.4	-1.3	-1.2	-1.3	-1.3	0.1	-1.3	-1.4	-1.3	-0.9	-1.4	-1.5	-1.6
Hearing aid user	1.1	1.3	2.2	-1.1	-1.3	-1.2	-1.1	-1.5	-1.1	-1.1	-1.1	-0.8	-0.5	-1.3	-1.1
Heart disease (siblings)	1.1	1.3	2.5	-1.2	-1.1	-1.1	-1.1	-0.6	-1.2	-1.2	-1.2	-1.5	-1.6	-1.0	-0.6
Neuroticism (Nagel 2018)	1.0	2.3	3.2	1.7	1.7	1.7	1.7	1.8	1.7	1.6	1.7	1.1	0.7	1.4	1.3
Schizophrenia (2018)	1.0	2.1	3.5	1.4	1.6	1.4	1.5	1.1	1.4	1.4	1.4	1.6	1.2	1.9	1.6
Neuroticism	1.0	2.4	3.0	1.7	1.7	1.7	1.7	1.2	1.7	1.7	1.7	1.4	1.3	1.1	1.3
Severe depression (siblings)	1.0	1.1	1.6	-1.1	-1.3	-1.2	-1.2	-0.8	-1.2	-1.1	-1.1	-0.9	-0.6	-1.3	-0.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.0	1.3	1.2	1.3	1.3	-0.5	1.3	1.4	1.3	1.2	1.4	0.6	0.5
Fluid intelligence score	1.0	2.1	3.3	-1.7	-1.5	-1.7	-1.7	-0.8	-1.7	-1.5	-1.7	-0.7	-0.7	-1.4	-1.8
Medication for pain relief, constipation, heartburn	1.0	1.7	2.4	1.4	1.5	1.4	1.4	0.1	1.4	1.5	1.4	0.8	1.5	1.2	1.1
Medication: Ibuprofen	1.0	1.2	1.7	-1.3	-1.3	-1.3	-1.3	-0.3	-1.3	-1.2	-1.3	-0.4	-0.7	-0.9	-1.0
Medication: Blood pressure	1.0	1.8	5.0	-1.3	-1.2	-1.3	-1.3	-0.4	-1.3	-1.4	-1.3	-1.0	-1.7	-1.1	-2.2
Vascular/heart problems diagnosed by doctor	1.0	2.6	5.0	1.5	1.6	1.5	1.6	-0.1	1.6	1.7	1.5	2.0	1.8	1.4	2.2
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.4	-1.1	-1.1	-1.1	-1.1	-0.5	-1.1	-1.2	-1.1	-1.5	-1.4	-1.0	-0.9
Worry (Nagel 2018)	0.9	2.0	2.4	1.5	1.5	1.6	1.5	0.5	1.5	1.5	1.5	1.4	1.0	1.4	1.5
Crohns Disease (2017)	0.9	1.9	4.8	1.6	1.5	1.5	1.5	0.6	1.5	1.5	1.6	2.2	0.8	0.6	0.4
Fasting Glucose	0.9	1.1	2.4	1.2	1.6	0.9	1.3	0.6	1.2	0.8	1.2	-0.1	0.7	1.4	0.4
Ever had hysterectomy (womb removed)	0.9	1.0	1.3	-1.0	-1.0	-1.0	-1.0	-1.1	-1.0	-1.0	-1.0	-0.5	-1.0	-1.1	-1.1
Worrier / anxious feelings	0.9	1.7	3.2	1.4	1.4	1.5	1.4	1.0	1.4	1.4	1.4	1.8	0.6	1.3	0.6
Standing height	0.9	9.0	19.3	-2.9	-2.9	-2.9	-2.9	-1.6	-2.9	-3.1	-2.9	-0.6	-4.0	-3.1	-4.4
Number of full brothers	0.9	1.1	2.3	-0.9	-1.1	-0.9	-0.9	-0.9	-0.9	-1.0	-0.9	-1.5	-1.2	-1.5	-0.8
Emphysema/chronic bronchitis	0.9	1.0	2.1	-1.0	-0.9	-1.0	-1.0	-0.9	-1.0	-1.0	-1.0	-1.4	-0.8	-1.0	-1.1
Smoking status: Previous	0.9	1.4	2.6	-1.1	-1.2	-1.0	-1.1	0.7	-1.1	-1.2	-1.1	-1.0	-1.5	-1.3	-1.6
Pain type(s) experienced in last month: Hip pain	0.9	1.2	1.6	-1.1	-1.2	-1.1	-1.1	0.6	-1.1	-1.2	-1.1	0.3	-1.3	-1.1	-1.2
Commuting to job workplace: Cycle	0.9	1.0	2.7	1.0	0.9	1.0	1.0	0.7	1.0	0.9	1.0	0.9	1.0	0.9	1.6
Depressed Affect (Nagel 2018)	0.8	1.6	2.6	1.4	1.5	1.5	1.5	1.6	1.4	1.3	1.4	0.7	0.4	1.2	0.8
Current tobacco smoking	0.8	1.4	1.9	-1.4	-1.3	-1.4	-1.4	0.1	-1.4	-1.4	-1.4	-0.9	-1.1	-1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	2.5	-1.6	-1.5	-1.5	-1.6	-1.2	-1.6	-1.4	-1.6	-0.9	-0.8	-1.4	-1.0
Osteoporosis (self-reported)	0.8	1.0	1.5	1.0	0.8	1.0	1.0	1.2	1.0	1.0	1.0	1.2	0.9	0.9	0.8
