Best TWAS P=1.9e-09 · Best GWAS P=1.05e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NT5DC2 | 0.11 | 0.05 | enet | 22 | 0.04 | 5.0e-06 | 3.4 | -5.1 | 3.0e-07 | -0.47 | 0.27 | 0.66 | FALSE |
2 | GTEx | Pancreas | RFT1 | 0.32 | 0.13 | lasso | 4 | 0.17 | 1.3e-07 | 5.7 | 5.2 | 1.9e-07 | 0.93 | 0.00 | 1.00 | FALSE |
3 | GTEx | Prostate | RFT1 | 0.39 | 0.18 | enet | 17 | 0.24 | 1.1e-06 | 3.6 | 5.7 | 1.4e-08 | 0.68 | 0.10 | 0.83 | FALSE |
4 | GTEx | Stomach | RFT1 | 0.23 | 0.03 | enet | 19 | 0.06 | 6.3e-04 | 3.6 | 5.6 | 1.8e-08 | 0.75 | 0.07 | 0.86 | FALSE |
5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RFT1 | 0.18 | 0.10 | lasso | 7 | 0.10 | 1.8e-08 | 5.2 | 5.4 | 7.8e-08 | 0.97 | 0.00 | 1.00 | TRUE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TMEM110 | 0.19 | 0.13 | blup | 59 | 0.13 | 4.2e-11 | 4.6 | 5.4 | 7.4e-08 | 0.84 | 0.06 | 0.94 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RFT1 | 0.10 | 0.08 | enet | 11 | 0.15 | 2.3e-29 | 5.0 | 5.4 | 5.7e-08 | 0.80 | 0.03 | 0.96 | TRUE |
8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RFT1 | 0.14 | 0.08 | enet | 12 | 0.15 | 5.5e-08 | 5.2 | 5.4 | 8.2e-08 | 0.78 | 0.01 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | RFT1 | 0.10 | 0.05 | enet | 12 | 0.05 | 1.0e-03 | 5.3 | 5.5 | 4.0e-08 | 0.87 | 0.01 | 0.93 | FALSE |
10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM110 | 0.27 | 0.10 | blup | 59 | 0.14 | 3.0e-15 | 4.5 | 5.2 | 2.4e-07 | 0.84 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RFT1 | 0.24 | 0.12 | lasso | 5 | 0.20 | 1.3e-11 | 5.0 | 5.2 | 1.7e-07 | 0.81 | 0.02 | 0.97 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NISCH | 0.06 | 0.05 | lasso | 4 | 0.04 | 7.5e-06 | 5.2 | 5.1 | 3.0e-07 | 0.54 | 0.00 | 1.00 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPCS1 | 0.15 | 0.03 | lasso | 3 | 0.04 | 4.3e-05 | 4.9 | 5.4 | 6.4e-08 | 0.58 | 0.00 | 0.78 | TRUE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM110 | 0.13 | 0.06 | blup | 59 | 0.08 | 3.3e-09 | 3.3 | 5.2 | 1.6e-07 | 0.67 | 0.70 | 0.25 | TRUE |
15 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RFT1 | 0.31 | 0.07 | blup | 45 | 0.19 | 1.8e-09 | 3.2 | 6.0 | 2.1e-09 | 0.86 | 0.02 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SFMBT1 | 0.17 | 0.08 | lasso | 2 | 0.06 | 5.5e-04 | 5.3 | 5.3 | 1.2e-07 | 0.97 | 0.01 | 0.94 | FALSE |
17 | The Cancer Genome Atlas | Lung Adenocarcinoma | RFT1 | 0.14 | 0.11 | blup | 45 | 0.11 | 1.9e-12 | 5.0 | 5.4 | 6.0e-08 | 0.92 | 0.01 | 0.99 | FALSE |
18 | The Cancer Genome Atlas | Lung Adenocarcinoma | SPCS1 | 0.11 | 0.00 | blup | 41 | 0.01 | 9.9e-03 | -3.6 | 5.9 | 3.5e-09 | 0.36 | 0.00 | 0.09 | TRUE |
19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RFT1 | 0.07 | 0.03 | enet | 7 | 0.06 | 1.2e-07 | 4.7 | 5.5 | 3.0e-08 | 0.75 | 0.02 | 0.98 | FALSE |
20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RFT1 | 0.21 | 0.10 | lasso | 6 | 0.23 | 1.9e-15 | 5.2 | 5.3 | 9.6e-08 | 0.82 | 0.01 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TMEM110 | 0.20 | 0.13 | blup | 59 | 0.15 | 3.0e-10 | 5.6 | 5.5 | 3.2e-08 | 0.82 | 0.00 | 1.00 | TRUE |
22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RFT1 | 0.18 | 0.09 | blup | 45 | 0.09 | 4.8e-10 | 5.2 | 5.2 | 1.7e-07 | 0.93 | 0.01 | 0.99 | TRUE |
23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM110 | 0.20 | 0.06 | blup | 59 | 0.10 | 1.2e-10 | 5.6 | 5.5 | 5.0e-08 | 0.83 | 0.00 | 1.00 | FALSE |
24 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RFT1 | 0.16 | 0.12 | enet | 16 | 0.14 | 1.7e-08 | 5.2 | 5.4 | 5.2e-08 | 0.90 | 0.01 | 0.99 | FALSE |
25 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TMEM110 | 0.12 | 0.07 | blup | 59 | 0.12 | 7.5e-08 | 5.4 | 5.3 | 1.4e-07 | 0.73 | 0.02 | 0.98 | FALSE |
26 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RFT1 | 0.29 | 0.04 | blup | 45 | 0.11 | 8.2e-04 | 5.0 | 5.8 | 7.8e-09 | 0.79 | 0.01 | 0.83 | FALSE |
27 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RFT1 | 0.13 | 0.05 | blup | 45 | 0.10 | 6.9e-08 | 5.3 | 6.0 | 2.8e-09 | 0.85 | 0.01 | 0.99 | FALSE |
28 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TMEM110 | 0.19 | 0.12 | blup | 59 | 0.13 | 1.6e-09 | 4.7 | 5.2 | 2.6e-07 | 0.79 | 0.14 | 0.85 | FALSE |
29 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RFT1 | 0.39 | 0.22 | lasso | 4 | 0.25 | 3.1e-09 | 5.0 | 5.3 | 1.3e-07 | 0.94 | 0.01 | 0.99 | FALSE |
30 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM110 | 0.20 | 0.01 | lasso | 2 | 0.09 | 3.2e-04 | 5.6 | 5.6 | 2.7e-08 | 0.97 | 0.00 | 0.90 | FALSE |
31 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RFT1 | 0.29 | 0.15 | blup | 45 | 0.15 | 6.5e-05 | 4.7 | 6.0 | 1.9e-09 | 0.85 | 0.01 | 0.85 | TRUE |