[Hub]/) : Traits : Arm fat percentage (left) :

chr14:102,544,860-104,892,153

Best TWAS P=7.9e-11 · Best GWAS P=5.87e-11 conditioned to 0.000103

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous KLC1 0.05 0.03 lasso 3 0.03 1.8e-03 4.4 5.9 3.5e-09 -0.02 0.10 0.67 FALSE
2 GTEx Adipose Subcutaneous APOPT1 0.06 0.02 lasso 5 0.02 8.2e-03 4.9 -5.4 8.2e-08 0.03 0.18 0.58 FALSE
3 GTEx Adipose Visceral Omentum KLC1 0.06 0.02 lasso 2 0.00 2.2e-01 -5.1 5.3 1.0e-07 0.00 0.09 0.45 FALSE
4 GTEx Adrenal Gland KLC1 0.15 0.03 lasso 3 0.06 4.6e-03 4.9 5.9 3.8e-09 -0.03 0.08 0.54 FALSE
5 GTEx Artery Aorta KLC1 0.10 0.14 lasso 3 0.14 6.1e-08 -5.0 5.5 3.6e-08 0.00 0.13 0.86 FALSE
6 GTEx Artery Tibial TRMT61A 0.07 0.07 lasso 3 0.06 2.4e-05 -5.4 -5.3 9.5e-08 0.03 0.04 0.95 FALSE
7 GTEx Brain Frontal Cortex BA9 APOPT1 0.17 0.07 lasso 3 0.08 4.6e-03 5.4 -6.1 1.3e-09 0.02 0.04 0.78 FALSE
8 GTEx Breast Mammary Tissue MARK3 0.12 0.11 lasso 2 0.08 3.9e-05 -5.2 -5.2 2.0e-07 0.02 0.06 0.90 FALSE
9 GTEx Breast Mammary Tissue KLC1 0.12 0.02 enet 26 0.07 2.9e-04 3.8 5.7 1.1e-08 0.00 0.34 0.61 FALSE
10 GTEx Cells Transformed fibroblasts KLC1 0.16 0.11 enet 17 0.10 3.1e-08 4.9 5.3 1.2e-07 -0.03 0.22 0.77 FALSE
11 GTEx Cells Transformed fibroblasts APOPT1 0.14 0.12 lasso 3 0.10 6.4e-08 -5.1 -5.5 4.3e-08 0.00 0.12 0.88 FALSE
12 GTEx Colon Transverse KLC1 0.16 0.01 lasso 7 0.00 1.9e-01 4.6 5.3 1.5e-07 -0.02 0.08 0.52 FALSE
13 GTEx Esophagus Muscularis KLC1 0.07 0.01 enet 10 0.02 2.6e-02 -5.1 5.1 2.7e-07 -0.04 0.09 0.57 FALSE
14 GTEx Lung MARK3 0.06 0.02 lasso 3 0.01 6.6e-02 -5.2 -5.3 9.0e-08 0.02 0.05 0.88 FALSE
15 GTEx Lung CKB 0.07 0.01 lasso 2 0.01 3.4e-02 -5.1 -5.6 1.7e-08 0.01 0.05 0.85 FALSE
16 GTEx Muscle Skeletal ZFYVE21 0.10 0.05 lasso 2 0.03 3.3e-04 -5.1 5.2 1.5e-07 -0.02 0.12 0.82 FALSE
17 GTEx Muscle Skeletal KLC1 0.11 0.07 lasso 7 0.08 3.3e-08 -5.0 5.5 3.4e-08 -0.02 0.13 0.87 FALSE
18 GTEx Muscle Skeletal APOPT1 0.14 0.21 enet 10 0.22 6.7e-21 -5.1 5.8 5.8e-09 -0.02 0.04 0.96 FALSE
19 GTEx Pituitary MARK3 0.21 0.27 enet 8 0.25 4.9e-07 -5.2 -5.5 4.8e-08 0.02 0.06 0.90 FALSE
20 GTEx Prostate MARK3 0.18 0.22 enet 11 0.20 8.0e-06 -5.2 -5.4 8.7e-08 0.03 0.06 0.88 FALSE