Ovarian Cancer	0.7	0.9	2.3	0.7	0.9	0.8	0.7	1.5	0.7	0.8	0.7	1.3	0.9	0.4	1.3
Lung FEV1/FVC ratio	0.7	3.7	7.3	1.6	1.5	1.5	1.6	2.6	1.6	1.8	1.6	2.1	2.7	1.5	2.4
Average weekly spirits intake	0.7	0.8	1.1	-1.0	-1.0	-1.0	-1.0	-0.6	-1.0	-1.0	-1.0	-1.0	-0.4	-1.0	-0.1
Sensitivity / hurt feelings	0.7	1.2	2.2	1.1	1.2	1.1	1.1	1.0	1.1	1.1	1.1	0.6	1.0	0.9	1.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.9	-0.9	-0.9	-0.9	-0.9	-0.2	-0.9	-0.9	-0.9	0.0	-0.9	-1.7	-1.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	-0.8	-0.8	-0.8	-0.8	-0.8	-0.8	-0.8	-0.8	-0.3	-1.3	-1.2	-1.0
Diabetes (father)	0.7	0.9	2.6	0.8	0.9	0.8	0.8	0.5	0.8	0.8	0.8	0.6	1.2	1.1	1.6
Had other major operations	0.7	0.9	1.4	1.0	1.1	1.0	1.0	0.4	1.0	1.0	1.0	0.5	1.2	1.2	0.2
Heart attack	0.7	0.9	2.1	-0.9	-0.9	-0.9	-0.9	-0.2	-0.9	-1.0	-0.9	-1.5	-1.2	-0.8	-0.8
Exposure to tobacco smoke outside home	0.7	0.9	1.6	-1.1	-1.1	-1.1	-1.1	0.2	-1.1	-1.1	-1.1	-1.3	-0.5	-0.3	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.7	3.8	-0.6	-0.7	-0.7	-0.7	-0.8	-0.7	-0.7	-0.6	-1.9	-0.8	-0.8	-0.2
Illnesses of siblings: Diabetes	0.7	0.9	1.9	-0.9	-0.7	-0.9	-0.9	0.0	-0.9	-0.9	-0.9	-1.4	-0.9	-1.2	-1.0
Medication for cholesterol	0.7	1.0	1.8	1.0	0.9	1.0	1.0	-0.8	1.0	1.1	1.0	0.9	1.1	0.9	1.4
Financial situation satisfaction	0.7	0.9	2.4	-0.8	-0.8	-0.8	-0.8	-0.5	-0.8	-0.9	-0.8	-1.2	-1.2	-1.0	-1.5
Illnesses of father: High blood pressure	0.7	0.9	3.2	-0.7	-0.8	-0.8	-0.7	0.0	-0.7	-0.8	-0.7	-1.3	-0.9	-0.8	-1.8
Cholesterol lowering medication	0.7	1.0	1.2	1.1	1.1	1.1	1.1	0.8	1.1	1.1	1.1	0.9	0.8	0.8	1.0
Breast Cancer	0.6	1.4	3.1	-1.1	-1.3	-1.1	-1.2	0.2	-1.1	-1.1	-1.1	-1.2	-1.4	-0.7	-1.8
Headache pain in last month	0.6	1.1	2.7	-0.9	-0.9	-0.9	-0.9	0.7	-0.9	-1.0	-0.9	-0.9	-1.6	-0.8	-1.6
Suffer from ‘nerves’	0.6	0.9	1.6	-0.9	-0.8	-0.8	-0.8	-1.1	-0.9	-0.8	-0.9	-1.2	-1.0	-1.2	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	-1.0	-1.1	-1.0	-1.0	-0.1	-1.0	-0.9	-1.0	0.1	-0.4	-0.6	-0.6
Smoking status: Current	0.6	0.9	1.3	-1.1	-1.1	-1.1	-1.1	0.2	-1.1	-1.1	-1.1	-0.6	-0.8	-0.9	-0.7
Pack years of smoking	0.6	0.9	4.4	-0.9	-0.8	-0.8	-0.8	0.5	-0.8	-0.8	-0.9	-2.1	-0.7	-0.7	-0.1
Mean Putamen Volume	0.5	0.6	0.8	-0.8	-0.8	-0.8	-0.8	-0.6	-0.8	-0.9	-0.8	-0.7	-0.8	-0.8	-0.8
Triglycerides	0.5	0.8	1.5	-0.9	-1.0	-1.0	-0.9	-1.2	-0.9	-1.0	-0.9	-0.4	-0.4	-0.9	-0.8
Heel T-Score	0.5	3.9	8.0	1.9	2.0	1.9	1.9	0.5	1.9	2.1	1.9	1.4	2.5	1.7	2.8
Respiratory disease	0.5	1.2	3.1	1.3	1.0	1.3	1.3	0.5	1.3	1.1	1.3	0.5	0.2	1.8	0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-0.8	-0.7	-0.8	-0.8	-0.7	-0.8	-0.7	-0.8	-1.0	-0.6	-1.2	-0.5
Medication: Ramipril	0.5	0.7	1.0	-0.7	-0.8	-0.8	-0.8	-0.8	-0.8	-0.8	-0.7	-1.0	-1.0	-0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	-1.0	-0.9	-1.0	-1.0	0.3	-1.0	-0.8	-1.0	-0.5	-0.4	-0.6	-0.7
