Best TWAS P=4.39e-20 · Best GWAS P=3.03e-20 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | GHR | 0.25 | 0.07 | bslmm | 382 | 0.13 | 2.6e-15 | -5.8 | 5.8 | 7.4e-09 | 0.20 | 0.17 | 0.83 | FALSE |
2 | GTEx | Adipose Subcutaneous | CCDC152 | 0.09 | 0.04 | lasso | 4 | 0.02 | 6.4e-03 | 9.0 | 9.0 | 1.7e-19 | 0.46 | 0.03 | 0.97 | FALSE |
3 | GTEx | Adipose Visceral Omentum | CCDC152 | 0.09 | 0.06 | lasso | 9 | 0.05 | 1.9e-03 | 8.9 | 8.3 | 7.1e-17 | 0.45 | 0.03 | 0.81 | FALSE |
4 | GTEx | Artery Aorta | CCDC152 | 0.31 | 0.24 | lasso | 8 | 0.24 | 2.5e-13 | 8.9 | 8.3 | 1.6e-16 | 0.45 | 0.03 | 0.97 | FALSE |
5 | GTEx | Artery Coronary | CCDC152 | 0.20 | 0.13 | lasso | 2 | 0.12 | 7.7e-05 | 8.9 | 8.9 | 5.0e-19 | 0.46 | 0.03 | 0.95 | FALSE |
6 | GTEx | Artery Tibial | CCDC152 | 0.22 | 0.17 | enet | 35 | 0.18 | 1.8e-14 | 8.9 | 7.1 | 1.5e-12 | 0.43 | 0.03 | 0.97 | FALSE |
7 | GTEx | Brain Frontal Cortex BA9 | GHR | 0.14 | 0.02 | lasso | 9 | 0.06 | 9.9e-03 | 7.4 | -6.2 | 5.3e-10 | -0.31 | 0.13 | 0.05 | TRUE |
8 | GTEx | Esophagus Muscularis | CCDC152 | 0.13 | 0.09 | lasso | 8 | 0.10 | 7.9e-07 | 8.0 | 7.8 | 4.8e-15 | 0.48 | 0.04 | 0.96 | TRUE |
9 | GTEx | Nerve Tibial | CCDC152 | 0.16 | 0.06 | enet | 25 | 0.06 | 2.9e-05 | 8.9 | 6.1 | 1.3e-09 | 0.19 | 0.05 | 0.95 | TRUE |
10 | GTEx | Stomach | SERBP1P6 | 0.12 | 0.03 | enet | 16 | 0.01 | 6.7e-02 | -4.0 | 6.7 | 1.7e-11 | 0.24 | 0.08 | 0.14 | TRUE |
11 | GTEx | Thyroid | GHR | 0.08 | 0.04 | enet | 25 | 0.04 | 2.5e-04 | 8.0 | 5.3 | 1.4e-07 | 0.33 | 0.06 | 0.57 | FALSE |
12 | GTEx | Thyroid | CCDC152 | 0.10 | 0.07 | lasso | 4 | 0.04 | 4.2e-04 | 8.9 | 8.9 | 4.2e-19 | 0.45 | 0.03 | 0.96 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | SEPP1 | 0.18 | 0.19 | lasso | 11 | 0.21 | 1.3e-26 | 8.6 | -9.0 | 1.6e-19 | -0.48 | 0.03 | 0.97 | FALSE |
14 | YFS | Blood | CCDC152 | 0.07 | 0.06 | enet | 16 | 0.06 | 2.0e-19 | 9.0 | 9.2 | 4.4e-20 | 0.47 | 0.02 | 0.98 | TRUE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEPP1 | 0.01 | 0.00 | enet | 7 | 0.01 | 1.5e-03 | 8.8 | -7.0 | 2.2e-12 | -0.39 | 0.01 | 0.70 | TRUE |
16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC152 | 0.06 | 0.06 | blup | 40 | 0.07 | 1.6e-08 | 8.5 | -8.9 | 4.2e-19 | -0.43 | 0.02 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC152 | 0.15 | 0.12 | lasso | 6 | 0.12 | 1.0e-12 | 8.8 | -8.8 | 1.7e-18 | -0.46 | 0.04 | 0.96 | TRUE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GHR | 0.12 | 0.11 | enet | 6 | 0.13 | 2.5e-13 | -7.5 | -8.3 | 1.5e-16 | -0.26 | 1.00 | 0.00 | FALSE |
19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEPP1 | 0.06 | 0.02 | blup | 38 | 0.04 | 5.2e-05 | 8.0 | -8.3 | 9.6e-17 | -0.40 | 0.05 | 0.93 | FALSE |