21 GTEx Skin Sun Exposed Lower leg MARK3 0.10 0.09 enet 13 0.08 7.5e-07 -5.3 -5.9 3.9e-09 0.02 0.06 0.94 FALSE
22 GTEx Spleen KLC1 0.15 0.05 lasso 3 0.03 6.4e-02 5.4 6.0 2.5e-09 -0.03 0.05 0.53 FALSE
23 GTEx Stomach MARK3 0.10 0.09 lasso 2 0.04 4.5e-03 -5.2 -5.3 1.2e-07 0.02 0.06 0.84 FALSE
24 GTEx Stomach TRMT61A 0.12 0.11 lasso 5 0.08 1.2e-04 -5.2 -5.2 1.9e-07 0.02 0.06 0.90 FALSE
25 GTEx Thyroid MARK3 0.38 0.48 lasso 4 0.48 2.8e-41 -5.2 -5.2 1.9e-07 0.02 0.08 0.92 FALSE
26 METSIM Adipose MARK3 0.03 0.02 lasso 6 0.03 6.3e-05 4.9 -6.0 1.9e-09 0.04 0.06 0.94 FALSE
27 METSIM Adipose TRAF3 0.04 0.02 enet 7 0.04 4.5e-06 5.2 5.5 3.1e-08 0.79 0.03 0.96 TRUE
28 The Cancer Genome Atlas Breast Invasive Carcinoma C14orf153 0.05 0.02 lasso 4 0.02 8.0e-05 -5.1 -5.5 3.2e-08 0.03 0.01 0.98 FALSE
29 The Cancer Genome Atlas Glioblastoma Multiforme C14orf153 0.14 0.01 blup 40 0.03 3.5e-02 -5.1 -6.1 1.3e-09 0.02 0.01 0.46 FALSE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MARK3 0.07 0.03 blup 64 0.06 5.5e-07 -4.1 -5.5 4.5e-08 0.03 0.04 0.95 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma C14orf153 0.04 0.01 blup 38 0.03 6.2e-04 4.4 -6.2 6.3e-10 0.03 0.03 0.68 FALSE
32 The Cancer Genome Atlas Lung Adenocarcinoma C14orf153 0.06 0.02 blup 38 0.04 2.4e-05 -5.1 -6.4 1.7e-10 0.03 0.03 0.88 FALSE
33 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CKB 0.03 0.00 blup 34 0.02 1.4e-03 4.9 -6.5 7.9e-11 0.03 0.02 0.66 TRUE
34 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma BAG5 0.08 0.09 lasso 2 0.08 3.7e-04 -5.2 -5.2 1.6e-07 0.02 0.01 0.90 FALSE
35 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C14orf153 0.11 0.11 lasso 3 0.10 1.1e-04 -5.4 -5.8 6.6e-09 0.03 0.01 0.96 FALSE
36 The Cancer Genome Atlas Prostate Adenocarcinoma C14orf153 0.09 0.08 blup 38 0.09 6.2e-10 -5.4 -6.3 2.2e-10 0.04 0.01 0.99 FALSE
37 The Cancer Genome Atlas Prostate Adenocarcinoma CKB 0.07 0.09 blup 32 0.10 1.1e-10 5.4 -6.1 9.5e-10 0.02 0.01 0.99 FALSE
38 The Cancer Genome Atlas Stomach Adenocarcinoma C14orf153 0.20 0.05 lasso 2 0.04 8.8e-04 5.4 -5.6 2.2e-08 0.02 0.01 0.85 FALSE
39 The Cancer Genome Atlas Thyroid Carcinoma KLC1 0.04 0.01 blup 82 0.03 5.4e-04 4.6 5.5 3.5e-08 -0.03 0.04 0.73 FALSE