Hair/balding pattern: Pattern 4	0.5	1.3	1.9	-1.3	-1.3	-1.4	-1.3	-0.1	-1.3	-1.3	-1.3	-0.6	-1.0	-1.1	-0.8
Pulse rate, automated reading	0.5	1.6	2.7	-1.4	-1.4	-1.4	-1.4	-0.8	-1.4	-1.2	-1.4	-0.5	-0.7	-1.6	-1.4
Ever had bowel cancer screening	0.5	0.6	4.2	0.5	0.5	0.4	0.5	2.1	0.5	0.4	0.5	0.8	0.2	0.6	-0.2
Mineral and other dietary supplements	0.5	0.7	3.0	-0.7	-0.7	-0.7	-0.7	1.0	-0.7	-0.7	-0.7	-0.5	-0.6	-0.9	-1.7
Commuting to job workplace: Public transport	0.5	0.6	2.0	0.7	0.7	0.7	0.7	1.1	0.7	0.7	0.7	1.4	0.6	0.4	0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	2.4	0.8	0.8	0.6	0.8	-0.0	0.8	0.6	0.8	1.5	0.9	0.8	-0.0
Allergy or Eczema	0.4	1.0	1.4	1.2	1.2	1.2	1.2	-0.4	1.2	1.2	1.2	0.2	0.9	1.0	0.8
Cardiovascular Disease	0.4	1.2	3.2	-0.8	-0.9	-0.8	-0.8	1.1	-0.8	-0.9	-0.8	-1.7	-1.5	-0.7	-1.8
Relative age of first facial hair	0.4	0.9	2.8	-1.0	-1.1	-1.0	-1.0	0.5	-1.0	-0.9	-1.0	-0.4	-0.7	-0.6	-1.7
Diabetes (mother)	0.4	0.5	1.9	-0.6	-0.5	-0.6	-0.6	-1.4	-0.6	-0.6	-0.6	-0.4	-0.8	-0.1	-0.7
Pack years adult smoking proportion	0.4	0.6	3.6	-0.6	-0.5	-0.6	-0.6	0.9	-0.6	-0.6	-0.6	-1.9	-0.6	-0.4	-0.1
Average weekly fortified wine intake	0.4	0.4	3.9	0.1	0.1	0.1	0.1	-2.0	0.1	0.2	0.1	0.2	0.5	0.1	1.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.1	1.0	1.0	1.0	1.0	-0.4	1.0	1.1	1.0	0.7	0.9	0.8	0.9
High blood pressure (mother)	0.4	0.6	2.9	0.6	0.5	0.6	0.5	1.7	0.5	0.5	0.6	1.1	-0.1	0.6	-0.3
Past tobacco smoking	0.4	0.8	1.7	0.7	0.9	0.7	0.8	-0.8	0.8	0.8	0.7	1.0	1.0	1.0	1.3
Loud music exposure frequency	0.4	0.4	1.1	0.6	0.8	0.6	0.7	-0.5	0.7	0.7	0.6	0.2	1.0	0.2	0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	-0.7	-0.7	-0.7	-0.7	-0.0	-0.7	-0.6	-0.7	-0.4	-0.3	-1.0	-0.9
Medication: Allopurinol	0.4	0.6	0.9	-0.9	-0.9	-0.9	-0.9	-0.2	-0.9	-0.9	-0.9	-0.3	-0.9	-0.6	-0.0
Number of full sisters	0.4	0.5	1.9	0.7	0.7	0.7	0.7	0.5	0.7	0.7	0.7	1.4	0.3	0.6	0.4
Hypertension (Self-reported)	0.4	1.1	1.9	-1.0	-1.0	-1.0	-1.0	0.0	-1.0	-1.1	-1.0	-1.4	-1.2	-0.9	-1.3
Back pain experienced in last month	0.4	0.6	1.8	-0.7	-0.8	-0.6	-0.7	-0.1	-0.7	-0.8	-0.7	-0.4	-1.3	-1.1	-1.0
Illnesses of father: None of the above (group 1)	0.4	0.4	0.7	-0.8	-0.7	-0.8	-0.8	-0.3	-0.8	-0.7	-0.8	0.6	-0.4	-0.7	-0.1
Miserableness	0.4	0.8	2.0	-0.8	-0.7	-0.7	-0.7	0.5	-0.7	-0.9	-0.8	-0.7	-1.3	-0.9	-1.4
Ever taken oral contraceptive pill	0.4	0.5	0.8	-0.8	-0.8	-0.8	-0.8	-0.5	-0.8	-0.7	-0.8	-0.0	-0.5	-0.9	-0.9
Myopia	0.4	0.6	2.2	-0.7	-0.7	-0.8	-0.7	-1.5	-0.7	-0.7	-0.7	-0.2	-0.7	-0.6	-0.3
Supplements: Calcium	0.4	0.4	3.7	-0.1	-0.1	-0.1	-0.1	-0.3	-0.1	0.1	-0.1	-0.7	0.8	0.3	1.9
Alcohol drinker status: Previous	0.4	0.4	0.6	-0.8	-0.7	-0.8	-0.8	-0.5	-0.8	-0.6	-0.8	-0.6	-0.0	-0.7	-0.3
Bipolar Disorder (2018)	0.3	0.4	1.7	-0.5	-0.4	-0.5	-0.5	-1.3	-0.5	-0.4	-0.5	-1.0	-0.0	-0.7	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.3	0.8	0.9	0.8	0.8	0.0	0.8	0.8	0.8	0.6	0.9	1.0	1.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	0.6	0.6	0.6	0.6	0.4	0.6	0.6	0.6	1.1	0.8	0.4	-0.2
Bipolar Disorder (2011)	0.3	0.3	1.9	0.3	0.2	0.0	0.3	-0.7	0.3	0.2	0.3	-0.5	1.4	-0.1	0.6
Neuroticism (2016)	0.3	0.4	0.9	0.7	0.9	0.6	0.7	1.0	0.7	0.5	0.7	0.6	0.6	0.4	-0.2
Rheumatoid Arthritis	0.3	0.4	1.6	-0.6	-0.6	-0.6	-0.6	-1.3	-0.6	-0.6	-0.6	-0.0	-1.1	-0.6	0.1
Blood Eosinophil Count	0.3	2.5	4.3	1.6	1.7	1.6	1.6	0.9	1.6	1.6	1.6	1.1	2.1	1.8	1.7
Hypothyroidism (self reported)	0.3	0.6	1.7	0.7	0.6	0.7	0.6	0.6	0.6	0.8	0.7	1.3	1.2	0.6	0.9
Hair Pigment	0.3	8.9	11.0	-3.3	-3.2	-3.3	-3.3	-2.0	-3.3	-3.3	-3.3	-2.8	-3.3	-2.3	-1.8
Hand grip strength (left)	0.3	0.7	3.2	-0.7	-0.7	-0.7	-0.7	-0.2	-0.7	-0.7	-0.7	-0.6	-0.9	-0.2	-1.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	0.6	0.5	0.6	0.6	1.1	0.6	0.6	0.6	-0.3	0.6	0.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	-0.6	-0.5	-0.6	-0.6	-0.0	-0.6	-0.6	-0.6	-0.8	-1.0	-0.3	-0.1
High blood pressure	0.3	0.9	2.6	-0.8	-0.8	-0.8	-0.8	0.6	-0.8	-0.9	-0.8	-1.0	-1.1	-0.7	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-0.5	-0.8	-0.5	-0.6	0.9	-0.5	-0.6	-0.5	-0.6	-0.7	-0.8	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.5	0.5	0.5	0.5	0.6	0.5	0.5	0.5	0.6	0.5	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	0.8	-0.9	-0.8	-0.9	-0.9	-0.9	-0.9	-0.8	-0.9	-0.3	-0.0	-0.9	-0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.0	-0.5	-0.5	-0.4	-0.5	-0.5	-0.5	-0.4	-0.5	-0.8	-0.1	-1.0	-0.3
Allergy	0.3	0.6	0.9	-0.9	-0.9	-0.9	-0.9	-0.1	-0.9	-0.8	-0.9	-0.2	-0.3	-1.0	-0.8
Diabetes (self-reported)	0.3	0.5	0.9	-0.7	-0.9	-0.8	-0.7	-0.5	-0.7	-0.8	-0.7	-0.1	-0.9	-0.8	-0.0
Number of live births	0.3	0.5	3.2	0.3	0.3	0.3	0.3	0.4	0.3	0.4	0.3	-0.4	1.0	0.6	1.8
Pulse rate	0.3	0.6	0.7	0.8	0.7	0.8	0.8	0.1	0.8	0.8	0.8	0.6	0.7	0.8	0.6
Noisy workplace	0.3	0.3	0.8	-0.6	-0.7	-0.6	-0.6	-0.6	-0.6	-0.5	-0.6	-0.6	-0.1	-0.9	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.3	-0.5	-0.3	-0.4	-0.4	-1.1	-0.4	-0.5	-0.5	-0.2	-0.7	-0.5	-1.1
Mouth/teeth dental problems: Dentures	0.3	0.6	1.2	-0.8	-0.9	-0.8	-0.8	-0.4	-0.8	-0.8	-0.8	-1.1	-0.8	-0.7	-0.3
Medication: Cholesterol lowering	0.3	0.4	2.2	0.5	0.4	0.5	0.5	1.5	0.5	0.4	0.5	0.1	-0.2	0.7	0.6
Prospective memory result	0.3	0.3	2.7	0.0	-0.0	0.0	0.0	1.7	0.0	0.1	0.0	1.0	0.1	-0.3	-0.1
Birth weight of first child	0.3	0.5	0.8	-0.9	-0.8	-0.8	-0.9	0.7	-0.9	-0.7	-0.9	0.1	-0.2	-0.9	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.9	0.6	0.5	0.6	0.6	-0.5	0.6	0.5	0.6	-0.7	-0.1	0.9	0.4
Medication: Omeprazole	0.3	0.4	0.8	-0.6	-0.8	-0.6	-0.6	-0.5	-0.6	-0.6	-0.6	-0.9	-0.8	-0.1	0.0
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.7	0.5	0.6	0.6	-0.1	0.7	0.7	0.7	0.7	0.6	0.2	0.3
Mean time to correctly identify matches	0.3	0.5	3.6	0.1	0.1	0.1	0.1	-1.9	0.1	0.2	0.1	1.0	0.3	-0.3	1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	-0.6	-0.7	-0.6	-0.6	-0.3	-0.6	-0.5	-0.6	-0.4	-0.3	-0.7	-0.8
Illnesses of father: Heart disease	0.3	0.4	1.1	0.7	0.6	0.7	0.7	1.0	0.7	0.6	0.7	0.1	0.3	0.8	0.0
Breast cancer (self-reported)	0.3	0.4	1.3	0.3	0.4	0.4	0.4	-0.2	0.4	0.6	0.3	1.0	1.1	0.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	0.8	0.7	0.8	0.8	1.1	0.8	0.8	0.8	0.7	0.9	0.8	0.5
Medication: Paracetamol	0.3	0.5	0.9	-0.8	-0.9	-0.8	-0.8	-0.1	-0.8	-0.8	-0.8	-0.2	-0.6	-0.6	-0.1
Medication: Lisinopril	0.3	0.4	1.2	-0.6	-0.7	-0.6	-0.6	-0.4	-0.6	-0.7	-0.6	-0.2	-1.1	-0.5	-0.9
Ever smoked	0.3	0.6	1.5	-0.6	-0.7	-0.6	-0.6	-0.1	-0.6	-0.7	-0.6	-0.9	-1.0	-1.0	-1.2
Irritability	0.3	0.5	1.2	-0.7	-0.8	-0.7	-0.7	0.0	-0.7	-0.8	-0.7	0.5	-1.1	-0.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	-0.6	-0.8	-0.6	-0.7	-0.4	-0.6	-0.7	-0.6	-0.4	-1.0	0.0	-0.3
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.5	-0.7	-0.6	-0.8	-0.7	0.5	-0.7	-0.7	-0.7	-0.5	-0.3	-0.7	-1.2
Major Depression (MDD)	0.2	0.2	0.5	-0.4	-0.4	-0.4	-0.4	-0.7	-0.4	-0.4	-0.4	-0.5	-0.3	-0.7	-0.5
Reaction Time	0.2	0.5	2.3	0.3	0.3	0.3	0.3	-1.5	0.3	0.4	0.3	1.1	0.4	-0.0	1.0
Coronary Artery Disease (CAD)	0.2	0.2	1.0	0.1	-0.0	0.1	0.1	-1.0	0.1	0.2	0.1	-0.5	0.3	-0.2	0.8
HbA1C	0.2	0.2	0.8	0.5	0.5	0.2	0.5	0.6	0.5	0.2	0.5	-0.1	-0.2	0.6	-0.9
Lupus	0.2	0.3	1.5	0.2	0.2	0.2	0.2	0.7	0.2	0.1	0.2	-1.2	-0.4	0.8	-0.3
Blood White Count	0.2	1.4	2.5	-1.1	-1.3	-1.1	-1.2	1.0	-1.2	-1.2	-1.1	-1.6	-1.2	-0.6	-1.2
Chronotype (morning person)	0.2	0.5	1.2	-0.7	-0.7	-0.7	-0.7	-0.2	-0.7	-0.7	-0.7	-0.1	-1.1	-0.7	-1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	0.5	0.6	0.5	0.5	-0.1	0.5	0.4	0.5	0.8	0.3	-0.1	0.2
Hand grip strength (right)	0.2	0.5	3.5	-0.4	-0.5	-0.4	-0.4	0.3	-0.4	-0.5	-0.4	-0.4	-1.0	-0.0	-1.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.6	-0.4	-0.5	-0.4	-0.5	1.2	-0.4	-0.4	-0.4	0.4	-0.4	-0.1	0.0
Medication: Atenolol	0.2	0.2	0.4	0.6	0.5	0.6	0.6	0.1	0.6	0.5	0.6	-0.1	0.4	0.1	0.1
Medication: Levothyroxine sodium	0.2	0.4	0.6	-0.7	-0.8	-0.7	-0.7	0.7	-0.7	-0.7	-0.7	0.1	-0.0	-0.5	-0.1
Father’s age at death	0.2	0.3	0.8	-0.4	-0.5	-0.4	-0.4	-0.9	-0.4	-0.5	-0.4	-0.4	-0.6	-0.9	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.0	-0.6	-0.8	-0.6	-0.6	0.6	-0.6	-0.7	-0.6	-0.4	-1.0	-0.7	0.1
Happiness	0.2	0.2	0.4	0.5	0.5	0.6	0.5	0.4	0.5	0.6	0.5	0.0	0.5	0.2	0.2
Length of working week for main job	0.2	0.3	1.8	0.1	0.0	0.1	0.0	0.9	0.1	-0.0	0.1	0.4	-0.5	-0.2	-1.3
Peak expiratory flow (PEF)	0.2	0.5	1.8	0.6	0.6	0.6	0.6	1.3	0.6	0.6	0.6	0.5	0.7	0.7	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	2.1	0.1	0.1	0.1	0.1	1.5	0.1	0.1	0.1	0.3	0.0	0.7	0.5
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.5	-0.7	-0.6	-0.5	0.5	-0.5	-0.5	-0.5	-0.8	-0.7	-0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	0.4	0.5	0.5	0.4	-1.0	0.4	0.6	0.4	0.5	0.7	0.2	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.3	-0.3	-0.3	-0.3	-0.9	-0.3	-0.3	-0.3	-0.7	0.1	-0.6	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	-0.5	-0.5	-0.5	-0.5	-0.2	-0.5	-0.6	-0.5	-1.1	-0.9	-0.5	-0.4
Shortness of breath walking on level ground	0.2	0.2	1.0	-0.5	-0.6	-0.5	-0.5	0.1	-0.5	-0.4	-0.5	-0.1	-0.4	-1.0	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	0.5	0.4	0.5	0.5	0.1	0.5	0.5	0.5	0.9	-0.0	0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.4	-0.3	-0.4	-0.4	-0.2	-0.4	-0.5	-0.4	-0.8	-0.7	-0.3	-1.0
Medication: Gliclazide	0.2	0.2	0.6	-0.3	-0.5	-0.3	-0.3	0.1	-0.3	-0.3	-0.3	-0.7	-0.8	0.0	0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.8	-0.6	-0.7	-0.5	-0.6	0.2	-0.6	-0.5	-0.6	0.4	-0.3	-0.9	-0.8
Guilty feelings	0.2	0.2	0.9	0.4	0.4	0.4	0.4	0.6	0.4	0.5	0.4	0.2	0.9	0.0	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.4	0.5	0.4	0.4	0.8	0.4	0.3	0.4	-0.1	0.2	0.4	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.2	0.3	0.2	0.3	0.3	-0.8	0.3	0.2	0.3	0.6	0.0	0.3	1.1
Diastolic blood pressure, automated reading	0.2	0.6	1.9	-0.9	-0.7	-0.8	-0.8	0.0	-0.9	-0.8	-0.9	-0.4	-0.6	-0.4	-1.4
Unable to work because of sickness or disability	0.2	0.2	1.2	-0.0	-0.2	-0.0	-0.0	-0.6	-0.0	0.1	-0.0	-1.1	0.6	-0.4	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.5	-0.6	-0.6	-0.5	0.5	-0.5	-0.5	-0.5	-0.8	-0.6	-0.5	0.0
Depression (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.3	-0.2	-0.4	0.2	-0.5	-0.3	-0.5	-0.4	-0.6	-0.5	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.1	-0.6	-0.5	-0.6	-0.6	0.0	-0.6	-0.4	-0.6	-0.2	0.5	-0.4	-1.0
Age at First Birth	0.1	0.2	0.6	0.5	0.3	0.2	0.4	-0.2	0.4	0.2	0.4	0.6	-0.1	0.7	-0.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.7	-0.5	-0.4	-0.4	-0.4	-0.0	-0.4	-0.3	-0.4	0.5	0.2	-0.8	-0.0
HDL Cholesterol	0.1	0.1	0.4	0.2	0.3	0.2	0.2	-0.1	0.2	0.3	0.2	0.6	0.4	0.4	0.1
LDL Cholesterol	0.1	0.2	0.9	-0.3	-0.3	-0.4	-0.3	-1.0	-0.3	-0.4	-0.3	-0.7	0.4	-0.6	-0.1
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.1	0.1	0.1	0.1	-0.2	0.1	-0.0	0.1	0.3	0.0	0.7	-0.5
Blood Red Count	0.1	0.6	3.1	-0.4	-0.4	-0.4	-0.4	-1.8	-0.4	-0.4	-0.4	-1.5	-0.5	-0.9	-0.2
Waist Hip Ratio (WHR)	0.1	0.3	2.2	0.3	0.2	0.3	0.3	0.5	0.3	0.4	0.3	-0.3	0.9	0.1	1.5
Lung FVC	0.1	0.4	1.1	-0.6	-0.5	-0.6	-0.6	-0.6	-0.6	-0.5	-0.6	-0.6	-0.3	-0.5	-1.1
Tanning	0.1	0.8	1.6	-0.8	-0.9	-0.9	-0.8	-0.3	-0.8	-1.1	-0.8	-0.4	-1.3	-1.0	-0.9
Supplements: Zinc	0.1	0.1	0.8	0.0	-0.0	0.0	0.0	-0.5	0.0	0.1	0.0	0.9	0.1	0.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	-0.3	-0.4	-0.3	-0.3	-0.4	-0.3	-0.4	-0.3	-0.1	-0.8	-0.7	-0.0
Age when periods started (menarche)	0.1	0.3	2.2	0.0	-0.1	0.0	-0.0	-0.5	0.0	0.2	0.0	0.8	0.5	0.2	1.5
Multivitamins +/- minerals	0.1	0.2	0.5	0.2	0.2	0.3	0.2	0.6	0.2	0.3	0.2	0.6	0.3	0.5	0.7
Stomach or abdominal pain in last month	0.1	0.1	0.7	-0.2	-0.4	-0.2	-0.2	-0.4	-0.2	-0.2	-0.2	0.1	-0.5	0.0	-0.8
Number of incorrect matches in round	0.1	0.2	0.9	0.3	0.3	0.3	0.3	-0.1	0.3	0.4	0.3	0.6	0.6	0.1	1.0
Alcohol usually taken with meals	0.1	0.1	1.2	-0.0	-0.1	-0.0	-0.1	-0.4	-0.1	-0.0	-0.0	1.1	-0.4	-0.4	-0.1
Nervous feelings	0.1	0.1	0.8	0.3	0.2	0.3	0.3	0.9	0.3	0.3	0.3	0.0	-0.4	0.4	-0.1
Hearing difficulty/problems with background noise	0.1	0.2	1.0	0.4	0.2	0.4	0.3	0.5	0.3	0.5	0.4	0.3	1.0	0.2	-0.2
Had menopause	0.1	0.1	0.4	0.4	0.6	0.4	0.4	-0.2	0.4	0.4	0.4	-0.6	0.1	0.1	0.0
Forced vital capacity (FVC)	0.1	0.6	3.8	-0.5	-0.5	-0.5	-0.5	0.0	-0.5	-0.5	-0.5	-0.1	-0.9	-0.6	-1.9
Qualifications: None of the above	0.1	0.3	1.1	-0.3	-0.3	-0.2	-0.3	-1.1	-0.3	-0.3	-0.3	-0.9	-0.0	-0.9	-0.3
Medication: Simvastatin	0.1	0.2	1.2	0.4	0.2	0.3	0.3	1.1	0.4	0.2	0.4	0.1	-0.3	0.6	0.3
Falls in the last year	0.1	0.1	0.8	-0.2	-0.1	-0.2	-0.2	-0.6	-0.2	-0.1	-0.2	-0.9	0.4	-0.5	-0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.4	0.4	0.4	0.4	-0.7	0.4	0.4	0.4	-0.4	0.3	-0.0	0.3
Depression (self-reported)	0.1	0.1	0.2	0.3	0.3	0.3	0.3	0.2	0.3	0.3	0.3	0.1	0.3	0.5	0.2
Medication: Lansoprazole	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.4	0.3	-0.4	-0.4	-0.4	0.5	-0.2	-0.0	-0.4
Lung cancer (father)	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.3	0.3	-0.3	-0.2	-0.3	-0.6	0.2	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.8	-0.0	-0.0	-0.0	-0.0	0.9	-0.0	-0.0	-0.0	0.8	-0.0	0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	1.1	0.2	0.1	0.2	0.2	-0.1	0.2	0.2	0.2	-1.0	0.3	-0.1	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.3	0.2	0.3	0.3	0.3	0.3	0.3	0.3	0.1	0.3	-0.2	0.2
Medication: Paracetamol	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.3	0.1	-0.3	-0.3	-0.3	-0.1	-0.1	-0.3	0.4
Glaucoma (self-reported)	0.1	0.1	0.3	0.2	0.4	0.2	0.2	-0.3	0.2	0.2	0.2	-0.5	0.5	-0.1	-0.3
Gout (self-reported)	0.1	0.1	0.8	-0.0	0.0	-0.1	-0.0	0.9	-0.0	-0.1	-0.0	0.5	-0.2	0.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	0.1	0.1	0.1	0.1	0.7	0.1	0.2	0.1	0.9	0.6	-0.1	0.5
Medication: Amlodipine	0.1	0.1	1.1	0.1	0.0	0.1	0.1	0.2	0.1	0.1	0.1	-1.0	-0.0	0.3	0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	2.8	-0.5	-0.5	-0.5	-0.5	0.3	-0.5	-0.6	-0.5	0.2	-1.0	-0.5	-1.7
Number of children fathered	0.1	0.1	0.4	0.2	0.1	0.2	0.2	-0.6	0.2	0.2	0.2	-0.6	0.1	0.0	0.3
Health satisfaction	0.1	0.2	0.9	-0.0	-0.1	-0.0	-0.0	0.7	-0.0	-0.1	-0.0	-0.6	-0.6	-0.4	-0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.8	-0.2	-0.2	-0.2	-0.2	-0.9	-0.2	-0.1	-0.2	-0.3	0.1	-0.4	0.2
Medication: Blood pressure	0.1	0.1	0.5	-0.3	-0.3	-0.3	-0.3	0.7	-0.3	-0.4	-0.3	-0.2	-0.4	-0.2	0.2
Family relationship satisfaction	0.1	0.1	0.2	0.4	0.4	0.4	0.4	-0.1	0.4	0.5	0.4	0.1	0.2	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.8	-0.2	-0.2	-0.2	-0.2	-0.3	-0.2	-0.2	-0.2	0.1	-0.7	0.4	-0.9
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.2	-0.5	-0.5	-0.4	-0.5	-0.3	-0.5	-0.4	-0.5	0.4	-0.5	-0.3	-0.2
Mood swings	0.1	0.2	1.0	0.3	0.3	0.4	0.3	1.0	0.3	0.3	0.3	-0.5	-0.1	0.3	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.5	-0.5	-0.4	-0.5	0.4	-0.5	-0.4	-0.5	0.4	-0.0	-0.3	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.5	-0.4	-0.5	-0.5	0.1	-0.5	-0.4	-0.5	-0.1	-0.2	-0.1	0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.2	-0.2	-0.2	-0.2	0.4	-0.2	-0.3	-0.2	-0.7	-0.8	-0.3	-0.6
Mother’s age at death	0.1	0.1	0.6	0.1	0.3	0.2	0.2	0.4	0.1	0.2	0.1	0.8	0.5	0.7	0.2
Average weekly beer plus cider intake	0.1	0.1	0.5	-0.1	-0.0	-0.1	-0.1	0.3	-0.1	0.0	-0.1	-0.6	0.7	-0.1	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	1.0	-0.0	-0.0	-0.0	-0.0	-0.5	-0.0	-0.1	-0.0	-1.0	-0.1	-0.3	-0.1
Ever depressed for a whole week	0.1	0.1	0.5	0.3	0.3	0.3	0.3	0.7	0.3	0.3	0.3	-0.0	0.3	0.2	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	1.0	0.2	0.1	0.1	0.2	0.1	0.2	0.2	0.2	0.3	0.8	0.3	1.0
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.0	-0.0	-0.0	0.0	-0.3	0.0	-0.0	0.0	0.1	0.0	0.2	0.1
Blood Platelet Count	0.0	0.4	2.8	-0.3	-0.5	-0.3	-0.4	-1.1	-0.4	-0.4	-0.3	-1.7	-0.1	-0.5	-0.2
Systolic Blood Pressure	0.0	0.2	0.9	0.3	0.4	0.4	0.3	0.7	0.3	0.4	0.3	-0.3	-0.0	0.9	0.3
Systolic blood pressure, automated reading	0.0	0.0	0.2	-0.0	0.1	0.0	-0.0	-0.3	-0.0	0.0	-0.0	-0.4	-0.1	0.4	0.1
Townsend deprivation index at recruitment	0.0	0.1	0.6	-0.1	-0.0	-0.1	-0.1	0.7	-0.1	-0.1	-0.1	0.0	0.1	0.1	-0.2
Maternal smoking around birth	0.0	0.1	0.3	0.2	0.2	0.1	0.2	-0.1	0.2	0.2	0.2	0.0	0.2	-0.6	0.3
Relative age voice broke	0.0	0.1	0.3	-0.2	-0.3	-0.2	-0.2	-0.1	-0.2	-0.2	-0.2	0.3	-0.5	0.1	-0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.9	-0.1	-0.1	-0.0	-0.1	0.4	-0.1	-0.0	-0.1	0.4	-0.0	-0.2	-0.9
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.0	-0.1	0.1	0.0	0.4	0.0	0.1	0.0	0.2	0.3	0.3	0.1
Comparative body size at age 10	0.0	0.1	0.4	-0.2	-0.2	-0.3	-0.2	-0.5	-0.2	-0.3	-0.2	-0.7	-0.4	-0.4	-0.5
Overall health rating	0.0	0.1	0.5	-0.0	-0.1	-0.0	-0.0	0.6	-0.0	-0.1	-0.0	-0.7	-0.5	-0.1	0.3
Chest pain or discomfort	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	0.1	0.1	0.1	-0.2	-0.0	-0.1	-0.1
Leg pain on walking	0.0	0.0	0.2	-0.1	-0.1	-0.0	-0.1	0.3	-0.1	-0.1	-0.1	-0.5	-0.4	-0.4	-0.1
Supplements: Vitamin C	0.0	0.0	0.3	-0.1	-0.0	-0.1	-0.1	0.3	-0.1	-0.1	-0.1	0.1	-0.6	0.2	-0.1
Medication: Bendroflumethiazide	0.0	0.1	0.3	-0.2	-0.1	-0.2	-0.2	0.5	-0.2	-0.1	-0.2	-0.1	0.3	-0.5	0.1

Hub : Genes

BRK1

Models

Trait associations